LOCUS       NM_148894              10567 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens biorientation of chromosomes in cell division 1 like 1
            (BOD1L1), mRNA.
ACCESSION   NM_148894
VERSION     NM_148894.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10567)
  AUTHORS   Hoshii,T., Kikuchi,S., Kujirai,T., Masuda,T., Ito,T., Yasuda,S.,
            Matsumoto,M., Rahmutulla,B., Fukuyo,M., Murata,T., Kurumizaka,H.
            and Kaneda,A.
  TITLE     BOD1L mediates chromatin binding and non-canonical function of H3K4
            methyltransferase SETD1A
  JOURNAL   Nucleic Acids Res 52 (16), 9463-9480 (2024)
   PUBMED   38989615
  REMARK    GeneRIF: BOD1L mediates chromatin binding and non-canonical
            function of H3K4 methyltransferase SETD1A.
REFERENCE   2  (bases 1 to 10567)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 10567)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 10567)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   5  (bases 1 to 10567)
  AUTHORS   Li,Y., Han,J., Zhang,Y., Cao,F., Liu,Z., Li,S., Wu,J., Hu,C.,
            Wang,Y., Shuai,J., Chen,J., Cao,L., Li,D., Shi,P., Tian,C.,
            Zhang,J., Dou,Y., Li,G., Chen,Y. and Lei,M.
  TITLE     Structural basis for activity regulation of MLL family
            methyltransferases
  JOURNAL   Nature 530 (7591), 447-452 (2016)
   PUBMED   26886794
REFERENCE   6  (bases 1 to 10567)
  AUTHORS   Higgs,M.R. and Stewart,G.S.
  TITLE     Protection or resection: BOD1L as a novel replication fork
            protection factor
  JOURNAL   Nucleus 7 (1), 34-40 (2016)
   PUBMED   26889944
  REMARK    GeneRIF: Protection or resection: BOD1L as a novel replication fork
            protection factor.
            Review article
            Erratum:[doi: 10.1016/j.molcel.2015.06.007]
REFERENCE   7  (bases 1 to 10567)
  AUTHORS   Higgs,M.R., Reynolds,J.J., Winczura,A., Blackford,A.N., Borel,V.,
            Miller,E.S., Zlatanou,A., Nieminuszczy,J., Ryan,E.L., Davies,N.J.,
            Stankovic,T., Boulton,S.J., Niedzwiedz,W. and Stewart,G.S.
  TITLE     BOD1L Is Required to Suppress Deleterious Resection of Stressed
            Replication Forks
  JOURNAL   Mol Cell 59 (3), 462-477 (2015)
   PUBMED   26166705
  REMARK    GeneRIF: Results show that BOD1L protects against severe genome
            instability caused by replication stress; it maintains fork
            stability by stabilizing RAD51 nucleofilaments.
REFERENCE   8  (bases 1 to 10567)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   9  (bases 1 to 10567)
  AUTHORS   van Nuland,R., Smits,A.H., Pallaki,P., Jansen,P.W., Vermeulen,M.
            and Timmers,H.T.
  TITLE     Quantitative dissection and stoichiometry determination of the
            human SET1/MLL histone methyltransferase complexes
  JOURNAL   Mol Cell Biol 33 (10), 2067-2077 (2013)
   PUBMED   23508102
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006445.11, AF528529.1, AK090534.1, BX648206.1 and AB037748.2.
            
            On Nov 22, 2018 this sequence version replaced NM_148894.2.
            
            CCDS Note: The coding region has been updated to extend the
            C-terminus following the addition of several exons at the 3' end.
            There are no full-length transcripts representing the update, but
            partial transcripts do span its length in both human and the mouse
            ortholog. The updated sequence includes a large exon 10 that has no
            single transcript spanning its full extent. Nonetheless, BX648206.1
            covers most of this exon, as does AB037748.2, which is spliced to
            the 3' neighboring exons. AF528529.1 and AK090534.1 are spliced to
            the 5' neighboring exons, supported by orangutan CR860680.1.
