LOCUS       NM_080574               1042 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens BPI fold containing family A member 2 (BPIFA2),
            transcript variant 1, mRNA.
ACCESSION   NM_080574 XM_114180
VERSION     NM_080574.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1042)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1042)
  AUTHORS   Kota,S.K., Pernicone,E., Leaf,D.E., Stillman,I.E., Waikar,S.S. and
            Kota,S.B.
  TITLE     BPI Fold-Containing Family A Member 2/Parotid Secretory Protein Is
            an Early Biomarker of AKI
  JOURNAL   J Am Soc Nephrol 28 (12), 3473-3478 (2017)
   PUBMED   28775000
REFERENCE   3  (bases 1 to 1042)
  AUTHORS   Prokopovic,V., Popovic,M., Andjelkovic,U., Marsavelski,A.,
            Raskovic,B., Gavrovic-Jankulovic,M. and Polovic,N.
  TITLE     Isolation, biochemical characterization and anti-bacterial activity
            of BPIFA2 protein
  JOURNAL   Arch Oral Biol 59 (3), 302-309 (2014)
   PUBMED   24581853
REFERENCE   4  (bases 1 to 1042)
  AUTHORS   Zeng,Z., Feingold,E., Wang,X., Weeks,D.E., Lee,M., Cuenco,D.T.,
            Broffitt,B., Weyant,R.J., Crout,R., McNeil,D.W., Levy,S.M.,
            Marazita,M.L. and Shaffer,J.R.
  TITLE     Genome-wide association study of primary dentition pit-and-fissure
            and smooth surface caries
  JOURNAL   Caries Res 48 (4), 330-338 (2014)
   PUBMED   24556642
REFERENCE   5  (bases 1 to 1042)
  AUTHORS   Abdolhosseini,M., Sotsky,J.B., Shelar,A.P., Joyce,P.B. and
            Gorr,S.U.
  TITLE     Human parotid secretory protein is a lipopolysaccharide-binding
            protein: identification of an anti-inflammatory peptide domain
  JOURNAL   Mol Cell Biochem 359 (1-2), 1-8 (2012)
   PUBMED   21833535
  REMARK    GeneRIF: PSP is a lipopolysaccharide-binding protein that is
            functionally related to lipopolysaccharide-binding protein, as
            suggested by their predicted structural similarities
REFERENCE   6  (bases 1 to 1042)
  AUTHORS   Bingle,L., Barnes,F.A., Lunn,H., Musa,M., Webster,S., Douglas,C.W.,
            Cross,S.S., High,A.S. and Bingle,C.D.
  TITLE     Characterisation and expression of SPLUNC2, the human orthologue of
            rodent parotid secretory protein
  JOURNAL   Histochem Cell Biol 132 (3), 339-349 (2009)
   PUBMED   19499239
  REMARK    GeneRIF: multiple SPLUNC2 isoforms are found in the oral cavity and
            suggest that these proteins may be differentially regulated in
            distinct tissues where they may function in the innate immune
            response.
REFERENCE   7  (bases 1 to 1042)
  AUTHORS   Ramachandran,P., Boontheung,P., Xie,Y., Sondej,M., Wong,D.T. and
            Loo,J.A.
  TITLE     Identification of N-linked glycoproteins in human saliva by
            glycoprotein capture and mass spectrometry
  JOURNAL   J Proteome Res 5 (6), 1493-1503 (2006)
   PUBMED   16740002
REFERENCE   8  (bases 1 to 1042)
  AUTHORS   Bingle,C.D., LeClair,E.E., Havard,S., Bingle,L., Gillingham,P. and
            Craven,C.J.
  TITLE     Phylogenetic and evolutionary analysis of the PLUNC gene family
  JOURNAL   Protein Sci 13 (2), 422-430 (2004)
   PUBMED   14739326
REFERENCE   9  (bases 1 to 1042)
  AUTHORS   Bingle,C.D. and Craven,C.J.
  TITLE     PLUNC: a novel family of candidate host defence proteins expressed
            in the upper airways and nasopharynx
  JOURNAL   Hum Mol Genet 11 (8), 937-943 (2002)
   PUBMED   11971875
REFERENCE   10 (bases 1 to 1042)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC065726.1.
            
            On Nov 23, 2018 this sequence version replaced NM_080574.3.
