LOCUS       NM_001406583            6411 bp    mRNA    linear   PRI 14-OCT-2024
DEFINITION  Homo sapiens bone morphogenetic protein receptor type 1A (BMPR1A),
            transcript variant 26, mRNA.
ACCESSION   NM_001406583
VERSION     NM_001406583.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6411)
  AUTHORS   Wang,Z., Shi,J., Tao,D., Xie,S., Yang,Y. and Liu,Y.
  TITLE     Nonsense suppression induces read-through of a novel BMPR1A variant
            in a Chinese family with hereditary colorectal cancer
  JOURNAL   Ann Hum Genet 88 (4), 300-306 (2024)
   PUBMED   38192234
  REMARK    GeneRIF: Nonsense suppression induces read-through of a novel
            BMPR1A variant in a Chinese family with hereditary colorectal
            cancer.
REFERENCE   2  (bases 1 to 6411)
  AUTHORS   Tan,N., Tang,J., Chen,G., Jiang,W. and Liu,Z.
  TITLE     ZEB1-AS1 mediates bone metastasis through targeting miR-320b/BMPR1A
            axis in lung cancer
  JOURNAL   Clin Respir J 18 (5), e13770 (2024)
   PUBMED   38783645
  REMARK    GeneRIF: ZEB1-AS1 mediates bone metastasis through targeting
            miR-320b/BMPR1A axis in lung cancer.
REFERENCE   3  (bases 1 to 6411)
  AUTHORS   Guo,R., Gu,T., Xiao,Y., Xiao,T., Liu,Q., Li,Z. and Yu,J.
  TITLE     Hsa-miR-27b-5p suppresses the osteogenic and odontogenic
            differentiation of stem cells from human exfoliated deciduous teeth
            via targeting BMPR1A: An ex vivo study
  JOURNAL   Int Endod J 56 (10), 1284-1300 (2023)
   PUBMED   37485765
  REMARK    GeneRIF: Hsa-miR-27b-5p suppresses the osteogenic and odontogenic
            differentiation of stem cells from human exfoliated deciduous teeth
            via targeting BMPR1A: An ex vivo study.
REFERENCE   4  (bases 1 to 6411)
  AUTHORS   Liu,S., Baeg,G.H., Yang,Y., Goh,F.G., Bao,H., Wagner,E.J., Yang,X.
            and Cai,Y.
  TITLE     The Integrator complex desensitizes cellular response to
            TGF-beta/BMP signaling
  JOURNAL   Cell Rep 42 (1), 112007 (2023)
   PUBMED   36641752
REFERENCE   5  (bases 1 to 6411)
  AUTHORS   Rosner,G., Petel-Galil,Y., Laish,I., Levi,Z., Kariv,R., Strul,H.,
            Gilad,O. and Gluck,N.
  TITLE     Adenomatous Polyposis Phenotype in BMPR1A and SMAD4 Variant
            Carriers
  JOURNAL   Clin Transl Gastroenterol 13 (10), e00527 (2022)
   PUBMED   36049049
  REMARK    GeneRIF: Adenomatous Polyposis Phenotype in BMPR1A and SMAD4
            Variant Carriers.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6411)
  AUTHORS   Yamada,N., Kato,M., ten Dijke,P., Yamashita,H., Sampath,T.K.,
            Heldin,C.H., Miyazono,K. and Funa,K.
  TITLE     Bone morphogenetic protein type IB receptor is progressively
            expressed in malignant glioma tumours
  JOURNAL   Br J Cancer 73 (5), 624-629 (1996)
   PUBMED   8605097
REFERENCE   7  (bases 1 to 6411)
  AUTHORS   Ishidou,Y., Kitajima,I., Obama,H., Maruyama,I., Murata,F.,
            Imamura,T., Yamada,N., ten Dijke,P., Miyazono,K. and Sakou,T.
  TITLE     Enhanced expression of type I receptors for bone morphogenetic
            proteins during bone formation
  JOURNAL   J Bone Miner Res 10 (11), 1651-1659 (1995)
   PUBMED   8592941
REFERENCE   8  (bases 1 to 6411)
  AUTHORS   Liu,F., Ventura,F., Doody,J. and Massague,J.
