LOCUS       NM_001204              12068 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens bone morphogenetic protein receptor type 2 (BMPR2),
            mRNA.
ACCESSION   NM_001204
VERSION     NM_001204.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12068)
  AUTHORS   Lotsios,N.S., Keskinidou,C., Dimopoulou,I., Kotanidou,A.,
            Langleben,D., Orfanos,S.E. and Vassiliou,A.G.
  TITLE     Effects of Modulating BMP9, BMPR2, and AQP1 on BMP Signaling in
            Human Pulmonary Microvascular Endothelial Cells
  JOURNAL   Int J Mol Sci 25 (15), 8043 (2024)
   PUBMED   39125626
  REMARK    GeneRIF: Effects of Modulating BMP9, BMPR2, and AQP1 on BMP
            Signaling in Human Pulmonary Microvascular Endothelial Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12068)
  AUTHORS   Awad,K.S., Wang,S., Dougherty,E.J., Keshavarz,A., Demirkale,C.Y.,
            Yu,Z.X., Miller,L., Elinoff,J.M. and Danner,R.L.
  TITLE     BMPR2 Loss Activates AKT by Disrupting DLL4/NOTCH1 and PPARgamma
            Signaling in Pulmonary Arterial Hypertension
  JOURNAL   Int J Mol Sci 25 (10), 5403 (2024)
   PUBMED   38791441
  REMARK    GeneRIF: BMPR2 Loss Activates AKT by Disrupting DLL4/NOTCH1 and
            PPARgamma Signaling in Pulmonary Arterial Hypertension.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12068)
  AUTHORS   Xiong,J.
  TITLE     BMPR2 spruces up the endothelium in pulmonary hypertension
  JOURNAL   Protein Cell 6 (10), 703-708 (2015)
   PUBMED   26373550
  REMARK    Review article
REFERENCE   4  (bases 1 to 12068)
  AUTHORS   Best,D.H., Austin,E.D., Chung,W.K. and Elliott,C.G.
  TITLE     Genetics of pulmonary hypertension
  JOURNAL   Curr Opin Cardiol 29 (6), 520-527 (2014)
   PUBMED   25159282
  REMARK    Review article
REFERENCE   5  (bases 1 to 12068)
  AUTHORS   Liu,D. and Morrell,N.W.
  TITLE     Genetics and the molecular pathogenesis of pulmonary arterial
            hypertension
  JOURNAL   Curr Hypertens Rep 15 (6), 632-637 (2013)
   PUBMED   24078385
  REMARK    Review article
REFERENCE   6  (bases 1 to 12068)
  AUTHORS   Nohno,T., Ishikawa,T., Saito,T., Hosokawa,K., Noji,S., Wolsing,D.H.
            and Rosenbaum,J.S.
  TITLE     Identification of a human type II receptor for bone morphogenetic
            protein-4 that forms differential heteromeric complexes with bone
            morphogenetic protein type I receptors
  JOURNAL   J Biol Chem 270 (38), 22522-22526 (1995)
   PUBMED   7673243
REFERENCE   7  (bases 1 to 12068)
  AUTHORS   Rosenzweig,B.L., Imamura,T., Okadome,T., Cox,G.N., Yamashita,H.,
            ten Dijke,P., Heldin,C.H. and Miyazono,K.
  TITLE     Cloning and characterization of a human type II receptor for bone
            morphogenetic proteins
  JOURNAL   Proc Natl Acad Sci U S A 92 (17), 7632-7636 (1995)
   PUBMED   7644468
REFERENCE   8  (bases 1 to 12068)
  AUTHORS   Liu,F., Ventura,F., Doody,J. and Massague,J.
  TITLE     Human type II receptor for bone morphogenic proteins (BMPs):
            extension of the two-kinase receptor model to the BMPs
  JOURNAL   Mol Cell Biol 15 (7), 3479-3486 (1995)
   PUBMED   7791754
REFERENCE   9  (bases 1 to 12068)
  AUTHORS   Kawabata,M., Chytil,A. and Moses,H.L.
