LOCUS       NM_004329               6417 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens bone morphogenetic protein receptor type 1A (BMPR1A),
            transcript variant 3, mRNA.
ACCESSION   NM_004329
VERSION     NM_004329.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6417)
  AUTHORS   Wang,Z., Shi,J., Tao,D., Xie,S., Yang,Y. and Liu,Y.
  TITLE     Nonsense suppression induces read-through of a novel BMPR1A variant
            in a Chinese family with hereditary colorectal cancer
  JOURNAL   Ann Hum Genet 88 (4), 300-306 (2024)
   PUBMED   38192234
  REMARK    GeneRIF: Nonsense suppression induces read-through of a novel
            BMPR1A variant in a Chinese family with hereditary colorectal
            cancer.
REFERENCE   2  (bases 1 to 6417)
  AUTHORS   Tan,N., Tang,J., Chen,G., Jiang,W. and Liu,Z.
  TITLE     ZEB1-AS1 mediates bone metastasis through targeting miR-320b/BMPR1A
            axis in lung cancer
  JOURNAL   Clin Respir J 18 (5), e13770 (2024)
   PUBMED   38783645
  REMARK    GeneRIF: ZEB1-AS1 mediates bone metastasis through targeting
            miR-320b/BMPR1A axis in lung cancer.
REFERENCE   3  (bases 1 to 6417)
  AUTHORS   Guo,R., Gu,T., Xiao,Y., Xiao,T., Liu,Q., Li,Z. and Yu,J.
  TITLE     Hsa-miR-27b-5p suppresses the osteogenic and odontogenic
            differentiation of stem cells from human exfoliated deciduous teeth
            via targeting BMPR1A: An ex vivo study
  JOURNAL   Int Endod J 56 (10), 1284-1300 (2023)
   PUBMED   37485765
  REMARK    GeneRIF: Hsa-miR-27b-5p suppresses the osteogenic and odontogenic
            differentiation of stem cells from human exfoliated deciduous teeth
            via targeting BMPR1A: An ex vivo study.
REFERENCE   4  (bases 1 to 6417)
  AUTHORS   Liu,S., Baeg,G.H., Yang,Y., Goh,F.G., Bao,H., Wagner,E.J., Yang,X.
            and Cai,Y.
  TITLE     The Integrator complex desensitizes cellular response to
            TGF-beta/BMP signaling
  JOURNAL   Cell Rep 42 (1), 112007 (2023)
   PUBMED   36641752
REFERENCE   5  (bases 1 to 6417)
  AUTHORS   Rosner,G., Petel-Galil,Y., Laish,I., Levi,Z., Kariv,R., Strul,H.,
            Gilad,O. and Gluck,N.
  TITLE     Adenomatous Polyposis Phenotype in BMPR1A and SMAD4 Variant
            Carriers
  JOURNAL   Clin Transl Gastroenterol 13 (10), e00527 (2022)
   PUBMED   36049049
  REMARK    GeneRIF: Adenomatous Polyposis Phenotype in BMPR1A and SMAD4
            Variant Carriers.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6417)
  AUTHORS   Yamada,N., Kato,M., ten Dijke,P., Yamashita,H., Sampath,T.K.,
            Heldin,C.H., Miyazono,K. and Funa,K.
  TITLE     Bone morphogenetic protein type IB receptor is progressively
            expressed in malignant glioma tumours
  JOURNAL   Br J Cancer 73 (5), 624-629 (1996)
   PUBMED   8605097
REFERENCE   7  (bases 1 to 6417)
  AUTHORS   Ishidou,Y., Kitajima,I., Obama,H., Maruyama,I., Murata,F.,
            Imamura,T., Yamada,N., ten Dijke,P., Miyazono,K. and Sakou,T.
  TITLE     Enhanced expression of type I receptors for bone morphogenetic
            proteins during bone formation
  JOURNAL   J Bone Miner Res 10 (11), 1651-1659 (1995)
   PUBMED   8592941
REFERENCE   8  (bases 1 to 6417)
  AUTHORS   Liu,F., Ventura,F., Doody,J. and Massague,J.
