LOCUS       NM_001365308            5287 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens BMP binding endothelial regulator (BMPER), transcript
            variant 1, mRNA.
ACCESSION   NM_001365308
VERSION     NM_001365308.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5287)
  AUTHORS   Garritson,J.D., Zhang,J., Achenbach,A., Ferhat,M., Eich,E.,
            Stubben,C.J., Martinez,P.L., Ibele,A.R., Hilgendorf,K.I. and
            Boudina,S.
  TITLE     BMPER is a marker of adipose progenitors and adipocytes and a
            positive modulator of adipogenesis
  JOURNAL   Commun Biol 6 (1), 638 (2023)
   PUBMED   37311809
  REMARK    GeneRIF: BMPER is a marker of adipose progenitors and adipocytes
            and a positive modulator of adipogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5287)
  AUTHORS   Ji,N. and Yu,Z.
  TITLE     IL-6/Stat3 suppresses osteogenic differentiation in ossification of
            the posterior longitudinal ligament via miR-135b-mediated BMPER
            reduction
  JOURNAL   Cell Tissue Res 391 (1), 145-157 (2023)
   PUBMED   36305971
  REMARK    GeneRIF: IL-6/Stat3 suppresses osteogenic differentiation in
            ossification of the posterior longitudinal ligament via
            miR-135b-mediated BMPER reduction.
REFERENCE   3  (bases 1 to 5287)
  AUTHORS   Batey,N., Spiller,M. and Balasubramanian,M.
  TITLE     Further evidence for attenuated phenotype with variants in the
            BMPER gene causing DSD: Case report and literature review
  JOURNAL   Eur J Med Genet 65 (4), 104470 (2022)
   PUBMED   35240322
  REMARK    GeneRIF: Further evidence for attenuated phenotype with variants in
            the BMPER gene causing DSD: Case report and literature review.
            Review article
REFERENCE   4  (bases 1 to 5287)
  AUTHORS   Ding,P., Chen,W., Yan,X., Zhang,J., Li,C., Zhang,G., Wang,Y. and
            Li,Y.
  TITLE     BMPER alleviates ischemic brain injury by protecting neurons and
            inhibiting neuroinflammation via Smad3-Akt-Nrf2 pathway
  JOURNAL   CNS Neurosci Ther 28 (4), 593-607 (2022)
   PUBMED   34904361
  REMARK    GeneRIF: BMPER alleviates ischemic brain injury by protecting
            neurons and inhibiting neuroinflammation via Smad3-Akt-Nrf2
            pathway.
REFERENCE   5  (bases 1 to 5287)
  AUTHORS   Braun,F., Gangfuss,A., Stobe,P., Haack,T.B., Schweiger,B., Roos,A.
            and Schara,U.
  TITLE     Expansion of the mutational spectrum of BMPER leading to
            diaphanospondylodysostosis and description of the associated
            disease process
  JOURNAL   Mol Genet Genomic Med 9 (12), e1767 (2021)
   PUBMED   34288564
  REMARK    GeneRIF: Expansion of the mutational spectrum of BMPER leading to
            diaphanospondylodysostosis and description of the associated
            disease process.
REFERENCE   6  (bases 1 to 5287)
  AUTHORS   Ben-Neriah,Z., Michaelson-Cohen,R., Inbar-Feigenberg,M.,
            Nadjari,M., Zeligson,S., Shaag,A., Zenvirt,S., Elpeleg,O. and
            Levy-Lahad,E.
  TITLE     A deleterious founder mutation in the BMPER gene causes
            diaphanospondylodysostosis (DSD)
  JOURNAL   Am J Med Genet A 155A (11), 2801-2806 (2011)
   PUBMED   21990102
  REMARK    GeneRIF: Diaphonospondylodysostosis is caused by loss of BMPER
            function.
REFERENCE   7  (bases 1 to 5287)
  AUTHORS   Funari,V.A., Krakow,D., Nevarez,L., Chen,Z., Funari,T.L.,
            Vatanavicharn,N., Wilcox,W.R., Rimoin,D.L., Nelson,S.F. and
            Cohn,D.H.
