LOCUS       NM_014753               7759 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens BMS1 ribosome biogenesis factor (BMS1), mRNA.
ACCESSION   NM_014753
VERSION     NM_014753.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7759)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 7759)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   3  (bases 1 to 7759)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7759)
  AUTHORS   Li,A.H., Hanchard,N.A., Azamian,M., D'Alessandro,L.C.A.,
            Coban-Akdemir,Z., Lopez,K.N., Hall,N.J., Dickerson,H., Nicosia,A.,
            Fernbach,S., Boone,P.M., Gambin,T., Karaca,E., Gu,S., Yuan,B.,
            Jhangiani,S.N., Doddapaneni,H., Hu,J., Dinh,H., Jayaseelan,J.,
            Muzny,D., Lalani,S., Towbin,J., Penny,D., Fraser,C., Martin,J.,
            Lupski,J.R., Gibbs,R.A., Boerwinkle,E., Ware,S.M. and Belmont,J.W.
  TITLE     Genetic architecture of laterality defects revealed by whole exome
            sequencing
  JOURNAL   Eur J Hum Genet 27 (4), 563-573 (2019)
   PUBMED   30622330
  REMARK    GeneRIF: We also observe evidence for an excess burden of rare,
            predicted loss-of-function variation in PXDNL and BMS1- two genes
            relevant to the broader laterality phenotype. These findings
            highlight potential new genes in the development of laterality
            defects, and suggest extensive locus heterogeneity and complex
            genetic models in this class of birth defects.
REFERENCE   5  (bases 1 to 7759)
  AUTHORS   Marneros,A.G.
  TITLE     BMS1 is mutated in aplasia cutis congenita
  JOURNAL   PLoS Genet 9 (6), e1003573 (2013)
   PUBMED   23785305
  REMARK    GeneRIF: The data provide a novel link between BMS1, the cell
            cycle, and skin morphogenesis.
REFERENCE   6  (bases 1 to 7759)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 7759)
  AUTHORS   Hoglinger,G.U., Melhem,N.M., Dickson,D.W., Sleiman,P.M., Wang,L.S.,
            Klei,L., Rademakers,R., de Silva,R., Litvan,I., Riley,D.E., van
            Swieten,J.C., Heutink,P., Wszolek,Z.K., Uitti,R.J., Vandrovcova,J.,
            Hurtig,H.I., Gross,R.G., Maetzler,W., Goldwurm,S., Tolosa,E.,
            Borroni,B., Pastor,P., Cantwell,L.B., Han,M.R., Dillman,A., van der
            Brug,M.P., Gibbs,J.R., Cookson,M.R., Hernandez,D.G.,
            Singleton,A.B., Farrer,M.J., Yu,C.E., Golbe,L.I., Revesz,T.,
            Hardy,J., Lees,A.J., Devlin,B., Hakonarson,H., Muller,U. and
            Schellenberg,G.D.
  CONSRTM   PSP Genetics Study Group
  TITLE     Identification of common variants influencing risk of the tauopathy
            progressive supranuclear palsy
  JOURNAL   Nat Genet 43 (7), 699-705 (2011)
   PUBMED   21685912
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7759)
  AUTHORS   Chapuis,J., Hot,D., Hansmannel,F., Kerdraon,O., Ferreira,S.,
            Hubans,C., Maurage,C.A., Huot,L., Bensemain,F., Laumet,G.,
            Ayral,A.M., Fievet,N., Hauw,J.J., DeKosky,S.T., Lemoine,Y.,
            Iwatsubo,T., Wavrant-Devrieze,F., Dartigues,J.F., Tzourio,C.,
            Buee,L., Pasquier,F., Berr,C., Mann,D., Lendon,C., Alperovitch,A.,
            Kamboh,M.I., Amouyel,P. and Lambert,J.C.
  TITLE     Transcriptomic and genetic studies identify IL-33 as a candidate
            gene for Alzheimer's disease
  JOURNAL   Mol Psychiatry 14 (11), 1004-1016 (2009)
   PUBMED   19204726
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 7759)
  AUTHORS   Crosier,M., Viggiano,L., Guy,J., Misceo,D., Stones,R., Wei,W.,
            Hearn,T., Ventura,M., Archidiacono,N., Rocchi,M. and Jackson,M.S.
