LOCUS       NM_001720               4826 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens bone morphogenetic protein 8b (BMP8B), mRNA.
ACCESSION   NM_001720
VERSION     NM_001720.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4826)
  AUTHORS   Wang,M., Zhong,L., Zhang,H., Wan,P., Chu,X., Shao,X., Chen,S.,
            Zhou,Z., Yu,L. and Liu,B.
  TITLE     p200CUX1-regulated BMP8B inhibits the progression of acute myeloid
            leukemia via the MAPK signaling pathway
  JOURNAL   Med Oncol 41 (7), 166 (2024)
   PUBMED   38819709
  REMARK    GeneRIF: p200CUX1-regulated BMP8B inhibits the progression of acute
            myeloid leukemia via the MAPK signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4826)
  AUTHORS   Mounika,N., Yadav,A., Kamboj,P., Banerjee,S.K., Deka,U.J., Kaur,S.
            and Adela,R.
  TITLE     Circulatory bone morphogenetic protein (BMP) 8B is a non-invasive
            predictive biomarker for the diagnosis of non-alcoholic
            steatohepatitis (NASH)
  JOURNAL   PLoS One 18 (12), e0295839 (2023)
   PUBMED   38127951
  REMARK    GeneRIF: Circulatory bone morphogenetic protein (BMP) 8B is a
            non-invasive predictive biomarker for the diagnosis of
            non-alcoholic steatohepatitis (NASH).
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4826)
  AUTHORS   Skok,D.J., Hauptman,N., Jerala,M. and Zidar,N.
  TITLE     Expression of Cytokine-Coding Genes BMP8B, LEFTY1 and INSL5 Could
            Distinguish between Ulcerative Colitis and Crohn's Disease
  JOURNAL   Genes (Basel) 12 (10), 1477 (2021)
   PUBMED   34680872
  REMARK    GeneRIF: Expression of Cytokine-Coding Genes BMP8B, LEFTY1 and
            INSL5 Could Distinguish between Ulcerative Colitis and Crohn's
            Disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4826)
  AUTHORS   Urisarri,A., Gonzalez-Garcia,I., Estevez-Salguero,A., Pata,M.P.,
            Milbank,E., Lopez,N., Mandia,N., Grijota-Martinez,C., Salgado,C.A.,
            Nogueiras,R., Dieguez,C., Villarroya,F., Fernandez-Real,J.M.,
            Couce,M.L. and Lopez,M.
  TITLE     BMP8 and activated brown adipose tissue in human newborns
  JOURNAL   Nat Commun 12 (1), 5274 (2021)
   PUBMED   34489410
  REMARK    GeneRIF: BMP8 and activated brown adipose tissue in human newborns.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4826)
  AUTHORS   Vacca,M., Leslie,J., Virtue,S., Lam,B.Y.H., Govaere,O.,
            Tiniakos,D., Snow,S., Davies,S., Petkevicius,K., Tong,Z.,
            Peirce,V., Nielsen,M.J., Ament,Z., Li,W., Kostrzewski,T.,
            Leeming,D.J., Ratziu,V., Allison,M.E.D., Anstee,Q.M., Griffin,J.L.,
            Oakley,F. and Vidal-Puig,A.
  TITLE     Bone morphogenetic protein 8B promotes the progression of
            non-alcoholic steatohepatitis
  JOURNAL   Nat Metab 2 (6), 514-531 (2020)
   PUBMED   32694734
  REMARK    GeneRIF: Bone morphogenetic protein 8B promotes the progression of
            non-alcoholic steatohepatitis.
            GeneRIF: BMP8B is upregulated in human NASH in hepatocytes and HSC.
            The absence of BMP8B prevents HSC activation, reduces inflammation
            and affects the wound-healing responses, thereby limiting NASH
            progression.
REFERENCE   6  (bases 1 to 4826)
  AUTHORS   Wang,R.N., Green,J., Wang,Z., Deng,Y., Qiao,M., Peabody,M.,
            Zhang,Q., Ye,J., Yan,Z., Denduluri,S., Idowu,O., Li,M., Shen,C.,
            Hu,A., Haydon,R.C., Kang,R., Mok,J., Lee,M.J., Luu,H.L. and
            Shi,L.L.
  TITLE     Bone Morphogenetic Protein (BMP) signaling in development and human
            diseases
  JOURNAL   Genes Dis 1 (1), 87-105 (2014)
   PUBMED   25401122
REFERENCE   7  (bases 1 to 4826)
  AUTHORS   Ying,Y., Liu,X.M., Marble,A., Lawson,K.A. and Zhao,G.Q.
