LOCUS       NM_058169               6422 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens BLOC-1 related complex subunit 5 (BORCS5), transcript
            variant 1, mRNA.
ACCESSION   NM_058169
VERSION     NM_058169.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6422)
  AUTHORS   Tunganuntarat,J., Kanjanasirirat,P., Khumpanied,T.,
            Benjaskulluecha,S., Wongprom,B., Palaga,T., Siregar,T.A.P.,
            Borwornpinyo,S., Chaiprasert,A., Palittapongarnpim,P. and
            Ponpuak,M.
  TITLE     BORC complex specific components and Kinesin-1 mediate autophagy
            evasion by the autophagy-resistant Mycobacterium tuberculosis
            Beijing strain
  JOURNAL   Sci Rep 13 (1), 1663 (2023)
   PUBMED   36717601
  REMARK    GeneRIF: BORC complex specific components and Kinesin-1 mediate
            autophagy evasion by the autophagy-resistant Mycobacterium
            tuberculosis Beijing strain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6422)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 6422)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6422)
  AUTHORS   Dupain,C., Gracia,C., Harttrampf,A.C., Riviere,J., Geoerger,B. and
            Massaad-Massade,L.
  TITLE     Newly identified LMO3-BORCS5 fusion oncogene in Ewing sarcoma at
            relapse is a driver of tumor progression
  JOURNAL   Oncogene 38 (47), 7200-7215 (2019)
   PUBMED   31488873
  REMARK    GeneRIF: our results suggest that LMO3-BORCS5 fusion oncogene plays
            an essential role in tumorigenesis
REFERENCE   5  (bases 1 to 6422)
  AUTHORS   Yordanov,T.E., Hipolito,V.E.B., Liebscher,G., Vogel,G.F.,
            Stasyk,T., Herrmann,C., Geley,S., Teis,D., Botelho,R.J., Hess,M.W.
            and Huber,L.A.
  TITLE     Biogenesis of lysosome-related organelles complex-1 (BORC)
            regulates late endosomal/lysosomal size through PIKfyve-dependent
            phosphatidylinositol-3,5-bisphosphate
  JOURNAL   Traffic 20 (9), 674-696 (2019)
   PUBMED   31314175
REFERENCE   6  (bases 1 to 6422)
  AUTHORS   Huang,H., Shen,H., Wang,Y., Wang,X., Chen,Q., Wang,Y., Yan,H.,
            Liu,Z. and Shi,X.
  TITLE     LOH12CR1 is a Novel Tumor Suppressor Inhibiting Tumor Growth
            Through Deregulation of G1/S Checkpoint in Human Colorectal
            Carcinoma
  JOURNAL   Curr Mol Med 18 (1), 25-35 (2018)
   PUBMED   29879888
  REMARK    GeneRIF: The present results suggest that LOH12CR1 might function
            as a tumor suppressor. Thus, loss of function of LOH12CR1 might be
            a potential driver in the development of colorectal carcinoma.
REFERENCE   7  (bases 1 to 6422)
  AUTHORS   Pu,J., Schindler,C., Jia,R., Jarnik,M., Backlund,P. and
            Bonifacino,J.S.
  TITLE     BORC, a multisubunit complex that regulates lysosome positioning
  JOURNAL   Dev Cell 33 (2), 176-188 (2015)
   PUBMED   25898167
REFERENCE   8  (bases 1 to 6422)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   9  (bases 1 to 6422)
  AUTHORS   Montpetit,A., Larose,J., Boily,G., Langlois,S., Trudel,N. and
            Sinnett,D.
  TITLE     Mutational and expression analysis of the chromosome 12p candidate
            tumor suppressor genes in pre-B acute lymphoblastic leukemia
  JOURNAL   Leukemia 18 (9), 1499-1504 (2004)
   PUBMED   15284860
REFERENCE   10 (bases 1 to 6422)
  AUTHORS   Montpetit,A., Boily,G. and Sinnett,D.
  TITLE     A detailed transcriptional map of the chromosome 12p12 tumour
            suppressor locus
  JOURNAL   Eur J Hum Genet 10 (1), 62-71 (2002)
   PUBMED   11896457
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007621.34, AK075028.1, AC007619.23 and AW449789.1.
