LOCUS       NM_004052               1542 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens BCL2 interacting protein 3 (BNIP3), mRNA.
ACCESSION   NM_004052
VERSION     NM_004052.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1542)
  AUTHORS   Nguyen-Dien,G.T., Townsend,B., Kulkarni,P.G., Kozul,K.L., Ooi,S.S.,
            Eldershaw,D.N., Weeratunga,S., Liu,M., Jones,M.J., Millard,S.S.,
            Ng,D.C., Pagano,M., Bonfim-Melo,A., Schneider,T., Komander,D.,
            Lazarou,M., Collins,B.M. and Pagan,J.K.
  TITLE     PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation
            via SCFFBXL4
  JOURNAL   EMBO Rep 25 (8), 3324-3347 (2024)
   PUBMED   38992176
  REMARK    GeneRIF: PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX
            degradation via SCF[FBXL4].
REFERENCE   2  (bases 1 to 1542)
  AUTHORS   Yamashita,S.I., Sugiura,Y., Matsuoka,Y., Maeda,R., Inoue,K.,
            Furukawa,K., Fukuda,T., Chan,D.C. and Kanki,T.
  TITLE     Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by
            downregulating mitochondrial reactive oxygen species
  JOURNAL   Cell Death Differ 31 (5), 651-661 (2024)
   PUBMED   38519771
  REMARK    GeneRIF: Mitophagy mediated by BNIP3 and NIX protects against
            ferroptosis by downregulating mitochondrial reactive oxygen
            species.
REFERENCE   3  (bases 1 to 1542)
  AUTHORS   Jeong,D.J., Um,J.H., Kim,Y.Y., Shin,D.J., Im,S., Lee,K.M.,
            Lee,Y.H., Lim,D.S., Kim,D. and Yun,J.
  TITLE     The Mst1/2-BNIP3 axis is required for mitophagy induction and
            neuronal viability under mitochondrial stress
  JOURNAL   Exp Mol Med 56 (3), 674-685 (2024)
   PUBMED   38443598
  REMARK    GeneRIF: The Mst1/2-BNIP3 axis is required for mitophagy induction
            and neuronal viability under mitochondrial stress.
REFERENCE   4  (bases 1 to 1542)
  AUTHORS   Wang,X., Wu,Z., Zhang,Y., Lian,B., Ma,L. and Zhao,J.
  TITLE     Autophagy induced by hypoxia in pulpitis is mediated by
            HIF-1alpha/BNIP3
  JOURNAL   Arch Oral Biol 159, 105881 (2024)
   PUBMED   38199116
  REMARK    GeneRIF: Autophagy induced by hypoxia in pulpitis is mediated by
            HIF-1alpha/BNIP3.
REFERENCE   5  (bases 1 to 1542)
  AUTHORS   Wang,W.T., Xing,T.Y., Du,K.X., Hua,W., Guo,J.R., Duan,Z.W.,
            Wu,Y.F., Wu,J.Z., Li,Y., Yin,H., Shen,H.R., Wang,L., Li,J.Y.,
            Liang,J.H. and Xu,W.
  TITLE     CD30 protects EBV-positive diffuse large B-cell lymphoma cells
            against mitochondrial dysfunction through BNIP3-mediated mitophagy
  JOURNAL   Cancer Lett 583, 216616 (2024)
   PUBMED   38211650
  REMARK    GeneRIF: CD30 protects EBV-positive diffuse large B-cell lymphoma
            cells against mitochondrial dysfunction through BNIP3-mediated
            mitophagy.
REFERENCE   6  (bases 1 to 1542)
  AUTHORS   Chen,G., Cizeau,J., Vande Velde,C., Park,J.H., Bozek,G., Bolton,J.,
            Shi,L., Dubik,D. and Greenberg,A.
  TITLE     Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial
            proteins
  JOURNAL   J Biol Chem 274 (1), 7-10 (1999)
   PUBMED   9867803
REFERENCE   7  (bases 1 to 1542)
  AUTHORS   Yasuda,M., Theodorakis,P., Subramanian,T. and Chinnadurai,G.