            Several tiled transcripts also span this exon in mouse, including
            AK140021.1, AF013969.1 and AK122495.1. Some transcripts appear to
            have polyA tails and terminate in this large exon, e.g.,
            BX648206.1, AK025965.1 and AF528529.1, but on closer inspection, it
            appears that these may be priming off internal 'A' nucleotides in
            exon 10, and they do not have polyA signals. The open reading frame
            represented in the update also shows good conservation in models
            from other species, including macaque XP_001098928.1, dog
            XP_536235.2, cow XP_585315.3, chicken XP_420784.2, and rat
            XP_001060944.1. It is also of note that the genomic alignments
            between these species show insertions/deletions in the region of
            exon 10 that are always in multiples of three, or else they are
            compensated in order to restore the reading frame. This is a strong
            signature of a protein-coding region and provides good supporting
            evidence for the validity of this exon/intron structure.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000040738.10/ ENSP00000040738.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC006445.11        25150-25170
            22-1629             AF528529.1         1-1608
            1630-1669           AK090534.1         614-653
            1670-2605           AF528529.1         1667-2602
            2606-4243           BX648206.1         221-1858
            4244-7324           AB037748.2         367-3447
            7325-7325           BX648206.1         4938-4938
            7326-9784           AB037748.2         3449-5907
            9785-10563          AB037748.2         5909-6687
            10564-10567         AC006445.11        84134-84137
FEATURES             Location/Qualifiers
     source          1..10567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.33"
     gene            1..10567
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /note="biorientation of chromosomes in cell division 1
                     like 1"
                     /db_xref="GeneID:259282"
                     /db_xref="HGNC:HGNC:31792"
                     /db_xref="MIM:616746"
     exon            1..381
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..9294
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /note="family with sequence similarity 44, member A;
                     biorientation of chromosomes in cell division 1-like"
                     /codon_start=1
                     /product="biorientation of chromosomes in cell division
                     protein 1-like 1"
                     /protein_id="NP_683692.2"
                     /db_xref="CCDS:CCDS3411.2"
                     /db_xref="GeneID:259282"
                     /db_xref="HGNC:HGNC:31792"
                     /db_xref="MIM:616746"
                     /translation="MATNPQPQPPPPAPPPPPPQPQPQPPPPPPGPGAGPGAGGAGGA
                     GAGAGDPQLVAMIVNHLKSQGLFDQFRRDCLADVDTKPAYQNLRQRVDNFVANHLATH
                     TWSPHLNKNQLRNNIRQQVLKSGMLESGIDRIISQVVDPKINHTFRPQVEKAVHEFLA
                     TLNHKEEGSGNTAPDDEKPDTSLITQGVPTPGPSANVANDAMSILETITSLNQEASAA