  TITLE     Cloning of a novel type II serine/threonine kinase receptor through
            interaction with the type I transforming growth factor-beta
            receptor
  JOURNAL   J Biol Chem 270 (10), 5625-5630 (1995)
   PUBMED   7890683
REFERENCE   10 (bases 1 to 12068)
  AUTHORS   Austin,E.D., Phillips,J.A. III and Loyd,J.E.
  TITLE     Heritable Pulmonary Arterial Hypertension Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA787547.1, DB233604.1,
            D50516.1, AC009960.10 and BC035097.1.
            
            On May 17, 2019 this sequence version replaced NM_001204.6.
            
            Summary: This gene encodes a member of the bone morphogenetic
            protein (BMP) receptor family of transmembrane serine/threonine
            kinases. The ligands of this receptor are members of the TGF-beta
            superfamily. BMPs are involved in endochondral bone formation and
            embryogenesis. These proteins transduce their signals through the
            formation of heteromeric complexes of two different types of serine
            (threonine) kinase receptors: type I receptors of about 50-55 kD
            and type II receptors of about 70-80 kD. Mutations in this gene
            have been associated with primary pulmonary hypertension, both
            familial and fenfluramine-associated, and with pulmonary
            venoocclusive disease. [provided by RefSeq, May 2020].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.138307.1,
                                           SRR1660809.258345.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374580.10/ ENSP00000363708.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               DA787547.1         1-230
            231-740             DB233604.1         64-573
            741-4328            D50516.1           1-3588
            4329-11176          AC009960.10        31131-37978
            11177-12068         BC035097.1         1798-2689
FEATURES             Location/Qualifiers
     source          1..12068
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1-q33.2"
     gene            1..12068
                     /gene="BMPR2"
                     /gene_synonym="BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1;
                     T-ALK"
                     /note="bone morphogenetic protein receptor type 2"
                     /db_xref="GeneID:659"
                     /db_xref="HGNC:HGNC:1078"
                     /db_xref="MIM:600799"
     exon            1..1224
                     /gene="BMPR2"
                     /gene_synonym="BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1;
                     T-ALK"
                     /inference="alignment:Splign:2.1.0"
     CDS             1149..4265
                     /gene="BMPR2"
                     /gene_synonym="BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1;
                     T-ALK"
                     /EC_number="2.7.11.30"
                     /note="type II activin receptor-like kinase; BMP type II
                     receptor; type II receptor for bone morphogenetic
                     protein-4; BMP type-2 receptor; bone morphogenetic protein
                     receptor type II; bone morphogenetic protein receptor,
                     type II (serine/threonine kinase)"
                     /codon_start=1
