LOCUS       NM_001203               5580 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens bone morphogenetic protein receptor type 1B (BMPR1B),
            transcript variant 2, mRNA.
ACCESSION   NM_001203 XM_005263179
VERSION     NM_001203.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5580)
  AUTHORS   Zheng,Y., Jiang,X., Wang,M., Yang,S., Deng,Y., Li,Y., Zhai,Z.,
            Wu,Y., Wang,N., Ren,X., Kang,H. and Chen,L.
  TITLE     BMPR1B Polymorphisms (rs1434536 and rs1970801) are Associated With
            Breast Cancer Susceptibility in Northwest Chinese Han Females: A
            Case-Control Study
  JOURNAL   Clin Breast Cancer 22 (5), e641-e646 (2022)
   PUBMED   35501253
  REMARK    GeneRIF: BMPR1B Polymorphisms (rs1434536 and rs1970801) are
            Associated With Breast Cancer Susceptibility in Northwest Chinese
            Han Females: A Case-Control Study.
REFERENCE   2  (bases 1 to 5580)
  AUTHORS   Bednarek,M., Trybus,M., Kolanowska,M., Koziej,M., Kiec-Wilk,B.,
            Dobosz,A., Kotlarek-Lysakowska,M., Kubiak-Dydo,A.,
            Uzarowska-Gaska,E., Starega-Roslan,J., Gaj,P., Gorzynska,I.,
            Serwan,K., Swierniak,M., Kot,A., Jazdzewski,K. and Wojcicka,A.
  TITLE     BMPR1B gene in brachydactyly type 2-A family with de novo R486W
            mutation and a disease phenotype
  JOURNAL   Mol Genet Genomic Med 9 (3), e1594 (2021)
   PUBMED   33486847
  REMARK    GeneRIF: BMPR1B gene in brachydactyly type 2-A family with de novo
            R486W mutation and a disease phenotype.
REFERENCE   3  (bases 1 to 5580)
  AUTHORS   Lin,Y.C., Niceta,M., Muto,V., Vona,B., Pagnamenta,A.T.,
            Maroofian,R., Beetz,C., van Duyvenvoorde,H., Dentici,M.L.,
            Lauffer,P., Vallian,S., Ciolfi,A., Pizzi,S., Bauer,P.,
            Gruning,N.M., Bellacchio,E., Del Fattore,A., Petrini,S.,
            Shaheen,R., Tiosano,D., Halloun,R., Pode-Shakked,B., Albayrak,H.M.,
            Isik,E., Wit,J.M., Dittrich,M., Freire,B.L., Bertola,D.R.,
            Jorge,A.A.L., Barel,O., Sabir,A.H., Al Tenaiji,A.M.J., Taji,S.M.,
            Al-Sannaa,N., Al-Abdulwahed,H., Digilio,M.C., Irving,M.,
            Anikster,Y., Bhavani,G.S.L., Girisha,K.M., Haaf,T., Taylor,J.C.,
            Dallapiccola,B., Alkuraya,F.S., Yang,R.B. and Tartaglia,M.
  CONSRTM   Genomics England Research Consortium
  TITLE     SCUBE3 loss-of-function causes a recognizable recessive
            developmental disorder due to defective bone morphogenetic protein
            signaling
  JOURNAL   Am J Hum Genet 108 (1), 115-133 (2021)
   PUBMED   33308444
REFERENCE   4  (bases 1 to 5580)
  AUTHORS   Yang,Z., Gao,X.J. and Zhao,X.
  TITLE     CDMP1 promotes type II collagen and aggrecan synthesis of nucleus
            pulposus cell via the mediation of ALK6
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (21), 10975-10983 (2020)
   PUBMED   33215411
  REMARK    GeneRIF: CDMP1 promotes type II collagen and aggrecan synthesis of
            nucleus pulposus cell via the mediation of ALK6.
REFERENCE   5  (bases 1 to 5580)
  AUTHORS   Mang,T., Kleinschmidt-Doerr,K., Ploeger,F., Schoenemann,A.,
            Lindemann,S. and Gigout,A.
  TITLE     BMPR1A is necessary for chondrogenesis and osteogenesis, whereas
            BMPR1B prevents hypertrophic differentiation
  JOURNAL   J Cell Sci 133 (16) (2020)
   PUBMED   32764110
  REMARK    GeneRIF: BMPR1A is necessary for chondrogenesis and osteogenesis,
            whereas BMPR1B prevents hypertrophic differentiation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5580)
  AUTHORS   Nishitoh,H., Ichijo,H., Kimura,M., Matsumoto,T., Makishima,F.,
            Yamaguchi,A., Yamashita,H., Enomoto,S. and Miyazono,K.
