LOCUS       NM_181809               5636 bp    mRNA    linear   PRI 31-MAY-2024
DEFINITION  Homo sapiens bone morphogenetic protein 8a (BMP8A), mRNA.
ACCESSION   NM_181809 XM_931937
VERSION     NM_181809.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5636)
  AUTHORS   Tang,J., Tan,M., Liao,S., Pang,M. and Li,J.
  TITLE     Recent progress in the biology and physiology of BMP-8a
  JOURNAL   Connect Tissue Res 64 (3), 219-228 (2023)
   PUBMED   36594156
  REMARK    GeneRIF: Recent progress in the biology and physiology of BMP-8a.
            Review article
REFERENCE   2  (bases 1 to 5636)
  AUTHORS   Wu,F.J., Wang,Y.W. and Luo,C.W.
  TITLE     Human bone morphogenetic protein 8A promotes expansion and prevents
            apoptosis of cumulus cells in vitro
  JOURNAL   Mol Cell Endocrinol 522, 111121 (2021)
   PUBMED   33338549
  REMARK    GeneRIF: Human bone morphogenetic protein 8A promotes expansion and
            prevents apoptosis of cumulus cells in vitro.
REFERENCE   3  (bases 1 to 5636)
  AUTHORS   Yu,Y.P., Cai,L.C., Wang,X.Y., Cheng,S.Y., Zhang,D.M., Jian,W.G.,
            Wang,T.D., Yang,J.K., Yang,K.B. and Zhang,C.
  TITLE     BMP8A promotes survival and drug resistance via Nrf2/TRIM24
            signaling pathway in clear cell renal cell carcinoma
  JOURNAL   Cancer Sci 111 (5), 1555-1566 (2020)
   PUBMED   32128917
  REMARK    GeneRIF: Bone morphogenetic protein 8A (BMP8) is highly expressed
            in clear cell renal cell carcinoma (ccRCC) suggesting a poor
            prognosis of ccRCC. BMP8 activates Nrf2 regulated reactive oxygen
            balance, and by regulating the transcription level of TRIM24, it is
            involved in the regulation of the Wnt pathway to promote the
            proliferation, invasion and metastasis of ccRCC and the resistance
            of As2O3.
REFERENCE   4  (bases 1 to 5636)
  AUTHORS   Wu,F.J., Wang,Y.W. and Luo,C.W.
  TITLE     Human BMP8A suppresses luteinization of rat granulosa cells via the
            SMAD1/5/8 pathway
  JOURNAL   Reproduction 159 (3), 315-324 (2020)
   PUBMED   31940275
  REMARK    GeneRIF: Human BMP8A suppresses luteinization of rat granulosa
            cells via the SMAD1/5/8 pathway.
REFERENCE   5  (bases 1 to 5636)
  AUTHORS   Liu,K., Gao,M., Qin,D., Wang,H. and Lu,Q.
  TITLE     Serous BMP8A has Clinical Significance in the Ultrasonic Diagnosis
            of Thyroid Cancer and Promotes Thyroid Cancer Cell Progression
  JOURNAL   Endocr Metab Immune Disord Drug Targets 20 (4), 591-598 (2020)
   PUBMED   31656161
  REMARK    GeneRIF: Serous BMP8A has Clinical Significance in the Ultrasonic
            Diagnosis of Thyroid Cancer and Promotes Thyroid Cancer Cell
            Progression.
REFERENCE   6  (bases 1 to 5636)
  AUTHORS   Mahoney,S.E., Yao,Z., Keyes,C.C., Tapscott,S.J. and Diede,S.J.
  TITLE     Genome-wide DNA methylation studies suggest distinct DNA
            methylation patterns in pediatric embryonal and alveolar
            rhabdomyosarcomas
  JOURNAL   Epigenetics 7 (4), 400-408 (2012)
   PUBMED   22419069
REFERENCE   7  (bases 1 to 5636)
  AUTHORS   Carson,A.R. and Scherer,S.W.
  TITLE     Identifying concerted evolution and gene conversion in mammalian
            gene pairs lasting over 100 million years
  JOURNAL   BMC Evol Biol 9, 156 (2009)
   PUBMED   19583854
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5636)
  AUTHORS   Zekri,A.R., Hafez,M.M., Bahnassy,A.A., Hassan,Z.K., Mansour,T.,
            Kamal,M.M. and Khaled,H.M.
