LOCUS       NM_015201               2428 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens BOP1 ribosomal biogenesis factor (BOP1), mRNA.
ACCESSION   NM_015201
VERSION     NM_015201.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2428)
  AUTHORS   Li,J., Hu,W., Zhang,R., Chen,W., Li,X. and Tang,Z.
  TITLE     PDGF-C promotes cell proliferation partially via downregulating
            BOP1
  JOURNAL   Cell Biol Int 47 (12), 1942-1949 (2023)
   PUBMED   37615370
  REMARK    GeneRIF: PDGF-C promotes cell proliferation partially via
            downregulating BOP1.
REFERENCE   2  (bases 1 to 2428)
  AUTHORS   Wu,X., Jing,Z., Huang,T. and Jing,Y.
  TITLE     BOP1 Promotes Prostate Cancer through the DUSP6/MAPK Pathway
  JOURNAL   Arch Esp Urol 76 (6), 445-453 (2023)
   PUBMED   37681336
  REMARK    GeneRIF: BOP1 Promotes Prostate Cancer through the DUSP6/MAPK
            Pathway.
REFERENCE   3  (bases 1 to 2428)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2428)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2428)
  AUTHORS   Yang,Y.P., Qin,R.H., Zhao,J.J. and Qin,X.Y.
  TITLE     BOP1 Silencing Suppresses Gastric Cancer Proliferation through p53
            Modulation
  JOURNAL   Curr Med Sci 41 (2), 287-296 (2021)
   PUBMED   33877544
  REMARK    GeneRIF: BOP1 Silencing Suppresses Gastric Cancer Proliferation
            through p53 Modulation.
REFERENCE   6  (bases 1 to 2428)
  AUTHORS   Strezoska,Z., Pestov,D.G. and Lau,L.F.
  TITLE     Functional inactivation of the mouse nucleolar protein Bop1
            inhibits multiple steps in pre-rRNA processing and blocks cell
            cycle progression
  JOURNAL   J Biol Chem 277 (33), 29617-29625 (2002)
   PUBMED   12048210
REFERENCE   7  (bases 1 to 2428)
  AUTHORS   Pestov,D.G., Stockelman,M.G., Strezoska,Z. and Lau,L.F.
  TITLE     ERB1, the yeast homolog of mammalian Bop1, is an essential gene
            required for maturation of the 25S and 5.8S ribosomal RNAs
  JOURNAL   Nucleic Acids Res 29 (17), 3621-3630 (2001)
   PUBMED   11522832
REFERENCE   8  (bases 1 to 2428)
  AUTHORS   Pestov,D.G., Strezoska,Z. and Lau,L.F.
  TITLE     Evidence of p53-dependent cross-talk between ribosome biogenesis
            and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S
            transition
  JOURNAL   Mol Cell Biol 21 (13), 4246-4255 (2001)
   PUBMED   11390653
REFERENCE   9  (bases 1 to 2428)
  AUTHORS   Nakatsura,T., Senju,S., Yamada,K., Jotsuka,T., Ogawa,M. and
            Nishimura,Y.
  TITLE     Gene cloning of immunogenic antigens overexpressed in pancreatic
            cancer
  JOURNAL   Biochem Biophys Res Commun 281 (4), 936-944 (2001)
   PUBMED   11237751
REFERENCE   10 (bases 1 to 2428)
  AUTHORS   Zhang,Y., Koushik,S., Dai,R. and Mivechi,N.F.
  TITLE     Structural organization and promoter analysis of murine heat shock
            transcription factor-1 gene
  JOURNAL   J Biol Chem 273 (49), 32514-32521 (1998)
   PUBMED   9829985
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA510177.1, BQ711345.1, BC013787.1, AI937005.1 and AC145291.3.
