LOCUS       NM_138278               2247 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens BCL2 interacting protein like (BNIPL), transcript
            variant 1, mRNA.
ACCESSION   NM_138278 XM_001127117
VERSION     NM_138278.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2247)
  AUTHORS   Wang,R., Gao,Y., Wen,S. and Guo,X.
  TITLE     BNIPL is a promising biomarker of laryngeal cancer: novel insights
            from bioinformatics analysis and experimental validation
  JOURNAL   BMC Med Genomics 17 (1), 45 (2024)
   PUBMED   38302910
  REMARK    GeneRIF: BNIPL is a promising biomarker of laryngeal cancer: novel
            insights from bioinformatics analysis and experimental validation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2247)
  AUTHORS   Gao,L., Liu,H., Yin,N., Zuo,S., Jin,G., Hu,Y., Hu,D., Li,Y.,
            Song,Q. and Fei,X.
  TITLE     BNIPL-2 expression is correlated with the prognosis and regulates
            the proliferation of colorectal cancer through CD44
  JOURNAL   Mol Med Rep 20 (5), 4073-4080 (2019)
   PUBMED   31485655
  REMARK    GeneRIF: The present study not only suggested that BNIPL2 may be a
            potential biomarker of CRC but also indicated that BNIPL2 regulates
            CRC cancer proliferation via CD44, which could be a diagnostic and
            clinical treatment target.
REFERENCE   3  (bases 1 to 2247)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 2247)
  AUTHORS   Kottgen,A., Pattaro,C., Boger,C.A., Fuchsberger,C., Olden,M.,
            Glazer,N.L., Parsa,A., Gao,X., Yang,Q., Smith,A.V., O'Connell,J.R.,
            Li,M., Schmidt,H., Tanaka,T., Isaacs,A., Ketkar,S., Hwang,S.J.,
            Johnson,A.D., Dehghan,A., Teumer,A., Pare,G., Atkinson,E.J.,
            Zeller,T., Lohman,K., Cornelis,M.C., Probst-Hensch,N.M.,
            Kronenberg,F., Tonjes,A., Hayward,C., Aspelund,T., Eiriksdottir,G.,
            Launer,L.J., Harris,T.B., Rampersaud,E., Mitchell,B.D.,
            Arking,D.E., Boerwinkle,E., Struchalin,M., Cavalieri,M.,
            Singleton,A., Giallauria,F., Metter,J., de Boer,I.H.,
            Haritunians,T., Lumley,T., Siscovick,D., Psaty,B.M.,
            Zillikens,M.C., Oostra,B.A., Feitosa,M., Province,M., de
            Andrade,M., Turner,S.T., Schillert,A., Ziegler,A., Wild,P.S.,
            Schnabel,R.B., Wilde,S., Munzel,T.F., Leak,T.S., Illig,T.,
            Klopp,N., Meisinger,C., Wichmann,H.E., Koenig,W., Zgaga,L.,
            Zemunik,T., Kolcic,I., Minelli,C., Hu,F.B., Johansson,A., Igl,W.,
            Zaboli,G., Wild,S.H., Wright,A.F., Campbell,H., Ellinghaus,D.,
            Schreiber,S., Aulchenko,Y.S., Felix,J.F., Rivadeneira,F.,
            Uitterlinden,A.G., Hofman,A., Imboden,M., Nitsch,D.,
            Brandstatter,A., Kollerits,B., Kedenko,L., Magi,R., Stumvoll,M.,
            Kovacs,P., Boban,M., Campbell,S., Endlich,K., Volzke,H.,
            Kroemer,H.K., Nauck,M., Volker,U., Polasek,O., Vitart,V.,
            Badola,S., Parker,A.N., Ridker,P.M., Kardia,S.L., Blankenberg,S.,
            Liu,Y., Curhan,G.C., Franke,A., Rochat,T., Paulweber,B.,
            Prokopenko,I., Wang,W., Gudnason,V., Shuldiner,A.R., Coresh,J.,
            Schmidt,R., Ferrucci,L., Shlipak,M.G., van Duijn,C.M., Borecki,I.,
            Kramer,B.K., Rudan,I., Gyllensten,U., Wilson,J.F., Witteman,J.C.,
            Pramstaller,P.P., Rettig,R., Hastie,N., Chasman,D.I., Kao,W.H.,
            Heid,I.M. and Fox,C.S.
  TITLE     New loci associated with kidney function and chronic kidney disease
  JOURNAL   Nat Genet 42 (5), 376-384 (2010)
   PUBMED   20383146
REFERENCE   5  (bases 1 to 2247)
  AUTHORS   Toulza,E., Mattiuzzo,N.R., Galliano,M.F., Jonca,N., Dossat,C.,
            Jacob,D., de Daruvar,A., Wincker,P., Serre,G. and Guerrin,M.
