LOCUS       NM_001406578            6709 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens bone morphogenetic protein receptor type 1A (BMPR1A),
            transcript variant 21, mRNA.
ACCESSION   NM_001406578
VERSION     NM_001406578.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6709)
  AUTHORS   Wang,Z., Shi,J., Tao,D., Xie,S., Yang,Y. and Liu,Y.
  TITLE     Nonsense suppression induces read-through of a novel BMPR1A variant
            in a Chinese family with hereditary colorectal cancer
  JOURNAL   Ann Hum Genet 88 (4), 300-306 (2024)
   PUBMED   38192234
  REMARK    GeneRIF: Nonsense suppression induces read-through of a novel
            BMPR1A variant in a Chinese family with hereditary colorectal
            cancer.
REFERENCE   2  (bases 1 to 6709)
  AUTHORS   Tan,N., Tang,J., Chen,G., Jiang,W. and Liu,Z.
  TITLE     ZEB1-AS1 mediates bone metastasis through targeting miR-320b/BMPR1A
            axis in lung cancer
  JOURNAL   Clin Respir J 18 (5), e13770 (2024)
   PUBMED   38783645
  REMARK    GeneRIF: ZEB1-AS1 mediates bone metastasis through targeting
            miR-320b/BMPR1A axis in lung cancer.
REFERENCE   3  (bases 1 to 6709)
  AUTHORS   Guo,R., Gu,T., Xiao,Y., Xiao,T., Liu,Q., Li,Z. and Yu,J.
  TITLE     Hsa-miR-27b-5p suppresses the osteogenic and odontogenic
            differentiation of stem cells from human exfoliated deciduous teeth
            via targeting BMPR1A: An ex vivo study
  JOURNAL   Int Endod J 56 (10), 1284-1300 (2023)
   PUBMED   37485765
  REMARK    GeneRIF: Hsa-miR-27b-5p suppresses the osteogenic and odontogenic
            differentiation of stem cells from human exfoliated deciduous teeth
            via targeting BMPR1A: An ex vivo study.
REFERENCE   4  (bases 1 to 6709)
  AUTHORS   Liu,S., Baeg,G.H., Yang,Y., Goh,F.G., Bao,H., Wagner,E.J., Yang,X.
            and Cai,Y.
  TITLE     The Integrator complex desensitizes cellular response to
            TGF-beta/BMP signaling
  JOURNAL   Cell Rep 42 (1), 112007 (2023)
   PUBMED   36641752
REFERENCE   5  (bases 1 to 6709)
  AUTHORS   Rosner,G., Petel-Galil,Y., Laish,I., Levi,Z., Kariv,R., Strul,H.,
            Gilad,O. and Gluck,N.
  TITLE     Adenomatous Polyposis Phenotype in BMPR1A and SMAD4 Variant
            Carriers
  JOURNAL   Clin Transl Gastroenterol 13 (10), e00527 (2022)
   PUBMED   36049049
  REMARK    GeneRIF: Adenomatous Polyposis Phenotype in BMPR1A and SMAD4
            Variant Carriers.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6709)
  AUTHORS   Yamada,N., Kato,M., ten Dijke,P., Yamashita,H., Sampath,T.K.,
            Heldin,C.H., Miyazono,K. and Funa,K.
  TITLE     Bone morphogenetic protein type IB receptor is progressively
            expressed in malignant glioma tumours
  JOURNAL   Br J Cancer 73 (5), 624-629 (1996)
   PUBMED   8605097
REFERENCE   7  (bases 1 to 6709)
  AUTHORS   Ishidou,Y., Kitajima,I., Obama,H., Maruyama,I., Murata,F.,
            Imamura,T., Yamada,N., ten Dijke,P., Miyazono,K. and Sakou,T.
  TITLE     Enhanced expression of type I receptors for bone morphogenetic
            proteins during bone formation
  JOURNAL   J Bone Miner Res 10 (11), 1651-1659 (1995)
   PUBMED   8592941
REFERENCE   8  (bases 1 to 6709)
  AUTHORS   Liu,F., Ventura,F., Doody,J. and Massague,J.