  TITLE     Requirement of Bmp8b for the generation of primordial germ cells in
            the mouse
  JOURNAL   Mol Endocrinol 14 (7), 1053-1063 (2000)
   PUBMED   10894154
REFERENCE   8  (bases 1 to 4826)
  AUTHORS   DiLeone,R.J., King,J.A., Storm,E.E., Copeland,N.G., Jenkins,N.A.
            and Kingsley,D.M.
  TITLE     The Bmp8 gene is expressed in developing skeletal tissue and maps
            near the Achondroplasia locus on mouse chromosome 4
  JOURNAL   Genomics 40 (1), 196-198 (1997)
   PUBMED   9070944
  REMARK    GeneRIF: Reports on the mouse homolog of this gene.
REFERENCE   9  (bases 1 to 4826)
  AUTHORS   Auffray,C., Behar,G., Bois,F., Bouchier,C., Da Silva,C.,
            Devignes,M.D., Duprat,S., Houlgatte,R., Jumeau,M.N., Lamy,B. et al.
  TITLE     [IMAGE: molecular integration of the analysis of the human genome
            and its expression]
  JOURNAL   C R Acad Sci III 318 (2), 263-272 (1995)
   PUBMED   7757816
REFERENCE   10 (bases 1 to 4826)
  AUTHORS   Ozkaynak,E., Schnegelsberg,P.N., Jin,D.F., Clifford,G.M.,
            Warren,F.D., Drier,E.A. and Oppermann,H.
  TITLE     Osteogenic protein-2. A new member of the transforming growth
            factor-beta superfamily expressed early in embryogenesis
  JOURNAL   J Biol Chem 267 (35), 25220-25227 (1992)
   PUBMED   1460021
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL033527.26, AY303955.1,
            BC023526.2 and BC080618.1.
            
            On Nov 24, 2018 this sequence version replaced NM_001720.4.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. The encoded protein stimulates
            thermogenesis in brown adipose tissue. Expression of this gene may
            be downregulated in pancreatic cancer. This gene may have arose
            from a gene duplication event and its gene duplicate is also
            present on chromosome 1. [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY303955.1, BC023526.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372827.8/ ENSP00000361915.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AL033527.26        29392-29395         c
            5-1051              AY303955.1         1-1047
            1052-1195           BC023526.2         647-790
            1196-3592           AY303955.1         1192-3588
            3593-4826           BC080618.1         655-1888
FEATURES             Location/Qualifiers
     source          1..4826
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..4826
                     /gene="BMP8B"
                     /gene_synonym="BMP8; OP2"
                     /note="bone morphogenetic protein 8b"
                     /db_xref="GeneID:656"
                     /db_xref="HGNC:HGNC:1075"
                     /db_xref="MIM:602284"
     exon            1..714
                     /gene="BMP8B"
                     /gene_synonym="BMP8; OP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             381..1589
                     /gene="BMP8B"
                     /gene_synonym="BMP8; OP2"
                     /note="osteogenic protein 2; bone morphogenetic protein 8
                     (osteogenic protein 2)"
                     /codon_start=1
                     /product="bone morphogenetic protein 8B preproprotein"
                     /protein_id="NP_001711.2"
                     /db_xref="CCDS:CCDS444.1"
                     /db_xref="GeneID:656"
                     /db_xref="HGNC:HGNC:1075"
                     /db_xref="MIM:602284"
                     /translation="MTALPGPLWLLGLALCALGGGGPGLRPPPGCPQRRLGARERRDV
                     QREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAERRLGRA
                     DLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRT
                     LHVSMFQVVQEQSNRESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRL
                     YVETEDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKS
                     NELPQANRLPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGEC
                     SFPLDSCMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHR
                     NMVVKACGCH"
     exon            715..904
                     /gene="BMP8B"
                     /gene_synonym="BMP8; OP2"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1053
                     /gene="BMP8B"
                     /gene_synonym="BMP8; OP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1248
                     /gene="BMP8B"
                     /gene_synonym="BMP8; OP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1328
                     /gene="BMP8B"
                     /gene_synonym="BMP8; OP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1439
                     /gene="BMP8B"
                     /gene_synonym="BMP8; OP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..4826
                     /gene="BMP8B"
                     /gene_synonym="BMP8; OP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4804..4809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMP8B"
                     /gene_synonym="BMP8; OP2"
                     /note="hexamer: ATTAAA"
     polyA_site      4826
                     /gene="BMP8B"
                     /gene_synonym="BMP8; OP2"
                     /note="major polyA site"
ORIGIN      
        1 agggactcgc gggaaccgca ccaagcgggt ggctgcagga gctcgcccat cgcccctgcg
       61 ctgctcggac cgcggccaca gccggactgg cgggtacggc ggcgacagac ggattggccg
      121 agagtcccag tccgcagagt agccccggcc tcgaggcggt ggcgtccgcg tcctctcgtc
      181 caggagccag gacaggtgtc gcgcggcggg cgctccaggg accgcgctga ggccgcggtc
      241 gccgcccgtc ccgccccgcc ccgccgcccg ccgcccgccg agcccagcct ccttgccgtc
      301 ggggcgtccc caggccctgg gtcggccgcg gagccgatgc gcgcccgctg agcgccccag
      361 ctgagcgccc ccggcctgcc atgaccgcgc tccccggccc gctctggctc ctgggcctgg
      421 cgctatgcgc gctgggcggg ggcggccccg gcctgcgacc cccgcccggc tgtccccagc
      481 gacgtctggg cgcgcgcgag cgccgggacg tgcagcgcga gatcctggcg gtgctcgggc
      541 tgcctgggcg gccccggccc cgcgcgccac ccgccgcctc ccggctgccc gcgtccgcgc
      601 cgctcttcat gctggacctg taccacgcca tggccggcga cgacgacgag gacggcgcgc
      661 ccgcggagcg gcgcctgggc cgcgccgacc tggtcatgag cttcgttaac atggtggagc
      721 gagaccgtgc cctgggccac caggagcccc attggaagga gttccgcttt gacctgaccc
      781 agatcccggc tggggaggcg gtcacagctg cggagttccg gatttacaag gtgcccagca
      841 tccacctgct caacaggacc ctccacgtca gcatgttcca ggtggtccag gagcagtcca
      901 acagggagtc tgacttgttc tttttggatc ttcagacgct ccgagctgga gacgagggct
      961 ggctggtgct ggatgtcaca gcagccagtg actgctggtt gctgaagcgt cacaaggacc
     1021 tgggactccg cctctatgtg gagactgagg acgggcacag cgtggatcct ggcctggccg
     1081 gcctgctggg tcaacgggcc ccacgctccc aacagccttt cgtggtcact ttcttcaggg
     1141 ccagtccgag tcccatccgc acccctcggg cagtgaggcc actgaggagg aggcagccga
     1201 agaaaagcaa cgagctgccg caggccaacc gactcccagg gatctttgat gacgtccacg
     1261 gctcccacgg ccggcaggtc tgccgtcggc acgagctcta cgtcagcttc caggacctcg
     1321 gctggctgga ctgggtcatc gctccccaag gctactcggc ctattactgt gagggggagt
     1381 gctccttccc actggactcc tgcatgaatg ccaccaacca cgccatcctg cagtccctgg
     1441 tgcacctgat gatgccagac gcagtcccca aggcgtgctg tgcacccacc aagctgagcg
     1501 ccacctctgt gctctactat gacagcagca acaatgtcat cctgcgcaag caccgcaaca
     1561 tggtggtcaa ggcctgcggc tgccactgag tccacccgcc cggcccagct gcagccaccc
     1621 ttctcatctg gatcgggccc ctcagaagca ggaaaccctc aaacccagcc agaccccagg
     1681 ccggggcatt gccagggagg accctcacaa ccacgtacat gaccctttct ccttcatgcc
     1741 aggctcctat gctccccttg ccctgccagg catttgtgtg actgtcctgt ttccagccca