  TITLE     BMPER mutation in diaphanospondylodysostosis identified by
            ancestral autozygosity mapping and targeted high-throughput
            sequencing
  JOURNAL   Am J Hum Genet 87 (4), 532-537 (2010)
   PUBMED   20869035
  REMARK    GeneRIF: BMPER-mediated signaling plays an essential role in
            vertebral segmentation early in human development, while defects in
            BMPER produce Diaphanospondylodysostosis.
REFERENCE   8  (bases 1 to 5287)
  AUTHORS   Heinke,J., Wehofsits,L., Zhou,Q., Zoeller,C., Baar,K.M.,
            Helbing,T., Laib,A., Augustin,H., Bode,C., Patterson,C. and
            Moser,M.
  TITLE     BMPER is an endothelial cell regulator and controls bone
            morphogenetic protein-4-dependent angiogenesis
  JOURNAL   Circ Res 103 (8), 804-812 (2008)
   PUBMED   18787191
  REMARK    GeneRIF: BMPER is an endothelial cell regulator and controls bone
            morphogenetic protein-4-dependent angiogenesis.
REFERENCE   9  (bases 1 to 5287)
  AUTHORS   Binnerts,M.E., Wen,X., Cante-Barrett,K., Bright,J., Chen,H.T.,
            Asundi,V., Sattari,P., Tang,T., Boyle,B., Funk,W. and Rupp,F.
  TITLE     Human Crossveinless-2 is a novel inhibitor of bone morphogenetic
            proteins
  JOURNAL   Biochem Biophys Res Commun 315 (2), 272-280 (2004)
   PUBMED   14766204
  REMARK    GeneRIF: Crossveinless-2 is an inhibitor of BMP function
REFERENCE   10 (bases 1 to 5287)
  AUTHORS   Moser,M., Binder,O., Wu,Y., Aitsebaomo,J., Ren,R., Bode,C.,
            Bautch,V.L., Conlon,F.L. and Patterson,C.
  TITLE     BMPER, a novel endothelial cell precursor-derived protein,
            antagonizes bone morphogenetic protein signaling and endothelial
            cell differentiation
  JOURNAL   Mol Cell Biol 23 (16), 5664-5679 (2003)
   PUBMED   12897139
  REMARK    GeneRIF: BMPER is a novel BMP-binding protein that is expressed by
            endothelial cell precursors, has BMP-antagonizing activity, and may
            play a role in endothelial cell differentiation by modulating local
            BMP activity
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010002.6 and AC007350.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a secreted protein that interacts with,
            and inhibits bone morphogenetic protein (BMP) function. It has been
            shown to inhibit BMP2- and BMP4-dependent osteoblast
            differentiation and BMP-dependent differentiation of the
            chondrogenic cells. Mutations in this gene are associated with a
            lethal skeletal disorder, diaphanospondylodysostosis. [provided by
            RefSeq, Dec 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.98746.1,
                                           SRR1803611.87572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000649409.2/ ENSP00000497748.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               AC010002.6         139918-140125       c
            209-294             AC010002.6         138761-138846       c
            295-394             AC010002.6         108276-108375       c
            395-477             AC010002.6         79103-79185         c
            478-568             AC010002.6         75245-75335         c
            569-651             AC010002.6         70880-70962         c
            652-751             AC007350.1         21454-21553
            752-861             AC007350.1         27009-27118
            862-1002            AC007350.1         30311-30451
            1003-1107           AC007350.1         33207-33311
            1108-1153           AC007350.1         37150-37195