  TITLE     Human paralogs of KIAA0187 were created through independent
            pericentromeric-directed and chromosome-specific duplication
            mechanisms
  JOURNAL   Genome Res 12 (1), 67-80 (2002)
   PUBMED   11779832
  REMARK    GeneRIF: Analysis of KIAA0187 paralogs show that exons 14-23 were
            formed through satellite-associated pericentromeric-directed
            duplication, whereas paralogs of exons 1-9 evolved via
            chromosome-specific satellite-independent duplications.
REFERENCE   10 (bases 1 to 7759)
  AUTHORS   Gelperin,D., Horton,L., Beckman,J., Hensold,J. and Lemmon,S.K.
  TITLE     Bms1p, a novel GTP-binding protein, and the related Tsr1p are
            required for distinct steps of 40S ribosome biogenesis in yeast
  JOURNAL   RNA 7 (9), 1268-1283 (2001)
   PUBMED   11565749
  REMARK    GeneRIF: Describes the distinct functions of yeast Bms1p and Tsr1p
            in ribosome biogenesis.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB064246.1, BC043345.1,
            AK308420.1, BC150252.1, AI184520.1, AL022344.3 and AI718109.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014753.3.
            
            Summary: This gene likely encodes a ribosome assembly protein. A
            similar protein in yeast functions in 35S-rRNA processing, which
            includes a series of cleavage steps critical for formation of 40S
            ribosomes. Related pseudogenes exist on chromosomes 2, 9, 10, 15,
            16, and 22.[provided by RefSeq, Mar 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.240369.1,
                                           SRR1803611.73866.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374518.6/ ENSP00000363642.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DB064246.1         259-274
            17-404              BC043345.1         1-388
            405-405             AK308420.1         401-401
            406-2513            BC043345.1         390-2497
            2514-4000           BC150252.1         2472-3958
            4001-4225           AI184520.1         4-228               c
            4226-7722           AL022344.3         181861-185357
            7723-7759           AI718109.1         2-38                c
FEATURES             Location/Qualifiers
     source          1..7759
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.21"
     gene            1..7759
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /note="BMS1 ribosome biogenesis factor"
                     /db_xref="GeneID:9790"
                     /db_xref="HGNC:HGNC:23505"
                     /db_xref="MIM:611448"
     exon            1..36
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            37..245
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..3918
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /note="ribosome assembly protein BMS1 homolog; BMS1-like,
                     ribosome assembly protein; BMS1 homolog, ribosome assembly
                     protein"
                     /codon_start=1
                     /product="ribosome biogenesis protein BMS1 homolog"
                     /protein_id="NP_055568.3"
                     /db_xref="CCDS:CCDS7199.1"
                     /db_xref="GeneID:9790"
                     /db_xref="HGNC:HGNC:23505"
                     /db_xref="MIM:611448"
                     /translation="MEAKDQKKHRKKNSGPKAAKKKKRLLQDLQLGDEEDARKRNPKA
