LOCUS       NM_001717               4579 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens basonuclin zinc finger protein 1 (BNC1), transcript
            variant 1, mRNA.
ACCESSION   NM_001717 XM_937947
VERSION     NM_001717.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4579)
  AUTHORS   Wang,F., Liu,Y., Ni,F., Jin,J., Wu,Y., Huang,Y., Ye,X., Shen,X.,
            Ying,Y., Chen,J., Chen,R., Zhang,Y., Sun,X., Wang,S., Xu,X.,
            Chen,C., Guo,J. and Zhang,D.
  TITLE     BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway
            induces primary ovarian insufficiency
  JOURNAL   Nat Commun 13 (1), 5871 (2022)
   PUBMED   36198708
  REMARK    GeneRIF: BNC1 deficiency-triggered ferroptosis through the NF2-YAP
            pathway induces primary ovarian insufficiency.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4579)
  AUTHORS   Liang,Z.Q., Zhong,L.Y., Li,J., Shen,J.H., Tu,X.Y., Zhong,Z.H.,
            Zeng,J.J., Chen,J.H., Wei,Z.X., Dang,Y.W., Huang,S.N. and Chen,G.
  TITLE     Clinicopathological significance and underlying molecular mechanism
            of downregulation of basonuclin 1 expression in ovarian carcinoma
  JOURNAL   Exp Biol Med (Maywood) 247 (2), 106-119 (2022)
   PUBMED   34644201
  REMARK    GeneRIF: Clinicopathological significance and underlying molecular
            mechanism of downregulation of basonuclin 1 expression in ovarian
            carcinoma.
REFERENCE   3  (bases 1 to 4579)
  AUTHORS   Gao,Y., Li,J., Jiao,J., Li,Y., Wang,C., Zhang,Y. and Zhang,L.
  TITLE     Upregulation of Basonuclin1 Is Associated with p63-Involved
            Epithelial Barrier Impairment and Type-2 Helper T-cell Inflammation
            in Chronic Rhinosinusitis with Nasal Polyps
  JOURNAL   Int Arch Allergy Immunol 182 (11), 1046-1057 (2021)
   PUBMED   34148047
  REMARK    GeneRIF: Upregulation of Basonuclin1 Is Associated with
            p63-Involved Epithelial Barrier Impairment and Type-2 Helper T-cell
            Inflammation in Chronic Rhinosinusitis with Nasal Polyps.
REFERENCE   4  (bases 1 to 4579)
  AUTHORS   Gambardella,L., McManus,S.A., Moignard,V., Sebukhan,D., Delaune,A.,
            Andrews,S., Bernard,W.G., Morrison,M.A., Riley,P.R., Gottgens,B.,
            Gambardella Le Novere,N. and Sinha,S.
  TITLE     BNC1 regulates cell heterogeneity in human pluripotent stem
            cell-derived epicardium
  JOURNAL   Development 146 (24) (2019)
   PUBMED   31767620
  REMARK    GeneRIF: Cell heterogeneity is conserved in human epicardium,
            regulated by BNC1 and associated with cell fate and function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4579)
  AUTHORS   Tseng,H.
  TITLE     Basonuclin, a zinc finger protein associated with epithelial
            expansion and proliferation
  JOURNAL   Front Biosci 3, D985-D988 (1998)
   PUBMED   9727087
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4579)
  AUTHORS   Iuchi,S. and Green,H.
  TITLE     Nuclear localization of basonuclin in human keratinocytes and the
            role of phosphorylation
  JOURNAL   Proc Natl Acad Sci U S A 94 (15), 7948-7953 (1997)
   PUBMED   9223293
REFERENCE   7  (bases 1 to 4579)
  AUTHORS   Yang,Z., Gallicano,G.I., Yu,Q.C. and Fuchs,E.