                     /product="bone morphogenetic protein receptor type-2
                     precursor"
                     /protein_id="NP_001195.2"
                     /db_xref="CCDS:CCDS33361.1"
                     /db_xref="GeneID:659"
                     /db_xref="HGNC:HGNC:1078"
                     /db_xref="MIM:600799"
                     /translation="MTSSLQRPWRVPWLPWTILLVSTAAASQNQERLCAFKDPYQQDL
                     GIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVT
                     TTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSV
                     LAVLIVALCFGYRMLTGDRKQGLHSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVY
                     KGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYL
                     LVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDL
                     NSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAV
                     NLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQ
                     VLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIW
                     ERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYSSSSYIEDSIHHTDSIVKNI
                     SSEHSMSSTPLTIGEKNRNSINYERQQAQARIPSPETSVTSLSTNTTTTNTTGLTPST
                     GMTTISEMPYPDETNLHTTNVAQSIGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSD
                     ENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEATGQQDFTQTANGQACLIPDVLPT
                     QIYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGSKHKSNLKQVETGVAKMNTINAAE
                     PHVVTVTMNGVAGRNHSVNSHAATTQYANGTVLSGQTTNIVTHRAQEMLQNQFIGEDT
                     RLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQD
                     VLAQGVPSTAADPGPSKPRRAQRPNSLDLSATNVLDGSSIQIGESTQDGKSGSGEKIK
                     KRVKTPYSLKRWRPSTWVISTESLDCEVNNNGSNRAVHSKSSTAVYLAEGGTATTMVS
                     KDIGMNCL"
     exon            1225..1395
                     /gene="BMPR2"
                     /gene_synonym="BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1;
                     T-ALK"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1566
                     /gene="BMPR2"
                     /gene_synonym="BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1;
                     T-ALK"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1677
                     /gene="BMPR2"
                     /gene_synonym="BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1;
                     T-ALK"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1769
                     /gene="BMPR2"
                     /gene_synonym="BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1;
                     T-ALK"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..2000
                     /gene="BMPR2"
                     /gene_synonym="BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1;
                     T-ALK"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2115
                     /gene="BMPR2"
                     /gene_synonym="BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1;
                     T-ALK"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2276
                     /gene="BMPR2"
                     /gene_synonym="BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1;
                     T-ALK"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2424