                     RASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAPK
                     SEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGER
                     KKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKED
                     FSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNK
                     TKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRR
                     QINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVL
                     EKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAK
                     SEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVER
                     SEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLS
                     VKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERK
                     LSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLG
                     SKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLKSKS
                     KTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEP
                     VLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSK
                     DIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEK
                     LAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQ
                     QDIDSENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLT
                     KKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQKNLKNTAAE
                     EHVAQGDATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFDKRTVLEGSTASTSPA
                     DHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAHQATLLDGK
                     QGKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNLKQTIKATVENGKKD
                     GIAVDHVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRNENSEVDTSAGSGSAPSV
                     LHQRNGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPATTTSSETRQSEVAL
                     PCTSIEADEGLIIGTHSRNNPLHVGAEASECTVFAAAEEGGAVVTEGFAESETFLTST
                     KEGESGECAVAESEDRAADLLAVHAVKIEANVNSVVTEEKDDAVTSAGSEEKCDGSLS
                     RDSEIVEGTITFISEVESDGAVTSAGTEIRAGSISSEEVDGSQGNMMRMGPKKETEGT
                     VTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVVLGDNDAPPGTSASQEGDGSVNDG
                     TEGESAVTSTGITEDGEGPASCTGSEDSSEGFAISSESEENGESAMDSTVAKEGTNVP
                     LVAAGPCDDEGIVTSTGAKEEDEEGEDVVTSTGRGNEIGHASTCTGLGEESEGVLICE
                     SAEGDSQIGTVVEHVEAEAGAAIMNANENNVDSMSGTEKGSKDTDICSSAKGIVESSV
                     TSAVSGKDEVTPVPGGCEGPMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEV
                     PECEVAHTSPSEKEDEDIITSVENEECDGLMATTASGDITNQNSLAGGKNQGKVLIIS
                     TSTTNDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEEFEAPMPSAVSGDDSQLTA
                     SRSEEKDECAMISTSIGEEFELPISSATTIKCAESLQPVAAAVEERATGPVLISTADF
                     EGPMPSAPPEAESPLASTSKEEKDECALISTSIAEECEASVSGVVVESENERAGTVME
                     EKDGSGIISTSSVEDCEGPVSSAVPQEEGDPSVTPAEEMGDTAMISTSTSEGCEAVMI
                     GAVLQDEDRLTITRVEDLSDAAIISTSTAECMPISASIDRHEENQLTADNPEGNGDLS
                     ATEVSKHKVPMPSLIAENNCRCPGPVRGGKEPGPVLAVSTEEGHNGPSVHKPSAGQGH
                     PSAVCAEKEEKHGKECPEIGPFAGRGQKESTLHLINAEEKNVLLNSLQKEDKSPETGT