  TITLE     Human type II receptor for bone morphogenic proteins (BMPs):
            extension of the two-kinase receptor model to the BMPs
  JOURNAL   Mol Cell Biol 15 (7), 3479-3486 (1995)
   PUBMED   7791754
REFERENCE   9  (bases 1 to 6411)
  AUTHORS   ten Dijke,P., Ichijo,H., Franzen,P., Schulz,P., Saras,J.,
            Toyoshima,H., Heldin,C.H. and Miyazono,K.
  TITLE     Activin receptor-like kinases: a novel subclass of cell-surface
            receptors with predicted serine/threonine kinase activity
  JOURNAL   Oncogene 8 (10), 2879-2887 (1993)
   PUBMED   8397373
REFERENCE   10 (bases 1 to 6411)
  AUTHORS   Larsen Haidle,J., MacFarland,S.P. and Howe,J.R.
  TITLE     Juvenile Polyposis Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301642
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC067750.5, AC021036.6 and
            AC025268.8.
            
            Summary: The bone morphogenetic protein (BMP) receptors are a
            family of transmembrane serine/threonine kinases that include the
            type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2.
            These receptors are also closely related to the activin receptors,
            ACVR1 and ACVR2. The ligands of these receptors are members of the
            TGF-beta superfamily. TGF-betas and activins transduce their
            signals through the formation of heteromeric complexes with 2
            different types of serine (threonine) kinase receptors: type I
            receptors of about 50-55 kD and type II receptors of about 70-80
            kD. Type II receptors bind ligands in the absence of type I
            receptors, but they require their respective type I receptors for
            signaling, whereas type I receptors require their respective type
            II receptors for ligand binding. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR4352443.430936.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               AC067750.5         54354-54654         c
            302-416             AC021036.6         83565-83679
            417-635             AC025268.8         140442-140660       c
            636-798             AC025268.8         126303-126465       c
            799-901             AC025268.8         124298-124400       c
            902-998             AC025268.8         116637-116733       c
            999-1098            AC025268.8         116401-116500       c
            1099-1243           AC025268.8         104143-104287       c
            1244-1430           AC025268.8         99201-99387         c
            1431-1728           AC025268.8         97058-97355         c
            1729-1904           AC025268.8         94832-95007         c
            1905-2035           AC025268.8         93021-93151         c
            2036-6411           AC025268.8         88558-92933         c
FEATURES             Location/Qualifiers
     source          1..6411
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.2"
     gene            1..6411
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /note="bone morphogenetic protein receptor type 1A"
                     /db_xref="GeneID:657"
                     /db_xref="HGNC:HGNC:1076"
                     /db_xref="MIM:601299"
     exon            1..301
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            302..416
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            417..635
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     CDS             569..2161
