LOCUS       NM_203281               2543 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens BMX non-receptor tyrosine kinase (BMX), transcript
            variant 1, mRNA.
ACCESSION   NM_203281
VERSION     NM_203281.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2543)
  AUTHORS   Sundaramoorthy,S., Colombo,D.F., Sanalkumar,R., Broye,L., Balmas
            Bourloud,K., Boulay,G., Cironi,L., Stamenkovic,I., Renella,R.,
            Kuttler,F., Turcatti,G., Rivera,M.N., Muhlethaler-Mottet,A.,
            Bardet,A.F. and Riggi,N.
  TITLE     Preclinical spheroid models identify BMX as a therapeutic target
            for metastatic MYCN nonamplified neuroblastoma
  JOURNAL   JCI Insight 9 (14), e169647 (2024)
   PUBMED   39133652
  REMARK    GeneRIF: Preclinical spheroid models identify BMX as a therapeutic
            target for metastatic MYCN nonamplified neuroblastoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2543)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 2543)
  AUTHORS   Li,X., Berk,M., Goins,C., Alyamani,M., Chung,Y.M., Wang,C.,
            Patel,M., Rathi,N., Zhu,Z., Willard,B., Stauffer,S., Klein,E. and
            Sharifi,N.
  TITLE     BMX controls 3betaHSD1 and sex steroid biosynthesis in cancer
  JOURNAL   J Clin Invest 133 (2), e163498 (2023)
   PUBMED   36647826
  REMARK    GeneRIF: BMX controls 3betaHSD1 and sex steroid biosynthesis in
            cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2543)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2543)
  AUTHORS   Kennedy,S.A., Jarboui,M.A., Srihari,S., Raso,C., Bryan,K.,
            Dernayka,L., Charitou,T., Bernal-Llinares,M., Herrera-Montavez,C.,
            Krstic,A., Matallanas,D., Kotlyar,M., Jurisica,I., Curak,J.,
            Wong,V., Stagljar,I., LeBihan,T., Imrie,L., Pillai,P., Lynn,M.A.,
            Fasterius,E., Al-Khalili Szigyarto,C., Breen,J., Kiel,C.,
            Serrano,L., Rauch,N., Rukhlenko,O., Kholodenko,B.N.,
            Iglesias-Martinez,L.F., Ryan,C.J., Pilkington,R., Cammareri,P.,
            Sansom,O., Shave,S., Auer,M., Horn,N., Klose,F., Ueffing,M.,
            Boldt,K., Lynn,D.J. and Kolch,W.
  TITLE     Extensive rewiring of the EGFR network in colorectal cancer cells
            expressing transforming levels of KRASG13D
  JOURNAL   Nat Commun 11 (1), 499 (2020)
   PUBMED   31980649
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2543)
  AUTHORS   Saharinen,P., Ekman,N., Sarvas,K., Parker,P., Alitalo,K. and
            Silvennoinen,O.
  TITLE     The Bmx tyrosine kinase induces activation of the Stat signaling
            pathway, which is specifically inhibited by protein kinase Cdelta
  JOURNAL   Blood 90 (11), 4341-4353 (1997)
   PUBMED   9373245
REFERENCE   7  (bases 1 to 2543)
  AUTHORS   Ekman,N., Lymboussaki,A., Vastrik,I., Sarvas,K., Kaipainen,A. and
            Alitalo,K.
  TITLE     Bmx tyrosine kinase is specifically expressed in the endocardium
            and the endothelium of large arteries
  JOURNAL   Circulation 96 (6), 1729-1732 (1997)
   PUBMED   9323053
REFERENCE   8  (bases 1 to 2543)
  AUTHORS   Kaukonen,J., Lahtinen,I., Laine,S., Alitalo,K. and Palotie,A.
  TITLE     BMX tyrosine kinase gene is expressed in granulocytes and myeloid
            leukaemias
  JOURNAL   Br J Haematol 94 (3), 455-460 (1996)
   PUBMED   8790141
REFERENCE   9  (bases 1 to 2543)
  AUTHORS   Robinson,D., He,F., Pretlow,T. and Kung,H.J.