                     AGGSSTASYSAGRGLEGNANSPAHLRGPEQTSGQTAKDPSVSIRYLAAVNTGAIKADD
                     MPPVQGTVAEHSFLPAEQQGSEDNLKTSTTKCITGQESKIAPSHTMIPPATYSVALLA
                     PKCEQDLTIKNDYSGKWTDQASAEKTGDDNSTRKSFPEEGDIMVTVSSEENVCDIGNE
                     ESPLNVLGGLKLKANLKMEAYVPSEEEKNGEILAPPESLCGGKPSGIAELQREPLLVN
                     ESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISGHSVEADPKEVEEEERHMPK
                     RKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSET
                     NSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETT
                     LKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSV
                     RRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGAT
                     TRSTTRSEAQRSKTQLSPSIKRKREVSPPGARTRGQQRVEEAPVKKAKR"
     exon            382..506
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            507..697
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            698..1312
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1462
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1629
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1741
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1880
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1953
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..8092
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            8093..8157
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            8158..8242
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            8243..8286
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            8287..8347
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            8348..8418
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            8419..8491
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            8492..8571
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            8572..8656
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            8657..8730
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            8731..8806
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            8807..8841
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            8842..8887
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            8888..8937
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            8938..9022
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            9023..9176
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     exon            9177..10567
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10549..10554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /note="hexamer: TATAAA"
     polyA_site      10567
                     /gene="BOD1L1"
                     /gene_synonym="BOD1L; FAM44A"
                     /note="major polyA site"
ORIGIN      
        1 acttccgggg ttgctctgga tccgctggtt ccgtaacaac atcccgttgg cttccctcag
       61 gcggcgggac cagtgcagcc gccgcctccc aggatcgtcc gccggtcagg gcccttgccc
      121 tccccggcac aggccaccat ggccaccaac ccacagccgc agccgcctcc tccggcgccg
      181 ccgcctcccc cgccgcagcc gcagccgcag ccaccgccgc cgccgccggg ccccggggct
      241 ggccccggcg cgggcggggc gggcggcgcg ggtgcgggcg ccggggaccc gcagctcgtg