  TITLE     Identification of type I and type II serine/threonine kinase
            receptors for growth/differentiation factor-5
  JOURNAL   J Biol Chem 271 (35), 21345-21352 (1996)
   PUBMED   8702914
REFERENCE   7  (bases 1 to 5580)
  AUTHORS   Yamada,N., Kato,M., ten Dijke,P., Yamashita,H., Sampath,T.K.,
            Heldin,C.H., Miyazono,K. and Funa,K.
  TITLE     Bone morphogenetic protein type IB receptor is progressively
            expressed in malignant glioma tumours
  JOURNAL   Br J Cancer 73 (5), 624-629 (1996)
   PUBMED   8605097
REFERENCE   8  (bases 1 to 5580)
  AUTHORS   Yamaji,N., Celeste,A.J., Thies,R.S., Song,J.J., Bernier,S.M.,
            Goltzman,D., Lyons,K.M., Nove,J., Rosen,V. and Wozney,J.M.
  TITLE     A mammalian serine/threonine kinase receptor specifically binds
            BMP-2 and BMP-4
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1944-1951 (1994)
   PUBMED   7811286
REFERENCE   9  (bases 1 to 5580)
  AUTHORS   ten Dijke,P., Yamashita,H., Ichijo,H., Franzen,P., Laiho,M.,
            Miyazono,K. and Heldin,C.H.
  TITLE     Characterization of type I receptors for transforming growth
            factor-beta and activin
  JOURNAL   Science 264 (5155), 101-104 (1994)
   PUBMED   8140412
REFERENCE   10 (bases 1 to 5580)
  AUTHORS   Austin,E.D., Phillips,J.A. III and Loyd,J.E.
  TITLE     Heritable Pulmonary Arterial Hypertension Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093634.3, AW299723.1,
            BC069796.1 and AC105395.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 23, 2019 this sequence version replaced NM_001203.2.
            
            Summary: This gene encodes a member of the bone morphogenetic
            protein (BMP) receptor family of transmembrane serine/threonine
            kinases. The ligands of this receptor are BMPs, which are members
            of the TGF-beta superfamily. BMPs are involved in endochondral bone
            formation and embryogenesis. These proteins transduce their signals
            through the formation of heteromeric complexes of 2 different types
            of serine (threonine) kinase receptors: type I receptors of about
            50-55 kD and type II receptors of about 70-80 kD. Type II receptors
            bind ligands in the absence of type I receptors, but they require
            their respective type I receptors for signaling, whereas type I
            receptors require their respective type II receptors for ligand
            binding. Mutations in this gene have been associated with primary
            pulmonary hypertension. Several transcript variants encoding two
            different isoforms have been found for this gene. [provided by
            RefSeq, Feb 2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (b) is
            shorter at the N-terminus compared to isoform a. Variants 2, 3, and
            4 all encode isoform b.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.85460.1,
                                           SRR1660809.177216.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000515059.6/ ENSP00000426617.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC093634.3         15385-15406
            23-216              AW299723.1         10-203
            217-1945            BC069796.1         107-1835
            1946-5580           AC105395.1         96565-100199
FEATURES             Location/Qualifiers
     source          1..5580
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.3"
     gene            1..5580
                     /gene="BMPR1B"
                     /gene_synonym="ALK-6; ALK6; AMD3; AMDD; BDA1D; BDA2;
                     CDw293"
                     /note="bone morphogenetic protein receptor type 1B"
                     /db_xref="GeneID:658"
                     /db_xref="HGNC:HGNC:1077"
                     /db_xref="MIM:603248"
     exon            1..114
                     /gene="BMPR1B"