  TITLE     An unexpected localization of basonuclin in the centrosome,
            mitochondria, and acrosome of developing spermatids
  JOURNAL   J Cell Biol 137 (3), 657-669 (1997)
   PUBMED   9151672
REFERENCE   8  (bases 1 to 4579)
  AUTHORS   Teumer,J., Tseng,H. and Green,H.
  TITLE     The human basonuclin gene
  JOURNAL   Gene 188 (1), 1-7 (1997)
   PUBMED   9099851
REFERENCE   9  (bases 1 to 4579)
  AUTHORS   Tseng,H. and Green,H.
  TITLE     Association of basonuclin with ability of keratinocytes to multiply
            and with absence of terminal differentiation
  JOURNAL   J Cell Biol 126 (2), 495-506 (1994)
   PUBMED   8034748
REFERENCE   10 (bases 1 to 4579)
  AUTHORS   Tseng,H. and Green,H.
  TITLE     Basonuclin: a keratinocyte protein with multiple paired zinc
            fingers
  JOURNAL   Proc Natl Acad Sci U S A 89 (21), 10311-10315 (1992)
   PUBMED   1332044
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L03427.1, AC103876.2,
            CN260997.1 and AI921950.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001717.3.
            
            Summary: This gene encodes a zinc finger protein present in the
            basal cell layer of the epidermis and in hair follicles. It is also
            found in abundance in the germ cells of testis and ovary. This
            protein is thought to play a regulatory role in keratinocyte
            proliferation and it may also be a regulator for rRNA
            transcription. Disruption of this gene has been implicated in
            premature ovarian failure as well as testicular premature aging.
            [provided by RefSeq, Sep 2020].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L03427.1, SRR14038193.4286790.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000345382.7/ ENSP00000307041.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                L03427.1           52-102
            52-79               AC103876.2         94927-94954         c
            80-501              L03427.1           128-549
            502-1239            AC103876.2         74389-75126         c
            1240-1949           L03427.1           1288-1997
            1950-2556           CN260997.1         95-701
            2557-4118           L03427.1           2605-4166
            4119-4560           AI921950.1         16-457              c
            4561-4579           AC103876.2         66225-66243         c
FEATURES             Location/Qualifiers
     source          1..4579
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.2"
     gene            1..4579
                     /gene="BNC1"
                     /gene_synonym="bn1; BNC; BSN1; HsT19447; POF16"
                     /note="basonuclin zinc finger protein 1"
                     /db_xref="GeneID:646"
                     /db_xref="HGNC:HGNC:1081"
                     /db_xref="MIM:601930"
     exon            1..135
                     /gene="BNC1"
                     /gene_synonym="bn1; BNC; BSN1; HsT19447; POF16"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..3021
