LOCUS       NM_001378074            4574 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens BOC cell adhesion associated, oncogene regulated
            (BOC), transcript variant 5, mRNA.
ACCESSION   NM_001378074 XM_005247892
VERSION     NM_001378074.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4574)
  AUTHORS   Dai,Z., Wang,Y., Wu,Z., Feng,Z., Sun,X., Qiu,Y., Cheng,J.C., Xu,L.
            and Zhu,Z.
  TITLE     Female-Specific Susceptibility Locus in BOC and SEC16B are
            Associated with Adolescent Idiopathic Scoliosis
  JOURNAL   Spine (Phila Pa 1976) 46 (22), E1178-E1184 (2021)
   PUBMED   33958541
  REMARK    GeneRIF: Female-Specific Susceptibility Locus in BOC and SEC16B are
            Associated with Adolescent Idiopathic Scoliosis.
REFERENCE   2  (bases 1 to 4574)
  AUTHORS   Ahmed,S., Ahmed,A., Bouzina,H., Lundgren,J. and Radegran,G.
  TITLE     Elevated plasma endocan and BOC in heart failure patients decrease
            after heart transplantation in association with improved
            hemodynamics
  JOURNAL   Heart Vessels 35 (11), 1614-1628 (2020)
   PUBMED   32651845
  REMARK    GeneRIF: Elevated plasma endocan and BOC in heart failure patients
            decrease after heart transplantation in association with improved
            hemodynamics.
REFERENCE   3  (bases 1 to 4574)
  AUTHORS   Hong,M., Srivastava,K., Kim,S., Allen,B.L., Leahy,D.J., Hu,P.,
            Roessler,E., Krauss,R.S. and Muenke,M.
  TITLE     BOC is a modifier gene in holoprosencephaly
  JOURNAL   Hum Mutat 38 (11), 1464-1470 (2017)
   PUBMED   28677295
  REMARK    GeneRIF: we report the identification of missense BOC variants in
            HPE patients. Consistent with these alleles functioning as HPE
            modifiers, individual variant BOC proteins had either loss- or
            gain-of-function properties in cell-based SHH signaling assays.
REFERENCE   4  (bases 1 to 4574)
  AUTHORS   Onodera,S., Saito,A., Hasegawa,D., Morita,N., Watanabe,K.,
            Nomura,T., Shibahara,T., Ohba,S., Yamaguchi,A. and Azuma,T.
  TITLE     Multi-layered mutation in hedgehog-related genes in Gorlin syndrome
            may affect the phenotype
  JOURNAL   PLoS One 12 (9), e0184702 (2017)
   PUBMED   28915250
  REMARK    GeneRIF: Multi-layered mutation in hedgehog-related genes in Gorlin
            syndrome may affect the phenotype
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4574)
  AUTHORS   Vuong,T.A., Leem,Y.E., Kim,B.G., Cho,H., Lee,S.J., Bae,G.U. and
            Kang,J.S.
  TITLE     A Sonic hedgehog coreceptor, BOC regulates neuronal differentiation
            and neurite outgrowth via interaction with ABL and JNK activation
  JOURNAL   Cell Signal 30, 30-40 (2017)
   PUBMED   27871935
  REMARK    GeneRIF: BOC interacts with ABL and activates JNK thereby promoting
            neuronal differentiation and neurite outgrowth.
REFERENCE   6  (bases 1 to 4574)
  AUTHORS   Kang,J.S., Yi,M.J., Zhang,W., Feinleib,J.L., Cole,F. and
            Krauss,R.S.
  TITLE     Netrins and neogenin promote myotube formation
  JOURNAL   J Cell Biol 167 (3), 493-504 (2004)
   PUBMED   15520228
  REMARK    Erratum:[J Cell Biol. 2023 Oct 2;222(10):e20040503909082023c. doi:
            10.1083/jcb.20040503909082023c.. PMID: 37702713]
REFERENCE   7  (bases 1 to 4574)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 4574)
  AUTHORS   Wegorzewska,M., Krauss,R.S. and Kang,J.S.