            
            On Nov 22, 2018 this sequence version replaced NM_058169.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.130625.1,
                                           SRR1803612.117148.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314565.9/ ENSP00000321546.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC007621.34        137430-137472
            44-969              AK075028.1         1-926
            970-1271            AC007619.23        67776-68077         c
            1272-2093           AK075028.1         1228-2049
            2094-6024           AC007619.23        63023-66953         c
            6025-6410           AW449789.1         17-402              c
            6411-6422           AC007619.23        62625-62636         c
FEATURES             Location/Qualifiers
     source          1..6422
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..6422
                     /gene="BORCS5"
                     /gene_synonym="LOH12CR1; LOH1CR12"
                     /note="BLOC-1 related complex subunit 5"
                     /db_xref="GeneID:118426"
                     /db_xref="HGNC:HGNC:17950"
                     /db_xref="MIM:616598"
     exon            1..432
                     /gene="BORCS5"
                     /gene_synonym="LOH12CR1; LOH1CR12"
                     /inference="alignment:Splign:2.1.0"
     CDS             375..965
                     /gene="BORCS5"
                     /gene_synonym="LOH12CR1; LOH1CR12"
                     /note="isoform 1 is encoded by transcript variant 1; loss
                     of heterozygosity 12 chromosomal region 1 protein; loss of
                     heterozygosity, 12, chromosomal region 1; myrlysin;
                     myristoylated lysosomal protein"
                     /codon_start=1
                     /product="BLOC-1-related complex subunit 5 isoform 1"
                     /protein_id="NP_477517.1"
                     /db_xref="CCDS:CCDS8649.1"
                     /db_xref="GeneID:118426"
                     /db_xref="HGNC:HGNC:17950"
                     /db_xref="MIM:616598"
                     /translation="MGSEQSSEAESRPNDLNSSVTPSPAKHRAKMDDIVVVAQGSQAS
                     RNVSNDPDVIKLQEIPTFQPLLKGLLSGQTSPTNAKLEKLDSQQVLQLCLRYQDHLHQ
                     CAEAVAFDQNALVKRIKEMDLSVETLFSFMQERQKRYAKYAEQIQKVNEMSAILRRIQ
                     MGIDQTVPLLDRLNSMLPEGERLEPFSMKPDRELRL"
     exon            433..576
                     /gene="BORCS5"
                     /gene_synonym="LOH12CR1; LOH1CR12"
                     /inference="alignment:Splign:2.1.0"
     exon            577..734
                     /gene="BORCS5"
                     /gene_synonym="LOH12CR1; LOH1CR12"
                     /inference="alignment:Splign:2.1.0"
     exon            735..6422
                     /gene="BORCS5"
                     /gene_synonym="LOH12CR1; LOH1CR12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1305..1310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BORCS5"
                     /gene_synonym="LOH12CR1; LOH1CR12"
