LOCUS       NM_001320622            1945 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens BOLA2-SMG1P6 readthrough (BOLA2-SMG1P6), transcript
            variant 1, mRNA.
ACCESSION   NM_001320622
VERSION     NM_001320622.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1945)
  AUTHORS   Kimura,K., Wakamatsu,A., Suzuki,Y., Ota,T., Nishikawa,T.,
            Yamashita,R., Yamamoto,J., Sekine,M., Tsuritani,K., Wakaguri,H.,
            Ishii,S., Sugiyama,T., Saito,K., Isono,Y., Irie,R., Kushida,N.,
            Yoneyama,T., Otsuka,R., Kanda,K., Yokoi,T., Kondo,H., Wagatsuma,M.,
            Murakawa,K., Ishida,S., Ishibashi,T., Takahashi-Fujii,A.,
            Tanase,T., Nagai,K., Kikuchi,H., Nakai,K., Isogai,T. and Sugano,S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res 16 (1), 55-65 (2006)
   PUBMED   16344560
REFERENCE   2  (bases 1 to 1945)
  AUTHORS   Bonaldo,M.F., Lennon,G. and Soares,M.B.
  TITLE     Normalization and subtraction: two approaches to facilitate gene
            discovery
  JOURNAL   Genome Res 6 (9), 791-806 (1996)
   PUBMED   8889548
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133555.3, BM451872.1 and AK295153.1.
            
            Summary: This gene represents naturally-occurring readthrough
            transcription between the upstream BOLA2 (bolA family member 2) and
            downstream SMG1 pseudogene 6 (SMG1P6) loci. Alternative splicing
            results in multiple transcript variants, some of which may encode
            proteins with an N-terminus similar to BOLA2 and a C-terminus
            related to SMG1 phosphatidylinositol 3-kinase-related kinase.
            [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.108372.1,
                                           SRR1163655.266526.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 552900,
                                      100422558
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-622               AC133555.3         75738-76359
            623-1332            BM451872.1         1-710
            1333-1873           AK295153.1         675-1215
            1874-1945           AC133555.3         87726-87797
FEATURES             Location/Qualifiers
     source          1..1945
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1945
                     /gene="BOLA2-SMG1P6"
                     /note="BOLA2-SMG1P6 readthrough"
                     /db_xref="GeneID:107282092"
                     /db_xref="HGNC:HGNC:53563"
     exon            1..774
                     /gene="BOLA2-SMG1P6"
                     /inference="alignment:Splign:2.1.0"
     CDS             514..1431
                     /gene="BOLA2-SMG1P6"
                     /note="isoform a is encoded by transcript variant 1;
                     BOLA2-SMG1P6 readthrough protein"
                     /codon_start=1
                     /product="BOLA2-SMG1P6 protein isoform a"
                     /protein_id="NP_001307551.1"
                     /db_xref="GeneID:107282092"
                     /db_xref="HGNC:HGNC:53563"
                     /translation="MASAKSLDRWKARLLEGGSTALTYALVRAEVSFPAEVAPVRQQG
                     SVAGARAGVVSLLGCRSSWTAAMELSAEYLREKLQRDLEAEHVLPSPGGVGQVRGETA
                     ASETQVLYRVMRCVTAANQVFFSEAVLTAANECVGVLLGSLDPSMTIHCDMVITYGLD
                     QLENCQTCGTDYIISVLNLLTLIVEQINTKLPSSFVEKLFIPSSKLLFLRYHKEKEVV
                     AVAHAVYQAMLSLKNIPVLETAYKLILGEMTCALNNLLHSLQLPEACSEIKHEAFKNH
                     VFNVDNAKFVVKFDLSALTTIGNAKNSSL"
     exon            775..834
                     /gene="BOLA2-SMG1P6"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1059
                     /gene="BOLA2-SMG1P6"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1161
                     /gene="BOLA2-SMG1P6"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1945
                     /gene="BOLA2-SMG1P6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcctcccg gcacagaagg cctccccctc tcaccagggc cctcgcccgc tggtccgcca
       61 ggccccgcct tttttgcggc ccccattgtg ctgctggacc cgacgagcag tgttgacagt
      121 gaaccccacg tagacgcggc cccggtaccg ggggttcagg cagtagagca ggtagacgcc
      181 gaaaaagcgc cctggcctcg ccgcgacccc cgcgggaccc atcgggcctt ggggttcggg
      241 aaccacagca gggggttgat tgccgtgacc tagggtccag gggagggctg gatcgctagg
      301 gctgcagggt gcttgcttcg gaacaagctc tcggggacta tccggaggca gcctgcagga
      361 agccgtagcg ccggtacgtg cccctctcct gtctggaggc gggtgtagaa gtccgaccgc
      421 ggaagccaga ctgctgtcca gtcggcgagc gcgtaccatt cagcatcggc tccgcccgag
      481 tcccaccttc ctcaggctct gattggctga cacatggcaa gcgcgaaaag cctggaccgc
      541 tggaaagccc ggctgcttga gggcggaagt actgcgttga cgtacgcctt agtaagggcg
      601 gaagtgagtt ttccagcgga agtggctcct gtaaggcagc aaggtagcgt ggccggcgcc
      661 cgagctgggg ttgtgtccct gctgggctgc cgttccagct ggactgccgc catggaactc
      721 agcgccgaat acctccgcga gaagctgcag cgggacctgg aggcggagca tgtgcttccg
      781 agtcctggtg gtgtcggcca agttcgaggg gaaaccgctg cttcagagac acaggttctg
      841 tacagagtaa tgagatgtgt gacggctgca aaccaggtgt ttttttctga ggctgtgttg
      901 acagctgcta atgagtgtgt tggtgttttg ctcggcagct tggatcctag catgactata
      961 cattgtgaca tggtcattac atatggatta gaccaactgg agaattgcca gacttgtggt
     1021 accgattata tcatctcagt cttgaattta ctcacgctga ttgttgaaca gataaatacg
     1081 aaactgccat catcatttgt agaaaaactg tttataccat catctaaact actattcttg
     1141 cgttatcata aagaaaaaga ggttgttgct gtagcccatg ctgtttatca agcaatgctc
     1201 agcttgaaga atattcctgt tttggagact gcctataagt taatattggg agaaatgact
     1261 tgtgccctaa acaacctcct gcacagtctg caacttcctg aggcctgttc tgaaataaaa
     1321 catgaggctt ttaagaatca tgtgttcaat gtagacaatg caaaatttgt agttaaattt
     1381 gacctcagtg ccctgactac aattggaaat gccaaaaact cgagtcttta attgtaatga
     1441 ctttgtttta tccacagtta agccttttct cattacatat ttatgtattt cactgtcatg
     1501 tcaacatgtc tgcagaatca ctgtatgtaa caaacagcca tatttaagac atgcctggat
     1561 aaataaaatt ggtaggaatg ttttcttgcc attatattta acgtttcttc tttttccttg
     1621 acaaatcttg ataagttttt ttatattagt tttattttct agaaaacgtc ttatgaattt
     1681 ctcccatttg ctctagcatg cttatagaaa atgtcagtgt ttcttacagc tcaaatttgt
     1741 atagttgttt taaaatgcgg tctctttctt cttcccctgg tacttttttc tttctgtcta
     1801 ctgaagttag ttcttataca tggtcttata ttttggctgt ctttttttcc ctaggaacat
     1861 tcatacaggt tgaatattcc ttatctgaaa tacttgggac tggaagtgtt tttgattttg
     1921 gagtttggaa tacttttttt ttttt
//