                     /gene="BMPR2"
                     /gene_synonym="BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1;
                     T-ALK"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2561
                     /gene="BMPR2"
                     /gene_synonym="BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1;
                     T-ALK"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2734
                     /gene="BMPR2"
                     /gene_synonym="BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1;
                     T-ALK"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..4014
                     /gene="BMPR2"
                     /gene_synonym="BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1;
                     T-ALK"
                     /inference="alignment:Splign:2.1.0"
     exon            4015..12068
                     /gene="BMPR2"
                     /gene_synonym="BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1;
                     T-ALK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12046..12051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMPR2"
                     /gene_synonym="BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1;
                     T-ALK"
                     /note="hexamer: ATTAAA"
     polyA_site      12068
                     /gene="BMPR2"
                     /gene_synonym="BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1;
                     T-ALK"
                     /note="major polyA site"
ORIGIN      
        1 gactcccccc tttgtgtctg gtctgctcgg agccactgga agtgcctccc ggagggacgc
       61 agggtgtctc gccgcctccc tgcccacccc cttccccggc taccttcatc cgccctcccg
      121 ccgccccccg ccctcggtcc gcgacgcccg agttccgtca ggagcccaga gctgcgggag
      181 aacgaggcgg cggcggcggc ggcggcggcg gcggcggcgg cagcagcagc ggcttcctcg
      241 gggggttgtg attcgctcac aggagccatt gacgggagaa gaggaggctt tcttggtgga
      301 atttacctca ggcaagatcg agccgcagga ataaaaagcg aggaagggaa gggagcgccg
      361 ccgggaggac tagaaggggc agcctctcac acccactccg cctgccgtct cggggagccc
      421 ggaccggggc cgcgaccgcg acccctcccc tcccccgctc ctacctctcc tcagccttcg
      481 ccagggcctc cccaaccctc tcacggttgt tctgcgaagg cgtggggact gtgagcttgt
      541 ccatggaggc aggcaccttt tttgatccag tcaaggaaga ggatttgttg ttttcgaaat
      601 cagagtgaag gaagcaccga agcgaaactt aaggaatcct gccttcccgg agccgcgggc
      661 gatgcgacta gggctgccgg gcgccgccgc cgcccgtccg gcttcgtcct tcccggcagt
      721 cgggaactag ttctgaccct cgccccccga ccccggatcg aatccccgcc ctccgcaccc
      781 tggatatgtt ttctcccaga cctggatatt tttttgatat cgtgaaacta cgagggaaat
      841 aatttggggg atttcttctt ggctccctgc tttccccaca gacatgcctt ccgtttggag
      901 ggccgcggca ccccgtccga ggcgaaggaa cccccccagc cgcgagggag agaaatgaag
      961 ggaatttctg cagcggcatg aaagctctgc agctaggtcc tctcatcagc catttgtcct
     1021 ttcaaactgt attgtgatac gggcaggatc agtccacggg agagaagacg agcctcccgg
     1081 ctgtttctcc gccggtctac ttcccatatt tcttttcttt gccctcctga ttcttggctg
     1141 gcccagggat gacttcctcg ctgcagcggc cctggcgggt gccctggcta ccatggacca
     1201 tcctgctggt cagcactgcg gctgcttcgc agaatcaaga acggctatgt gcgtttaaag
     1261 atccgtatca gcaagacctt gggataggtg agagtagaat ctctcatgaa aatgggacaa
     1321 tattatgctc gaaaggtagc acctgctatg gcctttggga gaaatcaaaa ggggacataa