                     /note="hexamer: AATAAA"
     polyA_site      1331
                     /gene="BORCS5"
                     /gene_synonym="LOH12CR1; LOH1CR12"
                     /note="major polyA site"
     regulatory      4580..4585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BORCS5"
                     /gene_synonym="LOH12CR1; LOH1CR12"
                     /note="hexamer: AGTAAA"
     polyA_site      4599
                     /gene="BORCS5"
                     /gene_synonym="LOH12CR1; LOH1CR12"
     regulatory      4861..4866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BORCS5"
                     /gene_synonym="LOH12CR1; LOH1CR12"
                     /note="hexamer: ATTAAA"
     polyA_site      4886
                     /gene="BORCS5"
                     /gene_synonym="LOH12CR1; LOH1CR12"
     regulatory      6391..6396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BORCS5"
                     /gene_synonym="LOH12CR1; LOH1CR12"
                     /note="hexamer: AATAAA"
     polyA_site      6422
                     /gene="BORCS5"
                     /gene_synonym="LOH12CR1; LOH1CR12"
ORIGIN      
        1 atctgcgtcc cggaaggagc gagcttgcgg agcgtgaacc agtgagtgaa agcggcgccg
       61 cccgccggcc gcaggtgcgg caaagccagt gtcatctgcc ggttctctta gggctcccgg
      121 aaagaaggag ggctagccgc gtgcgttcgc gccgcgcctc cttgcgtttc tgttccccaa
      181 atagggcctc tccttctccc gccgcccagg cccctgcgtg ggctggacgc gtcagcccca
      241 cacattagcc tcgctgcggc gcccagactc tgctttgcct ccccgtcccg gtccctggcc
      301 cctgccctgt cgcccgccgc cggagcggtg accgcccggc ccgccgttct tctgctgcca
      361 ccgctgtcgg caccatgggc agtgagcaga gctccgaggc cgagagccga cccaacgatc
      421 tgaactcctc agtgactcct tcaccagcca agcatagagc caagatggat gatattgtgg
      481 ttgtagctca gggctcccag gcctcacgga acgtcagcaa cgatcccgat gtcatcaagt
      541 tgcaagagat tccaaccttc cagccccttt tgaaagggct attgagtggc cagacttccc
      601 caacaaatgc caaattggag aaactggact ctcagcaggt gttgcagctc tgcctccgat
      661 atcaagatca cctgcatcag tgtgcagagg ccgttgcttt tgaccagaat gctttggtta
      721 aacgaatcaa agagatggat ctgtctgtag aaactctgtt cagcttcatg caggagcgcc
      781 agaaaagata cgccaagtat gccgagcaga tccagaaagt gaacgagatg tccgccatcc
      841 tccgccgcat acagatgggc atcgaccaga ctgtgcccct gctggacagg ctcaacagca
      901 tgctgcccga gggcgagcgg ctggagccct tcagcatgaa gcccgaccgc gagctcaggc
      961 tgtagctgct gcccggcctg cctggggctg ggagccccag acaccgacac cctgaggacg
     1021 tgtggagcta aggtcatatc atctgaccag gtctggaggc tggcgggagg ctccctgaaa
     1081 gtgggtgcga aggagtccgg ctggcatgaa aatctgactt tgcccagctc ttttccttga
     1141 tgcagtttcc cggtgtggaa ggaacctaac cagttctcgg tgataactga agctggaacg
     1201 tgtgaattat taggaattct ttgaagaact ctgcattgag aattattttt atttagtttt
     1261 tttttttttt taattgagag tatatagtcc agtccaggta ccggaataaa aatatggaga
     1321 caaggggaaa atattttacg aagctctgtg ttctcaacgc cctcatgaac ttttcagtag
     1381 gctgtctggt ttatgtgtgg tcaacttgaa aaactaattg aatctaggtc tctgtattgt
     1441 tcctgtttct accctgactg tttccgtcac accaagccct tatctggggc gcgtcttcct
     1501 gcccaggtgg aacactggca ttttgttgac tgtcaggtta ggtgtccctt agtcgtcatc