                     /gene="BNC1"
                     /gene_synonym="bn1; BNC; BSN1; HsT19447; POF16"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger protein basonuclin-1; basonuclin 1"
                     /codon_start=1
                     /product="zinc finger protein basonuclin-1 isoform a"
                     /protein_id="NP_001708.3"
                     /db_xref="CCDS:CCDS10324.1"
                     /db_xref="GeneID:646"
                     /db_xref="HGNC:HGNC:1081"
                     /db_xref="MIM:601930"
                     /translation="MRRRPPSRGGRGAARARETRRQPRHRSGRRMAEAISCTLNCSCQ
                     SFKPGKINHRQCDQCKHGWVAHALSKLRIPPMYPTSQVEIVQSNVVFDISSLMLYGTQ
                     AIPVRLKILLDRLFSVLKQDEVLQILHALDWTLQDYIRGYVLQDASGKVLDHWSIMTS
                     EEEVATLQQFLRFGETKSIVELMAIQEKEEQSIIIPPSTANVDIRAFIESCSHRSSSL
                     PTPVDKGNPSSIHPFENLISNMTFMLPFQFFNPLPPALIGSLPEQYMLEQGHDQSQDP
                     KQEVHGPFPDSSFLTSSSTPFQVEKDQCLNCPDAITKKEDSTHLSDSSSYNIVTKFER
                     TQLSPEAKVKPERNSLGTKKGRVFCTACEKTFYDKGTLKIHYNAVHLKIKHKCTIEGC
                     NMVFSSLRSRNRHSANPNPRLHMPMNRNNRDKDLRNSLNLASSENYKCPGFTVTSPDC
                     RPPPSYPGSGEDSKGQPAFPNIGQNGVLFPNLKTVQPVLPFYRSPATPAEVANTPGIL
                     PSLPLLSSSIPEQLISNEMPFDALPKKKSRKSSMPIKIEKEAVEIANEKRHNLSSDED
                     MPLQVVSEDEQEACSPQSHRVSEEQHVQSGGLGKPFPEGERPCHRESVIESSGAISQT
                     PEQATHNSERETEQTPALIMVPREVEDGGHEHYFTPGMEPQVPFSDYMELQQRLLAGG
                     LFSALSNRGMAFPCLEDSKELEHVGQHALARQIEENRFQCDICKKTFKNACSVKIHHK
                     NMHVKEMHTCTVEGCNATFPSRRSRDRHSSNLNLHQKALSQEALESSEDHFRAAYLLK
                     DVAKEAYQDVAFTQQASQTSVIFKGTSRMGSLVYPITQVHSASLESYNSGPLSEGTIL
                     DLSTTSSMKSESSSHSSWDSDGVSEEGTVLMEDSDGNCEGSSLVPGEDEYPICVLMEK
                     ADQSLASLPSGLPITCHLCQKTYSNKGTFRAHYKTVHLRQLHKCKVPGCNTMFSSVRS
                     RNRHSQNPNLHKSLASSPSHLQ"
     exon            136..235
                     /gene="BNC1"
                     /gene_synonym="bn1; BNC; BSN1; HsT19447; POF16"
                     /inference="alignment:Splign:2.1.0"
     exon            236..471
                     /gene="BNC1"
                     /gene_synonym="bn1; BNC; BSN1; HsT19447; POF16"
                     /inference="alignment:Splign:2.1.0"
     exon            472..2336
                     /gene="BNC1"
                     /gene_synonym="bn1; BNC; BSN1; HsT19447; POF16"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..4579
                     /gene="BNC1"
                     /gene_synonym="bn1; BNC; BSN1; HsT19447; POF16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4540..4545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BNC1"
                     /gene_synonym="bn1; BNC; BSN1; HsT19447; POF16"
                     /note="hexamer: AATAAA"
     regulatory      4546..4551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BNC1"
                     /gene_synonym="bn1; BNC; BSN1; HsT19447; POF16"
                     /note="hexamer: AATATA"