                     FAVQSAVRMARSFHRTQDLKTKKHHIPVVDRTPLEPPPIVVVVMGPPKVGKSTLIQCL
                     IRNFTRQKLTEIRGPVTIVSGKKRRLTIIECGCDINMMIDLAKVADLVLMLIDASFGF
                     EMETFEFLNICQVHGFPKIMGVLTHLDSFKHNKQLKKTKKRLKHRFWTEVYPGAKLFY
                     LSGMVHGEYQNQEIHNLGRFITVMKFRPLTWQTSHPYILADRMEDLTNPEDIRTNIKC
                     DRKVSLYGYLRGAHLKNKSQIHMPGVGDFAVSDISFLPDPCALPEQQKKRCLNEKEKL
                     VYAPLSGVGGVLYDKDAVYVDLGGSHVFQDEVGPTHELVQSLISTHSTIDAKMASSRV
                     TLFSDSKPLGSEDIDNQGLMMPKEEKQMDLNTGRMRRKAIFGDEDESGDSDDEEDDEM
                     SEDDGLENGSSDEEAEEEENAEMTDQYMAVKGIKRRKLELEEDSEMDLPAFADSDDDL
                     ERSSAEEGEAEEADESSEEEDCTAGEKGISGSKAAGEGSKAGLSPANCQSDRVNLEKS
                     LLMKKAALPTFDSGHCTAEEVFASEDESEESSSLSAEEEDSENEEAIRKKLSKPSQVS
                     SGQKLGPQNFIDETSDIENLLKEEEDYKEENNDSKETSGALKWKEDLSRKAAEAFLRQ
                     QQAAPNLRKLIYGTVTEDNEEEDDDTLEELGGLFRVNQPDRECKHKADSLDCSRFLVE
                     APHDWDLEEVMNSIRDCFVTGKWEDDKDAAKVLAEDEELYGDFEDLETGDVHKGKSGP
                     NTQNEDIEKEVKEEIDPDEEESAKKKHLDKKRKLKEMFDAEYDEGESTYFDDLKGEMQ
                     KQAQLNRAEFEDQDDEARVQYEGFRPGMYVRIEIENVPCEFVQNFDPHYPIILGGLGN
                     SEGNVGYVQMRLKKHRWYKKILKSRDPIIFSVGWRRFQTIPLYYIEDHNGRQRLLKYT
                     PQHMHCGAAFWGPITPQGTGFLAIQSVSGIMPDFRIAATGVVLDLDKSIKIVKKLKLT
                     GFPYKIFKNTSFIKGMFNSALEVAKFEGAVIRTVSGIRGQIKKALRAPEGAFRASFED
                     KLLMSDIVFMRTWYPVSIPAFYNPVTSLLKPVGEKDTWSGMRTTGQLRLAHGVRLKAN
                     KDSLYKPILRQKKHFNSLHIPKALQKALPFKNKPKTQAKAGKVPKDRRRPAVIREPHE
                     RKILALLDALSTVHSQKMKKAKEQRHLHNKEHFRAKQKEEEEKLKRQKDLRKKLFRIQ
                     GQKERRNQKSSLKGAEGQLQ"
     exon            246..436
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            437..516
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            517..705
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            706..848
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            849..970
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1158
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1298
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..2056
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2158
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2316
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2398
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2472
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2649
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2838
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2839..3019
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3078
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3201
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3202..3349
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3525
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3526..3687
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3688..7759
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4205..4210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /note="hexamer: ATTAAA"
     polyA_site      4224
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /note="major polyA site"
     regulatory      6995..7000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /note="hexamer: ATTAAA"
     polyA_site      7018
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