  TITLE     Human type II receptor for bone morphogenic proteins (BMPs):
            extension of the two-kinase receptor model to the BMPs
  JOURNAL   Mol Cell Biol 15 (7), 3479-3486 (1995)
   PUBMED   7791754
REFERENCE   9  (bases 1 to 6709)
  AUTHORS   ten Dijke,P., Ichijo,H., Franzen,P., Schulz,P., Saras,J.,
            Toyoshima,H., Heldin,C.H. and Miyazono,K.
  TITLE     Activin receptor-like kinases: a novel subclass of cell-surface
            receptors with predicted serine/threonine kinase activity
  JOURNAL   Oncogene 8 (10), 2879-2887 (1993)
   PUBMED   8397373
REFERENCE   10 (bases 1 to 6709)
  AUTHORS   Larsen Haidle,J., MacFarland,S.P. and Howe,J.R.
  TITLE     Juvenile Polyposis Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301642
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC067750.5, AC021036.6 and
            AC025268.8.
            
            Summary: The bone morphogenetic protein (BMP) receptors are a
            family of transmembrane serine/threonine kinases that include the
            type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2.
            These receptors are also closely related to the activin receptors,
            ACVR1 and ACVR2. The ligands of these receptors are members of the
            TGF-beta superfamily. TGF-betas and activins transduce their
            signals through the formation of heteromeric complexes with 2
            different types of serine (threonine) kinase receptors: type I
            receptors of about 50-55 kD and type II receptors of about 70-80
            kD. Type II receptors bind ligands in the absence of type I
            receptors, but they require their respective type I receptors for
            signaling, whereas type I receptors require their respective type
            II receptors for ligand binding. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.621918.1,
                                           SRR18074967.797093.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467143, SAMN03267752
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               AC067750.5         54354-54654         c
            302-416             AC021036.6         83565-83679
            417-708             AC021036.6         96178-96469
            709-927             AC025268.8         140442-140660       c
            928-1090            AC025268.8         126303-126465       c
            1091-1193           AC025268.8         124298-124400       c
            1194-1290           AC025268.8         116637-116733       c
            1291-1390           AC025268.8         116401-116500       c
            1391-1535           AC025268.8         104143-104287       c
            1536-1728           AC025268.8         99201-99393         c
            1729-2026           AC025268.8         97058-97355         c
            2027-2202           AC025268.8         94832-95007         c
            2203-2333           AC025268.8         93021-93151         c
            2334-6709           AC025268.8         88558-92933         c
FEATURES             Location/Qualifiers
     source          1..6709
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.2"
     gene            1..6709
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /note="bone morphogenetic protein receptor type 1A"
                     /db_xref="GeneID:657"
                     /db_xref="HGNC:HGNC:1076"
                     /db_xref="MIM:601299"
     exon            1..301
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            302..416
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            417..708
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            709..927