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /EC_number="2.7.11.30"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 26; serine/threonine-protein kinase receptor R5;
                     activin A receptor, type II-like kinase 3; BMP type-1A
                     receptor; activin receptor-like kinase 3; bone
                     morphogenetic protein receptor, type IA"
                     /codon_start=1
                     /product="bone morphogenetic protein receptor type-1A
                     isoform 4 precursor"
                     /protein_id="NP_001393512.1"
                     /db_xref="GeneID:657"
                     /db_xref="HGNC:HGNC:1076"
                     /db_xref="MIM:601299"
                     /translation="MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKS
                     ENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMK
                     YEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISM
                     AVCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGS
                     GSGLPLLRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIY
                     QTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAY
                     SAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEV
                     DVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEE
                     YQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPAS
                     RLTALRIKKTLAKMVESQDVKI"
     exon            636..798
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            799..901
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            902..998
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1098
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1243
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1430
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1728
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1904
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2035
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..6411
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3606..3611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /note="hexamer: AATAAA"
     polyA_site      3628
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /note="major polyA site"
     regulatory      6388..6393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /note="hexamer: AGTAAA"
     polyA_site      6411
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /note="major polyA site"
ORIGIN      
        1 aagagtcggc ggcggtggcg gcggccgctg cagagattgg aatccgcctg ccgggcttgg
       61 cgaaggagaa gggaggaggc aggagcgagg agggaggagg gccaagggcg ggcaggaagg
      121 cttaggctcg gcgcgtccgt ccgcgcgcgg cgaagatcgc acggcccgat cgaggggcga
      181 ccgggtcggg gccgctgcac gccaagggcg aaggccgatt cgggccccac ttcgccccgg
      241 cggctcgccg cgcccacccg ctccgcgccg agggctggag gatgcgttcc ctggggtccg
      301 gacttatgaa aatatgcatc agtttaatac tgtcttggaa ttcatgagat ggaagcatag
      361 gtcaaagctg tttggagaaa atcagaagta cagttttatc tagccacatc ttggaggagt
      421 cgtaagaaag cagtgggagt tgaagtcatt gtcaagtgct tgcgatcttt tacaagaaaa
      481 tctcactgaa tgatagtcat ttaaattggt gaagtagcaa gaccaattat taaaggtgac
      541 agtacacagg aaacattaca attgaacaat gcctcagcta tacatttaca tcagattatt
      601 gggagcctat ttgttcatca tttctcgtgt tcaaggacag aatctggata gtatgcttca
      661 tggcactggg atgaaatcag actccgacca gaaaaagtca gaaaatggag taaccttagc
      721 accagaggat accttgcctt ttttaaagtg ctattgctca gggcactgtc cagatgatgc