  TITLE     A tyrosine kinase profile of prostate carcinoma
  JOURNAL   Proc Natl Acad Sci U S A 93 (12), 5958-5962 (1996)
   PUBMED   8650201
REFERENCE   10 (bases 1 to 2543)
  AUTHORS   Tamagnone,L., Lahtinen,I., Mustonen,T., Virtaneva,K., Francis,F.,
            Muscatelli,F., Alitalo,R., Smith,C.I., Larsson,C. and Alitalo,K.
  TITLE     BMX, a novel nonreceptor tyrosine kinase gene of the
            BTK/ITK/TEC/TXK family located in chromosome Xp22.2
  JOURNAL   Oncogene 9 (12), 3683-3688 (1994)
   PUBMED   7970727
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP236451.1, X83107.1,
            BC016652.2 and AF045459.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_203281.2.
            
            Summary: This gene encodes a non-receptor tyrosine kinase belonging
            to the Tec kinase family. The protein contains a PH-like domain,
            which mediates membrane targeting by binding to
            phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain
            that binds to tyrosine-phosphorylated proteins and functions in
            signal transduction. The protein is implicated in several signal
            transduction pathways including the Stat pathway, and regulates
            differentiation and tumorigenicity of several types of cancer
            cells. Alternatively spliced transcript variants have been found
            for this gene. [provided by RefSeq, Mar 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1 and 2
            encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291824.1, SRR1803611.205953.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000348343.11/ ENSP00000308774.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               BP236451.1         31-140
            111-2245            X83107.1           1-2135
            2246-2541           BC016652.2         2231-2526
            2542-2543           AF045459.1         2584-2585
FEATURES             Location/Qualifiers
     source          1..2543
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     gene            1..2543
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /note="BMX non-receptor tyrosine kinase"
                     /db_xref="GeneID:660"
                     /db_xref="HGNC:HGNC:1079"
                     /db_xref="MIM:300101"
     exon            1..134
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            135..281
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..2171
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 1; NTK38
                     tyrosine kinase; Etk/Bmx cytosolic tyrosine kinase;
                     cytoplasmic tyrosine-protein kinase BMX; epithelial and
                     endothelial tyrosine kinase; bone marrow tyrosine kinase
                     gene in chromosome X protein; BTK-like on X chromosome"
                     /codon_start=1
                     /product="cytoplasmic tyrosine-protein kinase BMX isoform
                     1"
                     /protein_id="NP_975010.1"
                     /db_xref="CCDS:CCDS14168.1"
                     /db_xref="GeneID:660"
                     /db_xref="HGNC:HGNC:1079"
                     /db_xref="MIM:300101"
                     /translation="MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYD
                     KMKRGSRKGSIEIKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQW
                     LKALQKEIRGNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEK
                     HRVPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDS
                     NSKKIYGSQPNFNMQYIPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKIS
                     WEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSL
                     FSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPV
                     STKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEG
                     SMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGL
                     EPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQY
                     VSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLK
                     VSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKDKH"
     exon            282..386
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            387..468
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            469..588