     polyA_site      4558
                     /gene="BNC1"
                     /gene_synonym="bn1; BNC; BSN1; HsT19447; POF16"
     polyA_site      4579
                     /gene="BNC1"
                     /gene_synonym="bn1; BNC; BSN1; HsT19447; POF16"
                     /note="major polyA site"
ORIGIN      
        1 acttcgccgg gtcgcgcccc gacggccgga gcgtggatgc ggcggcgccc gccgagccgg
       61 ggcggacgcg gggcggcccg ggcccgggag acgcgccggc agccccggca ccgcagcggt
      121 cgcaggatgg ccgaggctat cagctgtact ctgaactgta gttgccaaag tttcaaaccc
      181 gggaaaataa accaccgtca gtgtgaccaa tgcaagcatg gatgggtggc ccacgctcta
      241 agtaagctaa ggatcccccc catgtatcca acaagccagg tggagattgt ccagtccaat
      301 gtagtgtttg atattagcag cctcatgctc tatgggaccc aggccatccc cgttcgccta
      361 aaaatcctac tggaccggct cttcagtgtg ttgaagcaag atgaggttct ccagatcctc
      421 catgccttgg actggacact tcaggattat atccgtggat acgtactgca ggatgcatca
      481 ggaaaggtgt tggatcactg gagcatcatg accagtgagg aagaagtggc caccttgcag
      541 cagttccttc gttttggaga gaccaaatct atagttgaac tcatggcaat tcaagagaaa
      601 gaagagcaat ccatcatcat accaccttcc acagcaaatg tagatatcag ggctttcatc
      661 gagagctgca gtcacaggag ttctagcctc cccactcctg tggacaaagg aaaccccagc
      721 agtatacacc cctttgagaa cctcataagc aacatgactt tcatgctgcc tttccagttc
      781 ttcaaccctc tgcctcctgc actgataggg tcattgcccg aacaatatat gttggagcag
      841 ggtcatgacc aaagtcagga ccccaaacag gaagtccatg ggcccttccc tgacagcagc
      901 ttcttaactt ccagttccac accatttcag gttgaaaaag atcagtgttt aaactgtccg
      961 gatgctatta ctaaaaaaga agacagcacc catttaagtg actccagctc atacaacatt
     1021 gtcactaagt ttgaaaggac acagttatcc cctgaggcca aagtgaagcc tgagaggaat
     1081 agccttggta caaagaaggg ccgggtgttc tgcactgcat gtgagaagac cttctatgac
     1141 aaaggcaccc tcaaaatcca ctacaatgcc gtccacttga agatcaagca taagtgcacc
     1201 atcgaagggt gtaacatggt gttcagctcc ctaaggagcc ggaatcgcca tagcgccaac
     1261 cccaaccctc ggctgcacat gccaatgaac agaaataacc gggacaaaga cctcaggaac
     1321 agcctgaacc tggccagctc tgagaactac aagtgcccag gtttcacagt gacgtcccca
     1381 gactgtaggc ctcctcccag ctaccctggt tcaggagagg attccaaagg ccaaccagcc
     1441 ttcccaaaca ttgggcaaaa tggtgtgctt tttcccaacc taaagacagt ccagccagtc
     1501 cttcctttct accgcagtcc agccacgcct gccgaggtag caaacacgcc tgggatactc
     1561 ccttccctcc cgctgttgtc ctcttcaatc ccagaacagc tcatttcaaa cgaaatgcca
     1621 tttgatgccc ttcccaagaa gaaatccagg aagtccagta tgcctatcaa aatagagaaa
     1681 gaagctgtgg aaatagctaa tgagaaaaga cacaacctca gctcagatga agacatgccc
     1741 ctacaggtgg tcagtgaaga tgagcaggag gcctgcagtc ctcagtcaca cagagtatct
     1801 gaggagcagc atgtacagtc aggaggctta gggaagcctt tccctgaagg ggagaggccc
     1861 tgccatcgtg aatcagtaat tgagtccagt ggagccatca gccaaacccc tgagcaggcc
     1921 acacacaatt cagagaggga gactgagcag acaccagcat tgatcatggt gccaagggag
     1981 gtcgaggatg gtggccatga acactacttc acacctggga tggaacccca agttcctttt
     2041 tctgactaca tggaactgca gcagcgcctg ctggctgggg gactcttcag tgctttgtcc
     2101 aacaggggaa tggcttttcc ttgtcttgaa gattctaaag aactggagca cgtgggtcag
