LOCUS       NM_130852               1075 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens BPI fold containing family A member 1 (BPIFA1),
            transcript variant 2, mRNA.
ACCESSION   NM_130852
VERSION     NM_130852.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1075)
  AUTHORS   Goriounova,A.S., Flori Sassano,M., Wrennall,J.A. and Tarran,R.
  TITLE     ELD607 specifically traffics Orai1 to the lysosome leading to
            inhibition of store operated calcium entry
  JOURNAL   Cell Calcium 123, 102945 (2024)
   PUBMED   39191091
  REMARK    GeneRIF: ELD607 specifically traffics Orai1 to the lysosome leading
            to inhibition of store operated calcium entry.
REFERENCE   2  (bases 1 to 1075)
  AUTHORS   Iannuzo,N., Welfley,H., Li,N.C., Johnson,M.D.L., Rojas-Quintero,J.,
            Polverino,F., Guerra,S., Li,X., Cusanovich,D.A., Langlais,P.R. and
            Ledford,J.G.
  TITLE     CC16 drives VLA-2-dependent SPLUNC1 expression
  JOURNAL   Front Immunol 14, 1277582 (2023)
   PUBMED   38053993
  REMARK    GeneRIF: CC16 drives VLA-2-dependent SPLUNC1 expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1075)
  AUTHORS   Jakkampudi,T., Lin,Q., Mitra,S., Vijai,A., Qin,W., Kang,A.,
            Chen,J., Ryan,E., Wang,R., Gong,Y., Heinrich,F., Song,J., Di,Y.P.
            and Tristram-Nagle,S.
  TITLE     Lung SPLUNC1 Peptide Derivatives in the Lipid Membrane Headgroup
            Kill Gram-Negative Planktonic and Biofilm Bacteria
  JOURNAL   Biomacromolecules 24 (6), 2804-2815 (2023)
   PUBMED   37223955
  REMARK    GeneRIF: Lung SPLUNC1 Peptide Derivatives in the Lipid Membrane
            Headgroup Kill Gram-Negative Planktonic and Biofilm Bacteria.
            Erratum:[Biomacromolecules. 2024 May 13;25(5):3215. doi:
            10.1021/acs.biomac.4c00501. PMID: 38640499]
REFERENCE   4  (bases 1 to 1075)
  AUTHORS   Chen,D., Han,W., Wang,P. and Ma,H.
  TITLE     [Correlation between the mRNA levels of BCRP and LUNX genes and
            pathological types and stages of patients with non-small cell lung
            cancer]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 40 (2), 202-207 (2023)
   PUBMED   36709941
  REMARK    GeneRIF: [Correlation between the mRNA levels of BCRP and LUNX
            genes and pathological types and stages of patients with non-small
            cell lung cancer].
REFERENCE   5  (bases 1 to 1075)
  AUTHORS   Clifton,C., Niemeyer,B.F., Novak,R., Can,U.I., Hainline,K. and
            Benam,K.H.
  TITLE     BPIFA1 is a secreted biomarker of differentiating human airway
            epithelium
  JOURNAL   Front Cell Infect Microbiol 12, 1035566 (2022)
   PUBMED   36519134
  REMARK    GeneRIF: BPIFA1 is a secreted biomarker of differentiating human
            airway epithelium.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1075)
  AUTHORS   Di,Y.P.
  TITLE     Functional roles of SPLUNC1 in the innate immune response against
            Gram-negative bacteria
  JOURNAL   Biochem Soc Trans 39 (4), 1051-1055 (2011)
   PUBMED   21787346
  REMARK    GeneRIF: BPIFA1 protein displays bacteriocidal activity against
            Gram-negative bacteria.
            Review article
REFERENCE   7  (bases 1 to 1075)
  AUTHORS   Ghafouri,B., Stahlbom,B., Tagesson,C. and Lindahl,M.
  TITLE     Newly identified proteins in human nasal lavage fluid from
            non-smokers and smokers using two-dimensional gel electrophoresis
            and peptide mass fingerprinting
  JOURNAL   Proteomics 2 (1), 112-120 (2002)
   PUBMED   11788998
REFERENCE   8  (bases 1 to 1075)
  AUTHORS   Lindahl,M., Stahlbom,B. and Tagesson,C.
