LOCUS       NM_001010903            3735 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens BCL2 interacting protein 5 (BNIP5), mRNA.
ACCESSION   NM_001010903 XM_371816
VERSION     NM_001010903.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3735)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3735)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3735)
  AUTHORS   DeBartolo,J., Taipale,M. and Keating,A.E.
  TITLE     Genome-wide prediction and validation of peptides that bind human
            prosurvival Bcl-2 proteins
  JOURNAL   PLoS Comput Biol 10 (6), e1003693 (2014)
   PUBMED   24967846
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z84484.1, BX648558.1 and BC140873.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001010903.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648558.1, BC140873.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000437635.3/ ENSP00000418983.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 Z84484.1           85663-85665         c
            4-36                BX648558.1         2-34
            37-37               Z84484.1           85629-85629         c
            38-533              BX648558.1         36-531
            534-2682            BC140873.1         454-2602
            2683-3735           BX648558.1         2681-3733
FEATURES             Location/Qualifiers
     source          1..3735
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..3735
                     /gene="BNIP5"
                     /gene_synonym="C6orf222"
                     /note="BCL2 interacting protein 5"
                     /db_xref="GeneID:389384"
                     /db_xref="HGNC:HGNC:33769"
     exon            1..177
                     /gene="BNIP5"
                     /gene_synonym="C6orf222"
                     /inference="alignment:Splign:2.1.0"
     exon            178..791
                     /gene="BNIP5"
                     /gene_synonym="C6orf222"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..2140
                     /gene="BNIP5"
                     /gene_synonym="C6orf222"
                     /note="uncharacterized protein C6orf222"
                     /codon_start=1
                     /product="protein BNIP5"
                     /protein_id="NP_001010903.3"
                     /db_xref="CCDS:CCDS34439.1"
                     /db_xref="GeneID:389384"
                     /db_xref="HGNC:HGNC:33769"
                     /translation="MENPRCPRRPLAEKKARSLDRPQAPGKGSESWDCHWLSLPTAPS
                     RKALHWTTSDWARHSDSPAPSAEAHCTTAAAPTPEETGDFLPSEQRPSQDTKKGWLKT
                     MLNFFVRTGPEEPREKASRRPRGKEGISQHPEPLEAAGEPALRKKAHHDKKPSRKKQG
                     HKKHAAEVTKAAQDQEARGREEGLSKAAAALRSGEADLGPARRGGEDSDHQSFLIKVD
                     GTGALDVSPHATGHQQEEELKKPDQDAIIQMIVELLKRVGDQWEEEQSLASQLGVALP
                     NPAPAVRKKSQEKKTSLKRTSKTNPKKHGSEEAKRGAADVSSPEAWPPKKSSFLPLCV
                     SGHRPSISSSYGLEEPKVQEAPSTEAGAPGPSVLPTPSESQEPGEELPLDRASEYKEF
                     IQKIISMLQDAEEQQGEEQPQVQQEEVGVENPAPHCRRKSQEKRSSFRRAFYHKKHTS
                     KEPRRAGAAGAASPEARRPKRPSFLPLCVGGHRPSTSSSLDPEDLECREPLPAEGEPV
                     VISEAPSQARGHTPEGAPQLSGACESKEIIIQKLVALLQEVDGQLGQQIRRHPSFKRF
                     FYEFSDSSLSKLVATLRSQVAHSSKLDRNRARRLYQFDVSLANKFAGSNSHAMCILMG