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     CDS             861..2459
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /EC_number="2.7.11.30"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 21; serine/threonine-protein kinase receptor R5;
                     activin A receptor, type II-like kinase 3; BMP type-1A
                     receptor; activin receptor-like kinase 3; bone
                     morphogenetic protein receptor, type IA"
                     /codon_start=1
                     /product="bone morphogenetic protein receptor type-1A
                     isoform 3 precursor"
                     /protein_id="NP_001393507.1"
                     /db_xref="GeneID:657"
                     /db_xref="HGNC:HGNC:1076"
                     /db_xref="MIM:601299"
                     /translation="MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKS
                     ENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMK
                     YEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISM
                     AVCIIAMIIFSSCFCYKHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGS
                     GSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETE
                     IYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKL
                     AYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTN
                     EVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIV
                     EEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNP
                     ASRLTALRIKKTLAKMVESQDVKI"
     exon            928..1090
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1193
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1290
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1390
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1535
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1728
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..2026
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2202
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2333
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..6709
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3904..3909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /note="hexamer: AATAAA"
     polyA_site      3926
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /note="major polyA site"
     regulatory      6686..6691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /note="hexamer: AGTAAA"
     polyA_site      6709
                     /gene="BMPR1A"
                     /gene_synonym="10q23del; ACVRLK3; ALK-3; ALK3; BMPR-1A;
                     CD292; SKR5"
                     /note="major polyA site"
ORIGIN      
        1 aagagtcggc ggcggtggcg gcggccgctg cagagattgg aatccgcctg ccgggcttgg
       61 cgaaggagaa gggaggaggc aggagcgagg agggaggagg gccaagggcg ggcaggaagg
      121 cttaggctcg gcgcgtccgt ccgcgcgcgg cgaagatcgc acggcccgat cgaggggcga
      181 ccgggtcggg gccgctgcac gccaagggcg aaggccgatt cgggccccac ttcgccccgg
      241 cggctcgccg cgcccacccg ctccgcgccg agggctggag gatgcgttcc ctggggtccg
      301 gacttatgaa aatatgcatc agtttaatac tgtcttggaa ttcatgagat ggaagcatag
      361 gtcaaagctg tttggagaaa atcagaagta cagttttatc tagccacatc ttggagtcac
      421 tacatggcac ataaccaagt catcattaag tcatttttga gtgaacattg ctcaagatct
      481 gcaaagcagc tgtgatgtgt gcggggtgta ctggaagttg aacgggactc ctcaagcagc
      541 ctaatgagtt gggattgagg attgcataca caagggaact cgcagatcaa gtcctgaaga
      601 gaacattgta gttactctgg caaagaacaa cgaagacaca aaagctgtgc agagtaatgg
      661 aagcctggaa ggagtgcctg tgaagggaga gcggctgcac tgactttgga gtcgtaagaa
      721 agcagtggga gttgaagtca ttgtcaagtg cttgcgatct tttacaagaa aatctcactg
      781 aatgatagtc atttaaattg gtgaagtagc aagaccaatt attaaaggtg acagtacaca