  TITLE     Identification of a new potential airway irritation marker, palate
            lung nasal epithelial clone protein, in human nasal lavage fluid
            with two-dimensional electrophoresis and matrix-assisted laser
            desorption/ionization-time of flight
  JOURNAL   Electrophoresis 22 (9), 1795-1800 (2001)
   PUBMED   11425234
REFERENCE   9  (bases 1 to 1075)
  AUTHORS   Iwao,K., Watanabe,T., Fujiwara,Y., Takami,K., Kodama,K.,
            Higashiyama,M., Yokouchi,H., Ozaki,K., Monden,M. and Tanigami,A.
  TITLE     Isolation of a novel human lung-specific gene, LUNX, a potential
            molecular marker for detection of micrometastasis in non-small-cell
            lung cancer
  JOURNAL   Int J Cancer 91 (4), 433-437 (2001)
   PUBMED   11251963
REFERENCE   10 (bases 1 to 1075)
  AUTHORS   Bingle,C.D. and Bingle,L.
  TITLE     Characterisation of the human plunc gene, a gene product with an
            upper airways and nasopharyngeal restricted expression pattern
  JOURNAL   Biochim Biophys Acta 1493 (3), 363-367 (2000)
   PUBMED   11018263
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF417257.1.
            
            On Nov 23, 2018 this sequence version replaced NM_130852.2.
            
            Summary: This gene is the human homolog of murine plunc, and like
            the mouse gene, is specifically expressed in the upper airways and
            nasopharyngeal regions. The encoded antimicrobial protein displays
            antibacterial activity against Gram-negative bacteria. It is
            thought to be involved in inflammatory responses to irritants in
            the upper airways and may also serve as a potential molecular
            marker for detection of micrometastasis in non-small-cell lung
            cancer. Multiple transcript variants resulting from alternative
            splicing in the 3' UTR have been detected, but the full-length
            nature of only three are known. [provided by RefSeq, Aug 2014].
            
            Transcript Variant: This variant (2) represents the longest
            transcript. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF417257.1, ERR279840.725.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000354297.9/
                                                  ENSP00000346251.4
            Protein has antimicrobial activity :: PMID: 21787346
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1075              AF417257.1         1-1075
FEATURES             Location/Qualifiers
     source          1..1075
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..1075
                     /gene="BPIFA1"
                     /gene_synonym="bA49G10.5; LUNX; NASG; PLUNC; SPLUNC1;
                     SPURT"
                     /note="BPI fold containing family A member 1"
                     /db_xref="GeneID:51297"
                     /db_xref="HGNC:HGNC:15749"
                     /db_xref="MIM:607412"
     exon            1..55
                     /gene="BPIFA1"
                     /gene_synonym="bA49G10.5; LUNX; NASG; PLUNC; SPLUNC1;
                     SPURT"
                     /inference="alignment:Splign:2.1.0"
     exon            56..230
                     /gene="BPIFA1"
                     /gene_synonym="bA49G10.5; LUNX; NASG; PLUNC; SPLUNC1;
                     SPURT"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..841
                     /gene="BPIFA1"
                     /gene_synonym="bA49G10.5; LUNX; NASG; PLUNC; SPLUNC1;
                     SPURT"
                     /note="secretory protein in upper respiratory tracts;
                     protein Plunc; ligand-binding protein RYA3; tracheal
                     epithelium enriched protein; nasopharyngeal
                     carcinoma-related protein; von Ebner protein Hl;
                     lung-specific protein X; palate lung and nasal epithelium
                     clone protein; palate, lung and nasal epithelium
                     associated; short PLUNC1"
                     /codon_start=1