  TITLE     Large-scale identification of human genes implicated in epidermal
            barrier function
  JOURNAL   Genome Biol 8 (6), R107 (2007)
   PUBMED   17562024
REFERENCE   6  (bases 1 to 2247)
  AUTHORS   Xie,L., Qin,W.X., Li,J.J., He,X.H., Shu,H.Q., Yao,G.F., Wan,D.F.
            and Gu,J.R.
  TITLE     cDNA expression array analysis of gene expression in human
            hepatocarcinoma Hep3B cells induced by BNIPL-1
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 37 (9), 618-624 (2005)
   PUBMED   16143817
  REMARK    GeneRIF: p16INK4, IL-12, TRAIL & lymphotoxin beta gene involved in
            growth suppression or cell apoptosis were up-regulated & PTEN was
            down-regulated by BNIPL-1;suggests that it might inhibit cell
            growth though cell cycle arrest &/or apoptotic cell death
            pathway(s)
REFERENCE   7  (bases 1 to 2247)
  AUTHORS   Xie,L., Qin,W.X., He,X.H., Shu,H.Q., Yao,G.F., Wan,D.F. and Gu,J.R.
  TITLE     Differential gene expression in human hepatocellular carcinoma
            Hep3B cells induced by apoptosis-related gene BNIPL-2
  JOURNAL   World J Gastroenterol 10 (9), 1286-1291 (2004)
   PUBMED   15112343
  REMARK    GeneRIF: Data suggest that Bcl-2/adenovirus E1B 19 ku interacting
            protein 2-like (BNIPL-2) may regulate apoptosis through changes in
            the expression of genes associated with cell apoptosis, growth
            inhibition and cell proliferation.
REFERENCE   8  (bases 1 to 2247)
  AUTHORS   Qin,W., Hu,J., Guo,M., Xu,J., Li,J., Yao,G., Zhou,X., Jiang,H.,
            Zhang,P., Shen,L., Wan,D. and Gu,J.
  TITLE     BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and
            Cdc42GAP in apoptosis
  JOURNAL   Biochem Biophys Res Commun 308 (2), 379-385 (2003)
   PUBMED   12901880
  REMARK    GeneRIF: BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2
            and Cdc42GAP in apoptosis.
REFERENCE   9  (bases 1 to 2247)
  AUTHORS   Shen,L., Hu,J., Lu,H., Wu,M., Qin,W., Wan,D., Li,Y.Y. and Gu,J.
  TITLE     The apoptosis-associated protein BNIPL interacts with two cell
            proliferation-related proteins, MIF and GFER
  JOURNAL   FEBS Lett 540 (1-3), 86-90 (2003)
   PUBMED   12681488
  REMARK    GeneRIF: interaction with cell proliferation-related proteins, MIF
            and GFER
REFERENCE   10 (bases 1 to 2247)
  AUTHORS   Zhou,Y.T., Soh,U.J., Shang,X., Guy,G.R. and Low,B.C.
  TITLE     The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha
            is a novel apoptosis-inducing sequence
  JOURNAL   J Biol Chem 277 (9), 7483-7492 (2002)
   PUBMED   11741952
  REMARK    GeneRIF: These results indicate the presence of two BNIP-S splicing
            variants as cellular regulators and that the BCH domain of
            BNIP-Salpha confers a novel apoptotic function. The significance of
            this is discussed
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC027868.1, CU451236.1,
            AK092595.1 and AL590133.32.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_138278.3.
            
            Summary: The protein encoded by this gene interacts with several
            other proteins, such as BCL2, ARHGAP1, MIF and GFER. It may
            function as a bridge molecule between BCL2 and ARHGAP1/CDC42 in
            promoting cell death. Alternatively spliced transcript variants
            encoding different isoforms have been described for this gene.
