LOCUS       NM_004331               3452 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens BCL2 interacting protein 3 like (BNIP3L), transcript
            variant 1, mRNA.
ACCESSION   NM_004331
VERSION     NM_004331.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3452)
  AUTHORS   Wang,Q., Wang,Y., Wu,J., Xie,X., Qin,H., Huang,C., Li,Z., Ling,Z.
            and Li,R.
  TITLE     Association between BCL2 interacting protein 3 like (BNIP3L)
            genetic polymorphisms and the risk of multiple myeloma in China
  JOURNAL   Hematology 29 (1), 2367918 (2024)
   PUBMED   38934722
  REMARK    GeneRIF: Association between BCL2 interacting protein 3 like
            (BNIP3L) genetic polymorphisms and the risk of multiple myeloma in
            China.
REFERENCE   2  (bases 1 to 3452)
  AUTHORS   Nguyen-Dien,G.T., Townsend,B., Kulkarni,P.G., Kozul,K.L., Ooi,S.S.,
            Eldershaw,D.N., Weeratunga,S., Liu,M., Jones,M.J., Millard,S.S.,
            Ng,D.C., Pagano,M., Bonfim-Melo,A., Schneider,T., Komander,D.,
            Lazarou,M., Collins,B.M. and Pagan,J.K.
  TITLE     PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation
            via SCFFBXL4
  JOURNAL   EMBO Rep 25 (8), 3324-3347 (2024)
   PUBMED   38992176
  REMARK    GeneRIF: PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX
            degradation via SCF[FBXL4].
REFERENCE   3  (bases 1 to 3452)
  AUTHORS   Pandey,A., Kakani,P. and Shukla,S.
  TITLE     CTCF and BORIS-mediated autophagy regulation via alternative
            splicing of BNIP3L in breast cancer
  JOURNAL   J Biol Chem 300 (7), 107416 (2024)
   PUBMED   38810696
  REMARK    GeneRIF: CTCF and BORIS-mediated autophagy regulation via
            alternative splicing of BNIP3L in breast cancer.
REFERENCE   4  (bases 1 to 3452)
  AUTHORS   Yamashita,S.I., Sugiura,Y., Matsuoka,Y., Maeda,R., Inoue,K.,
            Furukawa,K., Fukuda,T., Chan,D.C. and Kanki,T.
  TITLE     Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by
            downregulating mitochondrial reactive oxygen species
  JOURNAL   Cell Death Differ 31 (5), 651-661 (2024)
   PUBMED   38519771
  REMARK    GeneRIF: Mitophagy mediated by BNIP3 and NIX protects against
            ferroptosis by downregulating mitochondrial reactive oxygen
            species.
REFERENCE   5  (bases 1 to 3452)
  AUTHORS   Gao,K., Chen,Y., Mo,R. and Wang,C.
  TITLE     Excessive BNIP3- and BNIP3L-dependent mitophagy underlies the
            pathogenesis of FBXL4-mutated mitochondrial DNA depletion syndrome
  JOURNAL   Autophagy 20 (2), 460-462 (2024)
   PUBMED   37876279
  REMARK    GeneRIF: Excessive BNIP3- and BNIP3L-dependent mitophagy underlies
            the pathogenesis of FBXL4-mutated mitochondrial DNA depletion
            syndrome.
REFERENCE   6  (bases 1 to 3452)
  AUTHORS   Gubin,A.N., Njoroge,J.M., Bouffard,G.G. and Miller,J.L.
  TITLE     Gene expression in proliferating human erythroid cells
  JOURNAL   Genomics 59 (2), 168-177 (1999)
   PUBMED   10409428
REFERENCE   7  (bases 1 to 3452)
  AUTHORS   Ohi,N., Tokunaga,A., Tsunoda,H., Nakano,K., Haraguchi,K., Oda,K.,
            Motoyama,N. and Nakajima,T.
  TITLE     A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis
            induced by Nip3 by forming a heterodimer through the C-terminal
            hydrophobic region
  JOURNAL   Cell Death Differ 6 (4), 314-325 (1999)
   PUBMED   10381623
REFERENCE   8  (bases 1 to 3452)
  AUTHORS   Yasuda,M., Han,J.W., Dionne,C.A., Boyd,J.M. and Chinnadurai,G.