            1154-1483           AC007350.1         54005-54334
            1484-1820           AC007350.1         60904-61240
            1821-1951           AC007350.1         118378-118508
            1952-5287           AC007350.1         128240-131575
FEATURES             Location/Qualifiers
     source          1..5287
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.3"
     gene            1..5287
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /note="BMP binding endothelial regulator"
                     /db_xref="GeneID:168667"
                     /db_xref="HGNC:HGNC:24154"
                     /db_xref="MIM:608699"
     exon            1..208
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..2133
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; crossveinless 2; BMP-binding endothelial
                     regulator precursor protein; bone morphogenetic
                     protein-binding endothelial cell precursor-derived
                     regulator"
                     /codon_start=1
                     /product="BMP-binding endothelial regulator protein
                     isoform a precursor"
                     /protein_id="NP_001352237.1"
                     /db_xref="CCDS:CCDS5442.1"
                     /db_xref="GeneID:168667"
                     /db_xref="HGNC:HGNC:24154"
                     /db_xref="MIM:608699"
                     /translation="MLWFSGVGALAERYCRRSPGITCCVLLLLNCSGVPMSLASSFLT
                     GSVAKCENEGEVLQIPFITDNPCIMCVCLNKEVTCKREKCPVLSRDCALAIKQRGACC
                     EQCKGCTYEGNTYNSSFKWQSPAEPCVLRQCQEGVVTESGVRCVVHCKNPLEHLGMCC
                     PTCPGCVFEGVQYQEGEEFQPEGSKCTKCSCTGGRTQCVREVCPILSCPQHLSHIPPG
                     QCCPKCLGQRKVFDLPFGSCLFRSDVYDNGSSFLYDNCTACTCRDSTVVCKRKCSHPG
                     GCDQGQEGCCEECLLRVPPEDIKVCKFGNKIFQDGEMWSSINCTICACVKGRTECRNK
                     QCIPISSCPQGKILNRKGCCPICTEKPGVCTVFGDPHYNTFDGRTFNFQGTCQYVLTK
                     DCSSPASPFQVLVKNDARRTRSFSWTKSVELVLGESRVSLQQHLTVRWNGSRIALPCR
                     APHFHIDLDGYLLKVTTKAGLEISWDGDSFVEVMAAPHLKGKLCGLCGNYNGHKRDDL
                     IGGDGNFKFDVDDFAESWRVESNEFCNRPQRKPVPELCQGTVKVKLRAHRECQKLKSW
                     EFQTCHSTVDYATFYRSCVTDMCECPVHKNCYCESFLAYTRACQREGIKVHWEPQQNC
                     AATQCKHGAVYDTCGPGCIKTCDNWNEIGPCNKPCVAGCHCPANLVLHKGRCIKPVLC
                     PQR"
     exon            209..294
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /inference="alignment:Splign:2.1.0"
     exon            295..394
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /inference="alignment:Splign:2.1.0"
     exon            395..477
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /inference="alignment:Splign:2.1.0"
     exon            478..568
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /inference="alignment:Splign:2.1.0"
     exon            569..651
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /inference="alignment:Splign:2.1.0"
     exon            652..751
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /inference="alignment:Splign:2.1.0"
     exon            752..861
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1002
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1107
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1153
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1483
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1820
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1951
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..5287
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3331..3336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /note="hexamer: AATAAA"