  TITLE     Overexpression of the immunoglobulin superfamily members CDO and
            BOC enhances differentiation of the human rhabdomyosarcoma cell
            line RD
  JOURNAL   Mol Carcinog 37 (1), 1-4 (2003)
   PUBMED   12720294
  REMARK    GeneRIF: CDO and BOC play a role in differentiation of cells in the
            skeletal muscle lineage
REFERENCE   9  (bases 1 to 4574)
  AUTHORS   Kang,J.S., Feinleib,J.L., Knox,S., Ketteringham,M.A. and
            Krauss,R.S.
  TITLE     Promyogenic members of the Ig and cadherin families associate to
            positively regulate differentiation
  JOURNAL   Proc Natl Acad Sci U S A 100 (7), 3989-3994 (2003)
   PUBMED   12634428
REFERENCE   10 (bases 1 to 4574)
  AUTHORS   Kang,J.S., Mulieri,P.J., Hu,Y., Taliana,L. and Krauss,R.S.
  TITLE     BOC, an Ig superfamily member, associates with CDO to positively
            regulate myogenic differentiation
  JOURNAL   EMBO J 21 (1-2), 114-124 (2002)
   PUBMED   11782431
  REMARK    GeneRIF: BOC, along with CDO, defines a new subfamily of the
            immunoglobulin superfamily that is conserved from Drosophila to
            man. BOC and CDO form a putative receptor complex that stimulates
            differentiation of myoblasts.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026329.14.
            
            On Jan 27, 2020 this sequence version replaced XM_005247892.3.
            
            Summary: The protein encoded by this gene is a member of the
            immunoglobulin/fibronectin type III repeat family. It is a
            component of a cell-surface receptor complex that mediates
            cell-cell interactions between muscle precursor cells, and promotes
            myogenic differentiation. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2187093.1,
                                           SRR14038194.2998239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682979.1/ ENSP00000507783.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-460               AC026329.14        108124-108583       c
            461-548             AC026329.14        103866-103953       c
            549-726             AC026329.14        70241-70418         c
            727-1005            AC026329.14        69307-69585         c
            1006-1152           AC026329.14        51695-51841         c
            1153-1296           AC026329.14        49196-49339         c
            1297-1590           AC026329.14        47437-47730         c
            1591-1863           AC026329.14        46799-47071         c
            1864-2171           AC026329.14        45458-45765         c
            2172-2334           AC026329.14        41883-42045         c
            2335-2445           AC026329.14        41357-41467         c
            2446-2652           AC026329.14        40685-40891         c
            2653-2834           AC026329.14        40135-40316         c
            2835-2940           AC026329.14        39477-39582         c
            2941-3063           AC026329.14        38987-39109         c
            3064-3285           AC026329.14        36508-36729         c
            3286-3518           AC026329.14        35573-35805         c
            3519-3595           AC026329.14        35282-35358         c
            3596-3789           AC026329.14        34575-34768         c
            3790-4574           AC026329.14        32681-33465         c