  TITLE     BNIP3alpha: a human homolog of mitochondrial proapoptotic protein
            BNIP3
  JOURNAL   Cancer Res 59 (3), 533-537 (1999)
   PUBMED   9973195
REFERENCE   9  (bases 1 to 3452)
  AUTHORS   Chen,G., Cizeau,J., Vande Velde,C., Park,J.H., Bozek,G., Bolton,J.,
            Shi,L., Dubik,D. and Greenberg,A.
  TITLE     Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial
            proteins
  JOURNAL   J Biol Chem 274 (1), 7-10 (1999)
   PUBMED   9867803
REFERENCE   10 (bases 1 to 3452)
  AUTHORS   Matsushima,M., Fujiwara,T., Takahashi,E., Minaguchi,T., Eguchi,Y.,
            Tsujimoto,Y., Suzumori,K. and Nakamura,Y.
  TITLE     Isolation, mapping, and functional analysis of a novel human cDNA
            (BNIP3L) encoding a protein homologous to human NIP3
  JOURNAL   Genes Chromosomes Cancer 21 (3), 230-235 (1998)
   PUBMED   9523198
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD558918.1, AB004788.1,
            AF536326.1, AL132665.1, CD244492.1, BF337139.1, BQ719112.1 and
            AA946755.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004331.2.
            
            Summary: This gene encodes a protein that belongs to the
            pro-apoptotic subfamily within the Bcl-2 family of proteins. The
            encoded protein binds to Bcl-2 and possesses the BH3 domain. The
            protein directly targets mitochondria and causes apoptotic changes,
            including loss of membrane potential and the release of cytochrome
            c. [provided by RefSeq, Feb 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.143872.1,
                                           SRR1803615.247639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380629.7/ ENSP00000370003.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                CD558918.1         157-232
            77-1297             AB004788.1         45-1265
            1298-1512           AF536326.1         1276-1490
            1513-1542           AL132665.1         1529-1558
            1543-2109           CD244492.1         1-567
            2110-2256           BF337139.1         116-262
            2257-2743           BQ719112.1         190-676
            2744-3372           AL132665.1         2760-3388
            3373-3452           AA946755.1         7-86                c
FEATURES             Location/Qualifiers
     source          1..3452
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.2"
     gene            1..3452
                     /gene="BNIP3L"
                     /gene_synonym="BNIP3a; NIP3L; NIX"
                     /note="BCL2 interacting protein 3 like"
                     /db_xref="GeneID:665"
                     /db_xref="HGNC:HGNC:1085"
                     /db_xref="MIM:605368"
     exon            1..177
                     /gene="BNIP3L"
                     /gene_synonym="BNIP3a; NIP3L; NIX"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..737
                     /gene="BNIP3L"
                     /gene_synonym="BNIP3a; NIP3L; NIX"
                     /note="isoform 1 is encoded by transcript variant 1;
                     BCL2/adenovirus E1B 19-kd protein-interacting protein 3a;
                     BCL2/adenovirus E1B 19 kDa protein-interacting protein
                     3-like; BCL2/adenovirus E1B 19kDa interacting protein 3
                     like; adenovirus E1B19k-binding protein B5; NIP3-like