  TITLE     Genetic profile of Egyptian hepatocellular-carcinoma associated
            with hepatitis C virus Genotype 4 by 15 K cDNA microarray:
            preliminary study
  JOURNAL   BMC Res Notes 1, 106 (2008)
   PUBMED   18959789
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5636)
  AUTHORS   Katoh,Y. and Katoh,M.
  TITLE     Comparative integromics on BMP/GDF family
  JOURNAL   Int J Mol Med 17 (5), 951-955 (2006)
   PUBMED   16596286
REFERENCE   10 (bases 1 to 5636)
  AUTHORS   Zhao,G.Q. and Hogan,B.L.
  TITLE     Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that
            play a role in spermatogenesis and placental development
  JOURNAL   Mech Dev 57 (2), 159-168 (1996)
   PUBMED   8843393
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL365277.23, AY303954.1 and
            BU616301.1.
            
            On Nov 22, 2018 this sequence version replaced NM_181809.3.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein may play a role in
            development of the reproductive system. This gene may have arose
            from a gene duplication event and its gene duplicate is also
            present on chromosome 1. [provided by RefSeq, Jul 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279873.4817.1, AY303954.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331593.6/ ENSP00000327440.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AL365277.23        34398-34407
            11-1027             AY303954.1         1-1017
            1028-1028           AL365277.23        54665-54665
            1029-1171           AY303954.1         1019-1161
            1172-1172           AL365277.23        64280-64280
            1173-1233           AY303954.1         1163-1223
            1234-1234           AL365277.23        65174-65174
            1235-1702           AY303954.1         1225-1692
            1703-5205           AL365277.23        68698-72200
            5206-5636           BU616301.1         17-447              c
FEATURES             Location/Qualifiers
     source          1..5636
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..5636
                     /gene="BMP8A"
                     /gene_synonym="OP-2; Op2"
                     /note="bone morphogenetic protein 8a"
                     /db_xref="GeneID:353500"
                     /db_xref="HGNC:HGNC:21650"
                     /db_xref="MIM:620847"
     exon            1..690
                     /gene="BMP8A"
                     /gene_synonym="OP-2; Op2"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..1565
                     /gene="BMP8A"
                     /gene_synonym="OP-2; Op2"
                     /note="BMP-8A"
                     /codon_start=1
                     /product="bone morphogenetic protein 8A preproprotein"
                     /protein_id="NP_861525.2"
                     /db_xref="CCDS:CCDS437.1"
                     /db_xref="GeneID:353500"
                     /db_xref="HGNC:HGNC:21650"
                     /db_xref="MIM:620847"
                     /translation="MAARPGPLWLLGLTLCALGGGGPGLRPPPGCPQRRLGARERRDV
                     QREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAEQRLGRA
                     DLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRT
                     LHVSMFQVVQEQSNRESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRL
                     YVETEDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKS
                     NELPQANRLPGIFDDVRGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGEC
                     SFPLDSCMNATNHAILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRKHR
                     NMVVKACGCH"
     exon            691..880
                     /gene="BMP8A"
                     /gene_synonym="OP-2; Op2"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1029
                     /gene="BMP8A"
                     /gene_synonym="OP-2; Op2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1224
                     /gene="BMP8A"
                     /gene_synonym="OP-2; Op2"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1304
                     /gene="BMP8A"
                     /gene_synonym="OP-2; Op2"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1415
                     /gene="BMP8A"
                     /gene_synonym="OP-2; Op2"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..5636
                     /gene="BMP8A"
                     /gene_synonym="OP-2; Op2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5613..5618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMP8A"
                     /gene_synonym="OP-2; Op2"
                     /note="hexamer: ATTAAA"
     polyA_site      5636
                     /gene="BMP8A"
                     /gene_synonym="OP-2; Op2"
                     /note="major polyA site"
ORIGIN      
        1 gcgccgcccg ggtcgctgcc ggagctcgcc ggtcgcccct gcgctgcgcg gaccgcagcc
       61 acagccggac tggtgggaac ggcggcgaca gacggattgg ctgacagtcc cagccctcag
      121 aacagccccg gcctcgaagc gttggcgtct gcgtccgcgt cagcgtccgc ttgtcccgga
      181 gccggggcag gtgcgcgcgg ggggcgctcc agggaccgcg ctgaggccgc agacgccgcc
      241 cgccgagccc cgccccctgc tcgccgaact cagctccccg ttcgccgtcg gggcgtcccc
      301 gggcccaggg gcggcggcgg agctgatgtg cgcccgctga gcgcccccgg cccgccatgg
      361 ccgcgcgccc cggaccgctc tggcttctgg gcctgacgtt gtgcgcgctg ggcgggggcg
      421 gccccggcct gcgacccccg cccggctgtc cccagcgacg tctgggcgcg cgcgagcgcc
      481 gggacgtgca gcgcgagatc ctggcggtgc tcgggctacc cgggcggccc cggccccgcg
      541 cgccacccgc cgcctcccgg ctgcccgcgt ccgcgccgct cttcatgctg gacctgtacc
      601 acgccatggc tggcgacgac gacgaggacg gcgcgcccgc ggagcagcgc ctgggccgcg
      661 ccgacctggt catgagcttc gtcaacatgg tggagcgaga ccgtgccctg ggccaccagg
      721 agccccattg gaaggagttc cgctttgacc tgacccagat cccggctggg gaggcggtca
      781 cagctgcgga gttccggatt tacaaggtgc ccagcatcca cctgctcaac aggaccctcc
      841 acgtcagcat gttccaggtg gtccaggagc agtccaacag ggagtctgac ttgttctttt
      901 tggatcttca gacgctccga gctggagacg agggctggct ggtgctggat gtcacagcag
      961 ccagtgactg ctggttgctg aagcgtcaca aggacctggg actccgcctc tatgtggaga
     1021 ctgaggacgg gcacagcgtg gatcctggcc tggccggcct gctgggtcaa cgggccccac
     1081 gctcccaaca gcctttcgtg gtcactttct tcagggccag tccgagtccc atccgcaccc
     1141 ctcgggcagt gaggccactg aggaggaggc aaccgaagaa aagcaacgag ctgccgcagg
     1201 ccaaccgact cccagggatc tttgatgacg tccgcggctc ccacggccgg caggtctgcc
     1261 gtcggcacga gctctacgtc agcttccagg accttggctg gctggactgg gtcatcgccc
     1321 cccaaggcta ctcagcctat tactgtgagg gggagtgctc cttcccgctg gactcctgca
     1381 tgaacgccac caaccacgcc atcctgcagt ccctggtgca cctgatgaag ccaaacgcag
     1441 tccccaaggc gtgctgtgca cccaccaagc tgagcgccac ctctgtgctc tactatgaca
     1501 gcagcaacaa cgtcatcctg cgcaagcacc gcaacatggt ggtcaaggcc tgcggctgcc
     1561 actgagtcag cccgcccagc cctactgcag ccacccttct catctggatc gggccctgca
     1621 gaggcagaaa acccttaaat gctgtcacag ctcaagcagg agtgtcaggg gccctcactc