FEATURES             Location/Qualifiers
     source          1..4574
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.2"
     gene            1..4574
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /note="BOC cell adhesion associated, oncogene regulated"
                     /db_xref="GeneID:91653"
                     /db_xref="HGNC:HGNC:17173"
                     /db_xref="MIM:608708"
     exon            1..460
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /inference="alignment:Splign:2.1.0"
     exon            461..548
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /inference="alignment:Splign:2.1.0"
     exon            549..726
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /inference="alignment:Splign:2.1.0"
     CDS             630..3977
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 5; brother of CDO; Boc homolog; brother of CDON;
                     cell adhesion associated, oncogene regulated 2"
                     /codon_start=1
                     /product="brother of CDO isoform 1 precursor"
                     /protein_id="NP_001365003.1"
                     /db_xref="CCDS:CCDS77788.1"
                     /db_xref="GeneID:91653"
                     /db_xref="HGNC:HGNC:17173"
                     /db_xref="MIM:608708"
                     /translation="MLRGTMTAWRGMRPEVTLACLLLATAGCFADLNEVPQVTVQPAS
                     TVQKPGGTVILGCVVEPPRMNVTWRLNGKELNGSDDALGVLITHGTLVITALNNHTVG
                     RYQCVARMPAGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQ
                     VRYSVKQEWLEASRGNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDR
                     LRVRRSTAEAARIIYPPEAQTIIVTKGQSLILECVASGIPPPRVTWAKDGSSVTGYNK
                     TRFLLSNLLIDTTSEEDSGTYRCMADNGVGQPGAAVILYNVQVFEPPEVTMELSQLVI
                     PWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRLRLSRRALRVLSMGPEDEGVYQCM
                     AENEVGSAHAVVQLRTSRPSITPRLWQDAELATGTPPVSPSKLGNPEQMLRGQPALPR
                     PPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTDSYELVWRPRHEGSGRAPILYY
                     VVKHRKQVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTF
                     RTGRRPKPEIMASKEQQIQRDDPGASPQSSSQPDHGRLSPPEAPDRPTISTASETSVY
                     VTWIPRGNGGFPIQSFRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGTSYKFRV
                     RALNMLGESEPSAPSRPYVVSGYSGRVYERPVAGPYITFTDAVNETTIMLKWMYIPAS
                     NNNTPIHGFYIYYRPTDSDNDSDYKKDMVEGDKYWHSISHLQPETSYDIKMQCFNEGG
                     ESEFSNVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIERPVGTGAMVARSSDLPY
                     LIVGVVLGSIVLIIVTFIPFCLWRAWSKQKHTTDLGFPRSALPPSCPYTMVPLGGLPG
                     HQASGQPYLSGISGRACANGIHMNRGCPSAAVGYPGMKPQQHCPGELQQQSDTSSLLR
                     QTHLGNGYDPQSHQITRGPKSSPDEGSFLYTLPDDSTHQLLQPHHDCCQRQEQPAAVG
                     QSGVRRAPDSPVLEAVWDPPFHSGPPCCLGLVPVEEVDSPDSCQVSGGDWCPQHPVGA
                     YVGQEPGMQLSPGPLVRVSFETPPLTI"
     exon            727..1005
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1152
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1296
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1590
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1863
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2171
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2334
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2445
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2652