            [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027868.1, AK092595.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368931.8/ ENSP00000357927.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1230              BC027868.1         11-1240
            1231-1257           CU451236.1         606-632
            1258-2113           BC027868.1         1268-2123
            2114-2127           AK092595.1         2099-2112
            2128-2247           AL590133.32        133794-133913
FEATURES             Location/Qualifiers
     source          1..2247
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..2247
                     /gene="BNIPL"
                     /gene_synonym="BNIP-S; BNIP-Salpha; BNIP-Sbeta; BNIPL-1;
                     BNIPL-2; BNIPL1; BNIPL2; BNIPS; PP753"
                     /note="BCL2 interacting protein like"
                     /db_xref="GeneID:149428"
                     /db_xref="HGNC:HGNC:16976"
                     /db_xref="MIM:611275"
     exon            1..181
                     /gene="BNIPL"
                     /gene_synonym="BNIP-S; BNIP-Salpha; BNIP-Sbeta; BNIPL-1;
                     BNIPL-2; BNIPL1; BNIPL2; BNIPS; PP753"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1214
                     /gene="BNIPL"
                     /gene_synonym="BNIP-S; BNIP-Salpha; BNIP-Sbeta; BNIPL-1;
                     BNIPL-2; BNIPL1; BNIPL2; BNIPS; PP753"
                     /note="isoform a is encoded by transcript variant 1;
                     BNIP-2 similar; bcl-2/adenovirus E1B 19 kDa-interacting
                     protein 2-like protein; BCL2/adenovirus E1B 19kD
                     interacting protein like"
                     /codon_start=1
                     /product="bcl-2/adenovirus E1B 19 kDa-interacting protein
                     2-like protein isoform a"
                     /protein_id="NP_612122.2"
                     /db_xref="CCDS:CCDS978.2"
                     /db_xref="GeneID:149428"
                     /db_xref="HGNC:HGNC:16976"
                     /db_xref="MIM:611275"
                     /translation="MGTIQEAGKKTDVGVREIAEAPELGAALRHGELELKEEWQDEEF
                     PRLLPEEAGTSEDPEDPKGDSQAAAGTPSTLALCGQRPMRKRLSAPELRLSLTKGPGN
                     DGASPTQSAPSSPDGSSDLEIDELETPSDSEQLDSGHEFEWEDELPRAEGLGTSETAE
                     RLGRGCMWDVTGEDGHHWRVFRMGPREQRVDMTVIEPYKKVLSHGGYHGDGLNAVILF
                     ASCYLPRSSIPNYTYVMEHLFRYMVGTLELLVAENYLLVHLSGGTSRAQVPPLSWIRQ
                     CYRTLDRRLRKNLRALVVVHATWYVKAFLALLRPFISSKFTRKIRFLDSLGELAQLIS
                     LDQVHIPEAVRQLDRDLHGSGGT"
     exon            182..277
                     /gene="BNIPL"
                     /gene_synonym="BNIP-S; BNIP-Salpha; BNIP-Sbeta; BNIPL-1;
                     BNIPL-2; BNIPL1; BNIPL2; BNIPS; PP753"
                     /inference="alignment:Splign:2.1.0"
     exon            278..342
                     /gene="BNIPL"
                     /gene_synonym="BNIP-S; BNIP-Salpha; BNIP-Sbeta; BNIPL-1;
                     BNIPL-2; BNIPL1; BNIPL2; BNIPS; PP753"
                     /inference="alignment:Splign:2.1.0"
     exon            343..573
                     /gene="BNIPL"
                     /gene_synonym="BNIP-S; BNIP-Salpha; BNIP-Sbeta; BNIPL-1;
                     BNIPL-2; BNIPL1; BNIPL2; BNIPS; PP753"
                     /inference="alignment:Splign:2.1.0"
     exon            574..756
                     /gene="BNIPL"
                     /gene_synonym="BNIP-S; BNIP-Salpha; BNIP-Sbeta; BNIPL-1;
                     BNIPL-2; BNIPL1; BNIPL2; BNIPS; PP753"
                     /inference="alignment:Splign:2.1.0"
     exon            757..859
                     /gene="BNIPL"
                     /gene_synonym="BNIP-S; BNIP-Salpha; BNIP-Sbeta; BNIPL-1;
                     BNIPL-2; BNIPL1; BNIPL2; BNIPS; PP753"
                     /inference="alignment:Splign:2.1.0"
     exon            860..991
                     /gene="BNIPL"
                     /gene_synonym="BNIP-S; BNIP-Salpha; BNIP-Sbeta; BNIPL-1;