  TITLE     Human type II receptor for bone morphogenic proteins (BMPs):
            extension of the two-kinase receptor model to the BMPs
  JOURNAL   Mol Cell Biol 15 (7), 3479-3486 (1995)
   PUBMED   7791754
REFERENCE   9  (bases 1 to 6417)
  AUTHORS   ten Dijke,P., Ichijo,H., Franzen,P., Schulz,P., Saras,J.,
            Toyoshima,H., Heldin,C.H. and Miyazono,K.
  TITLE     Activin receptor-like kinases: a novel subclass of cell-surface
            receptors with predicted serine/threonine kinase activity
  JOURNAL   Oncogene 8 (10), 2879-2887 (1993)
   PUBMED   8397373
REFERENCE   10 (bases 1 to 6417)
  AUTHORS   Larsen Haidle,J., MacFarland,S.P. and Howe,J.R.
  TITLE     Juvenile Polyposis Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301642
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC067750.5, AC021036.6 and
            AC025268.8.
            
            On Nov 30, 2019 this sequence version replaced NM_004329.2.
            
            Summary: The bone morphogenetic protein (BMP) receptors are a
            family of transmembrane serine/threonine kinases that include the
            type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2.
            These receptors are also closely related to the activin receptors,
            ACVR1 and ACVR2. The ligands of these receptors are members of the
            TGF-beta superfamily. TGF-betas and activins transduce their
            signals through the formation of heteromeric complexes with 2
            different types of serine (threonine) kinase receptors: type I
            receptors of about 50-55 kD and type II receptors of about 70-80
            kD. Type II receptors bind ligands in the absence of type I
            receptors, but they require their respective type I receptors for
            signaling, whereas type I receptors require their respective type
            II receptors for ligand binding. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028383.1, Z22535.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372037.8/ ENSP00000361107.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               AC067750.5         54354-54654         c
            302-416             AC021036.6         83565-83679
            417-635             AC025268.8         140442-140660       c
            636-798             AC025268.8         126303-126465       c
            799-901             AC025268.8         124298-124400       c
            902-998             AC025268.8         116637-116733       c
            999-1098            AC025268.8         116401-116500       c
            1099-1243           AC025268.8         104143-104287       c
            1244-1436           AC025268.8         99201-99393         c
            1437-1734           AC025268.8         97058-97355         c
            1735-1910           AC025268.8         94832-95007         c
            1911-2041           AC025268.8         93021-93151         c
            2042-6417           AC025268.8         88558-92933         c
FEATURES             Location/Qualifiers
     source          1..6417
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.2"
     gene            1..6417
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /note="bone morphogenetic protein receptor type 1A"
                     /db_xref="GeneID:657"
                     /db_xref="HGNC:HGNC:1076"
                     /db_xref="MIM:601299"
     exon            1..301
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            302..416
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            417..635