     regulatory      7139..7144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /note="hexamer: AATAAA"
     polyA_site      7163
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
     regulatory      7733..7738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
                     /note="hexamer: AATAAA"
     polyA_site      7759
                     /gene="BMS1"
                     /gene_synonym="ACC; BMS1L"
ORIGIN      
        1 gtccatgctg acctgaggag tcgcggctgc gagcaggtta gagttacttg ttattggtaa
       61 atagccacta tggaggctaa ggaccagaag aaacacagaa agaaaaacag tggacccaaa
      121 gctgcaaaga aaaagaagcg gcttctgcag gatctccagc taggagacga agaagatgcc
      181 cggaagagaa atcccaaagc ttttgcagtt cagtctgctg tgcggatggc tcgatccttt
      241 cacaggactc aggatttgaa gacaaaaaag catcatattc cagtggttga tcgaactcca
      301 ctagagcccc caccaatagt ggtagtggtg atgggacctc caaaagttgg aaagagcact
      361 ttgatacaat gcctcattcg gaactttacc cggcagaagt tgactgagat cagaggccct
      421 gtgacgattg tgtcaggtaa aaagcgcaga ctcaccatta ttgaatgtgg gtgtgacatt
      481 aacatgatga ttgatctggc taaagtagca gatctggtac tgatgcttat agatgccagc
      541 tttgggtttg aaatggaaac gtttgagttt ctaaacatct gtcaagtaca tggctttcct
      601 aaaattatgg gagttctcac ccacctcgac tccttcaagc ataataagca actgaagaag
      661 acaaagaagc gattaaaaca caggttctgg acggaagttt acccgggtgc caagctgttc
      721 tacctttctg gaatggtgca tggagaatat caaaaccaag aaatccacaa tctgggccgt
      781 tttattacag ttatgaagtt taggcctctc acatggcaaa cttctcaccc ttatatcctg
      841 gcagacagga tggaagattt gacaaaccca gaggatatcc gaacaaacat caaatgtgac
      901 cggaaggtgt cactttatgg ttatttaaga ggagcacact tgaaaaataa aagccaaatt
      961 cacatgccag gggtaggaga ttttgccgtg agtgacatca gtttcctccc agacccttgc
     1021 gctcttcctg aacaacaaaa gaagcgctgt ttaaatgaga aggagaagct ggtttatgcg
     1081 cctctttctg gagttggggg tgtgctgtat gacaaagacg ctgtctatgt tgaccttggt
     1141 ggcagccacg tttttcagga tgaagtgggg cccacccatg agctggtcca gagtctcatc
     1201 tctacccact ccaccattga tgccaagatg gcttcaagtc gagtgacgct gttttctgat
     1261 tccaagccac ttgggtcaga ggatatagat aatcaagggc taatgatgcc aaaggaggaa
     1321 aaacaaatgg acttgaacac tggtcgaatg cgtcggaaag ccattttcgg agatgaagat
     1381 gaatctggag atagtgatga tgaagaagat gatgaaatgt ctgaagatga cgggttggaa
     1441 aacggctcta gtgatgagga agcagaagag gaggaaaatg ctgagatgac tgatcagtat
     1501 atggctgtta agggcatcaa acgacggaaa cttgagttgg aagaagacag tgaaatggat
     1561 ttgccagcat ttgctgacag tgacgatgac cttgagagga gctcagcgga agaaggggaa
     1621 gcggaggaag ctgatgaaag cagtgaagaa gaggactgca ctgcaggaga gaagggcatt
     1681 tcaggatcaa aggctgctgg agaaggtagt aaagcagggc tgtcaccagc taattgccag
     1741 agtgaccgtg tgaatctgga gaagtctttg ctgatgaaga aagcagctct ccccactttc
     1801 gattctgggc attgcacagc tgaagaggtg tttgcatctg aagatgaatc tgaagaaagc
     1861 tcctcactca gtgcagagga agaagactca gaaaatgaag aggctattag aaaaaagctt
     1921 tcaaagcctt ctcaagtgag cagtggtcag aaactggggc cacagaactt cattgatgag
     1981 accagtgata tagaaaattt actcaaagag gaagaagatt acaaggaaga aaataatgat
     2041 tccaaagaaa cgtcaggtgc cctcaagtgg aaggaagacc tttccagaaa ggcagctgag
     2101 gcctttctga ggcagcagca agcagctcca aacctccgaa agcttattta tgggacagtg
     2161 acagaagata atgaagaaga agatgatgat actctagaag agcttggagg gttgtttcgt
     2221 gtcaaccagc ctgacagaga gtgtaagcac aaggctgact ctttggactg ctccagattt
     2281 cttgtggagg ccccccatga ctgggattta gaggaggtta tgaacagtat cagagattgc
