LOCUS       NM_024808               2760 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens BORA aurora kinase A activator (BORA), transcript
            variant 1, mRNA.
ACCESSION   NM_024808 XM_005266533
VERSION     NM_024808.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2760)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2760)
  AUTHORS   Tavernier,N., Sicheri,F. and Pintard,L.
  TITLE     Aurora A kinase activation: Different means to different ends
  JOURNAL   J Cell Biol 220 (9) (2021)
   PUBMED   34287649
  REMARK    GeneRIF: Aurora A kinase activation: Different means to different
            ends.
REFERENCE   3  (bases 1 to 2760)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2760)
  AUTHORS   Tavernier,N., Thomas,Y., Vigneron,S., Maisonneuve,P., Orlicky,S.,
            Mader,P., Regmi,S.G., Van Hove,L., Levinson,N.M.,
            Gasmi-Seabrook,G., Joly,N., Poteau,M., Velez-Aguilera,G., Gavet,O.,
            Castro,A., Dasso,M., Lorca,T., Sicheri,F. and Pintard,L.
  TITLE     Bora phosphorylation substitutes in trans for T-loop
            phosphorylation in Aurora A to promote mitotic entry
  JOURNAL   Nat Commun 12 (1), 1899 (2021)
   PUBMED   33771996
  REMARK    GeneRIF: Bora phosphorylation substitutes in trans for T-loop
            phosphorylation in Aurora A to promote mitotic entry.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2760)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   6  (bases 1 to 2760)
  AUTHORS   Chan,E.H., Santamaria,A., Sillje,H.H. and Nigg,E.A.
  TITLE     Plk1 regulates mitotic Aurora A function through betaTrCP-dependent
            degradation of hBora
  JOURNAL   Chromosoma 117 (5), 457-469 (2008)
   PUBMED   18521620
  REMARK    GeneRIF: Plk1 controls Aurora A localization and function by
            regulating cellular levels of hBora.
REFERENCE   7  (bases 1 to 2760)
  AUTHORS   Seki,A., Coppinger,J.A., Jang,C.Y., Yates,J.R. and Fang,G.
  TITLE     Bora and the kinase Aurora a cooperatively activate the kinase Plk1
            and control mitotic entry
  JOURNAL   Science 320 (5883), 1655-1658 (2008)
   PUBMED   18566290
  REMARK    GeneRIF: study reports that the synergistic action of Bora & the
            kinase Aurora A controls G2-M transition; Bora accumulates in G2
            phase & promotes Aur-A-mediated activation of Polo-like kinase 1,
            leading to activation of cyclin-dependent kinase 1 & mitotic entry
REFERENCE   8  (bases 1 to 2760)
  AUTHORS   Seki,A., Coppinger,J.A., Du,H., Jang,C.Y., Yates,J.R. 3rd and
            Fang,G.
  TITLE     Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic
            progression
  JOURNAL   J Cell Biol 181 (1), 65-78 (2008)
   PUBMED   18378770
  REMARK    GeneRIF: Study concludes that tight regulation of the Bora protein
            by its synthesis and degradation is critical for cell cycle
            progression.
REFERENCE   9  (bases 1 to 2760)
  AUTHORS   Hutterer,A., Berdnik,D., Wirtz-Peitz,F., Zigman,M., Schleiffer,A.
            and Knoblich,J.A.
  TITLE     Mitotic activation of the kinase Aurora-A requires its binding
            partner Bora
  JOURNAL   Dev Cell 11 (2), 147-157 (2006)
   PUBMED   16890155
REFERENCE   10 (bases 1 to 2760)
  AUTHORS   Rozenblum,E., Vahteristo,P., Sandberg,T., Bergthorsson,J.T.,
            Syrjakoski,K., Weaver,D., Haraldsson,K., Johannsdottir,H.K.,
            Vehmanen,P., Nigam,S., Golberger,N., Robbins,C., Pak,E., Dutra,A.,
            Gillander,E., Stephan,D.A., Bailey-Wilson,J., Juo,S.H., Kainu,T.,
            Arason,A., Barkardottir,R.B., Nevanlinna,H., Borg,A. and
            Kallioniemi,O.P.
  TITLE     A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer
            development: identification and characterization of candidate genes
  JOURNAL   Hum Genet 110 (2), 111-121 (2002)
   PUBMED   11935316
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM923278.1, BC056876.1, BC007119.1 and CF529405.1.
            
            On May 17, 2019 this sequence version replaced NM_024808.4.