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     CDS             569..2167
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /EC_number="2.7.11.30"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; serine/threonine-protein kinase receptor R5;
                     activin A receptor, type II-like kinase 3; BMP type-1A
                     receptor; activin receptor-like kinase 3; bone
                     morphogenetic protein receptor, type IA"
                     /codon_start=1
                     /product="bone morphogenetic protein receptor type-1A
                     isoform 3 precursor"
                     /protein_id="NP_004320.2"
                     /db_xref="CCDS:CCDS7378.1"
                     /db_xref="GeneID:657"
                     /db_xref="HGNC:HGNC:1076"
                     /db_xref="MIM:601299"
                     /translation="MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKS
                     ENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMK
                     YEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISM
                     AVCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGS
                     GSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETE
                     IYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKL
                     AYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTN
                     EVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIV
                     EEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNP
                     ASRLTALRIKKTLAKMVESQDVKI"
     exon            636..798
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            799..901
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            902..998
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1098
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1243
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1436
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1734
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1910
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2041
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..6417
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3612..3617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /note="hexamer: AATAAA"
     polyA_site      3634
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /note="major polyA site"
     regulatory      6394..6399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /note="hexamer: AGTAAA"
     polyA_site      6417
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /note="major polyA site"
ORIGIN      
        1 aagagtcggc ggcggtggcg gcggccgctg cagagattgg aatccgcctg ccgggcttgg
       61 cgaaggagaa gggaggaggc aggagcgagg agggaggagg gccaagggcg ggcaggaagg
      121 cttaggctcg gcgcgtccgt ccgcgcgcgg cgaagatcgc acggcccgat cgaggggcga
      181 ccgggtcggg gccgctgcac gccaagggcg aaggccgatt cgggccccac ttcgccccgg
      241 cggctcgccg cgcccacccg ctccgcgccg agggctggag gatgcgttcc ctggggtccg
      301 gacttatgaa aatatgcatc agtttaatac tgtcttggaa ttcatgagat ggaagcatag
      361 gtcaaagctg tttggagaaa atcagaagta cagttttatc tagccacatc ttggaggagt
      421 cgtaagaaag cagtgggagt tgaagtcatt gtcaagtgct tgcgatcttt tacaagaaaa
      481 tctcactgaa tgatagtcat ttaaattggt gaagtagcaa gaccaattat taaaggtgac
      541 agtacacagg aaacattaca attgaacaat gcctcagcta tacatttaca tcagattatt
      601 gggagcctat ttgttcatca tttctcgtgt tcaaggacag aatctggata gtatgcttca
      661 tggcactggg atgaaatcag actccgacca gaaaaagtca gaaaatggag taaccttagc