      301 gccatgatcg tgaaccacct caagagccag gggctcttcg accagttccg cagagactgc
      361 ctggccgacg tggacaccaa gcctgcgtat cagaatctga gacagcgtgt tgacaacttt
      421 gttgcaaatc acttggcaac tcacacatgg agtccgcatc tcaataagaa ccagctaaga
      481 aacaacatta gacaacaagt cctcaaatca ggaatgttgg agtctggtat tgaccgaatt
      541 atttctcagg ttgtggaccc aaagatcaac cacacattca gacctcaggt agagaaagct
      601 gtgcatgagt ttttggccac gctaaatcac aaagaggaag gaagtggcaa cacagctccc
      661 gatgatgaga aaccagacac ttcccttatt acacaaggtg ttcctactcc tgggcccagt
      721 gctaatgtag ccaatgatgc catgtcgata ttggaaacca taacttctct taaccaagaa
      781 gccagtgctg ctagggcttc aacagaaaca tcaaatgcca agaccagtga gagagcgtca
      841 aaaaaacttc catctcagcc aaccactgat actagtactg acaaagaaag aacttcagag
      901 gacatggctg ataaagaaaa atctacagct gactctggag gtgaaggact ggaaacagcc
      961 ccaaagtctg aagagttcag cgacctcccc tgtccagtcg aagaaattaa aaattacaca
     1021 aaagagcata ataatttaat tctgctaaat aaggatgttc aacaggaaag cagtgagcaa
     1081 aaaaataaat caacagacaa aggtgaaaag aagccagaca gcaatgagaa aggagaaaga
     1141 aagaaagaaa agaaggaaaa gactgaaaag aaatttgatc actcaaaaaa gagtgaagat
     1201 acacagaaag ttaaagatga aaaacaagca aaggaaaaag aagtagagag tttaaaactt
     1261 ccttcagaaa agaacagtaa taaagctaaa actgttgaag ggacaaaaga agatttctct
     1321 ttgatagatt ctgatgtgga tggacttaca gacatcacag ttagctctgt tcataccagt
     1381 gacctttcat cttttgaaga agatactgag gaggaagttg taacgtctga tagcatggaa
     1441 gaaggagaga ttacgtcaga tgatgaagag aagaacaaac agaataaaac aaaaactcaa
     1501 actagtgatt ctagtgaagg aaaaacaaaa agtgtacggc atgcgtatgt ccacaaacca
     1561 tatctttact caaaatacta tagtgattct gatgatgagc ttactgtaga acaacgacga
     1621 cagtccattg ccaaagaaaa agaagagagg cttttaagaa ggcaaatcaa tagagaaaaa
     1681 cttgaagaaa aacgaaaaca gaaagcagaa aagacaaagt cttcaaaaac caagggtcaa
     1741 ggcaggagta gtgtggactt agaagaatca tcaacaaaga gtttggaacc taaagccgcc
     1801 agaattaaag aagtccttaa agaacggaaa gttttagaaa aaaaagtagc cttaagcaaa
     1861 aagagaaaaa aagattcaag gaatgttgaa gagaactcca aaaagaaaca gcaatatgaa
     1921 gaagattcca aagaaaccct taaaacaagt gagcattgtg aaaaggaaaa aatttcttct
     1981 tcaaaggagc tgaagcatgt tcatgcaaaa agtgaaccaa gtaaacctgc ccggagactt
     2041 tcagagtctt tgcatgtagt tgacgaaaac aaaaatgaat ccaaattaga aagagaacat
     2101 aaaagacgga catctacccc tgttatcatg gagggggtac aggaagagac tgacacaaga
     2161 gatgtaaaaa ggcaagtaga acgctcagaa atttgcaccg aagagcccca gaaacagaaa
     2221 agcacactta aaaacgaaaa gcatctaaag aaagatgatt ctgaaacacc acatttgaaa
     2281 agcctactta agaaagaggt gaaatcctcc aaggagaagc ctgaaagaga gaaaactcca
     2341 tcggaagaca aattgtctgt gaaacataaa tataaaggtg attgtatgca taaaacaggt
     2401 gatgagactg agcttcactc ttctgagaaa ggtttaaaag tagaggaaaa tattcaaaag
     2461 caaagtcaac aaacaaagct ttcttcagat gataaaaccg aacgaaaaag taaacatagg
     2521 aatgaaagga aattatcagt attaggcaaa gatggaaagc cagtttctga atatattata
     2581 aaaacagatg agaatgttcg taaagaaaac aacaaaaaag agagacgctt gtcagctgaa
     2641 aaaactaagg cagagcacaa atcaagaagg tcaagtgatt ctaaaattca gaaagattct
     2701 ctgggttcca agcaacatgg tatcacatta cagagaagaa gtgaaagtta ttcggaagat
     2761 aagtgtgata tggactccac taacatggat agtaatttga aaccagaaga ggttgttcac
     2821 aaggagaaac gacgaacaaa gagcttgtta gaagagaaac ttgtgttgaa gtctaaatca