     2341 ttcgtgactg gaaagtggga agatgataaa gatgcagcca aggtcttagc agaagatgag
     2401 gagctctacg gtgactttga agacttggaa acaggggacg tgcacaaggg aaaatcaggc
     2461 cccaatactc agaatgaaga tatagagaaa gaagttaagg aagaaattga ccccgacgaa
     2521 gaagaaagtg ccaagaaaaa gcatttggat aagaagagaa aattgaagga gatgtttgat
     2581 gcagaatatg atgaaggaga aagcacatat tttgatgatc ttaaaggaga aatgcagaaa
     2641 caagcacagc tgaatcgcgc agaatttgaa gatcaagatg atgaagccag agttcagtat
     2701 gagggttttc gacctgggat gtacgtccgc attgagattg aaaatgttcc ctgtgaattt
     2761 gtgcagaact ttgaccccca ttaccccatt atcctgggtg gcttgggcaa cagtgaggga
     2821 aatgttggct acgtgcagat gcgtctgaag aaacatcgct ggtataagaa aatcctcaag
     2881 tcccgagatc caatcatatt ttctgtaggg tggaggaggt ttcagaccat cccactgtat
     2941 tatatcgaag accacaatgg aagacaaagg cttctaaagt ataccccaca gcacatgcat
     3001 tgcggagcag ccttttgggg ccctatcact ccacagggaa ctggtttctt ggcaatacag
     3061 tctgtcagtg gcataatgcc tgattttcgg atagctgcta caggagttgt ccttgatctg
     3121 gataaatcca taaaaattgt gaagaaatta aagctaactg gttttccata taaaattttc
     3181 aagaacactt catttattaa gggaatgttt aattctgcct tggaagtggc caaatttgaa
     3241 ggtgctgtga ttcgaacagt cagtgggata agggggcaga tcaagaaagc actccgagct
     3301 ccagaaggag ctttcagggc cagctttgag gataagctgc tgatgagcga tattgtcttc
     3361 atgcgaactt ggtatcctgt ttccatccca gcgttctata acccagtaac atctttgttg
     3421 aaaccagtgg gtgagaaaga cacctggtca ggaatgcgga ccacgggcca actcaggctc
     3481 gcccatggcg tcagactaaa ggcgaacaag gactctctgt ataagccaat cctgaggcaa
     3541 aagaaacatt ttaattcact gcacattcca aaagccttgc agaaggccct gccatttaag
     3601 aacaagccca agacccaagc aaaggcaggc aaggtgccaa aggacaggcg gagaccggcc
     3661 gtcatacgcg agcctcatga aagaaagatc cttgcactgc tggatgctct gagtacggtg
     3721 catagtcaga agatgaagaa ggccaaggag cagcggcacc tgcacaataa agagcacttc
     3781 agagccaagc agaaggagga ggaggagaag ctgaagcggc agaaggacct caggaagaag
     3841 ctcttcagaa ttcaggggca gaaggaaaga agaaaccaga agtccagttt gaagggggct
     3901 gagggccaat tgcagtgagc ctttggactg gagggactgt ccctggatct gcggaggtag
     3961 acagtttcaa acatcacagt ttgaatgcct gtgaatgaca agtcagtggg aaagagctca
     4021 agagatgtct ctactcaaac tgtgcctgca ggaggaggaa cagagaagcc tgggctgctg
     4081 ggactgggtt cattctcatg acttggggct gtcgagattt aaagtgatgt aagctgtggt
     4141 tatgtggatt ctcttacttt cctctgcctg cctcagttta attattttgt cctacagaaa
     4201 tatcattaaa atattttttt gttacttttg gcttagtagt tttcattagg gatgaatgcc
     4261 tgacaattct ttgtggataa ttatttatac taccaccttc atgaggagtc ttccagaaga
     4321 gaaagaaata ttcacttgaa ctctgagctc ccatggaaga ttttagagaa tagtgtgtag
     4381 tgtttttgtt ttgttttttg tttgagtgac acacaaacct agatggtaca gcctactgtg
     4441 cacccaggat ctatgggctc ctttgatcac tggcccttgt ggacattttc tatcttattt
     4501 catatgttct gcacattagt atagtgacaa ggtaacagta agtacttttt taaagcttta
     4561 gacttaggag attattgtct caggtgcaga gaccaaggaa atcgtatgta tcagtgagat
     4621 aggcttcccg tattatgctc atgcgttata cctgcctagc tacattgcct ttttttaaat
     4681 taaacattat gttgaagtaa tcatactatt acataggcga tgtatgtatt ttatgattgt
     4741 atgttgatat agttatgggg aatctattcc tatacgatgt aatcatagat tcacatatag
     4801 ttgtatattt tgcccaattt ctctcagtgg taatgtttca cacatataac aatcaggatg
     4861 ttgacatcaa tacagcccgc tgattttatt cacatttccc cagctttact ttccccaacg
     4921 tatactcctc catgtatgca tgggtgtgta gaaatatgga acgcagctgg gcacagtgac
     4981 tcacgcctgt aatcccagca ctttgggatg ctaaggcagg aggatcactt gagcccagga