     1381 atcttgtaaa acaaggatgt tggtctcaca ttggagatcc ccaagagtgt cactatgaag
     1441 aatgtgtagt aactaccact cctccctcaa ttcagaatgg aacataccgt ttctgctgtt
     1501 gtagcacaga tttatgtaat gtcaacttta ctgagaattt tccacctcct gacacaacac
     1561 cactcagtcc acctcattca tttaaccgag atgagacaat aatcattgct ttggcatcag
     1621 tctctgtatt agctgttttg atagttgcct tatgctttgg atacagaatg ttgacaggag
     1681 accgtaaaca aggtcttcac agtatgaaca tgatggaggc agcagcatcc gaaccctctc
     1741 ttgatctaga taatctgaaa ctgttggagc tgattggccg aggtcgatat ggagcagtat
     1801 ataaaggctc cttggatgag cgtccagttg ctgtaaaagt gttttccttt gcaaaccgtc
     1861 agaattttat caacgaaaag aacatttaca gagtgccttt gatggaacat gacaacattg
     1921 cccgctttat agttggagat gagagagtca ctgcagatgg acgcatggaa tatttgcttg
     1981 tgatggagta ctatcccaat ggatctttat gcaagtattt aagtctccac acaagtgact
     2041 gggtaagctc ttgccgtctt gctcattctg ttactagagg actggcttat cttcacacag
     2101 aattaccacg aggagatcat tataaacctg caatttccca tcgagattta aacagcagaa
     2161 atgtcctagt gaaaaatgat ggaacctgtg ttattagtga ctttggactg tccatgaggc
     2221 tgactggaaa tagactggtg cgcccagggg aggaagataa tgcagccata agcgaggttg
     2281 gcactatcag atatatggca ccagaagtgc tagaaggagc tgtgaacttg agggactgtg
     2341 aatcagcttt gaaacaagta gacatgtatg ctcttggact aatctattgg gagatattta
     2401 tgagatgtac agacctcttc ccaggggaat ccgtaccaga gtaccagatg gcttttcaga
     2461 cagaggttgg aaaccatccc acttttgagg atatgcaggt tctcgtgtct agggaaaaac
     2521 agagacccaa gttcccagaa gcctggaaag aaaatagcct ggcagtgagg tcactcaagg
     2581 agacaatcga agactgttgg gaccaggatg cagaggctcg gcttactgca cagtgtgctg
     2641 aggaaaggat ggctgaactt atgatgattt gggaaagaaa caaatctgtg agcccaacag
     2701 tcaatccaat gtctactgct atgcagaatg aacgcaacct gtcacataat aggcgtgtgc
     2761 caaaaattgg tccttatcca gattattctt cctcctcata cattgaagac tctatccatc
     2821 atactgacag catcgtgaag aatatttcct ctgagcattc tatgtccagc acacctttga
     2881 ctatagggga aaaaaaccga aattcaatta actatgaacg acagcaagca caagctcgaa
     2941 tccccagccc tgaaacaagt gtcaccagcc tctccaccaa cacaacaacc acaaacacca
     3001 caggactcac gccaagtact ggcatgacta ctatatctga gatgccatac ccagatgaaa
     3061 caaatctgca taccacaaat gttgcacagt caattgggcc aacccctgtc tgcttacagc
     3121 tgacagaaga agacttggaa accaacaagc tagacccaaa agaagttgat aagaacctca
     3181 aggaaagctc tgatgagaat ctcatggagc actctcttaa acagttcagt ggcccagacc
     3241 cactgagcag tactagttct agcttgcttt acccactcat aaaacttgca gtagaagcaa
     3301 ctggacagca ggacttcaca cagactgcaa atggccaagc atgtttgatt cctgatgttc
     3361 tgcctactca gatctatcct ctccccaagc agcagaacct tcccaagaga cctactagtt
     3421 tgcctttgaa caccaaaaat tcaacaaaag agccccggct aaaatttggc agcaagcaca
     3481 aatcaaactt gaaacaagtc gaaactggag ttgccaagat gaatacaatc aatgcagcag
     3541 aacctcatgt ggtgacagtc accatgaatg gtgtggcagg tagaaaccac agtgttaact
     3601 cccatgctgc cacaacccaa tatgccaatg ggacagtact atctggccaa acaaccaaca
     3661 tagtgacaca tagggcccaa gaaatgttgc agaatcagtt tattggtgag gacacccggc
     3721 tgaatattaa ttccagtcct gatgagcatg agcctttact gagacgagag caacaagctg
     3781 gccatgatga aggtgttctg gatcgtcttg tggacaggag ggaacggcca ctagaaggtg
     3841 gccgaactaa ttccaataac aacaacagca atccatgttc agaacaagat gttcttgcac
     3901 agggtgttcc aagcacagca gcagatcctg ggccatcaaa gcccagaaga gcacagaggc
     3961 ctaattctct ggatctttca gccacaaatg tcctggatgg cagcagtata cagataggtg
     4021 agtcaacaca agatggcaaa tcaggatcag gtgaaaagat caagaaacgt gtgaaaactc