                     /gene_synonym="ALK-6; ALK6; AMD3; AMDD; BDA1D; BDA2;
                     CDw293"
                     /inference="alignment:Splign:2.1.0"
     exon            115..184
                     /gene="BMPR1B"
                     /gene_synonym="ALK-6; ALK6; AMD3; AMDD; BDA1D; BDA2;
                     CDw293"
                     /inference="alignment:Splign:2.1.0"
     exon            185..279
                     /gene="BMPR1B"
                     /gene_synonym="ALK-6; ALK6; AMD3; AMDD; BDA1D; BDA2;
                     CDw293"
                     /inference="alignment:Splign:2.1.0"
     exon            280..439
                     /gene="BMPR1B"
                     /gene_synonym="ALK-6; ALK6; AMD3; AMDD; BDA1D; BDA2;
                     CDw293"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..1805
                     /gene="BMPR1B"
                     /gene_synonym="ALK-6; ALK6; AMD3; AMDD; BDA1D; BDA2;
                     CDw293"
                     /EC_number="2.7.11.30"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; serine/threonine receptor kinase; activin
                     receptor-like kinase 6; BMPR-1B; BMP type-1B receptor;
                     bone morphogenetic protein receptor, type IB"
                     /codon_start=1
                     /product="bone morphogenetic protein receptor type-1B
                     isoform b precursor"
                     /protein_id="NP_001194.1"
                     /db_xref="CCDS:CCDS3642.1"
                     /db_xref="GeneID:658"
                     /db_xref="HGNC:HGNC:1077"
                     /db_xref="MIM:603248"
                     /translation="MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVN
                     NICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNEC
                     NKDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYS
                     IGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEV
                     WMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLY
                     LITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLK
                     SKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHF
                     QSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLR
                     PSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL"
     exon            440..542
                     /gene="BMPR1B"
                     /gene_synonym="ALK-6; ALK6; AMD3; AMDD; BDA1D; BDA2;
                     CDw293"
                     /inference="alignment:Splign:2.1.0"
     exon            543..645
                     /gene="BMPR1B"
                     /gene_synonym="ALK-6; ALK6; AMD3; AMDD; BDA1D; BDA2;
                     CDw293"
                     /inference="alignment:Splign:2.1.0"
     exon            646..742
                     /gene="BMPR1B"
                     /gene_synonym="ALK-6; ALK6; AMD3; AMDD; BDA1D; BDA2;
                     CDw293"
                     /inference="alignment:Splign:2.1.0"
     exon            743..881
                     /gene="BMPR1B"
                     /gene_synonym="ALK-6; ALK6; AMD3; AMDD; BDA1D; BDA2;
                     CDw293"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1074
                     /gene="BMPR1B"
                     /gene_synonym="ALK-6; ALK6; AMD3; AMDD; BDA1D; BDA2;
                     CDw293"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1372
                     /gene="BMPR1B"
                     /gene_synonym="ALK-6; ALK6; AMD3; AMDD; BDA1D; BDA2;
                     CDw293"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1548
                     /gene="BMPR1B"
                     /gene_synonym="ALK-6; ALK6; AMD3; AMDD; BDA1D; BDA2;
                     CDw293"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1679
                     /gene="BMPR1B"