      781 tattaataac acatgcataa ctaatggaca ttgctttgcc atcatagaag aagatgacca
      841 gggagaaacc acattagctt cagggtgtat gaaatatgaa ggatctgatt ttcagtgcaa
      901 agattctcca aaagcccagc tacgccggac aatagaatgt tgtcggacca atttatgtaa
      961 ccagtatttg caacccacac tgccccctgt tgtcataggt ccgttttttg atggcagcat
     1021 tcgatggctg gttttgctca tttctatggc tgtctgcata attgctatga tcatcttctc
     1081 cagctgcttt tgttacaaac attattgcaa gagcatctca agcagacgtc gttacaatcg
     1141 tgatttggaa caggatgaag catttattcc agttggagaa tcactaaaag accttattga
     1201 ccagtcacaa agttctggta gtgggtctgg actaccttta ttgcgaacta ttgccaaaca
     1261 gattcagatg gtccggcaag ttggtaaagg ccgatatgga gaagtatgga tgggcaaatg
     1321 gcgtggcgaa aaagtggcgg tgaaagtatt ctttaccact gaagaagcca gctggtttcg
     1381 agaaacagaa atctaccaaa ctgtgctaat gcgccatgaa aacatacttg gtttcatagc
     1441 ggcagacatt aaaggtacag gttcctggac tcagctctat ttgattactg attaccatga
     1501 aaatggatct ctctatgact tcctgaaatg tgctacactg gacaccagag ccctgcttaa
     1561 attggcttat tcagctgcct gtggtctgtg ccacctgcac acagaaattt atggcaccca
     1621 aggaaagccc gcaattgctc atcgagacct aaagagcaaa aacatcctca tcaagaaaaa
     1681 tgggagttgc tgcattgctg acctgggcct tgctgttaaa ttcaacagtg acacaaatga
     1741 agttgatgtg cccttgaata ccagggtggg caccaaacgc tacatggctc ccgaagtgct
     1801 ggacgaaagc ctgaacaaaa accacttcca gccctacatc atggctgaca tctacagctt
     1861 cggcctaatc atttgggaga tggctcgtcg ttgtatcaca ggagggatcg tggaagaata
     1921 ccaattgcca tattacaaca tggtaccgag tgatccgtca tacgaagata tgcgtgaggt
     1981 tgtgtgtgtc aaacgtttgc ggccaattgt gtctaatcgg tggaacagtg atgaatgtct
     2041 acgagcagtt ttgaagctaa tgtcagaatg ctgggcccac aatccagcct ccagactcac
     2101 agcattgaga attaagaaga cgcttgccaa gatggttgaa tcccaagatg taaaaatctg
     2161 atggttaaac catcggagga gaaactctag actgcaagaa ctgtttttac ccatggcatg
     2221 ggtggaatta gagtggaata aggatgttaa cttggttctc agactctttc ttcactacgt
     2281 gttcacaggc tgctaatatt aaacctttca gtactcttat taggatacaa gctgggaact
     2341 tctaaacact tcattcttta tatatggaca gctttatttt aaatgtggtt tttgatgcct
     2401 ttttttaagt gggtttttat gaactgcatc aagacttcaa tcctgattag tgtctccagt
     2461 caagctctgg gtactgaatt gcctgttcat aaaacggtgc tttctgtgaa agccttaaga
     2521 agataaatga gcgcagcaga gatggagaaa tagactttgc cttttacctg agactttcag
     2581 ttcgtttgta ttctaccttt gtaaaacagc ctatagatga tgatgtgttt gggatactgc
     2641 ttattttatg atagtttgtc ctgtgtcctt agtgatgtgt gtgtgtctcc atgcacatgc
     2701 acgccgggat tcctctgctg ccatttgaat tagaagaaaa taatttatat gcatgcacag
     2761 gaagatattg gtggccggtg gttttgtgct ttaaaaatgc aatatctgac caagattcgc
     2821 caatctcata caagccattt actttgcaag tgagatagct tccccaccag ctttattttt
     2881 taacatgaaa gctgatgcca aggccaaaag aagtttaaag catctgtaaa tttggactgt
     2941 tttccttcaa ccaccatttt ttttgtggtt attatttttg tcacggaaag catcctctcc
     3001 aaagttggag cttctattgc catgaaccat gcttacaaag aaagcacttc ttattgaagt
     3061 gaattcctgc atttgatagc aatgtaagtg cctataacca tgttctatat tctttattct
     3121 cagtaacttt taaaagggaa gttatttata ttttgtgtat aatgtgcttt atttgcaaat
     3181 cacccactcc tttacaacca tactttatat atgtacatac attcatactg tagaaaccag
     3241 ctcatgtgta cctcatatcc catccttaag agaagaaatg ttataaagta gaactaaata
     3301 taaattttca gaattaatgc attcaaagta atatatcaaa tccaggactt tgttaacttc
     3361 aggtaaaaac ttcattaggg taatatcatc tcaatttttt caaatgaaag gattctctaa
     3421 ttagaaattt atatgtcaga gctgttataa atttatcaac tgtcaaatat gttctggaca
     3481 gctaaatcat ttgagatttt tggttttttg atttctattc cctaacttgt gaagacaatg
     3541 aaaaatcagg cagaaatatt tagtatctag tcagtatctg tagctacact gtataactgt