     2881 aaaactcaag gcaaacaggt aaaagttgta gaaacagaat tacaagaagg tgccacaaaa
     2941 caggcaacca ctccaaaacc agacaaggag aagaacacag aagaaaatga ctcagaaaaa
     3001 cagcgtaagt ctaaagttga agacaaacct tttgaagaaa ctggtgttga acctgtatta
     3061 gagactgctt cttcttcagc acatagtaca cagaaggatt ctagtcatag agccaagtta
     3121 ccattagcaa aggagaaata taagagtgat aaagactcca cttccaccag gcttgagaga
     3181 aagttgtcag atggccacaa aagcagaagc ttaaagcata gtagtaaaga cataaaaaag
     3241 aaggacgaaa ataaatcaga tgacaaggat ggtaaagaag ttgacagtag tcatgaaaag
     3301 gccagaggta atagttcact catggaaaag aaattaagta gaaggttgtg cgaaaatcgg
     3361 agaggaagct tgtcacaaga aatggccaaa ggagaagaaa aattagcagc aaacactttg
     3421 agcactccca gcggttcctc ccttcagaga ccaaaaaaga gtggtgatat gacattgatc
     3481 cctgaacaag agccaatgga aattgattct gagccaggtg ttgaaaatgt gtttgaagta
     3541 tctaaaaccc aagacaaccg caataataat tctcagcaag acattgactc tgaaaatatg
     3601 aaacaaaaaa cttctgccac tgttcaaaag gatgaattga gaacttgcac agcagattca
     3661 aaagcaacag ctccagctta taagccaggc cgtggaacag gagttaatag taattctgaa
     3721 aagcatgccg atcatagaag caccttgacc aagaaaatgc atatacaaag tgctgtgtcc
     3781 aaaatgaacc ctggggagaa agaacccatt catagaggaa ctactgaagt gaatatagat
     3841 tctgaaactg ttcatagaat gttactgagt gccccatcag aaaatgatag ggtacagaag
     3901 aatttgaaaa acacagctgc tgaagaacat gttgctcaag gagatgccac tcttgaacat
     3961 tccacaaatt tagactcctc accatcctta agttcagtga ctgttgtgcc tctgagggaa
     4021 tcgtatgatc cagatgtaat tcctctgttt gacaaaagaa ctgttttgga aggtagcaca
     4081 gccagcacct cccctgcgga tcactctgct ctccctaacc aaagtctgac tgttagggaa
     4141 tcagaagtcc ttaagacaag tgacagcaaa gaaggtggtg aaggtttcac agtagataca
     4201 ccagcaaaag caagcatcac tagcaaaaga cacattccag aagctcacca ggctacttta
     4261 ttggatggta aacaaggaaa ggtaatcatg cctcttggaa gtaagttaac gggcgtgatt
     4321 gtggaaaatg agaatattac caaagaaggt ggcttagtgg acatggccaa gaaagaaaat
     4381 gacttaaatg cagagcccaa tttaaagcag acaattaaag caacagtaga gaatggcaag
     4441 aaggatggca ttgctgttga tcatgttgta ggcctgaata cagaaaaata tgctgaaact
     4501 gtcaaactta agcataaaag aagcccaggt aaagtaaaag acatatcaat tgatgttgaa
     4561 agaaggaatg aaaacagtga ggtagacacc agtgctggaa gtggctctgc accctctgtt
     4621 ttacaccaaa ggaacggaca aactgaggat gtggcaactg ggcctaggag agcagaaaag
     4681 acttctgttg ccactagtac tgaagggaag gacaaagatg tcaccttaag tccagtgaag
     4741 gctgggcctg ccacaaccac ttcttcagaa acaagacaaa gtgaggtggc tttgccttgc
     4801 accagcattg aggcagatga aggcctcata ataggaacac attccagaaa taatcctctt
     4861 catgttggtg cagaagccag tgaatgcact gtttttgctg cagctgaaga aggtggggct
     4921 gttgtcacag agggatttgc tgaaagtgaa accttcctca caagcactaa ggaaggggaa
     4981 agtggggagt gtgctgtggc tgaatctgag gacagagcag cagacctact ggctgtgcat
     5041 gcagttaaaa tcgaagccaa tgtaaatagc gttgtgacag aggaaaagga tgatgctgta
     5101 accagtgcag gctctgaaga aaaatgtgat ggttctttaa gtagagactc agaaatagtt
     5161 gaaggaacta ttacttttat tagtgaagtt gaaagtgatg gagcagttac aagtgctgga
     5221 acagagataa gagcaggatc tataagcagt gaagaggtgg atggctccca gggaaatatg
     5281 atgagaatgg gtcccaaaaa agaaacagag ggcactgtga catgtacagg agcagaaggc
     5341 agaagtgata actttgtgat ctgctcagta actggagcag ggccccggga ggaacgcatg
     5401 gttacaggtg caggtgttgt cctgggagat aatgatgcac caccaggaac aagtgccagc