     1801 ggtggtctca atcatcaggc agtgttctac ccaaatgcaa acgcctctcc cggaggcatg
     1861 tcctggctgg ttctttgggg ttggcacaga agtcctgtct gaggtcctat ccatgcccct
     1921 tactggctca ggtcgtgaga tagatgtgga atgacctgag aggcacctgg agcccactgt
     1981 tggccacctt gagctcttca ccatccatca cagggtgtgg tgtgtgtagt cagggtctgg
     2041 ttggctcccc attgcctgcc cgaggtgcaa ggtggggtat aaaactggat aacccctgaa
     2101 gtattgtata ttcatggatc tgaagcactg atccactggt cacaggtaga catgtggagt
     2161 caactcaaga aaaagctgag tgaacagcat gatttagggc taaagccaat ggcatttatc
     2221 ttcccttgtc ttcctgcttt gcatttgcct ctgccatcta ggaaagacat gtaagagcat
     2281 ggacatttta ctttggagaa acagaaaaat cttggggctt ccaattgacc catctatctg
     2341 ccaccatgtt gccccaccag gagctcagct ctgtggagtt ttccctttgc tgagcaagca
     2401 tgtggttgca ttgggtggcc caggatgaca atgcacagca cagatgccat catttccctt
     2461 tcccctctga atggcagaca tcagtaatca atctggaatg tttttcttcc aaatctgagt
     2521 ggaattttca aatgatcagc acagccactg ccaacagata tgatgtaaag tgaaacctgg
     2581 ttgccatctt ctgccatgct gaggagcagt ccatccctgc ccgagcatgt atcggcaaca
     2641 tgggcagcct gtgaccgggt ctggggcgag gccaggggcc atcaaaaaca ggctgatcac
     2701 caaagtcagt gtcaccctgg atgcccagca gccctgtcct gtgtcttggg cctgtgagtc
     2761 aaagaaaagg tccttttcag ggagtgacaa gtagtaatta ggctgagttg ggtggagagg
     2821 tttgtctcag cctctgctgt tctcggaaac tgctgttctc cttggagcag ccactgggag
     2881 ttggagtgtt tatttgattt ctgacttgct aagcctgtaa tttacctgct ggaatagaca
     2941 gagtccagct gcccaaaccg tgtcattaaa agcagatcct gcgcccgccc catccacagg
     3001 cacagcccgg cagagtggtt ccacctcccc atgggcccaa ggatgcgcct ctctggagtt
     3061 cacgtgctgc acccccaggg aggggcctgg ggaaagctgg tccagcagca ggggtggagg
     3121 ctggggccac actgcgggac agcagcccct ccacctggac cagggagggc ctccatgtgc
     3181 aagcgcagag gaagagaccc tcccatgtac gcaaagggca gccccaggct gtctggaagt
     3241 tggagaattc cctatcagca cagggatctc agctctggcc tggaggtgaa gagacctgcc
     3301 ttgtaggtgg cttccttatc tgcgcctcca ttttctatct gcactttttg atctccaaac
     3361 aaccttcagc caaagaatct gtctaccaac tcctcatagt gagccagaag cagcctcata
     3421 accctgaatg tggggctctg gtggctgtca cgaagcagag ttggcacata acatggaacc
     3481 tggccaggca tggtggctca cacctataac cccagcactt tgggaggcca aggcaggcag
     3541 atcacctgaa gtcaggagtt caagaccatc ctggccaaca cagtgaaacc ccatctgtac
     3601 taaaaataca agattacctg ggcatggtgg tgcatgccta taatcccagc tactcaggag
     3661 gctgaggcag aattgcttga acctgggagg tggaggttgc agtgagcaga gatcacaaca
     3721 ttgcacttca gcctggtgac atgagcaaaa ctgttgtctc aacaaaatga aattatggaa
     3781 cctgtttgcc atcctagtat ttacttaatt gttccttctt aacatcaaag atggtcttct
     3841 aggcaattgt aaattttaaa ttagccagtt attttgacaa ttaatttttt actccacctg
     3901 tatctttagt gcccagccaa tgatctggca tagttagggg tgcaccaaga atgtctgtaa
     3961 actacctgaa ggtttgtaga tatggagtac accttaccca ttaatcaagc tgtgcatagc
     4021 aggaaccaat acgagccgtg atcctcctgg ttcatacaga acaatggaaa aacataaggc
     4081 tttgtctacc tagttggcca tcagactttc agcaactttt atcatccaga tagtcaccaa
     4141 atgaaataaa atagaaaaat cccttgagca atgaaacaat tgtgaatgaa cacaaagtcc
     4201 atgaatttaa tccttatccg tttgctgagc caagcatgtg catctgcagt gggtggccca
     4261 ggctggcagc acagatacca ccatttccct tttctttgct cagggcatgg cctgtttatc
     4321 tcgttgcacc agatgagggt tggaaggatg atggtggtgg ttgtttcaga tctactgaca
     4381 gcaatgagaa atcaatgaca gttgacagga agagaggacg catacaacag gcaaaagagg
     4441 aatgcccagc agtcttggtc cttgcggtgc aatactggcc ttgaggccaa gtcagcaggg
     4501 gattcgtagt cactaacttc taactgaggc agggaagtaa catgttctgg aaaaggtcca
     4561 aagaaacagg aatagaggca gtgtagcaag aggcagattt ttggtgccaa atagatttga
     4621 atcctggttc tgcttcttcc tttgtagagt atgatattgg ttctttcctc ccaaagctat
     4681 tataaagact aaatatgtac acaaatcttt gggatgtctg acatataaat gcttaacaat
     4741 aggtatttgc tggtattatt acaaatgaat ttgcttattt ttgagccact tctatgtctg
     4801 tccattaaac caaaatgtgt tctgca
//