     polyA_site      3356
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /note="major polyA site"
     regulatory      3421..3426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /note="hexamer: ATTAAA"
     polyA_site      3440
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
     regulatory      3650..3655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
                     /note="hexamer: AATAAA"
     polyA_site      3674
                     /gene="BMPER"
                     /gene_synonym="CRIM3; CV-2; CV2"
ORIGIN      
        1 gactgtgagc tgcggcagct gagcagaggc ggcggcgcgg gacctgcagt cgccagggat
       61 tccctccagg tgacgatgct ctggttctcc ggcgtcgggg ctctggctga gcgttactgc
      121 cgccgctcgc ctgggattac gtgctgcgtc ttgctgctac tcaattgctc gggggtcccc
      181 atgtctctgg cttcctcctt cttgacaggt tctgttgcaa aatgtgaaaa tgaaggtgaa
      241 gtcctccaga ttccatttat cacagacaac ccttgcataa tgtgtgtctg cttgaacaag
      301 gaagtgacat gtaagagaga gaagtgcccc gtgctgtccc gagactgtgc cctggccatc
      361 aagcagaggg gagcctgttg tgaacagtgc aaaggttgca cctatgaagg aaatacctat
      421 aacagctcct tcaaatggca gagcccggct gagccttgtg ttctacgcca gtgccaggag
      481 ggcgttgtca cagagtctgg ggtgcgctgt gttgttcatt gtaaaaaccc tttggagcat
      541 ctgggaatgt gctgccccac atgtccaggc tgtgtgtttg agggtgtgca gtatcaagaa
      601 ggggaggaat ttcagccaga aggaagcaaa tgtaccaagt gttcctgcac tggaggcagg
      661 acacaatgtg tgagagaagt ctgtcccatt ctctcctgtc cccagcacct tagtcacata
      721 cccccaggac agtgctgccc caaatgtttg ggtcagagga aagtgtttga cctccctttt
      781 gggagctgcc tctttcgaag tgatgtttat gacaatggat cctcatttct gtacgataac
      841 tgcacagctt gtacctgcag ggactctact gtggtttgca agaggaagtg ctcccaccct
      901 ggtggctgtg accaaggcca ggagggctgt tgtgaagagt gcctcctacg agtgccccca
      961 gaagacatca aagtatgcaa atttggcaac aagattttcc aggatggaga gatgtggtcc
     1021 tctatcaatt gtaccatctg tgcttgtgtg aaaggcagga cggagtgtcg caataagcag
     1081 tgcattccca tcagtagctg cccacagggc aaaattctca acagaaaagg atgctgtcct
     1141 atttgcactg aaaagcccgg cgtttgcacg gtgtttggag atccccacta caacactttt
     1201 gacggtcgga catttaactt tcaggggacg tgtcagtacg ttttgacaaa agactgctcc
     1261 tcccctgcct cgcccttcca ggtgctggtg aagaacgacg cccgccggac acgctccttc
     1321 tcgtggacca agtcggtgga gctggtgctg ggcgagagca gggtcagcct gcagcagcac
     1381 ctcaccgtgc gctggaacgg ctcgcgcatc gcgctcccct gccgcgcgcc acacttccac
     1441 atcgacctgg atggctacct cttgaaagtg accaccaaag caggtttgga aatatcttgg
     1501 gatggagaca gttttgtaga agtcatggct gcgccgcatc tcaagggcaa gctctgtggt
     1561 ctttgtggca actacaatgg acataaacgt gatgacttaa ttggtggaga tggaaacttc
     1621 aagtttgatg tggatgactt tgctgaatct tggagggtgg agtccaatga gttctgcaac
     1681 agacctcaga gaaagccagt gcctgaactg tgtcaaggga cagtcaaggt aaagctccgg
     1741 gcccatcgag aatgccaaaa gctcaaatcc tgggagtttc agacctgcca ctcgactgtg
     1801 gactacgcca ctttctaccg gtcctgtgtg acagacatgt gtgaatgtcc agtccataaa
     1861 aactgttatt gcgagtcatt tttggcatat acccgggcct gccagagaga gggcatcaaa
     1921 gtccactggg agcctcagca gaattgtgca gccacccagt gtaagcatgg tgctgtgtac
     1981 gatacctgtg gtccgggatg tatcaagacg tgtgacaact ggaatgaaat tggtccatgc
     2041 aacaagccgt gcgttgctgg gtgccactgt ccagcaaact tggtccttca caagggaagg
     2101 tgcatcaagc cagtcctttg tccccagcgg tgacctttgt ttcgatcctt aagactctga
     2161 aatctggtga ctttgacact gaagcggaag agccaatgaa ggactgcagt atttgtgtgc
     2221 ccgattctgt aaacacacac acacagagta tatatgtgta tatatatata gatatattca
     2281 aaaacattgc atcatttata tgaactatag ggggattatt atatgtatat tttttgctat
     2341 aagacatgta ttgtttctag gatcctaacc tgtaagccat tgaacatgtt gtataaatac