     5041 atttgagacc aacttgggca acatggcaaa acctcatcgc tacaaaaaat aaaaaattcg
     5101 ccaggtgtgg tgggtgcaca cctgtagttc cagctgcttg ggaggctgag gtaggaggat
     5161 cacttgagct tgggaggttg aggctgcagt gagccatgat agcaccactg cactccagcc
     5221 tgggcgacag ggcaagaccc tgtttcaaaa aaaaaaaatt atacatatat gtatgtagaa
     5281 cacttcatga atttgtgtgt catctgtgca tggggcccat gctgacctct gtgttgtgcc
     5341 agttatagta tgtgtgctgc tgatatgagt gccacattgc ctttacaaca tcataggggc
     5401 caaagagggt tggcaggatt atgagcagtt ggcctagtct gagaggctct ctaaaagcct
     5461 aaagtctgta ggcaggtgct cagctttgta tctccataag aagggaagag gatgtgagga
     5521 tcctgtcagg gctaggtcca cctgggaagt gacaattgga acactcccag acctctctgg
     5581 gcaactctgg gtgtacattt tcctctgttc ctcaagagct attatgaatt tcatcatcca
     5641 ttatgctgat aggcctgggg actgacacat agtaagccca taacaattat aatttaaaac
     5701 taatttgtta tatagcataa ttgatatatt ttaaaatgca aaactataat tcaactaaaa
     5761 tatacaaggc actcaagtca taccatgttt taagtagctt acaaggtgat cagcaagtgt
     5821 cttatacaac aagcaaattt gttcaaagag aagcattgca aataagtatt tataattgta
     5881 tagttttata ttttagccag aagagtggaa tcctttagca atgggggaaa taaaagaatg
     5941 tttaattaca gttgcagata attgcctttt ccaaagacaa tgtatgtagg cagaactcat
     6001 acctgttaat attaaaaatc ttggtttatc atatttggag aacaagggaa ataaaaagtt
     6061 tgcatattaa gattatttaa actaaagtta aggaatctct aatgtctgaa agaaacaata
     6121 aatagcattt ttcatgtaga atttttattg gtgaaggttc cacctggcca ggttagtaaa
     6181 atacagtcac acatcagtta aggatgggga tatattctga gaaatgtatc attaggcaat
     6241 tttgtcattg tgtaaacatc atagagtgac acacaaacct agatggtaca gcctactgtg
     6301 cacctgggct ctatggtatg gcctgttgct cctaggctac aaacctgggc agcatgtgac
     6361 tgtactgact actgtaggca gttgtaacac agtggtaaac atttgtgtat cgaaacatag
     6421 aaaaggcgta gcaaaaatac agtattgtgg aaccactgcc atatacgtgg tccatccttg
     6481 actgaacatc atgcggcatg tggctgtatg tatacacata gtttttgctg tgagtttgca
     6541 tccatctcat aggaagacat atatcaaaat aaggaccaga ctggagagtg tgtaaattac
     6601 ttttcaatac taatggctta ttaatttgat attgtcagca agtatgttgc aaaaacaaat
     6661 tccaccagaa tgtgagttcc atgagagcag gaactgggtt gttcaccttg ttggcacttg
     6721 gagtagagcc actgagcttc gtgctgcata aaattgcttg gaagaaagaa gggagggcat
     6781 tccaggtaac tgaagcattg ctatgcaaag taagcatttg ccctctgaaa tattttaaca
     6841 atgtttatag aaacctttct caattgtatt aaactttgta aattgtaaaa attattctgt
     6901 tatacctttt ctatttacta ggcacaggca gccataggtg ctaggtatgt tttgaaaaca
     6961 tattgaacct acagtgtaca tatcattcca tgccattaaa tattcttatt taatcataga
     7021 tgtgttcagg tgtgtttggt ttcctatttg tggatgtact agattgtttt ctttttttaa
     7081 caaaacctgt gaacttgctt taagtattat catttggtga catgcccgcc atttcagaaa
     7141 taaatgtttg agcaaagagg aaagccaccg ggtctgattc agctctctgg aggctccaga
     7201 gcttacctcg ctgatgggaa aaagagcatc gatttaattg cccttggtac cgacttctag
     7261 tatctagtat tttgccagac tcaggtattt cttaaagcca ttattcagag tcttcagcaa
     7321 ggacattgta ttttacttgt gtctccttag ttttacctag tttatttcat ggttttaaag
     7381 tattgtacat ttttataatc ctttaacaag acaaaaggtt gagatgttgg acatttaaat
     7441 gccaaaggtg ttttattatg agacttagca tttcatattt ggggatggta ccttatcgaa
     7501 aatcagataa actttggttg gatgggtatt tggaggaatc ttttaagtct tttcttaagc
     7561 aaagtttgga cactctaaaa taaggttgcc aactggcatg tagagagaaa aggatgtgtc
     7621 atacatttag accaggtggc ctgtcctgta aatttttttg aggggagggg tgggcttgtt
     7681 tttttctgtg tttcggtttt ttccaatttt tgttttgtga taaaatatgc ataataaaac
     7741 ttattttatc aatttttaa
//