      721 accagaggat accttgcctt ttttaaagtg ctattgctca gggcactgtc cagatgatgc
      781 tattaataac acatgcataa ctaatggaca ttgctttgcc atcatagaag aagatgacca
      841 gggagaaacc acattagctt cagggtgtat gaaatatgaa ggatctgatt ttcagtgcaa
      901 agattctcca aaagcccagc tacgccggac aatagaatgt tgtcggacca atttatgtaa
      961 ccagtatttg caacccacac tgccccctgt tgtcataggt ccgttttttg atggcagcat
     1021 tcgatggctg gttttgctca tttctatggc tgtctgcata attgctatga tcatcttctc
     1081 cagctgcttt tgttacaaac attattgcaa gagcatctca agcagacgtc gttacaatcg
     1141 tgatttggaa caggatgaag catttattcc agttggagaa tcactaaaag accttattga
     1201 ccagtcacaa agttctggta gtgggtctgg actaccttta ttggttcagc gaactattgc
     1261 caaacagatt cagatggtcc ggcaagttgg taaaggccga tatggagaag tatggatggg
     1321 caaatggcgt ggcgaaaaag tggcggtgaa agtattcttt accactgaag aagccagctg
     1381 gtttcgagaa acagaaatct accaaactgt gctaatgcgc catgaaaaca tacttggttt
     1441 catagcggca gacattaaag gtacaggttc ctggactcag ctctatttga ttactgatta
     1501 ccatgaaaat ggatctctct atgacttcct gaaatgtgct acactggaca ccagagccct
     1561 gcttaaattg gcttattcag ctgcctgtgg tctgtgccac ctgcacacag aaatttatgg
     1621 cacccaagga aagcccgcaa ttgctcatcg agacctaaag agcaaaaaca tcctcatcaa
     1681 gaaaaatggg agttgctgca ttgctgacct gggccttgct gttaaattca acagtgacac
     1741 aaatgaagtt gatgtgccct tgaataccag ggtgggcacc aaacgctaca tggctcccga
     1801 agtgctggac gaaagcctga acaaaaacca cttccagccc tacatcatgg ctgacatcta
     1861 cagcttcggc ctaatcattt gggagatggc tcgtcgttgt atcacaggag ggatcgtgga
     1921 agaataccaa ttgccatatt acaacatggt accgagtgat ccgtcatacg aagatatgcg
     1981 tgaggttgtg tgtgtcaaac gtttgcggcc aattgtgtct aatcggtgga acagtgatga
     2041 atgtctacga gcagttttga agctaatgtc agaatgctgg gcccacaatc cagcctccag
     2101 actcacagca ttgagaatta agaagacgct tgccaagatg gttgaatccc aagatgtaaa
     2161 aatctgatgg ttaaaccatc ggaggagaaa ctctagactg caagaactgt ttttacccat
     2221 ggcatgggtg gaattagagt ggaataagga tgttaacttg gttctcagac tctttcttca
     2281 ctacgtgttc acaggctgct aatattaaac ctttcagtac tcttattagg atacaagctg
     2341 ggaacttcta aacacttcat tctttatata tggacagctt tattttaaat gtggtttttg
     2401 atgccttttt ttaagtgggt ttttatgaac tgcatcaaga cttcaatcct gattagtgtc
     2461 tccagtcaag ctctgggtac tgaattgcct gttcataaaa cggtgctttc tgtgaaagcc
     2521 ttaagaagat aaatgagcgc agcagagatg gagaaataga ctttgccttt tacctgagac
     2581 tttcagttcg tttgtattct acctttgtaa aacagcctat agatgatgat gtgtttggga
     2641 tactgcttat tttatgatag tttgtcctgt gtccttagtg atgtgtgtgt gtctccatgc
     2701 acatgcacgc cgggattcct ctgctgccat ttgaattaga agaaaataat ttatatgcat
     2761 gcacaggaag atattggtgg ccggtggttt tgtgctttaa aaatgcaata tctgaccaag
     2821 attcgccaat ctcatacaag ccatttactt tgcaagtgag atagcttccc caccagcttt
     2881 attttttaac atgaaagctg atgccaaggc caaaagaagt ttaaagcatc tgtaaatttg
     2941 gactgttttc cttcaaccac catttttttt gtggttatta tttttgtcac ggaaagcatc
     3001 ctctccaaag ttggagcttc tattgccatg aaccatgctt acaaagaaag cacttcttat
     3061 tgaagtgaat tcctgcattt gatagcaatg taagtgccta taaccatgtt ctatattctt
     3121 tattctcagt aacttttaaa agggaagtta tttatatttt gtgtataatg tgctttattt
     3181 gcaaatcacc cactccttta caaccatact ttatatatgt acatacattc atactgtaga
     3241 aaccagctca tgtgtacctc atatcccatc cttaagagaa gaaatgttat aaagtagaac
     3301 taaatataaa ttttcagaat taatgcattc aaagtaatat atcaaatcca ggactttgtt
     3361 aacttcaggt aaaaacttca ttagggtaat atcatctcaa ttttttcaaa tgaaaggatt
     3421 ctctaattag aaatttatat gtcagagctg ttataaattt atcaactgtc aaatatgttc
     3481 tggacagcta aatcatttga gatttttggt tttttgattt ctattcccta acttgtgaag
     3541 acaatgaaaa atcaggcaga aatatttagt atctagtcag tatctgtagc tacactgtat