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            589..653
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            654..895
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            896..973
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1027
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1082
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1162
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1290
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1365
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1537
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1754
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1819
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1938
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2096
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2543
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2522..2527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /note="hexamer: ATTAAA"
     polyA_site      2543
                     /gene="BMX"
                     /gene_synonym="ETK; PSCTK2; PSCTK3"
                     /note="major polyA site"
ORIGIN      
        1 agccatttct gacccggcag ccaggaaaat gtgaaacaat ttgcttctgg aaacaggaca
       61 gccggggccg tgttcctgca acagcagacc aagcaccgcg gcggacccag gcaagcacgg
      121 aacaagctga gacggatgat aatatggata caaaatctat tctagaagaa cttcttctca
      181 aaagatcaca gcaaaagaag aaaatgtcac caaataatta caaagaacgg ctttttgttt
      241 tgaccaaaac aaacctttcc tactatgaat atgacaaaat gaaaaggggc agcagaaaag
      301 gatccattga aattaagaaa atcagatgtg tggagaaagt aaatctcgag gagcagacgc
      361 ctgtagagag acagtaccca tttcagattg tctataaaga tgggcttctc tatgtctatg
      421 catcaaatga agagagccga agtcagtggt tgaaagcatt acaaaaagag ataaggggta
      481 acccccacct gctggtcaag taccatagtg ggttcttcgt ggacgggaag ttcctgtgtt
      541 gccagcagag ctgtaaagca gccccaggat gtaccctctg ggaagcatat gctaatctgc
      601 atactgcagt caatgaagag aaacacagag ttcccacctt cccagacaga gtgctgaaga
      661 tacctcgggc agttcctgtt ctcaaaatgg atgcaccatc ttcaagtacc actctagccc
      721 aatatgacaa cgaatcaaag aaaaactatg gctcccagcc accatcttca agtaccagtc
      781 tagcgcaata tgacagcaac tcaaagaaaa tctatggctc ccagccaaac ttcaacatgc
      841 agtatattcc aagggaagac ttccctgact ggtggcaagt aagaaaactg aaaagtagca
      901 gcagcagtga agatgttgca agcagtaacc aaaaagaaag aaatgtgaat cacaccacct
      961 caaagatttc atgggaattc cctgagtcaa gttcatctga agaagaggaa aacctggatg
     1021 attatgactg gtttgctggt aacatctcca gatcacaatc tgaacagtta ctcagacaaa
     1081 agggaaaaga aggagcattt atggttagaa attcgagcca agtgggaatg tacacagtgt
     1141 ccttatttag taaggctgtg aatgataaaa aaggaactgt caaacattac cacgtgcata
     1201 caaatgctga gaacaaatta tacctggcag aaaactactg ttttgattcc attccaaagc
     1261 ttattcatta tcatcaacac aattcagcag gcatgatcac acggctccgc caccctgtgt
     1321 caacaaaggc caacaaggtc cccgactctg tgtccctggg aaatggaatc tgggaactga
     1381 aaagagaaga gattaccttg ttgaaggagc tgggaagtgg ccagtttgga gtggtccagc
     1441 tgggcaagtg gaaggggcag tatgatgttg ctgttaagat gatcaaggag ggctccatgt
     1501 cagaagatga attctttcag gaggcccaga ctatgatgaa actcagccat cccaagctgg
     1561 ttaaattcta tggagtgtgt tcaaaggaat accccatata catagtgact gaatatataa
     1621 gcaatggctg cttgctgaat tacctgagga gtcacggaaa aggacttgaa ccttcccagc
     1681 tcttagaaat gtgctacgat gtctgtgaag gcatggcctt cttggagagt caccaattca
     1741 tacaccggga cttggctgct cgtaactgct tggtggacag agatctctgt gtgaaagtat
     1801 ctgactttgg aatgacaagg tatgttcttg atgaccagta tgtcagttca gtcggaacaa
     1861 agtttccagt caagtggtca gctccagagg tgtttcatta cttcaaatac agcagcaagt
     1921 cagacgtatg ggcatttggg atcctgatgt gggaggtgtt cagcctgggg aagcagccct
     1981 atgacttgta tgacaactcc caggtggttc tgaaggtctc ccagggccac aggctttacc
     2041 ggccccacct ggcatcggac accatctacc agatcatgta cagctgctgg cacgagcttc
     2101 cagaaaagcg tcccacattt cagcaactcc tgtcttccat tgaaccactt cgggaaaaag
     2161 acaagcattg aagaagaaat taggagtgct gataagaatg aatatagatg ctggccagca
     2221 ttttcattca ttttaaggaa agtagcaagg cataatgtaa tttagctagt ttttaatagt
     2281 gttctctgta ttgtctatta tttagaaatg aacaaggcag gaaacaaaag attcccttga
     2341 aatttagatc aaattagtaa ttttgtttat gctgctcctg atataacact ttccagccta
     2401 tagcagaagc acattttcag actgcaatat agagactgtg ttcatgtgta aagactgagc
     2461 agaactgaaa aattacttat tggatattca ttcttttctt tatattgtca ttgtcacaac
     2521 aattaaatat actaccaagt aca
//