            
            On Nov 23, 2018 this sequence version replaced NM_015201.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.548849.1, BC013980.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000569669.6/ ENSP00000455106.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                DA510177.1         1-91
            92-239              BQ711345.1         85-232
            240-2373            BC013787.1         202-2335
            2374-2427           AI937005.1         3-56                c
            2428-2428           AC145291.3         7353-7353
FEATURES             Location/Qualifiers
     source          1..2428
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2428
                     /gene="BOP1"
                     /note="BOP1 ribosomal biogenesis factor"
                     /db_xref="GeneID:23246"
                     /db_xref="HGNC:HGNC:15519"
                     /db_xref="MIM:610596"
     exon            1..167
                     /gene="BOP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..2309
                     /gene="BOP1"
                     /note="block of proliferation 1"
                     /codon_start=1
                     /product="ribosome biogenesis protein BOP1"
                     /protein_id="NP_056016.1"
                     /db_xref="CCDS:CCDS6418.2"
                     /db_xref="GeneID:23246"
                     /db_xref="HGNC:HGNC:15519"
                     /db_xref="MIM:610596"
                     /translation="MAGSRGAGRTAAPSVRPEKRRSEPELEPEPEPEPPLLCTSPLSH
                     STGSDSGVSDSEESVFSGLEDSGSDSSEDDDEGDEEGEDGALDDEGHSGIKKTTEEQV
                     QASTPCPRTEMASARIGDEYAEDSSDEEDIRNTVGNVPLEWYDDFPHVGYDLDGRRIY
                     KPLRTRDELDQFLDKMDDPDYWRTVQDPMTGRDLRLTDEQVALVRRLQSGQFGDVGFN
                     PYEPAVDFFSGDVMIHPVTNRPADKRSFIPSLVEKEKVSRMVHAIKMGWIQPRRPRDP
                     TPSFYDLWAQEDPNAVLGRHKMHVPAPKLALPGHAESYNPPPEYLLSEEERLAWEQQE
                     PGERKLSFLPRKFPSLRAVPAYGRFIQERFERCLDLYLCPRQRKMRVNVDPEDLIPKL
                     PRPRDLQPFPTCQALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRT
                     VPVGGVVKSVAWNPSPAVCLVAAAVEDSVLLLNPALGDRLVAGSTDQLLSAFVPPEEP
                     PLQPARWLEASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQL
                     SRRRSQSPFRRSHGQVQRVAFHPARPFLLVASQRSVRLYHLLRQELTKKLMPNCKWVS
                     SLAVHPAGDNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLFASGS
                     DDGSVIVCHGMVYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADG
                     TVRLFT"
     exon            168..377
                     /gene="BOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..458
                     /gene="BOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..613
                     /gene="BOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            614..731
                     /gene="BOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..833
                     /gene="BOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1046
                     /gene="BOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1208
                     /gene="BOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1289
                     /gene="BOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1359
                     /gene="BOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1492
                     /gene="BOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1673
                     /gene="BOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1962
                     /gene="BOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2047