     1561 agaagctgaa gccttccttt ccacaccctc atcagattca tctccactga taaccggttt
     1621 ccttgatgca gacatagttt agctttcttt gactgcagag atgtctcatt ccacagacat
     1681 ttcttgaacc catttgatgt gtccaatatt gtgccaggga tacaaatatg gccgtatagc
     1741 ctcaggcctt catttctgaa aagaaaaaag ctcaaaaagc tgctgaattt ctctgggagt
     1801 ttaggaaagg aagttatttg agtaacaaca aaagtgctta gtgtcgtact ttacacatca
     1861 taggtgttct aatggaagca aggactggag aagcaaagag tggaatgtga ggagcagacc
     1921 taggcagaca ccttgagact aaaagtcaga gctgaaggga gtcgctgggg ccaggacggc
     1981 atgcaggcct gtaccctgtt ccctaagttc ctgcaagcgt cgggaggtgt gttttcagat
     2041 accagaaaga gccttcagta gattcacaag attaaaattg atgcgcttaa tttaatgtat
     2101 cttggctaaa cttgatctga ttctaatctt ggtttgagac agggtcttgt gctgttgctc
     2161 aggctggagt gcagtggcgc aatcatagca cactgactcc tcaaactccc gggctccggg
     2221 gatcctcacg cctcagactc ctgagtagct gggattacag gtgtgtgcca ccaaatccag
     2281 ctaattaaaa aaaattaatt aattttacat tttcaaattc aaaagaataa tacaatgaat
     2341 attcatattt ctttcaccta gattgacaaa aagtggtata tttaagacat caccatcatt
     2401 gtctttcttc tggagtatac agaacctggt tctgaacaca gggatatgtt tgtagcttcg
     2461 aggaatgaag ggctgtttac agagctacaa aaatagctta ggtgccatta tcctcactgc
     2521 acttaataca ggtgacacat gaaagcacag agtgggtggc agttcaagcc tgcgagggcc
     2581 gagcctttcc actgctgcag ctgttagtgg ctggcacagg gcaggatggc agacctagtg
     2641 cagcacaaac aaaccacgca gtcagccagc tctccagcca actgtgtcta cttctaaagt
     2701 agaagttaga caaaacatgg ggttcactta gactggggtc ctgagtaggt gataggctac
     2761 ttattactgg gtggaagcgg agaagtatgg cagaagaaca ataggcaaat tcaatactcc
     2821 cggaaagaat tctagttagt ttaatatttt gatggcatgt tgtggtttct gcagtgtcgt
     2881 gaacttggct aaactgaact gtgttcccag aattcccttc cttgtttgtt tctctggtga
     2941 gggttggcca cgagagagat ttgcatgagg tttggaagtg gaagtagagc aacagccatg
     3001 tgtattcact ggaagtggat gtaggtcagg ccctgttcca tcacgtgcac gttaccatgg
     3061 atctcctgca cttgtggtgt gggcagccgc tgggcccacg gctcctccca ctcccgcaga
     3121 actctgcctt tggcttttcc agaccctggg ccgggtatga gaaccagctt cttggtctgc
     3181 agccacaagg atgaaggttt ggggatgaga gaccagcacg ggctctgatg agagacaggt
     3241 gcaggtccca gcttgtggct tgcaggtctc agtcgtactt gctctccctc accatccttt
     3301 ccaaccgcct ggcctgtggt ctggtgaaga agaaacagcc gaaccgagac tttcaccagc
     3361 ccctctaatt gctcaaaccg ctttcacaat cctctctttc tacatcattc ctagtggttc
     3421 ttttctgatg gaacctctga ctggtaacat ggcattacca gtcctttccc tctcatgttt
     3481 tgctatttcc tgatggaacc tgggagtctg agtgatttgt atttcaagaa gcagttatgc
     3541 tggatctctt tgttggttaa taccccatga cctatctggc cgttatggga tatttcaggg
     3601 ataggagttg tgaaagagcc cttggctgga cgtttctagc cttaatcttt ggcaagccat
     3661 ttcatttccc tgagcctcag tttccgcctt cctacagcgt gagcaggtct gggtgggctc
     3721 tcaagcccct ttcagctcta agattccaag tctgtgattc cgatacatct tgactacaat
     3781 gagcgtgttt accttttgtc tctgagcagt ggccctgggt cttggtagtg actaaattcc
     3841 gagctcccaa ggtgcagctg cttttcttcc ttttaattat aaattagctg ttcattggct
     3901 gcttctttct agagcctgtt ttgcttatct tgcaatctgt tcatttctgt tgatgaacac