                     /gene_synonym="ALK-6; ALK6; AMD3; AMDD; BDA1D; BDA2;
                     CDw293"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..5580
                     /gene="BMPR1B"
                     /gene_synonym="ALK-6; ALK6; AMD3; AMDD; BDA1D; BDA2;
                     CDw293"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5547..5552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMPR1B"
                     /gene_synonym="ALK-6; ALK6; AMD3; AMDD; BDA1D; BDA2;
                     CDw293"
                     /note="hexamer: AATAAA"
     polyA_site      5580
                     /gene="BMPR1B"
                     /gene_synonym="ALK-6; ALK6; AMD3; AMDD; BDA1D; BDA2;
                     CDw293"
                     /note="major polyA site"
ORIGIN      
        1 agaagttgac ggcgcagccg ggcgcggggc gcggagtcgg cggggcctcg cgggacgccg
       61 ggcagtgcgg agaccgcggc gctgaggacg cgggagccgg gagcgcagcc gcggggtgga
      121 gttcagccta ctctttctta gatgtgaaag gaaaggaaga tcatttcatg ccttgttgat
      181 aaaggttcag acttctgctg attcataacc atttggctct gagctatgac aagagaggaa
      241 acaaaaagtt aaacaagcaa gcctgccata agtgagaagc aaacttcctt gataacatgc
      301 ttttgcgaag tgcaggaaaa ttaaatgtgg gcaccaagaa agaggatggt gagagtacag
      361 cccccacccc ccgtccaaag gtcttgcgtt gtaaatgcca ccaccattgt ccagaagact
      421 cagtcaacaa tatttgcagc acagacggat attgtttcac gatgatagaa gaggatgact
      481 ctgggttgcc tgtggtcact tctggttgcc taggactaga aggctcagat tttcagtgtc
      541 gggacactcc cattcctcat caaagaagat caattgaatg ctgcacagaa aggaacgaat
      601 gtaataaaga cctacaccct acactgcctc cattgaaaaa cagagatttt gttgatggac
      661 ctatacacca cagggcttta cttatatctg tgactgtctg tagtttgctc ttggtcctta
      721 tcatattatt ttgttacttc cggtataaaa gacaagaaac cagacctcga tacagcattg
      781 ggttagaaca ggatgaaact tacattcctc ctggagaatc cctgagagac ttaattgagc
      841 agtctcagag ctcaggaagt ggatcaggcc tccctctgct ggtccaaagg actatagcta
      901 agcagattca gatggtgaaa cagattggaa aaggtcgcta tggggaagtt tggatgggaa
      961 agtggcgtgg cgaaaaggta gctgtgaaag tgttcttcac cacagaggaa gccagctggt
     1021 tcagagagac agaaatatat cagacagtgt tgatgaggca tgaaaacatt ttgggtttca
     1081 ttgctgcaga tatcaaaggg acagggtcct ggacccagtt gtacctaatc acagactatc
     1141 atgaaaatgg ttccctttat gattatctga agtccaccac cctagacgct aaatcaatgc
     1201 tgaagttagc ctactcttct gtcagtggct tatgtcattt acacacagaa atctttagta
     1261 ctcaaggcaa accagcaatt gcccatcgag atctgaaaag taaaaacatt ctggtgaaga
     1321 aaaatggaac ttgctgtatt gctgacctgg gcctggctgt taaatttatt agtgatacaa
     1381 atgaagttga cataccacct aacactcgag ttggcaccaa acgctatatg cctccagaag
     1441 tgttggacga gagcttgaac agaaatcact tccagtctta catcatggct gacatgtata
     1501 gttttggcct catcctttgg gaggttgcta ggagatgtgt atcaggaggt atagtggaag
     1561 aataccagct tccttatcat gacctagtgc ccagtgaccc ctcttatgag gacatgaggg
     1621 agattgtgtg catcaagaag ttacgcccct cattcccaaa ccggtggagc agtgatgagt
     1681 gtctaaggca gatgggaaaa ctcatgacag aatgctgggc tcacaatcct gcatcaaggc
     1741 tgacagccct gcgggttaag aaaacacttg ccaaaatgtc agagtcccag gacattaaac
     1801 tctgatagga gaggaaaagt aagcatctct gcagaaagcc aacaggtact cttctgtttg
     1861 tgggcagagc aaaagacatc aaataagcat ccacagtaca agccttgaac atcgtcctgc
     1921 ttcccagtgg gttcagacct cacctctcag ggagcgacct gggcaaagac agagaagctc
     1981 ccagaaggag agattgatcc atgtctgttt gtaggacgga gaaaccgctt gggtaacttg
     2041 ttcaagatat gatgcatgtt gctttctaag aaagccctgt attttgtgat tgcctttttt
     2101 tttttttaag atgctttcat tttgccaaaa taaaacagat aatgtggatg gtttaagggt
     2161 tatagtatta tagtttaaat aataacaaca aaattcttcc caggaactct gctggaaggt
     2221 aaattaaaat acttgttttt ccattggtaa aatattgttg cactctgtga accaaaagac
     2281 agtctaagtt ggaggacata gaacggaact catcttaaac atactcccca ccccgtcttg
     2341 gcctcctcag accactttgg ccatccctgc atttggggcc gctatggtaa tgtgaatgca
     2401 ctgggtacaa acaccgcctg tctaggacca catttggaat tcctgcaggt ggccttttgc
