LOCUS       NM_016074                891 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens bolA family member 1 (BOLA1), transcript variant 3,
            mRNA.
ACCESSION   NM_016074
VERSION     NM_016074.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 891)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 891)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 891)
  AUTHORS   Sen,S., Hendricks,A.L. and Cowan,J.A.
  TITLE     Cluster exchange reactivity of [2Fe-2S]-bridged heterodimeric
            BOLA1-GLRX5
  JOURNAL   FEBS J 288 (3), 920-929 (2021)
   PUBMED   32542995
  REMARK    GeneRIF: Cluster exchange reactivity of [2Fe-2S]-bridged
            heterodimeric BOLA1-GLRX5.
REFERENCE   4  (bases 1 to 891)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 891)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 891)
  AUTHORS   Willems,P., Wanschers,B.F., Esseling,J., Szklarczyk,R., Kudla,U.,
            Duarte,I., Forkink,M., Nooteboom,M., Swarts,H., Gloerich,J.,
            Nijtmans,L., Koopman,W. and Huynen,M.A.
  TITLE     BOLA1 is an aerobic protein that prevents mitochondrial morphology
            changes induced by glutathione depletion
  JOURNAL   Antioxid Redox Signal 18 (2), 129-138 (2013)
   PUBMED   22746225
  REMARK    GeneRIF: is an aerobic, mitochondrial protein that prevents
            mitochondrial morphology aberrations induced by GSH depletion and
            reduces the associated oxidative shift of the mitochondrial thiol
            redox potential
REFERENCE   7  (bases 1 to 891)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 891)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 891)
  AUTHORS   Zhou,Y.B., Cao,J.B., Wan,B.B., Wang,X.R., Ding,G.H., Zhu,H.,
            Yang,H.M., Wang,K.S., Zhang,X. and Han,Z.G.
  TITLE     hBolA, novel non-classical secreted proteins, belonging to
            different BolA family with functional divergence
  JOURNAL   Mol Cell Biochem 317 (1-2), 61-68 (2008)
   PUBMED   18548201
  REMARK    GeneRIF: This study reported that all three human BolA proteins
            (hBolA1, hBolA2, and hBolA3) are novel non-classical secreted
            proteins identified with bioinformatics and molecular biology
            experiments.
REFERENCE   10 (bases 1 to 891)
  AUTHORS   Kasai,T., Inoue,M., Koshiba,S., Yabuki,T., Aoki,M., Nunokawa,E.,
            Seki,E., Matsuda,T., Matsuda,N., Tomo,Y., Shirouzu,M., Terada,T.,
            Obayashi,N., Hamana,H., Shinya,N., Tatsuguchi,A., Yasuda,S.,
            Yoshida,M., Hirota,H., Matsuo,Y., Tani,K., Suzuki,H., Arakawa,T.,
            Carninci,P., Kawai,J., Hayashizaki,Y., Kigawa,T. and Yokoyama,S.
  TITLE     Solution structure of a BolA-like protein from Mus musculus
  JOURNAL   Protein Sci 13 (2), 545-548 (2004)
   PUBMED   14718656
  REMARK    GeneRIF: BOLA-like proteins are widely conserved from prokaryotes
            to eukaryotes and may be involved in cell proliferation or
            cell-cycle regulation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC239868.2 and BQ277416.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016074.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.345497.1,
                                           SRR1163657.585642.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369152.6/ ENSP00000358148.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AC239868.2         184138-184242
            106-887             AC239868.2         184580-185361
            888-891             BQ277416.1         240-243
FEATURES             Location/Qualifiers
     source          1..891
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..891
                     /gene="BOLA1"
                     /gene_synonym="CGI-143"
                     /note="bolA family member 1"
                     /db_xref="GeneID:51027"
                     /db_xref="HGNC:HGNC:24263"
                     /db_xref="MIM:613181"
     exon            1..105
                     /gene="BOLA1"
                     /gene_synonym="CGI-143"
                     /inference="alignment:Splign:2.1.0"
     exon            106..891
                     /gene="BOLA1"
                     /gene_synonym="CGI-143"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..569
                     /gene="BOLA1"
                     /gene_synonym="CGI-143"
                     /note="bolA-like 1; bolA homolog 1"
                     /codon_start=1
                     /product="bolA-like protein 1"
                     /protein_id="NP_057158.1"
                     /db_xref="CCDS:CCDS939.1"
                     /db_xref="GeneID:51027"
                     /db_xref="HGNC:HGNC:24263"
                     /db_xref="MIM:613181"
                     /translation="MLSGRLVLGLVSMAGRVCLCQGSAGSGAIGPVEAAIRTKLEEAL
                     SPEVLELRNESGGHAVPPGSETHFRVAVVSSRFEGLSPLQRHRLVHAALAEELGGPVH
                     ALAIQARTPAQWRENSQLDTSPPCLGGNKKTLGTP"
     regulatory      870..875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BOLA1"
                     /gene_synonym="CGI-143"
                     /note="hexamer: ATTAAA"
     polyA_site      891
                     /gene="BOLA1"
                     /gene_synonym="CGI-143"
                     /note="major polyA site"
ORIGIN      
        1 atttcccagc gtgcctcagg aagggcgcca ggactgcatt ttgctccgga gcgtccagag
       61 tcctggccct gagcgggaat cgcagtggcc gaggctgagc ggcaggcgga tcgccccgac
      121 cctcactcct ggcgtctgag tctctggcgt agcccatgct gagtgggcgg ctggtcctgg
      181 gtctggtctc catggctggc cgcgtttgtt tgtgccaggg cagcgcggga tccggggcca
      241 tcggtccggt ggaggccgcc attcgcacga agttggagga ggccctgagc cccgaggtgc
      301 tagagcttcg caacgagagc ggtggccacg cggtcccgcc tggcagtgag actcacttcc
      361 gcgtggctgt ggtgagctct cgtttcgagg gactgagccc cctacaacga caccggctgg
      421 tccacgcagc gctggccgag gagctgggag gtccggtcca tgcgctggcc atccaggcac
      481 ggacccccgc ccagtggaga gagaactctc agctggacac tagcccccca tgcctgggtg
      541 ggaacaagaa aactctagga accccctgaa ccccaagaga gggaggacca ggatccgaat
      601 gggctgggtg agcacgaatt accgaggcct tccctttgat acagtccagg atttgtaagg
      661 gatgaagacc cctgggcccc attctgttgg ggtccataca tactctccga agatagcaac
      721 ttgcttcagg tcaaagtgaa cccgagaaaa gagaagaatc actcactact gctcttgccc
      781 tggactattc aggaagggca gcccggatgt tccatgttaa atcgtgacag aattgcacca
      841 gacctgatga gttggaaaca atcctataca ttaaaagaaa ttacactatg a
//
