LOCUS       NM_017622               1836 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens BLOC-1 related complex subunit 6 (BORCS6), mRNA.
ACCESSION   NM_017622 NM_018628
VERSION     NM_017622.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1836)
  AUTHORS   Tunganuntarat,J., Kanjanasirirat,P., Khumpanied,T.,
            Benjaskulluecha,S., Wongprom,B., Palaga,T., Siregar,T.A.P.,
            Borwornpinyo,S., Chaiprasert,A., Palittapongarnpim,P. and
            Ponpuak,M.
  TITLE     BORC complex specific components and Kinesin-1 mediate autophagy
            evasion by the autophagy-resistant Mycobacterium tuberculosis
            Beijing strain
  JOURNAL   Sci Rep 13 (1), 1663 (2023)
   PUBMED   36717601
  REMARK    GeneRIF: BORC complex specific components and Kinesin-1 mediate
            autophagy evasion by the autophagy-resistant Mycobacterium
            tuberculosis Beijing strain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1836)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1836)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1836)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1836)
  AUTHORS   Yordanov,T.E., Hipolito,V.E.B., Liebscher,G., Vogel,G.F.,
            Stasyk,T., Herrmann,C., Geley,S., Teis,D., Botelho,R.J., Hess,M.W.
            and Huber,L.A.
  TITLE     Biogenesis of lysosome-related organelles complex-1 (BORC)
            regulates late endosomal/lysosomal size through PIKfyve-dependent
            phosphatidylinositol-3,5-bisphosphate
  JOURNAL   Traffic 20 (9), 674-696 (2019)
   PUBMED   31314175
REFERENCE   6  (bases 1 to 1836)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 1836)
  AUTHORS   Schweitzer,L.D., Comb,W.C., Bar-Peled,L. and Sabatini,D.M.
  TITLE     Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1
  JOURNAL   Cell Rep 12 (9), 1445-1455 (2015)
   PUBMED   26299971
REFERENCE   8  (bases 1 to 1836)
  AUTHORS   Pu,J., Schindler,C., Jia,R., Jarnik,M., Backlund,P. and
            Bonifacino,J.S.
  TITLE     BORC, a multisubunit complex that regulates lysosome positioning
  JOURNAL   Dev Cell 33 (2), 176-188 (2015)
   PUBMED   25898167
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA199264.1, DR006664.1, AI174760.1 and CA423621.1.
            
            On May 17, 2019 this sequence version replaced NM_017622.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR3476690.1008396.1,
                                        SRR3476690.95520.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389017.6/ ENSP00000373669.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-401               DA199264.1         67-467
            402-916             DR006664.1         87-601
            917-1248            AI174760.1         1-332               c
            1249-1836           CA423621.1         17-604              c
FEATURES             Location/Qualifiers
     source          1..1836
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1836
                     /gene="BORCS6"
                     /gene_synonym="C17orf59; PRO2472"
                     /note="BLOC-1 related complex subunit 6"
                     /db_xref="GeneID:54785"
                     /db_xref="HGNC:HGNC:25939"
                     /db_xref="MIM:616599"
     exon            1..1836
                     /gene="BORCS6"
                     /gene_synonym="C17orf59; PRO2472"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1114
                     /gene="BORCS6"
                     /gene_synonym="C17orf59; PRO2472"
                     /note="lyspersin; lysosome-dispersing protein"