                     /gene="BOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2155
                     /gene="BOP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2428
                     /gene="BOP1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2371
                     /gene="BOP1"
                     /note="major polyA site"
     regulatory      2408..2413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BOP1"
                     /note="hexamer: AACAAA"
     polyA_site      2428
                     /gene="BOP1"
ORIGIN      
        1 ctcctgcgca cgcggcccgg tcgctgtcgg aagcggctgt gcgggtggcg gccggcgcgc
       61 ggtggggcat ggcgggttcg cggggtgcgg ggcgcacggc ggcgccgagc gtgcggccgg
      121 agaagcggcg gtctgagccc gaactggagc ctgagcccga gccggagccc cccctcctct
      181 gcacctctcc tctcagccac agcaccggca gcgattctgg cgtctccgac agcgaggaaa
      241 gtgtgttctc aggcctggaa gattccggca gtgacagcag tgaggatgat gacgaaggcg
      301 acgaggaggg agaggacgga gcccttgatg acgagggcca cagtgggatt aaaaagacca
      361 ctgaggagca ggtgcaggcc agcactcctt gcccgaggac agagatggcg agcgcccgga
      421 ttggggatga gtatgcggag gacagctctg atgaggagga catccggaac acggtgggca
      481 acgtgccctt ggagtggtac gatgacttcc cccacgtggg ctacgacctg gatggcaggc
      541 gcatctacaa gcccctgcgg acccgggatg agctggacca gttcctggac aagatggacg
      601 atcctgacta ctggcgcacc gtgcaggacc cgatgacagg gcgggacctg agactgacgg
      661 atgagcaggt ggccctggtg cggcggctgc agagtggcca gtttggggat gtgggcttca
      721 acccctatga gccggctgtc gacttcttca gcggggacgt catgatccac ccggtgacca
      781 accgcccggc cgacaagcgc agcttcatcc cctccctggt ggagaaggag aaggtctctc
      841 gcatggtgca cgccatcaag atgggctgga tccagcctcg ccggccccga gaccccaccc
      901 ccagcttcta tgacctgtgg gcccaggagg accccaacgc cgtgctcggg cgccacaaga
      961 tgcacgtacc tgctcccaag ctggccctgc caggccacgc cgagtcgtac aacccacccc
     1021 ctgaatacct gctcagcgag gaggagcgct tggcgtggga acagcaggag ccaggcgaga
     1081 ggaagctgag ctttttgcca cgcaagttcc cgagcctgcg ggccgtgcct gcctacggac
     1141 gcttcatcca ggaacgcttc gagcgctgcc ttgacctgta cctgtgccca cggcagcgca
     1201 agatgagggt gaatgtagac cctgaggacc tcatccccaa gctgcctcgg ccgagggacc
     1261 tgcagccctt ccccacgtgc caggccctgg tctacagggg ccacagtgac cttgtccggt
     1321 gcctcagtgt ctctcctggg ggccagtggc tggtttcagg ctctgacgac ggctccctgc
     1381 ggctctggga ggtggccact gcccgctgtg tgaggactgt tcccgtgggg ggcgtggtga
     1441 agagtgtggc ctggaacccc agccccgctg tctgcctggt ggctgcagcc gtggaggact
     1501 cggtgctgct gctgaaccca gctctggggg accggctggt ggcgggcagc acagatcagc
     1561 tgttgagcgc cttcgtcccg cctgaggagc cccccttgca gccggcccgc tggctggagg
     1621 cctcagagga ggagcgccaa gtgggcctgc ggctgcgcat ctgccacggg aagccagtga
     1681 cgcaggtgac ctggcacggg cgtggggact acctggccgt ggtgctggcc acccaaggcc
     1741 acacccaggt gctgattcac cagctgagcc gtcgccgcag ccagagtccg ttccgccgca
     1801 gccacggaca ggtgcagcga gtggccttcc accctgcccg gcccttcctg ttggtggcgt
     1861 cccagcgcag cgtccgcctc taccacctgc tgcgccagga gctcaccaag aagctgatgc
     1921 ccaactgcaa gtgggtgtcc agcctggcgg tgcaccctgc aggtgacaac gtcatctgtg
     1981 ggagctacga tagcaagctg gtgtggtttg acctggatct ttccaccaag ccatacagga
     2041 tgctgagaca ccacaagaag gctctgcggg ctgtggcctt ccacccgcgg tacccactct
     2101 ttgcgtcagg ctcggacgac ggcagtgtca tcgtctgcca tggcatggtg tacaatgacc
     2161 ttctgcagaa ccccttgctg gtgcccgtca aggtgctgaa gggacacgtg ctgacccgag
     2221 atctgggagt gctggacgtc atcttccacc ccacccagcc gtgggtcttc tcctcggggg
     2281 cagacgggac tgtccgcctc ttcacctagc tgttctgcct gcctggggct ggggtggtcg
     2341 tgctgaagtc aacagagcct ttaccctgtg ctgcctggtg ctcccacctt cttgaattgg
     2401 ggttgccaac aaagccgccc ccaccaca
//