            
            Summary: BORA is an activator of the protein kinase Aurora A
            (AURKA; MIM 603072), which is required for centrosome maturation,
            spindle assembly, and asymmetric protein localization during
            mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by
            OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.514499.1,
                                           SRR1803616.233412.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000390667.11/ ENSP00000375082.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-546               BM923278.1         184-729
            547-2013            BC056876.1         544-2010
            2014-2754           BC007119.1         972-1712
            2755-2760           CF529405.1         21-26               c
FEATURES             Location/Qualifiers
     source          1..2760
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q21.33"
     gene            1..2760
                     /gene="BORA"
                     /gene_synonym="C13orf34"
                     /note="BORA aurora kinase A activator"
                     /db_xref="GeneID:79866"
                     /db_xref="HGNC:HGNC:24724"
                     /db_xref="MIM:610510"
     exon            1..85
                     /gene="BORA"
                     /gene_synonym="C13orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            86..253
                     /gene="BORA"
                     /gene_synonym="C13orf34"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1780
                     /gene="BORA"
                     /gene_synonym="C13orf34"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein aurora borealis"
                     /codon_start=1
                     /product="protein aurora borealis isoform 1"
                     /protein_id="NP_079084.4"
                     /db_xref="CCDS:CCDS9446.3"
                     /db_xref="GeneID:79866"
                     /db_xref="HGNC:HGNC:24724"
                     /db_xref="MIM:610510"
                     /translation="MGDVKESKMQITPETPGRIPVLNPFESPSDYSNLHEQTLASPSV
                     FKSTKLPTPGKFRWSIDQLAVINPVEIDPEDIHRQALYLSHSRIDKDVEDKRQKAIEE
                     FFTKDVIVPSPWTDHEGKQLSQCHSSKCTNINSDSPVGKKLTIHSEKSDAACQTLLSL
                     PVDFNLENILGDYFRADEFADQSPGNLSSSSLRRKLFLDGNGSISDSLPSASPGSPHS
                     GVQTSLEMFYSIDLSPVKCRSPLQTPSSGQFSSSPIQASAKKYSLGSITSPSPISSPT
                     FSPIEFQIGETPLSEQRKFTVHSPDASSGTNSNGITNPCIRSPYIDGCSPIKNWSPMR
                     LQMYSGGTQYRTSVIQIPFTLETQGEDEEDKENIPSTDVSSPAMDAAGIHLRQFSNEA
                     STHGTHLVVTAMSVTQNQSSASEKELALLQDVEREKDNNTVDMVDPIEIADETTWIKE
                     PVDNGSLPMTDFVSGIAFSIENSHMCMSPLAESSVIPCESSNIQMDSGYNTQNCGSNI
                     MDTVGAESYCKESDAQTCEVESKSQAFNMKQDHTTQRCWMKTASPFQCSSP"
     exon            254..360
                     /gene="BORA"
                     /gene_synonym="C13orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            361..406
                     /gene="BORA"
                     /gene_synonym="C13orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            407..488
                     /gene="BORA"
                     /gene_synonym="C13orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            489..554
                     /gene="BORA"
                     /gene_synonym="C13orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            555..611
                     /gene="BORA"
                     /gene_synonym="C13orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            612..838
                     /gene="BORA"
                     /gene_synonym="C13orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            839..971
                     /gene="BORA"
                     /gene_synonym="C13orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1582
                     /gene="BORA"
                     /gene_synonym="C13orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1714
                     /gene="BORA"
                     /gene_synonym="C13orf34"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..2760
                     /gene="BORA"