     2161 catgcattag caaggcagat agaagaaaat cgcttccagt gtgacatctg caagaagacc
     2221 tttaaaaatg cttgtagtgt gaaaattcat cacaagaata tgcatgtcaa agaaatgcac
     2281 acatgcacag tggagggctg taatgctacc tttccctccc gcaggagcag agacagacac
     2341 agctcaaacc taaacctcca ccaaaaagca ttgagccagg aagcattgga gagtagtgaa
     2401 gatcatttcc gtgcagctta ccttctgaaa gatgtggcta aggaagccta tcaggatgtg
     2461 gcttttacac agcaagcctc ccagacatct gtcatcttca aaggaacaag tcgaatgggc
     2521 agtctggttt acccaataac gcaagtccac agtgccagcc tggagagcta caactctggc
     2581 cccttgagcg agggcaccat cctggatttg agcactacct cgagcatgaa gtcagagagt
     2641 agcagccatt cttcctggga ctctgacggg gtgagtgagg aaggcactgt gcttatggag
     2701 gacagtgatg ggaactgtga agggtcgagc cttgtccctg gggaagatga gtaccccatc
     2761 tgtgtcctga tggagaaggc tgaccagagc cttgctagcc tgccttctgg gttgcccata
     2821 acctgtcatc tctgccaaaa gacatacagt aacaaaggga cctttagggc ccactacaaa
     2881 actgtgcacc tccggcagct ccacaaatgc aaagtaccag gctgcaacac catgttttcg
     2941 tctgttcgca gtcgaaacag acacagccag aatcccaacc tgcacaaaag cctggcctca
     3001 tctccaagtc acctccagta acaagatggc aaaccaagta tgctcagata agcttttttc
     3061 ataattcagg aataaagtag tccatagaaa tgtttctgtt tcatatcatt tggggcgagt
     3121 caggcaaaag tatttgattt gactttatag ttttccacag cacaatgagc aaaagacaaa
     3181 cctcgtggga agatgacact ggggcagccc ttcctattat ttttcttagc ccaagaggtc
     3241 tttcactgat acaaggaaaa cttgcagaaa tgtgattttt cccagatttg tttacatgtt
     3301 ccctgggaca gatccaggtc tgcagatcga caccagtggg cccaggacct gggggtggct
     3361 ttaaatgagg cttgcagtgt taaaggtctt ggataagaag ggtcctgggg aagaagactc
     3421 tgtggacaag ataccagtcc ccaaaacagc attttcagtt ccttcttcaa ttagtttgaa
     3481 atccagacct gagtttggaa gactgatttt ttgagaccat ccctgtgttt ggagtggata
     3541 attgtccctc ccctcagccc tgcaccagag gtctcatatg ttaccccagg gagttctcag
     3601 aggattgggt tggcctctaa catgttcctt gttaattctt gttctgtaac atgcattcaa
     3661 gaagctaggg gaaaaatatc tcatgcactt aaataatggt cttcaattta atttaaaaat
     3721 attttgacaa tatttaattt gtgcttatgt ggtgtttggt gtgagtgcag atattgcact
     3781 gtgtcacctc tggatctctg ctcagaagca gaacaagtga tgacctaaat gtcaaaatca
     3841 ctgctcgttt tcatttggtg aacttcaaac tctgttcttt ttggtcacct gtggaatgaa
     3901 tgcaagcatg attttggcag gaacatttgt acatattctg ccgtagataa tgtggttctg
     3961 atggttgttg tgtattttca gtatcactgg atccctcagt cttcaccgtt ttataaacgt
     4021 ataagattag gatgaacttt tgaatttact tggtaggaaa aaaagtagga cattattgcc
     4081 atattgtatg tcttaatatt taacttattc ggaaatatat tccacactgt tacatacatt
     4141 ttccatggta gaaaggaagt tcagtcagtc ctgtggaatg aaaccatctc ctaaaattca
     4201 gcatttgcag cattctaaaa gcctgtgtag gtacaaggac attgattttg tattcagaat
     4261 tcaagttaac tatcttttaa attcgtggtt gatgtaagta ataaaaaaca ttcttaaagt
     4321 tgagggttat aagagagatt atttctgtgg tctaaaggtt aaaaagccaa caacctgtta
     4381 ccaattattt cagctttttt tgttttaata agtgtgacaa cttaaaactt gtttctattt
     4441 aaagtgaaat gtatctttca actgtttagt tacccagctg tttaatattc cagtcttccc
     4501 aaagtgaaaa gatttgtata caaatgtttt ctatgattta ataaaaatat atggcacacc
     4561 ttttgtttaa aaaggcaaa
//