     4081 cctattctct taagcggtgg cgcccctcca cctgggtcat ctccactgaa tcgctggact
     4141 gtgaagtcaa caataatggc agtaacaggg cagttcattc caaatccagc actgctgttt
     4201 accttgcaga aggaggcact gctacaacca tggtgtctaa agatatagga atgaactgtc
     4261 tgtgaaatgt tttcaagcct atggagtgaa attatttttt gcatcattta aacatgcaga
     4321 agatgtttaa aaataaaaaa aaaactgctt tatcctcctg tcagcacccc ctcccacccc
     4381 tgcaacaaag acttgcttta aatagatttc agctatgcag aaaaatttag cttatgcttc
     4441 catattttta aattttgttt tttaagtttt gcacttttgt ttagtctcgc taaagttata
     4501 tttgtctgtt atgaccacag agttatatgt gtgtgtatca aaagtggtct caaaatattt
     4561 ttttaagaaa aaaagcaaaa acaatgtatt gctgataatc agtttggacc agtttcttaa
     4621 ggtcattaaa acagaagcaa attaagacag gtttgactgc agtggtgtct ggtatccatg
     4681 ttttatttct gggcacaagc tagtttttat gttgatacgt tcctgaacat attatcttgt
     4741 tggacatctt ttctcttgtg ttttgtttga atgtgcaata gtttataggc cacaaataag
     4801 ctttcttgta agctctcttc ctaacagggc acatattctt ccataatata aacacttttc
     4861 tgccccatct cccatacttt tgaaggtcag ttctatgaca gtgaattttg cacaggagaa
     4921 gcagctacct gatttcttac tttctctctc cttatcatgg agaatacaga aacattgtct
     4981 gaaagggctc taaagaagga actaccaaaa cctgacttga aatgccattt cttttaacct
     5041 tccaaatcct aaatgtttcc ttcaaggcat cttaataaac ttatttgctt ctggttttgg
     5101 gagttcataa gagagaatag aacaaaatac aggacatcaa atattagcca tttcccattt
     5161 tattttattt ttctatgtag gttcatgttc catgttcatt tatttaagaa atacattttt
     5221 attggtaagc ttatagagct acacttatgg aatttttaag taggtaaata aatggttaag
     5281 acaaaatagt gttatagcct tcattctctg aataggccat ctttgactca taaaattacc
     5341 cttactgttt attataactt cagaagtaat ttatagttct gaacctatag tatcttttac
     5401 cctgttccca agcaaagact ggtgacttta tctgaaaatg attcctcttc ccatgaccta
     5461 aaacactgtg aggaaaaatc attcaagtgg catgccaagt ccctatgaag gaagggctgc
     5521 tatcaaacct accttttttg agcaaactga gactaaactt ctctcttttc aaaattgtgt
     5581 tatcttcctt aatcctattt tcataatttt tccttttgcc agtttttcac attatctttg
     5641 atatgtgagc aacatttatt atttacatta gagtatacct tttagtaata aaatgacttg
     5701 aaatcatatt atttttaaaa gccctttgct tctttcatta cttataatct cctctaaaac
     5761 aacctctgca tgtttttttt aaataaagca ctttctgtca aataatggac ttttttctaa
     5821 acagaaatta ttttctatta atttgcaaac tgatgatttc actttttttt actttttttt
     5881 cgattatcag agtacttagt aaatgttata tagtttagtt ctaagatagt tccagggatt
     5941 aaaaggttaa gaggaaaaca caaatcacca aatttctgat ttatgttttt atctcctgaa
     6001 caatattttc tcactcatat tcctctatct tatcacttag ctaaagacag cctaaatttc
     6061 ccaattttct gtccaaaata tttgtgattt acttgtatat aagccttctc atttgccatg
     6121 tgctgtgatc ttacaagtta gatgttacta tacctaccat ttattcagct ggattgctga
     6181 acacagttct ggattcatag aattaagaat atcttgttag tgcccaggat ttccacgttt
     6241 tgtgttttat tggccctttt ctttattcag ccccttaatc tattttcagt cttctggcac
     6301 gtaatttttt tcacagttat tattcttcta ttaacaaatt atttttatct ttcctagtac
     6361 attttcactt agttctcttg cccttaaata tctttcacat gcattttagg atattctttt
     6421 caaatatttg taggacaact ttgaatcaaa ataaattatg ttccttctcc aatttgaagc
     6481 attgaggata aatgaccatt tgaggtctaa ctgatctttt cctgccagaa gagttatctt
     6541 acgttctgct atatttgtat ttgggccagt tgattgtagg ttgtccaaca ttttttaata
     6601 ttgggaaaat tatgataaaa tgctttaaaa attaatatgc cagattaaaa taactgaata
     6661 gtttactatt tcattcaagc atgtttaaaa caaataattt cctttcacca gtttttctta