      841 ggaaacatta caattgaaca atgcctcagc tatacattta catcagatta ttgggagcct
      901 atttgttcat catttctcgt gttcaaggac agaatctgga tagtatgctt catggcactg
      961 ggatgaaatc agactccgac cagaaaaagt cagaaaatgg agtaacctta gcaccagagg
     1021 ataccttgcc ttttttaaag tgctattgct cagggcactg tccagatgat gctattaata
     1081 acacatgcat aactaatgga cattgctttg ccatcataga agaagatgac cagggagaaa
     1141 ccacattagc ttcagggtgt atgaaatatg aaggatctga ttttcagtgc aaagattctc
     1201 caaaagccca gctacgccgg acaatagaat gttgtcggac caatttatgt aaccagtatt
     1261 tgcaacccac actgccccct gttgtcatag gtccgttttt tgatggcagc attcgatggc
     1321 tggttttgct catttctatg gctgtctgca taattgctat gatcatcttc tccagctgct
     1381 tttgttacaa acattattgc aagagcatct caagcagacg tcgttacaat cgtgatttgg
     1441 aacaggatga agcatttatt ccagttggag aatcactaaa agaccttatt gaccagtcac
     1501 aaagttctgg tagtgggtct ggactacctt tattggttca gcgaactatt gccaaacaga
     1561 ttcagatggt ccggcaagtt ggtaaaggcc gatatggaga agtatggatg ggcaaatggc
     1621 gtggcgaaaa agtggcggtg aaagtattct ttaccactga agaagccagc tggtttcgag
     1681 aaacagaaat ctaccaaact gtgctaatgc gccatgaaaa catacttggt ttcatagcgg
     1741 cagacattaa aggtacaggt tcctggactc agctctattt gattactgat taccatgaaa
     1801 atggatctct ctatgacttc ctgaaatgtg ctacactgga caccagagcc ctgcttaaat
     1861 tggcttattc agctgcctgt ggtctgtgcc acctgcacac agaaatttat ggcacccaag
     1921 gaaagcccgc aattgctcat cgagacctaa agagcaaaaa catcctcatc aagaaaaatg
     1981 ggagttgctg cattgctgac ctgggccttg ctgttaaatt caacagtgac acaaatgaag
     2041 ttgatgtgcc cttgaatacc agggtgggca ccaaacgcta catggctccc gaagtgctgg
     2101 acgaaagcct gaacaaaaac cacttccagc cctacatcat ggctgacatc tacagcttcg
     2161 gcctaatcat ttgggagatg gctcgtcgtt gtatcacagg agggatcgtg gaagaatacc
     2221 aattgccata ttacaacatg gtaccgagtg atccgtcata cgaagatatg cgtgaggttg
     2281 tgtgtgtcaa acgtttgcgg ccaattgtgt ctaatcggtg gaacagtgat gaatgtctac
     2341 gagcagtttt gaagctaatg tcagaatgct gggcccacaa tccagcctcc agactcacag
     2401 cattgagaat taagaagacg cttgccaaga tggttgaatc ccaagatgta aaaatctgat
     2461 ggttaaacca tcggaggaga aactctagac tgcaagaact gtttttaccc atggcatggg
     2521 tggaattaga gtggaataag gatgttaact tggttctcag actctttctt cactacgtgt
     2581 tcacaggctg ctaatattaa acctttcagt actcttatta ggatacaagc tgggaacttc
     2641 taaacacttc attctttata tatggacagc tttattttaa atgtggtttt tgatgccttt
     2701 ttttaagtgg gtttttatga actgcatcaa gacttcaatc ctgattagtg tctccagtca
     2761 agctctgggt actgaattgc ctgttcataa aacggtgctt tctgtgaaag ccttaagaag
     2821 ataaatgagc gcagcagaga tggagaaata gactttgcct tttacctgag actttcagtt
     2881 cgtttgtatt ctacctttgt aaaacagcct atagatgatg atgtgtttgg gatactgctt
     2941 attttatgat agtttgtcct gtgtccttag tgatgtgtgt gtgtctccat gcacatgcac
     3001 gccgggattc ctctgctgcc atttgaatta gaagaaaata atttatatgc atgcacagga
     3061 agatattggt ggccggtggt tttgtgcttt aaaaatgcaa tatctgacca agattcgcca
     3121 atctcataca agccatttac tttgcaagtg agatagcttc cccaccagct ttatttttta
     3181 acatgaaagc tgatgccaag gccaaaagaa gtttaaagca tctgtaaatt tggactgttt
     3241 tccttcaacc accatttttt ttgtggttat tatttttgtc acggaaagca tcctctccaa
     3301 agttggagct tctattgcca tgaaccatgc ttacaaagaa agcacttctt attgaagtga
     3361 attcctgcat ttgatagcaa tgtaagtgcc tataaccatg ttctatattc tttattctca
     3421 gtaactttta aaagggaagt tatttatatt ttgtgtataa tgtgctttat ttgcaaatca
     3481 cccactcctt tacaaccata ctttatatat gtacatacat tcatactgta gaaaccagct
     3541 catgtgtacc tcatatccca tccttaagag aagaaatgtt ataaagtaga actaaatata
     3601 aattttcaga attaatgcat tcaaagtaat atatcaaatc caggactttg ttaacttcag
     3661 gtaaaaactt cattagggta atatcatctc aattttttca aatgaaagga ttctctaatt
     3721 agaaatttat atgtcagagc tgttataaat ttatcaactg tcaaatatgt tctggacagc