                     BNIPL-2; BNIPL1; BNIPL2; BNIPS; PP753"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1078
                     /gene="BNIPL"
                     /gene_synonym="BNIP-S; BNIP-Salpha; BNIP-Sbeta; BNIPL-1;
                     BNIPL-2; BNIPL1; BNIPL2; BNIPS; PP753"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1177
                     /gene="BNIPL"
                     /gene_synonym="BNIP-S; BNIP-Salpha; BNIP-Sbeta; BNIPL-1;
                     BNIPL-2; BNIPL1; BNIPL2; BNIPS; PP753"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..2247
                     /gene="BNIPL"
                     /gene_synonym="BNIP-S; BNIP-Salpha; BNIP-Sbeta; BNIPL-1;
                     BNIPL-2; BNIPL1; BNIPL2; BNIPS; PP753"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2090..2095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BNIPL"
                     /gene_synonym="BNIP-S; BNIP-Salpha; BNIP-Sbeta; BNIPL-1;
                     BNIPL-2; BNIPL1; BNIPL2; BNIPS; PP753"
                     /note="hexamer: AATAAA"
     polyA_site      2126
                     /gene="BNIPL"
                     /gene_synonym="BNIP-S; BNIP-Salpha; BNIP-Sbeta; BNIPL-1;
                     BNIPL-2; BNIPL1; BNIPL2; BNIPS; PP753"
                     /note="major polyA site"
ORIGIN      
        1 cccttccaca cctccctcct tggaggcaag agctacaaca gctgagacag aaaagaggta
       61 aggaagtgtt gggggctggg acaaccagct ccccaacaac tcctaggtgt ttaaagaagg
      121 aggcaggaag acttgtgaag atgggaacta tacaagaggc aggaaaaaag acagatgttg
      181 gggtcaggga gattgcagaa gcaccagaac taggagcagc cctgagacat ggggagttgg
      241 agctgaagga ggaatggcag gatgaagaat tccctagatt gcttcctgag gaggctggca
      301 cttctgaaga tcctgaagac cctaaaggag attcacaggc agctgcaggt acccccagca
      361 ctttagccct gtgtggccag cgccccatgc gcaagcgtct ttctgcccca gagttgcggc
      421 tgagtctgac taaggggcct ggaaatgatg gagcttcacc cacccagtct gcaccttcct
      481 ctcctgatgg cagttctgac ctggagatag acgaattgga gacaccttca gactcggagc
      541 agctggacag tggacatgaa tttgaatggg aagatgaact accccgggca gagggtctgg
      601 gcaccagtga gacagctgaa aggctgggcc gaggttgtat gtgggatgtg actggagaag
      661 atggacatca ctggagggtg ttccgaatgg gaccacggga gcagcgcgta gacatgactg
      721 tcattgagcc ctataagaaa gtcctgtctc atggaggtta ccacggtgat ggcctcaatg
      781 ctgtcatcct ttttgcttcc tgttatctac ccagaagcag catccccaac tacacctatg
      841 tcatggaaca cttgtttagg tatatggtgg gaactctgga gctgctagta gctgaaaatt
      901 acctgcttgt tcatttgagt ggaggcacaa gcagggccca agttccacct ctaagctgga
      961 tacgtcagtg ttaccgtacc ctggatcggc ggctacggaa aaacctgcga gccctggtgg
     1021 ttgtccatgc tacatggtat gtgaaagcat ttctggcact gcttcggccc ttcatcagtt
     1081 ccaaattcac acgaaaaatc cgttttctgg acagcctggg ggagctggcc caactcatat
     1141 ccctggatca agtccacatc cctgaagctg tcagacagct ggaccgggat ctccatggct
     1201 caggagggac atagcacagg actggataaa aggccttaga accagttagt gatctgccta
     1261 cacctgaatc cctgaaacat ctgaactgtt ttgtaaatca tcttatcccc aacctcagta
     1321 ccaccggatc ttcacttctc agtgggattt tgtcctttgc atgaccctac tttcagcagg
     1381 gctttgaggc tgggaaactg atctgctggg tgactttcat tccagttgct gggacggaag
     1441 gctgaatgta gggtcatttt gtatgggata tgcagagctc tgggtttttt tgttttttgt
     1501 tttttgagac ggagtctcgc tctgtcgcca ggctggagtg cagtggtgcg atctcggctc
     1561 actgcaacct ccgcctcccg gttcaagcca ttcttctgcc tcagcctcag cgagtagctg
     1621 agactaccgg cgcacgccac cacgcccagc taattgtttt gtatttttag tagagacggg
     1681 gtttcaccat gttggccagg atggtctcga tctcttgacc tcgtgatctg cccgcctcgg
     1741 cctcccaaag tgccgagatt acaggtgtga gccaccgcgc tcggccagag ctctgggttt
     1801 taatcctact ttagctgtag aaccttgggc aaataacttc atctttttgg gtcctaattt
     1861 tcctcctgtc taactggagg gactgtgatc cttccacctt ggatggaaga ggcttacctg
     1921 acagccagcc tgcctgctgg gagccaggag agtcagctca ttaaatcttg aagaaccgct
     1981 gtatgccctt tttccttcta agtcatgtct gctgcctgtg agcctgggaa ggagtgcttt
     2041 caaaacctgt atttttgccc tctttagtaa atttagaact gtagaggcta ataaactgcg
     2101 atgagacatt taagctctgc tccaaagaag tgaacgactc tttcaccacc ccttgcatcc
     2161 caaaccttcg gttctggcag agttcttgcc gcagaggttc cttaggagca ccccgcgcgg
     2221 cccgcgcgag cgcgcctgcg cgtcgaa
//