     3601 tcttcaataa aatggttcat attttataga tgccttgtta tctcaagaaa tctgatttac
     3661 ataaacttat acttctttaa tgctttttaa atatttattc tgagcaaaca attcatgagt
     3721 acatcaagtg agatagtttt atttgattat aacataaaat aaatgtgatt atatcacatc
     3781 atcatcaaaa aggtttaaat taaatgggag gaaatcagca tatgtccacc cattaccaaa
     3841 atttgactat catttaaggt taaaacttac aaatttgtct gcacatcaaa tttcacaaat
     3901 ttgaaaattg ccttaaccat tttgattaat aagtttcatc tgccataatt aaagtctgaa
     3961 gtgttcatca agataagtaa atttgcatat ggataatacc caataacttg ttttttcaga
     4021 atttttcacc atatgtatac tgagaaatac aaatatttta atctgcgttg ccgtatgata
     4081 tgattgcact tagaacaccc aatttactta aatcttggtt tacttttgac ttgataccat
     4141 aatctttaaa atcatttgtc atcttttttt tttttttttt gagacggagt ctcgctctgt
     4201 cgcccaggct ggactgcgga ctgcagtggc gcaatctcgg ctcactgcaa gctccgcttc
     4261 ccgggttcac gccattctcc tgcctcagcc tcccgagtag ctgggactac aggcgcccgc
     4321 caccgcgccc ggctaatttt ttgtattttt agtagagacg gggtttcacc ttgttagcca
     4381 ggatggtctc aatctcctga cctcatgatc cacctgcctc ggcctcccaa agttcatttg
     4441 tcatcttaat aaaaatataa agacaggcaa agtttattgg aaatgttcaa atggtgtgtg
     4501 gaagcaaaaa attacagcca gtatatgaga ccactattat ggttttttaa aattaacttg
     4561 gtctagtaaa agtgatatca agagttaatc ttagaaactt gctcagtaaa aacattttct
     4621 agtataacat gttctttaaa aagcaaatgc tgccgtcttt ggaatcttaa tctaaaaatg
     4681 tggccgggcg cggtggctca cgcctgtaat cccaacactt tgggaggctg aggcgggtgg
     4741 atcacaaggt caggagttca agaccagcct ggccaacatg gtgaaacccc atctctacta
     4801 aaaataaaaa actcagccag gcgtggtggc gggtgcctgt aatcccagct actcgggagg
     4861 ctgaagcagg agaattgctt aaaatcagaa ggtggaggtt gcagtgagct gagatcgtgt
     4921 cactgcactc cagcctgggc aaaagagcga aactccatct caaataaaca aacaaataaa
     4981 taacaaaaaa caaaaatgtt gcattaaact tagttcttgt ctctcctttc cactcttatt
     5041 cttaaatctg aagctcatcg actaagtgaa atatttaaag aatatgatag gccagcaaga
     5101 agaagtatta tgtagtacca tagttagtaa attcgtaaaa ccttggaagc cattatttgg
     5161 tcccacttgc aatttagtgt ttttgaagtg tgtagcttca ttcagatagc tctttaaata
     5221 attaaaatat aaaagcaaac aacccaaact acctgactat aaacaggaaa agttaaccct
     5281 caaagagagt tcttgtgaat tctctttatg ctggcaaata gctctaggat taaaggcaca
     5341 ttagggtttc cttcagtttg tttattctaa gcttttactg tgctttttac tgaacaagtt
     5401 tctgatgtat aaaacttgca tctgatttct ttggaaatat tttcacaaaa gttattttaa
     5461 tcagtatttt tacattgcct ttccagtgtc cagaagtgtt tctaaactta gaaagtgacc
     5521 tatagttttt taaaattatg ttttcctaga acgtgccaaa ttttgattta ctctaacaat
     5581 cagtactttt cttcagatgc tttgttctgt ttagaacaaa aatgcactat agtttttaaa
     5641 gaatcatgca tctttgggtt ggcccaggat caaatttgat attgaataat ttattccagg
     5701 gcagctttca taaacatact tcatagatgt tgttttgaaa tgtttctaaa tatctaaaat
     5761 catttcaaca gcagaaatga tttttatttt aacaaaagat tatgatagcc cttgtagtgt
     5821 ttaaaagtgg tcatatttat tactgacttt gagtcaggtg ttaaaatagc agtgccacag
     5881 ctcgtctctt gccttagtgt gctgctgtga gagtcacagt ggaaactgca gggaggaggt
     5941 gtgttcctaa gaaccaaaat ccagcacagc atcctgtgaa gccacgtgta atgatggtcc
     6001 cataaggaaa gtatgtgaat atggctcttg taaaggatta actattgtaa ttttagctta
     6061 tgctctgtat tctgttttct atggaattat ttaagccctt ttagtgacct ttgtcctggc
     6121 ccatttaaaa actaaaatgt agtatatatt gtataaaatg gaaatatcat tattgcttca
     6181 ttaggggaaa ctgtacatag gcattgaaag aagggtaaaa gcaagcagtt ttatcaggca
     6241 gttgtaaaac accaaaaata tagattcgtc tttgacgtgt aacacactaa atgtattttg
     6301 tacagcatct ggtttaaaag gtgccttaag agtttaccat tacttgcttt gttctatata
     6361 cagattatgt ccaatgtatc attttgaagt aaataacctt attttagtat a
//