     3601 aactgttctt caataaaatg gttcatattt tatagatgcc ttgttatctc aagaaatctg
     3661 atttacataa acttatactt ctttaatgct ttttaaatat ttattctgag caaacaattc
     3721 atgagtacat caagtgagat agttttattt gattataaca taaaataaat gtgattatat
     3781 cacatcatca tcaaaaaggt ttaaattaaa tgggaggaaa tcagcatatg tccacccatt
     3841 accaaaattt gactatcatt taaggttaaa acttacaaat ttgtctgcac atcaaatttc
     3901 acaaatttga aaattgcctt aaccattttg attaataagt ttcatctgcc ataattaaag
     3961 tctgaagtgt tcatcaagat aagtaaattt gcatatggat aatacccaat aacttgtttt
     4021 ttcagaattt ttcaccatat gtatactgag aaatacaaat attttaatct gcgttgccgt
     4081 atgatatgat tgcacttaga acacccaatt tacttaaatc ttggtttact tttgacttga
     4141 taccataatc tttaaaatca tttgtcatct tttttttttt ttttttgaga cggagtctcg
     4201 ctctgtcgcc caggctggac tgcggactgc agtggcgcaa tctcggctca ctgcaagctc
     4261 cgcttcccgg gttcacgcca ttctcctgcc tcagcctccc gagtagctgg gactacaggc
     4321 gcccgccacc gcgcccggct aattttttgt atttttagta gagacggggt ttcaccttgt
     4381 tagccaggat ggtctcaatc tcctgacctc atgatccacc tgcctcggcc tcccaaagtt
     4441 catttgtcat cttaataaaa atataaagac aggcaaagtt tattggaaat gttcaaatgg
     4501 tgtgtggaag caaaaaatta cagccagtat atgagaccac tattatggtt ttttaaaatt
     4561 aacttggtct agtaaaagtg atatcaagag ttaatcttag aaacttgctc agtaaaaaca
     4621 ttttctagta taacatgttc tttaaaaagc aaatgctgcc gtctttggaa tcttaatcta
     4681 aaaatgtggc cgggcgcggt ggctcacgcc tgtaatccca acactttggg aggctgaggc
     4741 gggtggatca caaggtcagg agttcaagac cagcctggcc aacatggtga aaccccatct
     4801 ctactaaaaa taaaaaactc agccaggcgt ggtggcgggt gcctgtaatc ccagctactc
     4861 gggaggctga agcaggagaa ttgcttaaaa tcagaaggtg gaggttgcag tgagctgaga
     4921 tcgtgtcact gcactccagc ctgggcaaaa gagcgaaact ccatctcaaa taaacaaaca
     4981 aataaataac aaaaaacaaa aatgttgcat taaacttagt tcttgtctct cctttccact
     5041 cttattctta aatctgaagc tcatcgacta agtgaaatat ttaaagaata tgataggcca
     5101 gcaagaagaa gtattatgta gtaccatagt tagtaaattc gtaaaacctt ggaagccatt
     5161 atttggtccc acttgcaatt tagtgttttt gaagtgtgta gcttcattca gatagctctt
     5221 taaataatta aaatataaaa gcaaacaacc caaactacct gactataaac aggaaaagtt
     5281 aaccctcaaa gagagttctt gtgaattctc tttatgctgg caaatagctc taggattaaa
     5341 ggcacattag ggtttccttc agtttgttta ttctaagctt ttactgtgct ttttactgaa
     5401 caagtttctg atgtataaaa cttgcatctg atttctttgg aaatattttc acaaaagtta
     5461 ttttaatcag tatttttaca ttgcctttcc agtgtccaga agtgtttcta aacttagaaa
     5521 gtgacctata gttttttaaa attatgtttt cctagaacgt gccaaatttt gatttactct
     5581 aacaatcagt acttttcttc agatgctttg ttctgtttag aacaaaaatg cactatagtt
     5641 tttaaagaat catgcatctt tgggttggcc caggatcaaa tttgatattg aataatttat
     5701 tccagggcag ctttcataaa catacttcat agatgttgtt ttgaaatgtt tctaaatatc
     5761 taaaatcatt tcaacagcag aaatgatttt tattttaaca aaagattatg atagcccttg
     5821 tagtgtttaa aagtggtcat atttattact gactttgagt caggtgttaa aatagcagtg
     5881 ccacagctcg tctcttgcct tagtgtgctg ctgtgagagt cacagtggaa actgcaggga
     5941 ggaggtgtgt tcctaagaac caaaatccag cacagcatcc tgtgaagcca cgtgtaatga
     6001 tggtcccata aggaaagtat gtgaatatgg ctcttgtaaa ggattaacta ttgtaatttt
     6061 agcttatgct ctgtattctg ttttctatgg aattatttaa gcccttttag tgacctttgt
     6121 cctggcccat ttaaaaacta aaatgtagta tatattgtat aaaatggaaa tatcattatt
     6181 gcttcattag gggaaactgt acataggcat tgaaagaagg gtaaaagcaa gcagttttat
     6241 caggcagttg taaaacacca aaaatataga ttcgtctttg acgtgtaaca cactaaatgt
     6301 attttgtaca gcatctggtt taaaaggtgc cttaagagtt taccattact tgctttgttc
     6361 tatatacaga ttatgtccaa tgtatcattt tgaagtaaat aaccttattt tagtata
//