                     LRDHYNCTQFPYREDQPNITSPKVESPD"
     exon            792..908
                     /gene="BNIP5"
                     /gene_synonym="C6orf222"
                     /inference="alignment:Splign:2.1.0"
     exon            909..973
                     /gene="BNIP5"
                     /gene_synonym="C6orf222"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1217
                     /gene="BNIP5"
                     /gene_synonym="C6orf222"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1349
                     /gene="BNIP5"
                     /gene_synonym="C6orf222"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1411
                     /gene="BNIP5"
                     /gene_synonym="C6orf222"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1652
                     /gene="BNIP5"
                     /gene_synonym="C6orf222"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1784
                     /gene="BNIP5"
                     /gene_synonym="C6orf222"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1849
                     /gene="BNIP5"
                     /gene_synonym="C6orf222"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2104
                     /gene="BNIP5"
                     /gene_synonym="C6orf222"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..3735
                     /gene="BNIP5"
                     /gene_synonym="C6orf222"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3716..3721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BNIP5"
                     /gene_synonym="C6orf222"
                     /note="hexamer: AATAAA"
     polyA_site      3735
                     /gene="BNIP5"
                     /gene_synonym="C6orf222"
                     /note="major polyA site"
ORIGIN      
        1 gacactcaga aaattgccag caccaaagta gtggcatctt ctccctggga gagctgggtc
       61 tgacttctca ctggacacaa cttccagctg acagggagca gagcctaaca cagagacctc
      121 ttgtctgaag atcccagccc agggtgttca ggacagaagc gatttctgtg gtccaagccc
      181 gatggagaat ccaaggtgcc caaggaggcc cctggcggag aagaaagcca ggtctctgga
      241 caggccgcag gcccccggga aaggctcgga gtcgtgggac tgccattggc tctccctgcc
      301 cactgccccc tccaggaagg cgcttcactg gacgaccagt gattgggcca gacattcaga
      361 cagcccagct ccatctgcag aggctcactg caccaccgct gcagccccca ctcccgagga
      421 gaccggagat tttctcccca gcgagcagag gccttcgcaa gacaccaaga aggggtggct
      481 gaagaccatg ctgaacttct tcgtgaggac gggccctgag gagcccagag aaaaggccag
      541 caggaggcca agggggaagg agggtatctc ccagcatccg gagcccctgg aagcagcagg
      601 ggagccagcc ctcaggaaga aagcccacca cgacaagaag cccagccgca agaagcaagg
      661 tcacaagaaa cacgcggccg aggtgactaa ggcagctcaa gaccaggagg ccagaggccg
      721 agaggaaggg ttgtccaagg cagctgctgc cttgcgctcc ggggaggctg acctgggccc
      781 agctcgcagg ggtggggaag attctgatca ccagtccttc ctcatcaaag tggatggtac
      841 tggagctttg gatgtttctc cccatgccac aggtcatcag caagaagagg agctcaaaaa
      901 gcctgaccag gatgctatca ttcagatgat agtggaattg ctcaaaagag tgggagacca
      961 gtgggaagaa gagcaatctc tggcctcaca gctgggggtg gccctgccaa acccagcacc
     1021 agctgttagg aagaaatccc aagagaaaaa gacaagcctc aagagaacct caaagacaaa
     1081 ccccaagaaa cacggctccg aggaggccaa gaggggggct gcagatgttt ccagtccaga