     2401 accaggtgtt tttaatttaa taaggtggca tgcagataca ttggatagtg ttaacatcac
     2461 atacatttgt catttttaag gaagttttct aagagccctc aattgcctgc ctgtattaat
     2521 tttagttttg agtcaggatt tgtaatggag tgggaaatgt gtttctctgg agaagggcac
     2581 atttatctag gggcatttca ggtttccaaa gaaaggaatg tatgcctggg aaagacagca
     2641 ggagattggt gaccggccct aatggtgcat gaaaagcgag tgataggctg ttagaatgta
     2701 ttaggtcatg ggctaacatt atttccaaaa ttgattggct ggttgccaag aaatatatat
     2761 ttgtcactag ggcataaccg aagaatcaag tgatttcttg ccatccttgc gtagtcctca
     2821 agtcttctaa tcatctatgt gtgtatgatg gatgtgacca tttatatgtc atgtgttgaa
     2881 attaaagggt gtctggatgc catgttaatt ttattgagca tgagaaagta tttgaagaaa
     2941 ctgttgcaca acatatgatg aaattttgat ttctctgaat ctcagagtaa tttaagatgg
     3001 gcaaatccaa tgagttgatg taacccatct acattttgtg gctatttcat gtataaaatg
     3061 aaaggcttta gttatttcta gaggagtccc atccaacact atttggcgac tgttaatatg
     3121 ttataattat tagacagtgg aaaagccttt attgactaat tgatttaacc tcagtccaaa
     3181 gaacagtctc tatacttgcc ctcatttact gataggctgc tactagttac catttgattg
     3241 tcttgacttt cgtcttcagt tgaattggtg aaaacatcaa caaaaacaaa acccactgtg
     3301 tcttaaaata aaatgttctg cattgtagtc aataaagggc ttaagatgta aaacaatgca
     3361 ttttctctct caagatgtcc tgtgttatac tttacaatta gttgtatcaa cttcagattc
     3421 attaaatttt aacagctgta tttagttata atttttgtat cttacaacag tatatataaa
     3481 gactattatt aatagacaaa agcaaaccca cgtttttgac aagccagcat attgccaatg
     3541 ctcgtcaaag acatttatgt ttcttttaca ttcatgacag ctaaagtatt aacttggaat
     3601 tttttttttt ttttttgact ggaaaatccc tagttgtttg aattaactga ataaagtgca
     3661 gggcgtaata gtgactggct gggggcactg ggcctttgtg ttttttttca ttcctgtgtt
     3721 tggatactaa tcaccctcgt atctgcagcc tgaggtagtc aggtcattgt ttcaatgctg
     3781 cccttggaaa gaagactttg acttaggtgc tttgggatct aagtgtggtt tgtgactatc
     3841 cccattattt aagcatttgg gggtctcact tttgcttatc tgtaacacaa agaggccatg
     3901 tagtatagtg agcagggttg agaatcggga aaactagacc cctgccacta acaggctagg
     3961 agactttggg cagtaatggg aggcactgag ggtttgcaaa tactttccta cttgtaatct
     4021 cattgattcc ctgctctgcc ctgacaggag gggtagggaa aatcagttga cgttgcctgg
     4081 tggttcctac cttctgtaaa acgaacagat tccttaagat tagctttaaa tcccttttca
     4141 gttcactgtt ggttctcatc tttgaaagag ggcagcataa gggaaatgat ggagaaggga
     4201 gaattgtgga tggttattta tagctcatga ttcatccaag gactgagtta ttctccccat
     4261 gaggctaacc ggcctctttc ccaacactta atcatggcag ccaggatggg tgaatgatga
     4321 aagctcttct gcatgagccg gtttcatcat cttgggtggg ttgattacaa gtttgtgtgg
     4381 cattccttta gctggggatt agcttaatct ctgtacattt ttctcatttc taattgaaga
     4441 agaaagggag ggcagagagg acagaaaatt acttgggttt actaattcaa agagccatct
     4501 ctgatgggag agggtgagga aatcagctga atggttggcc tgcatattct tttttaggcc
     4561 acaggctaca gctgagcaat ggcttagtct aatgattggg cacaatgagg atttaccaag
     4621 tgcttcaatg agagcagtcc tgtttcattc acatgggatg ttttcaattg gttcttcaac
     4681 taagctcttg cagagtgaga tgacttgaaa taaaaatgtt ctatgaatat tgaatttgat
     4741 gagaaacaag caccctcaat gaagaacaag cataattatg attctaattg cccattgttg
     4801 gtactcagta aaactaagtt ctttcttctc tccctctgta aataggaata tttgagggtc
     4861 ctgacctaaa attttttagc tgggaagaaa agatatctct ttggcatcga caagagcaat
     4921 ttttgttaaa actgtggtac actaagaatc actaactctt caggttgaag gcctcactca
     4981 tcttaactcg ttgactgctt cctgaccatc agaccgtcct gtaagagggc atctttcaat
     5041 aagaacgaga aagacccagg aggttgacta gcttctccca gctttcactg aaacacggat
     5101 aaaccatttc aactggaaaa ctcttccttt ttatgagata tttcagacac acaaaaaggc
     5161 atagagaaaa atgttgcaaa catccatgac tacattaccc taattaagaa acataacctg
     5221 gtaagtagtc aataaatttt tcttgaatca ataaataaaa cctaataaat gctgtctcat
     5281 ggttgca
//