                     protein X; BCL2/adenovirus E1B 19 kDa protein-interacting
                     protein 3A; NIP-3-like protein X"
                     /codon_start=1
                     /product="BCL2/adenovirus E1B 19 kDa protein-interacting
                     protein 3-like isoform 1"
                     /protein_id="NP_004322.1"
                     /db_xref="CCDS:CCDS6050.1"
                     /db_xref="GeneID:665"
                     /db_xref="HGNC:HGNC:1085"
                     /db_xref="MIM:605368"
                     /translation="MSSHLVEPPPPLHNNNNNCEENEQSLPPPAGLNSSWVELPMNSS
                     NGNDNGNGKNGGLEHVPSSSSIHNGDMEKILLDAQHESGQSSSRGSSHCDSPSPQEDG
                     QIMFDVEMHTSRDHSSQSEEEVVEGEKEVEALKKSADWVSDWSSRPENIPPKEFHFRH
                     PKRSVSLSMRKSGAMKKGGIFSAEFLKVFIPSLFLSHVLALGLGIYIGKRLSTPSAST
                     Y"
     exon            178..361
                     /gene="BNIP3L"
                     /gene_synonym="BNIP3a; NIP3L; NIX"
                     /inference="alignment:Splign:2.1.0"
     exon            362..434
                     /gene="BNIP3L"
                     /gene_synonym="BNIP3a; NIP3L; NIX"
                     /inference="alignment:Splign:2.1.0"
     exon            435..538
                     /gene="BNIP3L"
                     /gene_synonym="BNIP3a; NIP3L; NIX"
                     /inference="alignment:Splign:2.1.0"
     exon            539..688
                     /gene="BNIP3L"
                     /gene_synonym="BNIP3a; NIP3L; NIX"
                     /inference="alignment:Splign:2.1.0"
     exon            689..3452
                     /gene="BNIP3L"
                     /gene_synonym="BNIP3a; NIP3L; NIX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1295..1300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BNIP3L"
                     /gene_synonym="BNIP3a; NIP3L; NIX"
                     /note="hexamer: AATAAA"
     polyA_site      1317
                     /gene="BNIP3L"
                     /gene_synonym="BNIP3a; NIP3L; NIX"
                     /note="major polyA site"
     regulatory      3432..3437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BNIP3L"
                     /gene_synonym="BNIP3a; NIP3L; NIX"
                     /note="hexamer: ATTAAA"
     polyA_site      3452
                     /gene="BNIP3L"
                     /gene_synonym="BNIP3a; NIP3L; NIX"
ORIGIN      
        1 ggactcggct tgttgtgttg ctgcctgagt gccggagacg gtcctgctgc tgccgcagtc
       61 ctgccagctg tccgacaatg tcgtcccacc tagtcgagcc gccgccgccc ctgcacaaca
      121 acaacaacaa ctgcgaggaa aatgagcagt ctctgccccc gccggccggc ctcaacagtt
      181 cctgggtgga gctacccatg aacagcagca atggcaatga taatggcaat gggaaaaatg
      241 gggggctgga acacgtacca tcctcatcct ccatccacaa tggagacatg gagaagattc
      301 ttttggatgc acaacatgaa tcaggacaga gtagttccag aggcagttct cactgtgaca
      361 gcccttcgcc acaagaagat gggcagatca tgtttgatgt ggaaatgcac accagcaggg
      421 accatagctc tcagtcagaa gaagaagttg tagaaggaga gaaggaagtc gaggctttga
      481 agaaaagtgc ggactgggta tcagactggt ccagtagacc cgaaaacatt ccacccaagg
      541 agttccactt cagacaccct aaacgttctg tgtctttaag catgaggaaa agtggagcca
      601 tgaagaaagg gggtattttc tccgcagaat ttctgaaggt gttcattcca tctctcttcc
      661 tttctcatgt tttggctttg gggctaggca tctatattgg aaagcgactg agcacaccct
      721 ctgccagcac ctactgaggg aaaggaaaag cccctggaaa tgcgtgtgac ctgtgaagtg