                     /gene_synonym="C13orf34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1994..1999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BORA"
                     /gene_synonym="C13orf34"
                     /note="hexamer: AATAAA"
     polyA_site      2013
                     /gene="BORA"
                     /gene_synonym="C13orf34"
                     /note="major polyA site"
     regulatory      2740..2745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BORA"
                     /gene_synonym="C13orf34"
                     /note="hexamer: AATAAA"
     polyA_site      2760
                     /gene="BORA"
                     /gene_synonym="C13orf34"
                     /note="major polyA site"
ORIGIN      
        1 aaagagtcta tgcctgtcgt ggaagctggc ctggcccccg gagctccctg gagtcggtac
       61 tgggggcttc gttttgtacg caccgttttc tctctgtgct atgggagatg tcaaggaatc
      121 aaagatgcaa ataacaccag aaactccagg aaggatccct gttttaaatc cttttgaaag
      181 tcctagtgat tattctaatc tccatgaaca aactctcgcc agtccttctg tttttaaatc
      241 aacaaaatta ccaactccag ggaaatttag atggtctatt gatcaactag ctgtaataaa
      301 tcctgtagaa atagacccag aagatattca tcgtcaagct ttatacttaa gtcattctcg
      361 aatagataaa gatgtggaag acaaaagaca aaaagccatt gaagagtttt tcactaaaga
      421 tgtcatcgta ccctctcctt ggactgatca tgaagggaaa cagctttcac aatgtcattc
      481 cagtaaatgc actaacataa atagtgactc tccagttgga aaaaagctga ccattcattc
      541 tgagaaaagc gatgctgctt gtcagacatt gctgtctctt cctgtggatt ttaatttaga
      601 aaatatatta ggtgactatt ttagagctga tgaatttgca gatcaatctc ctggaaacct
      661 cagttcttca tccctcagaa gaaagctgtt tttagatggg aacggaagca tctccgactc
      721 cttaccttcg gcttctcccg gaagtcctca cagtggtgtt caaacatcac tagagatgtt
      781 ttattcaata gatttgtctc ctgtaaagtg taggagcccc ttgcagacac caagttcggg
      841 gcagttttct tctagcccta ttcaggctag tgcaaaaaaa tacagcttgg gaagcataac
      901 tagtccttcg cctatttctt cacccacttt ctcaccaatt gaatttcaga taggagagac
      961 tccactctca gaacaaagga agtttactgt tcattctcct gatgcttcat ctggaacaaa
     1021 ttctaatggg ataactaatc cgtgtatcag aagtccttat atagatggct gctcgccaat
     1081 taaaaattgg tctcctatga gacttcagat gtatagtggt ggtactcagt atcggacctc
     1141 agtgattcag atacctttta ctcttgagac tcaaggtgaa gatgaggaag ataaagagaa
     1201 tattccttcc acagatgtct catcacccgc catggatgct gctggaatac acctacggca
     1261 gtttagtaat gaggcttcta cccatggtac acatttggtt gtgactgcca tgtctgttac
     1321 acaaaatcag tccagtgctt ctgagaaaga attagcactg ttgcaggatg ttgaaaggga
     1381 gaaagacaat aacactgtgg atatggttga tcctatagag atagcagatg agaccacttg
     1441 gattaaggag ccggttgata atggcagttt acccatgact gattttgtaa gtggcattgc
     1501 cttcagtatt gaaaactctc atatgtgcat gtcacctctt gctgaaagca gtgtcattcc
     1561 ttgtgaaagc agtaacattc agatggatag tggctataat acgcagaatt gtggaagcaa
     1621 tattatggat acagttgggg cagaaagtta ctgcaaagaa agtgatgcac aaacatgtga
     1681 agttgagagt aaatctcaag catttaatat gaagcaagac cacacaacac agaggtgttg
     1741 gatgaaaaca gcaagccctt ttcaatgcag cagtccatag aatgcctctg tcagaatcaa
     1801 agactaagct taagagttcc tcgcatatat cgttgtgcac aggatcaaca tgatggtgac
     1861 tgggaaaaaa ttacttcaag taacatgctt agctttccct ccttaatgtg aaaaatcaag
     1921 ggcttactga cataggaaca acagaaatgc tcctggaact tcaagttgct gaattataag
     1981 tttatttttt atcaataaat atttttatac ttacattgag tgatgtgttt aacaacaaat
     2041 tgtgacagag ctgagtgctc ctatcttaca gggtcaatga actacttatt aagccttact
     2101 ggtagcactg aatttagcag ttctgagaac atgtgaaact atgttaaaac tgaaggcact
     2161 atatattttt acataaaagc ttgaacatac agatgaatta taacctatgt gaagaaatct
     2221 tagatataaa actaactttt caaagataca aaagaaatta aacaggtttc ctgaaatttt
     2281 agttcttggt ctgttcacct ctgtggggaa aattcttagt tccagtgata actgttctag
     2341 ttactacttt taagtatgta aatactagaa aggtagtact agtgacatca tcacgtgtat
     2401 tgttatctat ggggcaaatg tgtggtgccc agaataaaat atacctcatg cctagggtag
     2461 ggacatcctt tccagctcaa acgtgggtag ggatgtggga gaataagaat gtgggagaac
     2521 caagagaaaa agtggggctg ggagagtgga gttcccgtag ggcataggcc tgtgaagtaa
     2581 cactggggca gatatgtatg ttatatacaa ctattttttt aaaaaactta tatccatgtt
     2641 gggagtagat gggtatataa cagtttggaa atactatctt tggagaatgt atttttgtat
     2701 ttataaatca acttttaaaa actgtctcat tcaaaaggga ataaagacct gtgttatcaa
//
