LOCUS       NM_178466               1139 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens BPI fold containing family A member 3 (BPIFA3),
            transcript variant 1, mRNA.
ACCESSION   NM_178466 NM_001014978
VERSION     NM_178466.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1139)
  AUTHORS   Bingle,C.D., Seal,R.L. and Craven,C.J.
  TITLE     Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a
            subfamily of the BPI fold-containing superfamily
  JOURNAL   Biochem Soc Trans 39 (4), 977-983 (2011)
   PUBMED   21787333
REFERENCE   2  (bases 1 to 1139)
  AUTHORS   Bingle,C.D., LeClair,E.E., Havard,S., Bingle,L., Gillingham,P. and
            Craven,C.J.
  TITLE     Phylogenetic and evolutionary analysis of the PLUNC gene family
  JOURNAL   Protein Sci 13 (2), 422-430 (2004)
   PUBMED   14739326
REFERENCE   3  (bases 1 to 1139)
  AUTHORS   Bingle,C.D. and Craven,C.J.
  TITLE     PLUNC: a novel family of candidate host defence proteins expressed
            in the upper airways and nasopharynx
  JOURNAL   Hum Mol Genet 11 (8), 937-943 (2002)
   PUBMED   11971875
REFERENCE   4  (bases 1 to 1139)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY050111.1, BF966133.1, BC066354.1 and AI638623.1.
            
            On May 17, 2019 this sequence version replaced NM_178466.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.108696.1,
                                           SRR5189667.59577.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375454.8/ ENSP00000364603.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-512               HY050111.1         2-513
            513-606             BF966133.1         516-609
            607-1084            BC066354.1         499-976
            1085-1139           AI638623.1         15-69               c
FEATURES             Location/Qualifiers
     source          1..1139
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..1139
                     /gene="BPIFA3"
                     /gene_synonym="C20orf71; SPLUNC3"
                     /note="BPI fold containing family A member 3"
                     /db_xref="GeneID:128861"
                     /db_xref="HGNC:HGNC:16204"
     exon            1..312
                     /gene="BPIFA3"
                     /gene_synonym="C20orf71; SPLUNC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..950
                     /gene="BPIFA3"
                     /gene_synonym="C20orf71; SPLUNC3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; short long palate, lung and nasal epithelium
                     carcinoma associated 3"
                     /codon_start=1
                     /product="BPI fold-containing family A member 3 isoform 1
                     precursor"
                     /protein_id="NP_848561.2"
                     /db_xref="CCDS:CCDS13216.2"
                     /db_xref="GeneID:128861"
                     /db_xref="HGNC:HGNC:16204"
                     /translation="MMCPLWRLLIFLGLLALPLAPHKQPWPGLAQAHRDNKSTLARII
                     AQGLIKHNAESRIQNIHFGDRLNASAQVAPGLVGWLISGRKHQQQQESSINITNIQLD
                     CGGIQISFHKEWFSANISLEFDLELRPSFDNNIVKMCAHMSIVVEFWLEKDEFGRRDL
                     VIGKCDAEPSSVHVAILTEAIPPKMNQFLYNLKENLQKVLPHMVESQVCPLIGEILGQ
                     LDVKLLKSLIEQEAAHEPTHHETSQPSACQAGESPS"
     exon            313..463
                     /gene="BPIFA3"
                     /gene_synonym="C20orf71; SPLUNC3"
                     /inference="alignment:Splign:2.1.0"
     exon            464..571
                     /gene="BPIFA3"
                     /gene_synonym="C20orf71; SPLUNC3"
                     /inference="alignment:Splign:2.1.0"
     exon            572..721
                     /gene="BPIFA3"
                     /gene_synonym="C20orf71; SPLUNC3"
                     /inference="alignment:Splign:2.1.0"
     exon            722..806
                     /gene="BPIFA3"
                     /gene_synonym="C20orf71; SPLUNC3"
                     /inference="alignment:Splign:2.1.0"
     exon            807..870
                     /gene="BPIFA3"
                     /gene_synonym="C20orf71; SPLUNC3"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1139
                     /gene="BPIFA3"
                     /gene_synonym="C20orf71; SPLUNC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1068..1073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BPIFA3"
                     /gene_synonym="C20orf71; SPLUNC3"
                     /note="hexamer: AATAAA"
     polyA_site      1091
                     /gene="BPIFA3"
                     /gene_synonym="C20orf71; SPLUNC3"
                     /note="major polyA site"
ORIGIN      
        1 aatgtgagca agccctggtg gcagcgccag ggtccagtgc agcccctccc cacagcatgc
       61 tgggggctaa ttctgatgtc atctttctgc agaaaaccat tagaccatcc ctccagactg
      121 ccaccctcaa agccgtctgc ccaggcccca tctgacactc ttgacatctg caggtcccag
      181 accctatgat gtgtccactc tggaggctcc tcatcttcct cgggttgctg gccttgccct
      241 tggcaccaca caagcagcct tggcctggcc tggcccaagc ccacagagac aacaaatcca
      301 ccctggcaag aattattgct cagggcctca taaagcacaa cgcagaaagc cgaattcaga
      361 acatccactt tggggacaga ctgaatgcct cagcacaagt ggccccaggg ctggtgggct
      421 ggctaatcag cggcaggaaa caccagcagc agcaagagag cagcatcaac atcaccaaca
      481 ttcagctgga ctgtggtggg atccagatat cattccataa ggagtggttc tcggcaaata
      541 tctcacttga atttgacctt gaattgagac cgtccttcga taacaacatc gtaaagatgt
      601 gtgcacatat gagcatcgtt gtggagttct ggctggagaa agacgagttt ggccggaggg
      661 atctggtgat aggcaaatgc gatgcagagc ccagcagtgt ccatgtggcc atcctcactg
      721 aggctatccc accaaagatg aatcagtttc tctacaacct caaagagaat ctgcaaaaag
      781 ttctcccaca catggtagaa agtcaggtat gtcctctgat cggtgaaatc ctcgggcagc
      841 tggatgtgaa actgttgaaa agcctcatag aacaggaggc tgctcatgaa ccaacccacc
      901 atgaaaccag ccaaccctct gcatgccagg ctggagagtc ccccagctga cttctgctga
      961 tcagaaggaa agtccacatc ttgcaacctt aagtctccct tagagtgggg cttctgctac
     1021 cctaaaaact ttaccccagg ctctgtggac ataccatcct ctcctacaat aaactctagc
     1081 tctgaagggt gcacaggtcc ctcccacctg ggccctgggg tttaggtcta gaagtcaga
//