     1141 ggcctggcca cccaagaagt ccagctttct gcccctgtgt gtcagcggcc atcggccttc
     1201 catctccagc agctatggct tggaagaacc taaagtccag gaggccccat ctacagaggc
     1261 tggggctcca ggtccctccg tgcttcccac cccatcagag agccaggaac ctggagagga
     1321 gcttccgctg gacagagcct cggaatacaa agaattcatt cagaagatca tttccatgct
     1381 ccaagatgca gaagaacagc aaggagagga gcaacctcaa gtccagcagg aagaggtggg
     1441 tgtagaaaac ccggccccac actgcagaag gaaatctcaa gaaaaaaggt cgagcttcag
     1501 gagagcgttt taccataaga aacacacctc caaggaaccc agaagagcgg gggcagcagg
     1561 ggctgccagc ccagaggccc gacgacccaa gaggcccagc tttctgcccc tgtgtgttgg
     1621 tggccatcgg ccctccacct ccagcagcct tgatccagaa gatctcgagt gccgggagcc
     1681 cctgcccgca gaaggggagc cagttgtgat ctcagaagca ccctcccagg ctagaggcca
     1741 cacgccagaa ggggcacctc agctgagtgg agcatgtgaa tctaaggaga tcatcatcca
     1801 gaagcttgtg gcacttctcc aagaagtgga tggccaactg gggcagcaga tcaggcgcca
     1861 ccccagcttt aagaggtttt tttacgagtt ctcggactcc tccctcagca agctggtagc
     1921 caccctgcgc agccaggtgg ctcactcctc taagctggac aggaaccgcg ccaggagact
     1981 ctaccagttt gacgttagct tagctaacaa atttgctggc agcaacagcc atgccatgtg
     2041 catcctcatg ggcctaagag accactacaa ttgcacccag ttcccataca gggaggacca
     2101 gccgaacatc acaagtccta aggttgaaag tccagattga aagctgtgtc ttgcactcaa
     2161 attcccttga actagccaaa tggttcgcag ctttagccag gagaccctga agatgctctg
     2221 tgatgtccca atccctgctt cacaaacgtg atggaagaca agagcagaca atcattctgt
     2281 gtccataccc tagtatctga gaagcacaga gcattcttcc acaaggcaag acacagaggc
     2341 catgtctggg gaaatcagca ctggactggg aatgaggaag actggggctc tacctgctga
     2401 acctacccca gacttgctgc atgaccctct acacattccc cctcctctcc agactttgga
     2461 gtctaggatc ccacccagaa ggcctactga tattttctca gatgttcatg ttaactgagt
     2521 ctagttttta aactaaattt ttatttaatc tctaaacaga acatccacat gcatccaaac
     2581 agatatgcat cgaagtgtat cccatcattt cttcagttga ccagtagttc ttcatgctca
     2641 tatggatttg tagatgcctc ccaggaactc tgcaggccca agatggaaaa acctagagac
     2701 tggggacact tggtctctca gaatccttct aaccctgtgt cctgtcattc tatgactaga
     2761 gaaatggagc tgataccttg cacctctccc atctcatggg attggctagg agtcagtgag
     2821 aaaatggatg tgaagagttc tgaaaattac ctagtgccat gtccatgtag gcactatagc
     2881 ttcttttggg tagttttcag gaagtggagg agggcttcaa tgggctggac tgccatggat
     2941 tgttgcacag gggtgcactg ctcaagagca ccatactcca ggaggtacta ttcatgtcct
     3001 agacattgtg gatttgtaga tttatcatga cagttttgca gctggtagca gtaacatgtc
     3061 ttgagaaaag ggctattttt tgtatttgca caaaggtgaa gtgtgggggt gccagaggct
     3121 ctgccttctg tatagctcaa cagtttcaat agcttgactc aggtgtgaaa tttgccacat
     3181 gttcatatct atgtgcagga aggacaagac tgtagacaga cagtcggctc ccttggacac
     3241 tgcccagaac atgtggtcat gggggaaagg gtgttaaacc tggatggcaa gtgagatctt
     3301 gtgacccttg gggacatggt attgccgtgt tgaacctgct gtcgcaccat ggggtaggac
     3361 tggggaggag gagcagtcta gagcggagag gccctgggtg cttatatggg actggcctcc
     3421 aacctgaggc actggcttca taagctcaac tcagcctatc cggaaagcca tttagttttt
     3481 attgctgctt ctgagaagtg ggggagaggt gagctatttg tggatttgtt ttaggcagtg
     3541 ttcacaatca tagcacctaa atatgaagga tcagaataag ttatgaaatg aaggtcagga
     3601 accttttgta catagtttct tatttggaat gatgttcttt aagccctatg agtatttggt
     3661 atgtgctcct gatgctggca tctgagtctc atttttgtac cgtgttattt gagcaaataa
     3721 atacattaac ttgca
//