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2834
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2940
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /inference="alignment:Splign:2.1.0"
     exon            2941..3063
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /inference="alignment:Splign:2.1.0"
     exon            3064..3285
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /inference="alignment:Splign:2.1.0"
     exon            3286..3518
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /inference="alignment:Splign:2.1.0"
     exon            3519..3595
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /inference="alignment:Splign:2.1.0"
     exon            3596..3789
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /inference="alignment:Splign:2.1.0"
     exon            3790..4574
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4542..4547
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /note="hexamer: AATAAA"
     polyA_site      4574
                     /gene="BOC"
                     /gene_synonym="Boi; CDON2"
                     /note="major polyA site"
ORIGIN      
        1 agtcatccaa aaagcttctt ccatatggag ggaccgggtg cgctgggcgc ggcgtcccct
       61 gcgttgtcct cctgctgccg cccccgcggc cgccgctttc tgccgcgggg accctgagcc
      121 ccggcccgcc ggtgtcagcc gccgcgcgcg cgcacagaca cacacacaga gacacacaaa
      181 cacacacaga aaagacacac acgcgcacac acggcgcgca caccctcacg cccgccacag
      241 ccacaacacg cccgcacgcg ccctccctct ccggcccgca acttctcggt cctcggctcc
      301 tttgttgctc cagccgcggc cgctcgcccg tgttgtgtgt ccccggtgtc accgagcgtg
      361 ttgtgtgtcc gtgcggcgcg gcgctgtgtg gctccctcgc gcccaccacg ctggcccccg
      421 ggccccggct cgcccttccc aggcgccggc tgcagcagag tttcagaaca agcttcctgg
      481 aacccatgac ccatgaagtc ttgtcgacat ttataccgtc tgagggtagc agctcgaaag
      541 tagaagaaag tgttgccagg gacggcagta tctctttgtg tgaccctggc ggcttatggg
      601 acgttggctt cagacctttg tgatacacca tgctgcgtgg gacgatgacg gcgtggagag
      661 gaatgaggcc tgaggtcaca ctggcttgcc tcctcctagc cacagcaggc tgctttgctg
      721 acttgaacga ggtccctcag gtcaccgtcc agcctgcgtc caccgtccag aagcccggag
      781 gcactgtgat cttgggctgc gtggtggaac ctccaaggat gaatgtaacc tggcgcctga
      841 atggaaagga gctgaatggc tcggatgatg ctctgggtgt cctcatcacc cacgggaccc
      901 tcgtcatcac tgcccttaac aaccacactg tgggacggta ccagtgtgtg gcccggatgc
      961 ctgcgggggc tgtggccagc gtgccagcca ctgtgacact agccaatctc caggacttca
     1021 agttagatgt gcagcacgtg attgaagtgg atgagggaaa cacagcagtc attgcctgcc
     1081 acctgcctga gagccacccc aaagcccagg tccggtacag cgtcaaacaa gagtggctgg
     1141 aggcctccag aggtaactac ctgatcatgc cctcagggaa cctccagatt gtgaatgcca
     1201 gccaggagga cgagggcatg tacaagtgtg cagcctacaa cccagtgacc caggaagtga
     1261 aaacctccgg ctccagcgac aggctacgtg tgcgccgctc caccgctgag gctgcccgca
     1321 tcatctaccc cccagaggcc caaaccatca tcgtcaccaa aggccagagt ctcattctgg
     1381 agtgtgtggc cagtggaatc ccacccccac gggtcacctg ggccaaggat gggtccagtg
     1441 tcaccggcta caacaagacg cgcttcctgc tgagcaacct cctcatcgac accaccagcg
     1501 aggaggactc aggcacctac cgctgcatgg ccgacaatgg ggttgggcag cccggggcag
     1561 cggtcatcct ctacaatgtc caggtgtttg aaccccctga ggtcaccatg gagctatccc
     1621 agctggtcat cccctggggc cagagtgcca agcttacctg tgaggtgcgt gggaaccccc
     1681 cgccctccgt gctgtggctg aggaatgctg tgcccctcat ctccagccag cgcctccggc
     1741 tctcccgcag ggccctgcgc gtgctcagca tggggcctga ggacgaaggc gtctaccagt
     1801 gcatggccga gaacgaggtt gggagcgccc atgccgtagt ccagctgcgg acctccaggc