     3961 agtcaaatag gcctctatgt gcagtctcct ggtttccctg gtcaaagtgg aaggttggta
     4021 gaaactggcc ttcatgtctt tgtttccctc aaagttttat tcttagtaac gctatatatg
     4081 gttttataga ccacacatat atagtttcct gtgtcttaga tgataacatc cttaaaatat
     4141 gaaatatatt ttgaacctag atacctaccc agtattctct gcacagagta aacatttcat
     4201 taaatgagtt tcaaggactc cataccctga tataggagta cattcaagaa atgagtttag
     4261 gccgggcgcg gtggctcaca cctgtaatcc cagcactttg ggaggccgag acgagtggat
     4321 cacctgaggt caggagttcc agaccagcct gaccaacatg gtgaaacccc atctctacta
     4381 aaaaaaatac agaaattacc cgggcatggt ggctggtgcc tgtaatcccc gctacttggg
     4441 aggccaaggt gggagaatcg cttgaacctg ggaggcggag gttgcagtga gccaagttcg
     4501 tgccattgca ctctggcctg ggtaacaaga gtgaaactcc gtttagaaat gagtttagtc
     4561 tgggagaatc tgctttttga gtaaaaaagt ttgattttat gtatgtgtgc gtctgtatat
     4621 atgtttctgt atcctgagta tttctttgcg gcttcttcag ttatgaaaga ggttggtact
     4681 gttaccctta cgttataggt attacaaact cggttttaca aggttacata aactaatggc
     4741 cctggggcga atgacgtatg ccacttttgt gttgatttgt agaacttact tagctttggc
     4801 atttccccta gtaattccca aggcaaaacc aggaattgtc agagacgtga ccagacatgt
     4861 attaaaattc tagtgcaatt gggaaacttg gtcttcctga tttgtttata cttcagccaa
     4921 acccagatat atagtgctca gcagaaatta ttcaaaatgt tgatactcaa gattgaagga
     4981 tggattaggg agaaatgaaa acttttcttc ttgtggactt tttaggtatg aaatttaatc
     5041 acgagagtag ttttgctttt ctttccctga cctttcgctt cattcctttg ttaagaacta
     5101 tatagtgcct ctgaggaggt ggcattattg ttcactaact taccataaat caggggtctc
     5161 caaaccccag gccacagact ggtacccatc tgtggcgtgt gaggaagtgt gctgcacagc
     5221 aggaggtgag cggcggatga gcaggtgaag cttcacgtgt tgttgttgtt gtttattgag
     5281 atggagtctc gctctgttgc ccaggctgga gtgcagtggc acgatctcgg ctcactgcaa
     5341 cctccgcctc ccgggttcaa gcagttatac tgtctcagcc tcccgagtag ctgggactac
     5401 aggtgcccgc caccacaccc ggctaatttt ttatttttag tagagatggg gtttcaccat
     5461 gttggccagg caggtctcaa actcctgacc tcgtgatctg cccgacttgg cctcccaaag
     5521 tactgggatt acaggcgtga gccactgcac ctggccagct tcgtgtgtat ttatagctgc
     5581 tccccatcac tcacatcact gcctgagctc cacctcctgt cagaacagac ccagcattag
     5641 actcccctaa gagcgtgaac cctattgtga actgcgcacg tgaaggatct aggttttgcg
     5701 ctccttatga gaatctaatg cctgatgatc tgagatggaa cggtttcatc cagaaaccat
     5761 ccccctgctt ccctgtctgt agaaaaattg tcttctatga aatgggtccc tggtgccaga
     5821 aaggttgggg actgctgtca taaataacat tgaatttcat gtgggttttt tttttttgac
     5881 acaccaggca tgtctcttcc attcaaatgc tatggctaca gagggaaagg gtagccagat
     5941 aattatccac atgcttcaaa ccaaaaagat aaaaaagttg gcaactagat ctagttgcct
     6001 gccaggatga ccagcgttat gctggtgtgt gcgtgtccat gcctccggga tttttccagg
     6061 gttatcaatg tcagtgtaag atctgatgga atttaccgtt gactcaattt tcttcaccaa
     6121 tcaaggctca ttccttgagg catgagttat gcgaaaagct tttctgcacc aagtactttc
     6181 attctggtct ttggaattgt cataattctg acagagaaca cagaccatta ctgaatgctc
     6241 ttcaggttac cctatttgcc tgtcacattg cttctaccgg ccacatcctg catttcctgt
     6301 gggacagcat tttcaaacgg attctagtgt ttgagctgga accaaaagaa tgaaactgtt
     6361 tttacataag tgcatattgc tgtctctgca aataaagtac aacaatatga ctgacttgta
     6421 aa
//