            
            Summary: This gene encodes a member of the palate, lung and nasal
            epithelium clone (Plunc) family of proteins. Members of this family
            have been proposed to play a role in the local antibacterial
            response in nose, mouth and upper respiratory pathways. The encoded
            soluble salivary protein binds bacterial lipopolysaccharide (LPS)
            and inhibits bacterial growth. This gene is present in a gene
            cluster on chromosome 20. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065726.1, AK291854.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354932.6/ ENSP00000347012.5
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1042              BC065726.1         10-1051
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..1042
                     /gene="BPIFA2"
                     /gene_synonym="bA49G10.1; C20orf70; PSP; SPLUNC2"
                     /note="BPI fold containing family A member 2"
                     /db_xref="GeneID:140683"
                     /db_xref="HGNC:HGNC:16203"
     exon            1..51
                     /gene="BPIFA2"
                     /gene_synonym="bA49G10.1; C20orf70; PSP; SPLUNC2"
                     /inference="alignment:Splign:2.1.0"
     exon            52..223
                     /gene="BPIFA2"
                     /gene_synonym="bA49G10.1; C20orf70; PSP; SPLUNC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..816
                     /gene="BPIFA2"
                     /gene_synonym="bA49G10.1; C20orf70; PSP; SPLUNC2"
                     /note="short palate, lung and nasal epithelium
                     carcinoma-associated protein 2; parotid secretory protein"
                     /codon_start=1
                     /product="BPI fold-containing family A member 2 precursor"
                     /protein_id="NP_542141.1"
                     /db_xref="CCDS:CCDS13214.1"
                     /db_xref="GeneID:140683"
                     /db_xref="HGNC:HGNC:16203"
                     /translation="MLQLWKLVLLCGVLTGTSESLLDNLGNDLSNVVDKLEPVLHEGL
                     ETVDNTLKGILEKLKVDLGVLQKSSAWQLAKQKAQEAEKLLNNVISKLLPTNTDIFGL
                     KISNSLILDVKAEPIDDGKGLNLSFPVTANVTVAGPIIGQIINLKASLDLLTAVTIET
                     DPQTHQPVAVLGECASDPTSISLSLLDKHSQIINKFVNSVINTLKSTVSSLLQKEICP
                     LIRIFIHSLDVNVIQQVVDNPQHKTQLQTLI"
     exon            224..368
                     /gene="BPIFA2"
                     /gene_synonym="bA49G10.1; C20orf70; PSP; SPLUNC2"
                     /inference="alignment:Splign:2.1.0"
     exon            369..476
                     /gene="BPIFA2"
                     /gene_synonym="bA49G10.1; C20orf70; PSP; SPLUNC2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..629
                     /gene="BPIFA2"
                     /gene_synonym="bA49G10.1; C20orf70; PSP; SPLUNC2"
                     /inference="alignment:Splign:2.1.0"
     exon            630..711
                     /gene="BPIFA2"
                     /gene_synonym="bA49G10.1; C20orf70; PSP; SPLUNC2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..775
                     /gene="BPIFA2"
                     /gene_synonym="bA49G10.1; C20orf70; PSP; SPLUNC2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..853
                     /gene="BPIFA2"
                     /gene_synonym="bA49G10.1; C20orf70; PSP; SPLUNC2"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1042
                     /gene="BPIFA2"
                     /gene_synonym="bA49G10.1; C20orf70; PSP; SPLUNC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1023..1028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BPIFA2"
                     /gene_synonym="bA49G10.1; C20orf70; PSP; SPLUNC2"
                     /note="hexamer: AATAAA"
     polyA_site      1042
                     /gene="BPIFA2"
                     /gene_synonym="bA49G10.1; C20orf70; PSP; SPLUNC2"
                     /note="major polyA site"
ORIGIN      
        1 agcagactgt gcagtggggc aaggatttca tgagcatcct cctctaaacg cgtgtcaaga
       61 caaaagatgc ttcagctttg gaaacttgtt ctcctgtgcg gcgtgctcac tgggacctca
      121 gagtctcttc ttgacaatct tggcaatgac ctaagcaatg tcgtggataa gctggaacct
      181 gttcttcacg agggacttga gacagttgac aatactctta aaggcatcct tgagaaactg
      241 aaggtcgacc taggagtgct tcagaaatcc agtgcttggc aactggccaa gcagaaggcc
      301 caggaagctg agaaattgct gaacaatgtc atttctaagc tgcttccaac taacacggac
      361 atttttgggt tgaaaatcag caactccctc atcctggatg tcaaagctga accgatcgat
      421 gatggcaaag gccttaacct gagcttccct gtcaccgcga atgtcactgt ggccgggccc
      481 atcattggcc agattatcaa cctgaaagcc tccttggacc tcctgaccgc agtcacaatt
      541 gaaactgatc cccagacaca ccagcctgtt gccgtcctgg gagaatgcgc cagtgaccca
      601 accagcatct cactttcctt gctggacaaa cacagccaaa tcatcaacaa gttcgtgaat
      661 agcgtgatca acacgctgaa aagcactgta tcctccctgc tgcagaagga gatatgtcca
      721 ctgatccgca tcttcatcca ctccctggat gtgaatgtca ttcagcaggt cgtcgataat
      781 cctcagcaca aaacccagct gcaaaccctc atctgaagag gacgaatgag gaggaccact
      841 gtggtgcatg ctgattggtt cccagtggct tgccccaccc ccttatagca tctccctcca
      901 ggaagctgct gccaccacct aaccagcgtg aaagcctgag tcccaccaga aggaccttcc
      961 cagatacccc ttctcctcac agtcagaaca gcagcctcta cacatgttgt cctgcccctg
     1021 gcaataaagg cccatttctg ca
//