     5461 caagaaggag atggttctgt gaatgatggt acagaaggtg agagtgcagt caccagcacg
     5521 gggataacag aagatggaga ggggccagca agttgcacag gttcagaaga tagcagcgaa
     5581 ggctttgcta taagttctga atcggaagaa aatggagaga gtgcaatgga cagcacagtg
     5641 gccaaagaag gcactaatgt accattagtt gctgctggtc cttgtgatga tgaaggcatt
     5701 gtgactagca caggcgcaaa agaggaagac gaggaagggg aggatgttgt gactagtact
     5761 ggaagaggaa atgaaattgg gcatgcttca acttgtacag ggttaggaga agaaagtgaa
     5821 ggggtcttga tttgtgaaag tgcagaaggg gacagtcaga ttggtactgt ggtagagcat
     5881 gtggaagctg aggctggagc tgccatcatg aatgcaaatg aaaataatgt tgacagcatg
     5941 agtggcacag agaaaggaag taaagacaca gatatctgct ccagtgcaaa agggattgta
     6001 gaaagcagtg tgaccagtgc agtctcagga aaggatgaag tgacaccagt tccaggaggt
     6061 tgtgagggtc ctatgactag tgctgcatct gatcaaagtg acagtcagct cgaaaaagtt
     6121 gaagatacca ctatttccac tggcctggtc gggggtagtt acgatgttct tgtatctggt
     6181 gaagtcccag aatgtgaagt tgctcacaca tcaccaagtg aaaaagaaga tgaggacatc
     6241 atcacctctg tagaaaatga agagtgtgat ggtctcatgg caactacagc cagtggtgat
     6301 attaccaacc agaatagctt agcagggggt aaaaatcaag gcaaagtttt gattatttcc
     6361 accagtacca caaatgatta cacccctcag gtaagcgcaa ttacagatgt ggaaggaggt
     6421 ctctcagatg ctctgagaac tgaagaaaat atggaaggta ccagagtaac cacagaagaa
     6481 tttgaggccc ccatgcccag tgcagtctca ggagatgaca gccaactcac tgccagcaga
     6541 agtgaagaga aagatgagtg tgccatgatt tccacaagca taggggaaga attcgaattg
     6601 cctatctcca gtgcaacaac catcaagtgt gctgaaagtc ttcagccggt tgctgcagca
     6661 gtggaagaaa gggctacagg tccagtcttg ataagcaccg ccgactttga ggggcctatg
     6721 cccagtgcgc ccccagaagc tgaaagtcct cttgcctcaa ccagcaagga ggagaaggat
     6781 gaatgtgctc tcatttccac tagcatagca gaagaatgtg aggcttctgt ttccggtgta
     6841 gttgttgaaa gtgaaaatga gcgagctggc acagtcatgg aagaaaaaga cgggagtggc
     6901 atcatctcta cgagctcggt ggaagactgt gagggcccag tgtccagtgc tgtccctcaa
     6961 gaggaaggcg acccctcagt cacaccagcg gaagagatgg gtgacaccgc catgatttcc
     7021 acaagcacct ctgaagggtg tgaagcagtc atgattggtg ctgtcctcca ggatgaagat
     7081 cggctcacca tcacaagagt agaagacttg agcgatgctg ccatcatctc caccagcaca
     7141 gcagaatgta tgccaatttc cgccagcatt gacagacatg aagagaatca gctgactgca
     7201 gacaacccag aagggaacgg tgacctgtca gccacagaag tgagcaagca caaggtcccc
     7261 atgcccagcc taattgctga gaataactgt cggtgtcctg ggccagtcag gggaggcaaa
     7321 gaaccgggtc ccgtgttggc agtgagcacc gaggaggggc acaacgggcc atcagtccac
     7381 aagccctctg cagggcaagg ccatccaagt gctgtttgtg cggaaaaaga agagaagcat
     7441 ggcaaggagt gccccgaaat aggaccattt gcaggaagag gacagaaaga gagcacttta
     7501 cacctcataa atgcagaaga gaagaatgta ttgttgaact cccttcagaa agaagataag
     7561 agcccagaga cagggacagc agggggcagt agcacagcaa gttattcagc aggaaggggc
     7621 ttagagggga atgctaactc acctgcccac ctgagaggac cagaacagac gtctgggcag
     7681 acggctaagg atccctctgt cagcattcgc tatttggcag cagtaaacac cggtgctata
     7741 aaagctgatg acatgccacc tgttcaaggg accgtggctg agcattcctt tcttcctgct
     7801 gagcagcagg ggtctgaaga caacttgaaa accagtacca ccaaatgtat tactggccaa
     7861 gaatcaaaaa ttgctccttc ccacacaatg atccctccag ctacttacag tgtagctctg
     7921 ttggctccta aatgtgagca ggacttgact ataaagaatg attatagtgg caaatggact