                     /product="BPI fold-containing family A member 1 precursor"
                     /protein_id="NP_570913.1"
                     /db_xref="CCDS:CCDS13217.1"
                     /db_xref="GeneID:51297"
                     /db_xref="HGNC:HGNC:15749"
                     /db_xref="MIM:607412"
                     /translation="MFQTGGLIVFYGLLAQTMAQFGGLPVPLDQTLPLNVNPALPLSP
                     TGLAGSLTNALSNGLLSGGLLGILENLPLLDILKPGGGTSGGLLGGLLGKVTSVIPGL
                     NNIIDIKVTDPQLLELGLVQSPDGHRLYVTIPLGIKLQVNTPLVGASLLRLAVKLDIT
                     AEILAVRDKQERIHLVLGDCTHSPGSLQISLLDGLGPLPIQGLLDSLTGILNKVLPEL
                     VQGNVCPLVNEVLRGLDITLVHDIVNMLIHGLQFVIKV"
     exon            231..390
                     /gene="BPIFA1"
                     /gene_synonym="bA49G10.5; LUNX; NASG; PLUNC; SPLUNC1;
                     SPURT"
                     /inference="alignment:Splign:2.1.0"
     exon            391..498
                     /gene="BPIFA1"
                     /gene_synonym="bA49G10.5; LUNX; NASG; PLUNC; SPLUNC1;
                     SPURT"
                     /inference="alignment:Splign:2.1.0"
     exon            499..651
                     /gene="BPIFA1"
                     /gene_synonym="bA49G10.5; LUNX; NASG; PLUNC; SPLUNC1;
                     SPURT"
                     /inference="alignment:Splign:2.1.0"
     exon            652..736
                     /gene="BPIFA1"
                     /gene_synonym="bA49G10.5; LUNX; NASG; PLUNC; SPLUNC1;
                     SPURT"
                     /inference="alignment:Splign:2.1.0"
     exon            737..800
                     /gene="BPIFA1"
                     /gene_synonym="bA49G10.5; LUNX; NASG; PLUNC; SPLUNC1;
                     SPURT"
                     /inference="alignment:Splign:2.1.0"
     exon            801..875
                     /gene="BPIFA1"
                     /gene_synonym="bA49G10.5; LUNX; NASG; PLUNC; SPLUNC1;
                     SPURT"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1075
                     /gene="BPIFA1"
                     /gene_synonym="bA49G10.5; LUNX; NASG; PLUNC; SPLUNC1;
                     SPURT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1053..1058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BPIFA1"
                     /gene_synonym="bA49G10.5; LUNX; NASG; PLUNC; SPLUNC1;
                     SPURT"
                     /note="hexamer: AATAAA"
     polyA_site      1075
                     /gene="BPIFA1"
                     /gene_synonym="bA49G10.5; LUNX; NASG; PLUNC; SPLUNC1;
                     SPURT"
                     /note="major polyA site"
ORIGIN      
        1 gagtggggga gagagaggag accaggacag ctgctgagac ctctaagaag tccagatact
       61 aagagcaaag atgtttcaaa ctgggggcct cattgtcttc tacgggctgt tagcccagac
      121 catggcccag tttggaggcc tgcccgtgcc cctggaccag accctgccct tgaatgtgaa
      181 tccagccctg cccttgagtc ccacaggtct tgcaggaagc ttgacaaatg ccctcagcaa
      241 tggcctgctg tctgggggcc tgttgggcat tctggaaaac cttccgctcc tggacatcct
      301 gaagcctgga ggaggtactt ctggtggcct ccttggggga ctgcttggaa aagtgacgtc
      361 agtgattcct ggcctgaaca acatcattga cataaaggtc actgaccccc agctgctgga
      421 acttggcctt gtgcagagcc ctgatggcca ccgtctctat gtcaccatcc ctctcggcat
      481 aaagctccaa gtgaatacgc ccctggtcgg tgcaagtctg ttgaggctgg ctgtgaagct
      541 ggacatcact gcagaaatct tagctgtgag agataagcag gagaggatcc acctggtcct
      601 tggtgactgc acccattccc ctggaagcct gcaaatttct ctgcttgatg gacttggccc
      661 cctccccatt caaggtcttc tggacagcct cacagggatc ttgaataaag tcctgcctga
      721 gttggttcag ggcaacgtgt gccctctggt caatgaggtt ctcagaggct tggacatcac
      781 cctggtgcat gacattgtta acatgctgat ccacggacta cagtttgtca tcaaggtcta
      841 agccttccag gaaggggctg gcctctgctg agctgggtct tcccccaaca gaactatttc
      901 ttgctgctca atccatttcc tctggcccag cttcccagtg ctcacagatg gctggcccat
      961 gtgctggaag atgacacagt tgccttctct ccgaggaacc tgccccctct cctttcccac
     1021 caggcgtgtg taacatccca tgtgcctcac ctaataaaat ggctcttctt ctgca
//