     6721 gtaaactcct gaaaaagtag gaaaggtgga aagtatatat catttttata aattttaaat
     6781 tgtacatcag acttttaaaa tctgtaatat acaagcaagc aaaattattt taaatgactt
     6841 aattgtatgc taatactcat ctgataataa atgcttctta aagttgacat ttaactgcta
     6901 tcacaaagtt ttatatgtag aaaagtgggg tccttttgaa taaaagatca ttcaactaaa
     6961 aatattaaaa tttatttcac tggatggtaa tgtaacctta aaagcatcat aataggtaaa
     7021 gtctaatatt agttccctta acaaaatcct aactgtatac cagaattagg tcactgaaag
     7081 aacttgattt gaattacgtt tagacaaaaa tgatttaatt gtaaattctt aaaactttct
     7141 aaatgcataa ttggcaaaaa aaaaaaccca ctgttaccag tgtaggaagt tacaagaagg
     7201 cacatactga atgctgaagt atacatatgc tatttctctt aaacctcaga gcaaccatat
     7261 gagcattgta attaatattc ccattttaca gatgaggaaa ctgaagctaa gagaagctaa
     7321 gtaatatgcc caaggtccac atctagtaac agacaaagct gggatttcag tctatgtctg
     7381 cctctctcca catctctttc atccatacca cactgcctac atgccatatg acaggatgtg
     7441 taatgggcta acgtttattt aaaaagttca ggccaggtgc agtggcttat gcctataatc
     7501 cccgcacttt gggaggccga gccgggtgga tcatgaggtc agacgttcaa caccagcctg
     7561 gccaagatgg tgaaaccccg tctctattaa aaatattttt taaaaattaa ctgagcgtgg
     7621 tggtgggcgc ctgtagtccc agctactcag gaggctaagg caggagaatc tcttgaaccc
     7681 gagaggtgga ggttgcagtg agctgagatc gcgccactgc actgcagcct aggcgacaga
     7741 gcaagactgc ctcaaaaaaa aaacataaaa attcagtcac tatactctgg cacaattttc
     7801 atttgtatat gagccaaacc acatacctta atgatttggg aagttaggca aatatgagat
     7861 atgtagacat atctatgctg attgttgctt gagaaataat tactaattct agacaaaact
     7921 caatcctgta tcttccatca tgaatcttaa aatcatttca cttcactcct aacatttctt
     7981 acattgcaga actaatggta aagtaaattt tacggaaaaa gttaagatag ctttgggaac
     8041 agagaccttt ccctaaattg attccatagc agatttgggg gaattaacaa agaatttcag
     8101 tctcatcaat cctttgaatc catcttcaaa acttctgctt ttaataactt tagaaaattt
     8161 actaatctat agaactaatt gagtaggata taggaaggat acaaggatat aatgtccttt
     8221 ttataaaagt ttagtatagc ttctttacat gtatccactt gttccagaaa atgtgcattg
     8281 gttctgaatg tgaaaatatt taaagagaga aaggaacact caagtaagtg tgggcttcag
     8341 tgggaattat cacaaaacat tggcaagtat ttttatttaa attattttca aatttgactt
     8401 ctacagccaa gtggaattgg taggctgtag ctgttacact gaaatttcta gtctttgtaa
     8461 gtgcctcctg aaagtcattt aaaatggaaa aatatttcaa tgagcttttc cttttttcat
     8521 atttatggac atgaatattt tattggagat cattaactcc tagaatttga gattatattt
     8581 ccatacaaca ttttataaag ttatgttgaa cttactacct gttatgtgca ggttattatg
     8641 taactattca cagattgctt catatattgc tttatcttcc catctaactt cttaaagtta
     8701 aaatccggac acacatgttg attatctaga ccagtcattc tggaaattgt aacactccca
     8761 cataaacccc aggagacttt ttcagaatgc aatgtttcta aatgtactgt tactggcagt
     8821 ttactctcca gcatataagg ttgcatttta acttttagat tatgaactgt gcaaacttta
     8881 cccaaaacta tcttgcatga ttccctccta aatatattcc ttgattaagt aaatctggca
     8941 aatcactgtt tgagctagtt acataaaatt tgttatcaag agaaggcttt tctacaagtt
     9001 tccagattaa cataaagaaa agagggaatc acagggcatt taagtgcacc ttcccattac
     9061 tttccttaaa tcacctcata gttaggctgg gcgcggtggc tcacgcctgt aatcccagca
     9121 ctttgggagg ccgagacggt ggatcacgag gtcaggggac tgagatcatc ctggctaaca
     9181 cgatgaaacc tcatctctac taaaaataca aataattagc caggcatggt ggcacgcgcc
     9241 tgtagtccca gctactcggg aggcagagac aggagaatcg tttgcacccg ggaggcggag
     9301 gttgttgcag tgagccgaga tcgcgccaat gcactccagc ctgggctaca gagtgagact
     9361 ccatctcaaa aaaaaacaaa aaaaatcacc tcatagttta tgtctgactt actccaaacc