     7981 gatcaagcat ctgctgagaa aacaggagat gataacagca caaggaaatc attccctgag
     8041 gaaggagaca taatggttac tgtgtcttct gaagaaaatg tgtgtgacat aggcaatgaa
     8101 gagtctccat tgaatgtttt gggaggattg aaactgaaag ccaacttgaa aatggaggct
     8161 tatgtgcctt cagaggaaga gaaaaatggt gaaattctgg caccaccaga aagtctgtgt
     8221 gggggaaagc caagtggaat agctgaactc cagagggagc ctttgttggt gaatgaatca
     8281 ctaaatgttg aaaattcagg cttcagaaca aatgaagaaa ttcatagcga atcttataac
     8341 aaaggagaga tatccagtgg tagaaaagac aacgcagaag ccataagcgg tcacagtgtt
     8401 gaagcagatc ctaaagaggt tgaagaggaa gaaaggcata tgcctaaaag aaaaagaaag
     8461 cagcattatc tctcttcaga agatgaacca gatgataatc cagatgtcct ggattccaga
     8521 atagaaacag cacaaaggca gtgtcctgaa acggagccac atgacacaaa ggaagagaac
     8581 tccagagatt tggaagaatt acctaaaacc agttctgaga caaatagcac tacctcaagg
     8641 gtcatggaag aaaaagatga atatagcagc agtgaaacta ctggtgaaaa gccagagcag
     8701 aacgatgatg acaccataaa atctcaggag gaagatcagc caataattat taaaaggaaa
     8761 agaggaagac ctcgcaaata ccctgtagaa acaacgttaa aaatgaaaga cgactccaaa
     8821 acagatactg gcattgtcac tgtagaacaa tctccatcta gcagcaaact gaaagtaatg
     8881 caaacagatg aatccaataa agaaacagct aacctacaag aaagaagtat aagcaatgat
     8941 gatggtgaag aaaaaatagt aacaagtgtg cgtcggagag gaagaaaacc caaacgttct
     9001 ctcactgtat cagatgatgc tgaatcctca gagccagaaa gaaaacgcca gaaatcagtt
     9061 tctgatccag tggaggacaa gaaagagcag gagtctgatg aggaagagga agaagaggaa
     9121 gaggacgagc cttcaggagc caccacaaga tccaccacca gatcagaggc tcagagatca
     9181 aagacacagc tctccccttc tatcaagcgc aagagagaag tcagccctcc tggggcccga
     9241 acaagaggcc agcaaagggt ggaggaagcc cctgtgaaaa aagcgaagcg ataatcctga
     9301 ccactgctgc cctaggctta tggaggaaca cggtggagag gaaagagaca tgccttggtg
     9361 gccataggct tctctttaac caggaaaaag atatgcatgt gctgtaagtc cctaggtgca
     9421 agctttttct tgttatgttt taaacagctt tataaactat tgttcataga agatattatg
     9481 tacatttatt tcagataaag gacaataagt ttactttgta tctgaactca aaacaaagta
     9541 gttgtatatt ttaacattca aaattgggat ttcccaatgt gacacatcat gaatgcaaac
     9601 ccctccagcc catcagacgc caggctgcct actggtaatc tgtgtatagt atataaacat
     9661 gtaaaaatag gttgtatttt actctatgta tgatgctaat caatgaacac tttatttatt
     9721 ttacagagaa aacttatctg tgaactttac tatatatctg tttattttac tttatttttt
     9781 ttttaaataa aaagggtttt aaatgctatg cagtcattag tagaaaattt tttaggactc
     9841 tgcctgctct gtaactatct taatatgatc tggcagaaac tcgcatgtat ccaagtaaag
     9901 tagtttagct aaagaaaggt tcttcattgc ttttctgttc acagttgtgg ctctgttttt
     9961 taagaatgta acttgttttt agattatact tgcatctgtg actttactac cagccacgtt
    10021 gacacaaaac aggttctggt tcaggtaaag ttgcgtcagt cacctgcagc agaaatccct
    10081 cttcattcct cttctctgtg ttcattcctc ttctgtgctg ttctgaagct tctaccaata
    10141 ctctttccat attgtctttt tcagtgaaga gaaatgcatt caagattagg tccctcctgt
    10201 ctatccagtt tcaggatttt atgttgtttt atacacagtt atttcagtat agaaactggc
    10261 tttattgcca agtgtttttt taaacatgtt ttaactctca tatgagcaaa ctgtccaact
    10321 tcagtttttc ataagattaa acttcttacg atcaaatttg tctcttgcaa tgatgtgatg
    10381 agttgccaaa taattgagat tattttaaaa tgttttgttc atattcttgt tttataatta
    10441 aaatttacat tcagtgtgta tgggtttttt tttttatttt gactcttaat gtaaggtgga
    10501 tatttctgtc attttacatg gtttcttact gagattttat atataaatta taaaatgttt
    10561 accaaaa
//