                     /codon_start=1
                     /product="BLOC-1-related complex subunit 6"
                     /protein_id="NP_060092.2"
                     /db_xref="CCDS:CCDS11133.2"
                     /db_xref="GeneID:54785"
                     /db_xref="HGNC:HGNC:25939"
                     /db_xref="MIM:616599"
                     /translation="MESSRGRPGPETDLLAVAEHQALVFGGGPGRTSSEPPAGLRVSG
                     EEETENVGGANRHPRTSPKTSSCGVVHRPEREALENEPGPQGTLSGAGSRRGAPGAEH
                     EPSLSSRHKNPAPPEGKPSSGRDCRRGGPGGGMDVEQQEEEDNDEEAAAGSRAGRSFS
                     SRLQDSRSLDGLSEACGGAGSSGSAESGAGGGRRATISSPLELEGTVSRHGDLTHFVA
                     NNLQLKIRLSGAPPPPPSAPARPCPAPAPTPTPAIPPIDPEVLRDLERLSRELGGRVD
                     RLLRGLGGAVQELTALSVGCIQTYRDAVDSLGEAVDMSIKGMYTLLARCEELERALQP
                     VQGLARQVRDIRRTLEVLEALCK"
     regulatory      1815..1820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BORCS6"
                     /gene_synonym="C17orf59; PRO2472"
                     /note="hexamer: ATTAAA"
     polyA_site      1836
                     /gene="BORCS6"
                     /gene_synonym="C17orf59; PRO2472"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgaacc aattcctccg ttgcggcccc cacctgcagt atggagtcgt ctcgggggcg
       61 gcccgggccc gagacggacc ttctggctgt agcggaacat caggccctag tctttggcgg
      121 cgggccgggc cgaacgtcct ctgagccgcc cgcaggcctc cgggtgtccg gggaggaaga
      181 gaccgagaac gttgggggcg cgaaccgcca ccccaggacg tccccgaaga cgtcaagctg
      241 cggcgtcgtc caccggccgg aacgggaggc tctggagaac gagcccggcc ctcaagggac
      301 gctgtctggg gccgggagcc gcaggggggc gccgggtgca gagcacgaac cttccctgtc
      361 ctcccggcac aagaacccgg cgccgcccga gggcaagccc tcctccggga gggactgccg
      421 tcgaggggga ccaggcggcg ggatggatgt tgagcagcag gaggaggaag acaacgacga
      481 ggaggcggcc gcgggcagca gagccggccg ctcgttctcc agccgtcttc aggacagccg
      541 cagcctggac gggctgagcg aggcgtgcgg tggcgccggg tcctcaggga gtgccgagtc
      601 cggcgcgggc ggcggacgcc gcgccaccat ctccagtccc ctggagctcg aaggcacagt
      661 gagccgccac ggcgacctta cccactttgt cgccaacaac ctgcaactca agatccgtct
      721 gagcggcgcg cctccacccc cgccttctgc ccctgcgcgg ccctgcccag cgcctgcacc
      781 cacacccaca ccggccattc ccccaatcga ccccgaggtg ctgcgggatc tggagcggtt
      841 gagtcgggag ctgggaggcc gggtggaccg tctgcttcgc ggtctgggtg gcgcggtgca
      901 ggagctgacg gcgctgagcg tgggttgcat ccagacctac cgcgatgctg tggactcctt
      961 aggtgaagcc gtggacatga gcatcaaggg catgtacacc ctgctggcgc gctgcgagga
     1021 gctggagcgg gctctgcagc cggttcaggg gctggcgcgc caagtccggg atatccgacg
     1081 tactctggag gtgttggagg ccctgtgcaa gtgaccagga ggacaggaga ggccggtcct
     1141 ggccagggca gggcccagca ggaccctaag gactcttcag ggagtcctgg tgggaagtgc
     1201 ccactgaggg gaggcctgtg tgttggaggc tcttccagat gcgttcagct ggcccgtgcc
     1261 cactcgctgg gccttaggct ggtgtatgtg gggaagttct aacggctctc ctggtgggaa
     1321 gggatgttgc tctgcttgta ttcagttggc catctgtagc taccctgttc ttcccaactc
     1381 tcctccctag ctagagcacc agccctggga acacggggct ttaggtctgc ttgaaggtga
     1441 ggacgtgact cccacatgta atcaggagaa agggacagag gaagccccag cccccactgt
     1501 ggctatcctg actccagtgg ccacatctca ggtgccaggg gctgtgggag cttgtgccgt
     1561 ccttggccaa acaccccgca ggcaaagatg cacccctgct gatggagagc cttctgcttc
     1621 tgccctctgg ccctctacca taccacttcc ccagccagaa ccggcgtgca gctaggagga
     1681 atgggttgca cggcggaggg ggtgaggtgg gaggcgtctc actgctctca gggttcaggt
     1741 agaatgttgc tggttttgaa gctcacctgt tgtggagtgt tctaatcagt tttggctttc
     1801 tgagtttttg tggaattaaa gtgctgctgc tgcgaa
//