      781 gtgtattgtc acagtagctt atttgaactt gagaccattg taagcatgac ccaacctacc
      841 accctgtttt tacatatcca attccagtaa ctctcaaatt caatatttta ttcaaactct
      901 gttgaggcat tttactaacc ttataccctt tttggcctga agacatttta gaatttccta
      961 acagagttta ctgttgttta gaaatttgca agggcttctt ttccgcaaat gccaccagca
     1021 gattataatt ttgtcagcaa tgctattatc tctaattagt gccaccagac tagacctgta
     1081 tcattcatgg tataaatttt actcttgcaa cataactacc atctctctct taaaacgaga
     1141 tcaggttagc aaatgatgta aaagaagctt tattgtctag ttgttttttt tcccccaaga
     1201 caaaggcaag tttccctaag tttgagttga tagttattaa aaagaaaaca aaacaaaaaa
     1261 aaaaggcaag gcacaacaaa aaaatatcct gggcaataaa aaaaatattt taaaccagct
     1321 ttggagccac ttttttgtct aagcctccta atagcgtctt ttaatttata ggaggcaaac
     1381 tgtataaatg ataggtatga aatagaataa gaagtaaaat acatcagcag attttcatac
     1441 tagtatgttg taatgctgtc ttttctatgg tgtagaatct ttctttctga taaggaacgt
     1501 ctcaggctta gaaatatatg aaattgcttt ttgagatttt tgcgtgtgtg tttgatattt
     1561 tttacgataa ttagctgcat gtgaattttt catgaccttc tttacatttt ttatttttta
     1621 tttctttatt tttttttctc taagaagagg ctttggaatg agttccaatt tgtgatgtta
     1681 atacaggctt cttgttttag gaagcatcac ctatactctg aagcctttaa actctgaaga
     1741 gaattgtttc agagttattc caagcacttg tgcaacttgg aaaaacagac ttgggttgtg
     1801 ggaacagttg acagcgttct gaaaagatgc catttgtttc cttctgatct ctcactgaat
     1861 aatgtttact gtacagtctt cccaaggtga ttcctgcgac tgcaggcact ggtcattttc
     1921 tcatgtagct gtcttttcag ttatggtaaa ctcttaaagt tcagaacact caacagattc
     1981 cttcagtgat atacttgttc gttcatttct aaaatgtgaa gctttaggac caaattgtta
     2041 gaaagcatca ggatgaccag ttatctcgag tagattttct tggatttcag aacatctagc
     2101 atgactctga aggataccac atgttttata tataaataat tactgtttat gatatagaca
     2161 ttgatattga ctatttagag aaccgttgtt aattttaaaa ctagcaatct ataaagtgca
     2221 ccaggtcaac ttgaataaaa acactatgac agacaggttt gccagtttgc agaaactaac
     2281 tcttttctca catcaacatt tgtaaaattg atgtgttata gtggaaaata acatatagat
     2341 taaacaaaat ttttatcttt tttcaagaat atagctggct atctttaaga aagatgatat
     2401 atcctagttt tgaaagtaat tttctttttt ctttctagca tttgatgtct aaataatttt
     2461 ggacatcttt ttcctagacc atgtttctgt cttactctta aacctggtaa cacttgattt
     2521 gccttctata acctatttat ttcaagtgtt catatttgaa tttctttggg aagaaagtaa
     2581 atctgatggc tcactgattt ttgaaaagcc tgaataaaat tggaaagact ggaaagttag
     2641 gagaactgac tagctaaact gctacagtat gcaatttcta ttacaattgg tattacaggg
     2701 gggaaaagta aaattacact ttacctgaaa gtgacttctt acagctagtg cattgtgctc
     2761 tttccaagtt cagcagcagt tctatcagtg gtgccactga aactgggtat atttatgatt
     2821 tctttcagcg ttaaaaagaa acatagtgtt gccctttttc ttaaagcatc agtgaaatta
     2881 tggaaaatta cttaaaacgt gaatacatca tcacagtaga atttattatg agagcatgta
     2941 gtatgtatct gtagccctaa cacatgggat gaacgtttta ctgctacacc cagatttgtg
     3001 ttgaacgaaa acattgtggt ttggaaagga gaattcaaca attaatagtt gaaattgtga
     3061 ggttaatgtt taaaaagctt tacacctgtt tacaatttgg ggacaaaaag gcaggcttca
     3121 tttttcatat gtttgatgaa aactggctca agatgtttgt aaatagaatc aagagcaaaa
     3181 ctgcacaaac ttgcacattg gaaagtgcaa caagttcccg tgattgcagt aaaaatattt
     3241 actattctaa aaaaatgaga attgaagact tagccagtca gataagtttt ttcatgaacc
     3301 cgttgtggaa attattggaa ttaactgagc caaagtgatt atgcattctt catctatttt
     3361 agttagcact ttgtatcgtt atatacagtt tacaatacat gtataacttg tagctataaa
     3421 cattttgtgc cattaaagct ctcacaaaac tt
//