  TITLE     Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3
            domain and a mitochondrial targeting sequence
  JOURNAL   J Biol Chem 273 (20), 12415-12421 (1998)
   PUBMED   9575197
REFERENCE   8  (bases 1 to 1542)
  AUTHORS   Chen,G., Ray,R., Dubik,D., Shi,L., Cizeau,J., Bleackley,R.C.,
            Saxena,S., Gietz,R.D. and Greenberg,A.H.
  TITLE     The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial
            protein that activates apoptosis
  JOURNAL   J Exp Med 186 (12), 1975-1983 (1997)
   PUBMED   9396766
REFERENCE   9  (bases 1 to 1542)
  AUTHORS   Kataoka,N., Ohno,M., Moda,I. and Shimura,Y.
  TITLE     Identification of the factors that interact with NCBP, an 80 kDa
            nuclear cap binding protein
  JOURNAL   Nucleic Acids Res 23 (18), 3638-3641 (1995)
   PUBMED   7478990
REFERENCE   10 (bases 1 to 1542)
  AUTHORS   Boyd,J.M., Malstrom,S., Subramanian,T., Venkatesh,L.K.,
            Schaeper,U., Elangovan,B., D'Sa-Eipper,C. and Chinnadurai,G.
  TITLE     Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set
            of cellular proteins
  JOURNAL   Cell 79 (2), 341-351 (1994)
   PUBMED   7954800
  REMARK    Erratum:[Cell. 1994 Dec 16;79(6):1121.. PMID: 8001138]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162274.17 and AL732395.9.
            
            On Jan 15, 2021 this sequence version replaced NM_004052.3.
            
            Summary: This gene is encodes a mitochondrial protein that contains
            a BH3 domain and acts as a pro-apoptotic factor. The encoded
            protein interacts with anti-apoptotic proteins, including the E1B
            19 kDa protein and Bcl2. This gene is silenced in tumors by DNA
            methylation. [provided by RefSeq, Dec 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222626.1, BC021989.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267751 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000368636.9/
                                                  ENSP00000357625.6
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               AL162274.17        15688-15850         c
            164-314             AL162274.17        7720-7870           c
            315-399             AL162274.17        6961-7045           c
            400-506             AL162274.17        4791-4897           c
            507-656             AL162274.17        4565-4714           c
            657-1152            AL162274.17        2001-2496           c
            1153-1542           AL732395.9         53661-54050         c
FEATURES             Location/Qualifiers
     source          1..1542
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.3"
     gene            1..1542
                     /gene="BNIP3"
                     /gene_synonym="HABON; NIP3"
                     /note="BCL2 interacting protein 3"
                     /db_xref="GeneID:664"
                     /db_xref="HGNC:HGNC:1084"
                     /db_xref="MIM:603293"
     exon            1..163
                     /gene="BNIP3"
                     /gene_synonym="HABON; NIP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..702
                     /gene="BNIP3"
                     /gene_synonym="HABON; NIP3"
                     /note="BCL2/adenovirus E1B 19kDa interacting protein 3;
                     BCL2/adenovirus E1B interacting protein 3; nineteen kD
                     interacting protein-3; Hypoxia-Activated BNIP3 Overlapping
                     Non-coding RNA"
                     /codon_start=1
                     /product="BCL2/adenovirus E1B 19 kDa protein-interacting
                     protein 3"
                     /protein_id="NP_004043.4"
                     /db_xref="CCDS:CCDS7663.3"
                     /db_xref="GeneID:664"