     1861 caagcataac cccaaggcta tggcaggatg ctgagctggc tactggcaca cctcctgtat
     1921 caccctccaa actcggcaac cctgagcaga tgctgagggg gcaaccggcg ctccccagac
     1981 ccccaacgtc agtggggcct gcttccccgc agtgtccagg agagaagggg cagggggctc
     2041 ccgccgaggc tcccatcatc ctcagctcgc cccgcacctc caagacagac tcatatgaac
     2101 tggtgtggcg gcctcggcat gagggcagtg gccgggcgcc aatcctctac tatgtggtga
     2161 aacaccgcaa gcaggtcaca aattcctctg acgattggac catctctggc attccagcca
     2221 accagcaccg cctgaccctc accagacttg accccgggag cttgtatgaa gtggagatgg
     2281 cagcttacaa ctgtgcggga gagggccaga cagccatggt caccttccga actggacggc
     2341 ggcccaaacc cgagatcatg gccagcaaag agcagcagat ccagagagac gaccctggag
     2401 ccagtcccca gagcagcagc cagccagacc acggccgcct ctccccccca gaagctcccg
     2461 acaggcccac catctccacg gcctccgaga cctcagtgta cgtgacctgg attccccgtg
     2521 ggaatggtgg gttcccaatc cagtccttcc gtgtggagta caagaagcta aagaaagtgg
     2581 gagactggat tctggccacc agcgccatcc ccccatcgcg gctgtccgtg gagatcacgg
     2641 gcctagagaa aggcacctcc tacaagtttc gagtccgggc tctgaacatg ctgggggaga
     2701 gcgagcccag cgccccctct cggccctacg tggtgtcggg ctacagcggt cgcgtgtacg
     2761 agaggcccgt ggcaggtcct tatatcacct tcacggatgc ggtcaatgag accaccatca
     2821 tgctcaagtg gatgtacatc ccagcaagta acaacaacac cccaatccat ggcttttata
     2881 tctattatcg acccacagac agtgacaatg atagtgacta caagaaggat atggtggaag
     2941 gggacaagta ctggcactcc atcagccacc tgcagccaga gacctcctac gacattaaga
     3001 tgcagtgctt caatgaagga ggggagagcg agttcagcaa cgtgatgatc tgtgagacca
     3061 aagctcggaa gtcttctggc cagcctggtc gactgccacc cccaactctg gccccaccac
     3121 agccgcccct tcctgaaacc atagagcggc cggtgggcac tggggccatg gtggctcgct
     3181 ccagcgacct gccctatctg attgtcgggg tcgtcctggg ctccatcgtt ctcatcatcg
     3241 tcaccttcat ccccttctgc ttgtggaggg cctggtctaa gcaaaaacat acaacagacc
     3301 tgggttttcc tcgaagtgcc cttccaccct cctgcccgta tactatggtg ccattgggag
     3361 gactcccagg ccaccaggcc agtggacagc cctacctcag tggcatcagt ggacgggcct
     3421 gtgctaatgg gatccacatg aataggggct gcccctcggc tgcagtgggc tacccgggca
     3481 tgaagcccca gcagcactgc ccaggcgagc ttcagcagca gagtgacacc agcagcctgc
     3541 tgaggcagac ccatcttggc aatggatatg acccccaaag tcaccagatc acgaggggtc
     3601 ccaagtctag cccggacgag ggctctttct tatacacact gcccgacgac tccactcacc
     3661 agctgctgca gccccatcac gactgctgcc aacgccagga gcagcctgct gctgtgggcc
     3721 agtcaggggt gaggagagcc cccgacagtc ctgtcctgga agcagtgtgg gaccctccat
     3781 ttcactcagg gcccccatgc tgcttgggcc ttgtgccagt tgaagaggtg gacagtcctg
     3841 actcctgcca agtgagtgga ggagactggt gtccccagca ccccgtaggg gcctacgtag
     3901 gacaggaacc tggaatgcag ctctccccgg ggccactggt gcgtgtgtct tttgaaacac
     3961 cacctctcac aatttaggca gaagctgata tcccagaaag actatatatt gttttttttt
     4021 taaaaaaaaa aagaagaaaa aagagacaga gaaaattggt atttattttt ctattatagc
     4081 catatttata tatttatgca cttgtaaata aatgtatatg ttttataatt ctggagagac
     4141 ataaggagtc ctacccgttg aggttggaga gggaaaataa agaagctgcc acctaacagg
     4201 agtcacccag gaaagcaccg cacaggctgg cgcgggacag actcctaacc tggggcctct
     4261 gcagtggcag gcgaggctgc aggaggccca cagataagct ggcaagagga aggatcccag
     4321 gcacatggtt catcacgagc atgagggaac agcaaggggc acggtatcac agcctggaga
     4381 cacccacaca gatggctgga tccggtgcta cgggaaacat tttcctaaga tgcccatgag
     4441 aacagaccaa gatgtgtaca gcactatgag cattaaaaaa ccttccagaa tcaataatcc
     4501 gtggcaacat atctctgtaa aaacaaacac tgtaacttct aaataaatgt ttagtcttcc
     4561 ctgtaacctt caaa
//