     9421 tcagttatct gatttgtagt ctgtgtcagg aaagttttct tcatatctat tctgtctccc
     9481 tcctctttga ttttaaattt ttttctttta cccagtagga caaaaaagag cagttggtca
     9541 tcatccccaa tattcttagt cttcagtatg cttcaggcct ctcaatgaac acttaagtct
     9601 caattcttca gacaaaattg cttaagctct tctcctcagt cctattttaa tgactttata
     9661 tttaagaata tagaattata ttttctttta tattcaaatt cattactcca gttaagtaat
     9721 agtttgatag tttgatagaa tcgagagtta agatgtttct atttgaaagt ggattcaacc
     9781 atcagaccac cagcaaatcg gcacttaatt tttgtgttat ctaacatttt ctattgtgga
     9841 attttatgat tttatattct cattagttat aactaaaaag ccatgcacac agaattgtat
     9901 atcattttgc cattaaaatt ttttaacata ttgcagcaag cttagtttta tgattgagcc
     9961 acaacctttt acatattttt tgtatgaaat attaaacact aaatgcaaga ttaactttca
    10021 aaagcaaacc ctacattaat caggtattat ctatggacat ttttgtagac cacttttgaa
    10081 atacttatta ttttgcaaca tagactggac tatacaactt tcatttaact tttaggtgac
    10141 tgatttaagt tgagtgtgca tatagagaaa aacctagaaa tttatctcat ggcagataca
    10201 tttgaaagta cttcagaaga atttatgctg tatattaaaa ctaggctcaa aataaatcta
    10261 tcgtatcttt aaaagtccaa ttctgttatt actgtgatgt ttgtagtgtt actattaaac
    10321 attgtgaaca tacacatttt taaaacaact tgaaacccat tttaaaatct gggtaagaga
    10381 gaaggaatct tcagaacaaa atcacatcat tagggtgtcc agtttatgat tgaattttta
    10441 agcaaattac tgtatttgaa actacaactt gatttggttt tcagttttaa aaggcaacat
    10501 gtgggtttta tccattttat ttataccttt agatttcaga aacatcttca tgttttagat
    10561 gcattctaca gacatcatgt tacttaaaaa ctcagggccc ctttcatccc tttgtacact
    10621 gaaaaagttc aattgttagc aagtaagcaa ttagatccag ttgaatattt aaagtgtttg
    10681 ttgcacagtt catttaatgt ttcatcttat ttgacttttt cacatagata taatatcaga
    10741 tttcattaat tataaaaagt tgcccagttc tgtaattact gaacagaggg aatgactcaa
    10801 ctaattggct acatgttgca acaaatttag gcctttagag ttgaagcact gacttaaaac
    10861 gacttacatt tctgttcttt ggtcaaatga ccatacatga tatgggacaa attgtttcat
    10921 tttgtttgtt ttttaataag ggaacttggt aaagtagttc ctgtcagata ggattttctc
    10981 aagagacaat ttaacgttat aaagccttct aaaagtgaac taaatatttt ataactttag
    11041 taatagcttg gatggttttg agaaaataac ctgtatttat cacattgtca aacagaattt
    11101 ttctttgaat cagacaagtt caagctctaa attgatgtgc tatatactta aaatcctagg
    11161 aagttatctg taaccagtct cttgtctcag gctcttcacc ttgttaccaa tcctcgtaag
    11221 tatgtaaagg aaacatattt ttaaagaagc ttaacagtaa gaaaaaatta ctaaaagatg
    11281 caattcaaag ataggtccca gtttaacact gaattgcttg acttctgtgg cttttctttt
    11341 tctggccaca tttatttatt taagcaattt ttgtatgcct tgttatttca tttccataga
    11401 gattatattg tatcagtgtt tatgtaagct ggaatcatcc tcagtttttt gctgataatt
    11461 tttcaaataa agatacatgg ataattgtaa aatacactaa ctcttagggt gttgtagtag
    11521 ctgaaacatg gagatgcgta gctgtcatgc tttttctgaa tggacaggag aaacataagc
    11581 tacggagtat tcacttctga ggatgctttt ccggaaaaag aaaggctaga aaatactcgc
    11641 acttcctcag aaccctcttt cttgttaacg ggtatctttt gttggtgtgt tttgctctta
    11701 cattacagat agactatcat atatgacttt atgaataatt tcagttattt tgcttttgta
    11761 taagctgtct gaagccttgc tatgctgtat aagttgtgtt tgatggatca gtgtgagtat
    11821 aaaataaagc aaatcacttt tcttttgtat tatctatgga tgccactatg aaagctgaca
    11881 ttaagccact aaagagtttt ctatgaataa gtgtaagtaa atgctttgat atatataaac
    11941 ctaaataaaa agattgtatt gatacagaga cattggagaa ggagatttta aggcagttct
    12001 ttaggtttaa aaaggcttgc tgtaaaatgg tgcgttattc cgtttattaa agatcatatt
    12061 aatgacaa
//