                     /db_xref="HGNC:HGNC:1084"
                     /db_xref="MIM:603293"
                     /translation="MSQNGAPGMQEESLQGSWVELHFSNNGNGGSVPASVSIYNGDME
                     KILLDAQHESGRSSSKSSHCDSPPRSQTPQDTNRASETDTHSIGEKNSSQSEEDDIER
                     RKEVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMRNTSVMKKGGIFSAE
                     FLKVFLPSLLLSHLLAIGLGIYIGRRLTTSTSTF"
     exon            164..314
                     /gene="BNIP3"
                     /gene_synonym="HABON; NIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            315..399
                     /gene="BNIP3"
                     /gene_synonym="HABON; NIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            400..506
                     /gene="BNIP3"
                     /gene_synonym="HABON; NIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            507..656
                     /gene="BNIP3"
                     /gene_synonym="HABON; NIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            657..1542
                     /gene="BNIP3"
                     /gene_synonym="HABON; NIP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      845..850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BNIP3"
                     /gene_synonym="HABON; NIP3"
                     /note="hexamer: AATAAA"
     polyA_site      866
                     /gene="BNIP3"
                     /gene_synonym="HABON; NIP3"
                     /note="major polyA site"
     regulatory      1517..1522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BNIP3"
                     /gene_synonym="HABON; NIP3"
                     /note="hexamer: AATAAA"
     polyA_site      1542
                     /gene="BNIP3"
                     /gene_synonym="HABON; NIP3"
ORIGIN      
        1 agtccgggag cgcagctggg ccgcggcgct ccgacctccg ctttcccacc gcccgcagct
       61 gaagcacatc ccgcagcccg gcgcggactc cgatcgccgc agttgccctc tggcgccatg
      121 tcgcagaacg gagcgcccgg gatgcaggag gagagcctgc agggctcctg ggtagaactg
      181 cacttcagca ataatgggaa cgggggcagc gttccagcct cggtttctat ttataatgga
      241 gacatggaaa aaatactgct ggacgcacag catgagtctg gacggagtag ctccaagagc
      301 tctcactgtg acagcccacc tcgctcgcag acaccacaag ataccaacag agcttctgaa
      361 acagataccc atagcattgg agagaaaaac agctcacagt ctgaggaaga tgatattgaa
      421 agaaggaaag aagttgaaag catcttgaag aaaaactcag attggatatg ggattggtca
      481 agtcggccgg aaaatattcc ccccaaggag ttcctcttta aacacccgaa gcgcacggcc
      541 accctcagca tgaggaacac gagcgtcatg aagaaagggg gcatattctc tgcagaattt
      601 ctgaaagttt tccttccatc tctgctgctc tctcatttgc tggccatcgg attggggatc
      661 tatattggaa ggcgtctgac aacctccacc agcacctttt gatgaagaac tggagtctga
      721 cttggttcgt tagtggatta cttctgagct tgcaacatag ctcactgaag agctgttaga
      781 tcctggggtg gccacgtcac ttgtgtttat ttgttctgta aatgctgcgt tcctaattta
      841 gtaaaataaa agaatagaca ctaaaatcat gttgatctat aattacacct atgggatcaa
      901 taagcatgtc agactgatta atgtctactg tgaaaatttg gtagtaaatt ttcatttgat
      961 attagatata aatatctgaa tataaataat tttaatatac tagtcatgat gtgtgttgta
     1021 ttttaaaaat tatctgcaac cttaattcag ctgaagtact ttatatttca aaagaatgaa
     1081 taacattgat aataaaatcg ctactttaag gggtttgtcc aaaataaata ttgtggcctt
     1141 atatatcaca ctattgtaga aagtattatt taatttaaat ggatgcaggt tgtctactaa
     1201 agaaagatta tatataacta tgctaattgt tcataatcaa cagaaaccaa gatagagcta
     1261 caaactcagc tgtacagttc gtacactaaa ctcttcttgc ttttgcatta taaggaatta
     1321 agtctccgat tattaggtga tcaccctgga tgatcagttt tctgctgaag gcacctactc
     1381 agtatctttt cctctttatc actctgcatt ggtgaattta atcctctcct ttgtgttcaa
     1441 cttttgtgtg cttttaaaat cagctttatt ctaagcaaat ctgtgtctac tttaaaaaac
     1501 tggaaatgga aaaaaaaata aatctttgcc aaatccttca ga
//