     3781 taaatcattt gagatttttg gttttttgat ttctattccc taacttgtga agacaatgaa
     3841 aaatcaggca gaaatattta gtatctagtc agtatctgta gctacactgt ataactgttc
     3901 ttcaataaaa tggttcatat tttatagatg ccttgttatc tcaagaaatc tgatttacat
     3961 aaacttatac ttctttaatg ctttttaaat atttattctg agcaaacaat tcatgagtac
     4021 atcaagtgag atagttttat ttgattataa cataaaataa atgtgattat atcacatcat
     4081 catcaaaaag gtttaaatta aatgggagga aatcagcata tgtccaccca ttaccaaaat
     4141 ttgactatca tttaaggtta aaacttacaa atttgtctgc acatcaaatt tcacaaattt
     4201 gaaaattgcc ttaaccattt tgattaataa gtttcatctg ccataattaa agtctgaagt
     4261 gttcatcaag ataagtaaat ttgcatatgg ataataccca ataacttgtt ttttcagaat
     4321 ttttcaccat atgtatactg agaaatacaa atattttaat ctgcgttgcc gtatgatatg
     4381 attgcactta gaacacccaa tttacttaaa tcttggttta cttttgactt gataccataa
     4441 tctttaaaat catttgtcat cttttttttt ttttttttga gacggagtct cgctctgtcg
     4501 cccaggctgg actgcggact gcagtggcgc aatctcggct cactgcaagc tccgcttccc
     4561 gggttcacgc cattctcctg cctcagcctc ccgagtagct gggactacag gcgcccgcca
     4621 ccgcgcccgg ctaatttttt gtatttttag tagagacggg gtttcacctt gttagccagg
     4681 atggtctcaa tctcctgacc tcatgatcca cctgcctcgg cctcccaaag ttcatttgtc
     4741 atcttaataa aaatataaag acaggcaaag tttattggaa atgttcaaat ggtgtgtgga
     4801 agcaaaaaat tacagccagt atatgagacc actattatgg ttttttaaaa ttaacttggt
     4861 ctagtaaaag tgatatcaag agttaatctt agaaacttgc tcagtaaaaa cattttctag
     4921 tataacatgt tctttaaaaa gcaaatgctg ccgtctttgg aatcttaatc taaaaatgtg
     4981 gccgggcgcg gtggctcacg cctgtaatcc caacactttg ggaggctgag gcgggtggat
     5041 cacaaggtca ggagttcaag accagcctgg ccaacatggt gaaaccccat ctctactaaa
     5101 aataaaaaac tcagccaggc gtggtggcgg gtgcctgtaa tcccagctac tcgggaggct
     5161 gaagcaggag aattgcttaa aatcagaagg tggaggttgc agtgagctga gatcgtgtca
     5221 ctgcactcca gcctgggcaa aagagcgaaa ctccatctca aataaacaaa caaataaata
     5281 acaaaaaaca aaaatgttgc attaaactta gttcttgtct ctcctttcca ctcttattct
     5341 taaatctgaa gctcatcgac taagtgaaat atttaaagaa tatgataggc cagcaagaag
     5401 aagtattatg tagtaccata gttagtaaat tcgtaaaacc ttggaagcca ttatttggtc
     5461 ccacttgcaa tttagtgttt ttgaagtgtg tagcttcatt cagatagctc tttaaataat
     5521 taaaatataa aagcaaacaa cccaaactac ctgactataa acaggaaaag ttaaccctca
     5581 aagagagttc ttgtgaattc tctttatgct ggcaaatagc tctaggatta aaggcacatt
     5641 agggtttcct tcagtttgtt tattctaagc ttttactgtg ctttttactg aacaagtttc
     5701 tgatgtataa aacttgcatc tgatttcttt ggaaatattt tcacaaaagt tattttaatc
     5761 agtattttta cattgccttt ccagtgtcca gaagtgtttc taaacttaga aagtgaccta
     5821 tagtttttta aaattatgtt ttcctagaac gtgccaaatt ttgatttact ctaacaatca
     5881 gtacttttct tcagatgctt tgttctgttt agaacaaaaa tgcactatag tttttaaaga
     5941 atcatgcatc tttgggttgg cccaggatca aatttgatat tgaataattt attccagggc
     6001 agctttcata aacatacttc atagatgttg ttttgaaatg tttctaaata tctaaaatca
     6061 tttcaacagc agaaatgatt tttattttaa caaaagatta tgatagccct tgtagtgttt
     6121 aaaagtggtc atatttatta ctgactttga gtcaggtgtt aaaatagcag tgccacagct
     6181 cgtctcttgc cttagtgtgc tgctgtgaga gtcacagtgg aaactgcagg gaggaggtgt
     6241 gttcctaaga accaaaatcc agcacagcat cctgtgaagc cacgtgtaat gatggtccca
     6301 taaggaaagt atgtgaatat ggctcttgta aaggattaac tattgtaatt ttagcttatg
     6361 ctctgtattc tgttttctat ggaattattt aagccctttt agtgaccttt gtcctggccc
     6421 atttaaaaac taaaatgtag tatatattgt ataaaatgga aatatcatta ttgcttcatt
     6481 aggggaaact gtacataggc attgaaagaa gggtaaaagc aagcagtttt atcaggcagt
     6541 tgtaaaacac caaaaatata gattcgtctt tgacgtgtaa cacactaaat gtattttgta
     6601 cagcatctgg tttaaaaggt gccttaagag tttaccatta cttgctttgt tctatataca
     6661 gattatgtcc aatgtatcat tttgaagtaa ataaccttat tttagtata
//