     2461 agcttcaggc aatatggaac aaatgaaggt ttatgtgact ctaatagaag taattgttga
     2521 taggtgttct tcagatccac ttctgtttct gattgagtta ggcatctctt tcatggtaaa
     2581 acccttttca ttaaacacaa agaaagcttt tttttttttt tttttttttt ttttttttta
     2641 atgtgcagag gattgacctg tgcatgcttt tgatctctca ttcaaaggat caatattaaa
     2701 taaaattgtc atgagctgtg ttgaagacag ggtgctttca aatagaggta atttgctctt
     2761 gtgttgtaag aggaacatgt caacaaagat aggaaatgag ggtgatcgtg cagatggctt
     2821 gtatcttata tatgcaaagg agccaatctc agaagcacaa agaaaaaagt gtgcatacct
     2881 tattttgtac agataaagat gatgtctttt tgttattgtc tgtctgtttt gtatgtgtct
     2941 gagataaggg atagagagga aacatccgtc aggctaattt aactacattt tattttaaaa
     3001 atagagaaac ataacctcta gatgggacag cagaggacag ttagtagagg ccacaaactg
     3061 ttatgggctg ctgtgttttg ttctaaaatc aatatggttg gagcatgtat atcttaggtg
     3121 atcatttcac atcttaggaa tgcctactca ttttatttta ttctagtgat gctcaattca
     3181 ctatttaatt tattatattt tctcttctgt ggcacttata caaaatatct cttcacctac
     3241 ttagttctac agggttttaa ctttggagca acatgaataa aatcatcgag aaggccaata
     3301 ttgtttagca acatgaatac aatacagttt aaagttgtac acatcctgct caactttatt
     3361 catatacatt tcctttctgt ggttttcttt tgcttcttag aaattctgtt agtggttagt
     3421 aaagaatttg aaagtacttt ctccttgctg tttttttttt tttttaagac attcctccca
     3481 gaatactcca gggggcagtg ttttataaca cattttcccc actgggtgat tgaaggatgg
     3541 aggatttttg aaaatttgac agctacatga aacatgagaa aacattttcc tcacttctga
     3601 agtcggtttg cagctggtaa cttgttcatc cagaaaacat tctaaagcaa tgagactttg
     3661 tgagctgtgc ttacagtttg ggagaatcat gaagattctt tctatatttt gcatttactt
     3721 cccagtgctt catagctgca ttttgtttgt aactaagaca gaagaatttc gtaatccttg
     3781 aaattgaaaa aaaaaaaatt gtgtttttaa agagtgaaaa cagttagaaa acaagtagaa
     3841 ctgtaatcag aacgctgctt caattgatat taaaaataac ctcaataata atgtaaaggt
     3901 tcctttctct tgtgtcagtt atattcttag ggatagccta gaaggaatat atggttagaa
     3961 ctaagtgtga ctaatcatct gagccttgaa gagaaacttc agtgcctcta aacagatcat
     4021 ctacaaaaca acaggtaaac atttatgcca gttaagtggg tcatgttttt gtttcttggg
     4081 tttttcctaa atttaagtga ggttgggctt accttgtaga taaaattatg ttttcttttt
     4141 ggtaaatact tgaacgtgga taacgtcaaa tcagaatatt ttgtgaggag gtgatgattt
     4201 gaaattaagc tagatttcta gggaggtgtt ggttccaatg aaggatggga agaaattaaa
     4261 atagtcttca aacttcttcc ttattatatt tggttgcttt ggaaaagatt ggtcctatcc
     4321 tcaatctaat ttattcacta ttaatatttt aaaaacattc ctgagatact taaaaagacc
     4381 cacttagcga ttatagttgc tcaatgaaac aagaatttat ttatgcatag atttttctct
     4441 gtatcttacc aaaatccact ttacttagat aacactaaat tgttcttaaa gactactcat
     4501 ttcccaataa tcctttatga tttcaaaatt tctagtggct cagaagtgaa ttttatttta
     4561 tttgtctttc acttgaataa atgagaaccc agaaattaat aatgttgttt attgcttact
     4621 gtcaggacta tttcaaagac taagaagagt ttcttctaac ccctccctct caaaggaatc
     4681 ctaaattatt agttgttaga taagttttgt atgctaagat attcaggttt atagtttatg
     4741 tatgtgtgta tatatataaa tatatatgta tatataaata ttatgttcag tttggagtct
     4801 ggcacaactc cattatgtgg attagagagt aagatattat ggatgataaa gtactaaatg
     4861 aaacataata tttatttata aaagtgtgta gattgttaaa tcacaaaaag agtgctatga
     4921 ccattatgta tgaggaaaca ggcctttgac ctcctggaaa gcactgctca aaagtcatta
     4981 gtgcccattt ttgaattccc caaacagaaa gcttcttaga aaacatgctg agattttatt
     5041 tacagggaat tctttgacac atttcaattg gtgtgtagtc aagtatagca agtacttaat
     5101 aatgactgaa tttcatgttc ctacagtcat acatattcat tagaagtttt atgttgttgg
     5161 tctgatctga ttcttctttg tttgtgggtg gaacggcact gagagaagta tagtttttta
     5221 aacttgaaca tgttcagtag ttacattgcc ttagaaaacc cagacacata gcagtggaaa
     5281 tgaaagaaat ggcatcagaa gtgacttaat ttagcaattg tgattcctct tgtaaaacaa
     5341 aacaaaaaaa caatgccata ttttttggag aaaagttggc aatatagggg tttcgttgtc
     5401 tgtttcacaa gaagactcat ttgttctttt gggggaacca gtgccttaca gattttgtat
     5461 atactgtaat tattcaggac tagggaacaa acaattgtat tgtatttgtt acagattgta
     5521 tatggctttg ttttaacatt cccctaaata aaatggcttc attctcccct tggaaaaaaa
//