     1681 tcggtgccta cttcctgtca ggcttctggt cctttctcgg tacctctgtg cccctcccct
     1741 ggggtttgtg gctgtcactc tgcccgacac tttggtggcc taaggcacac agcagcctca
     1801 gagcctgtgc tgactgcact gtctggagtc agcacagaag tcctatctta ggacctgtca
     1861 gactgtggct ggccccggat ggtctgaggt tggctgaccc gagcttttct ccattcacca
     1921 gagggtttag gtgtgaggag aagggctctg cctcttccca ggtacaacac tggccatttc
     1981 tgggcaaaat tggacacgct tatgttctca gcacagtgtg ttctgggatt cttctcattt
     2041 ggtccagggt gcagttagca tattagaaaa agaataagct ggacatcccc acgaagccac
     2101 tggggatttt tttttttttt ttccagatag agtctcactc tgtcacccag gctggagtgc
     2161 agtggtgcaa tcctggctca ctgcaacctc tgcctcccag gttcaagcaa ttctcgtgcc
     2221 tcagcctcct gagtagctgg gattacaggg gcccaccacc acgcccagct cattcttgta
     2281 tttttagtag agacggggtt tcaccatatc ggccaggctg gtcttgaact cctgacctca
     2341 ggtgatccac ccgcccggcc tcccaaagtg ttgggatgac aggcatgagc caccgtgcct
     2401 ggccactggg gatattttat gtcatgtgta ttcccttgcc ctgggcctgc cccttctcct
     2461 gcctgggaaa gaggtatgac tcccacagga gcaaagaatc ctgggggctt ccagttccct
     2521 ccaccatctc taccatgctg acccatttgg ggctcagcac tgagacagag gcaagaccag
     2581 cagctccaac atgtagtgta ggctggcaca gagcaaatgc ccccgcagcc tgctcccctt
     2641 gcccatggct catgtcagta atcaacctac gtacctttcc cactgaacca ggacagggcc
     2701 tccaggcctc agcacagaac tgcagacagc caccaccagg cattgtcaat aagacctcag
     2761 ttccccctcc tgccccactg cagagcaatc cattccatcc aaagcagggt gactggcagt
     2821 ctccggccag gcatggggca agggtgggga ctgccagtgt ttgcttgtgt ctaggagtta
     2881 tgaacaagct ggccaccaaa attggcgtca ccctgggtgc ccaccagcgc tgtcctgtgt
     2941 cttgggtctg tgagtcaaag aaaaggtccc tgtcccaggg agtgacaggc agtaattagg
     3001 ctgagttggg tggggaggtt tgtctcggcc tccactgttc ccggaaaccg ctgttctcct
     3061 tggaacagcc actgggagtt ggagtgttta tttgatttct gacttgctaa gcctgtaatt
     3121 tacctgctgg aacagacaga gtccagctgc ccaaaccgtg tcattaaaag cagatcctgg
     3181 gcccgcccca tccacaggca cagcctggca gagtggttcc acctccccat gggcccaagg
     3241 atgcgcctct ctggagttca cgtgctgcac ccccagggag gggcctgggg agagctggtc
     3301 cagcagcagg ggtggaggct ggggccacac tgcgggacag cagcccctcc acctggacca
     3361 gggagggcct ccatgtgcaa gcgcagagga agagaccctc tcatgtacat aaagggtggg
     3421 cccaggctgt ctggaagatg gtgagttccc cactagtcta aggcttcaag ctcagctagc
     3481 agagattgga agaggcaatg gcctgagtgt taggagacag gtattctggt tccaactcag
     3541 ccactgactt ggtgtcagga caagtcccct ttcttattca cgcttcagtt tctcatctgc
     3601 aacatgagga cataggactc tttaattcca aaggctcttc caacccagag aacccatctg
     3661 cccccatgac cttctcccag agcttgagac atggcctgag ccccctgctg ccataggact
     3721 tggggcctat ctgccattgc aggacctgat ttaacagctc tcttcttcca atactgggca
     3781 gtagagtttc ggaaactgac aaatgtgtgg tctcttcagt gcccagtgtg taacctggca
     3841 tggtttgggt gtgctaggag tttgtgaaat gaatgttttc aagacgcaaa cgctgctatg
     3901 cccatcaggt gtgcacagca ggcctgagga tcatgatgag actccctttt tatgcagcaa
     3961 agcacaaagt gtgacagtcg tggccttcct ggtggccaga cttctagcaa ctttagccac
     4021 ccaccaaatg acatcacata cagaaggcct cagaaaggga ggaggtcgta aggacacaca
     4081 gctgatgaag ggtcagtgct cagctatcaa ggtcatcttc tggcctggtt gcctcccaca
     4141 gcccaggatg cattcaaggc tgcacatcag gagcataaat aagggtggtc agctcaggcc
     4201 cactggctgc aacaagtagc cactgacagg gagtctgggg ccatttggtg cagaacaacc
     4261 cccaacccag tggccatctt cacaactgca gcacagtgct ggccctaatg ccaggtgagc
     4321 gtgcaaagtc ctgtttcttt gtctttacat agggaccggg cgatgcgctt tagagaaatt
     4381 ccctattatt tcacaggaaa ggaggctgtg aaaaggagag ggcaggtttt ggagccaagt
     4441 cgacctggca tcaggtcctg gctgcctttt tttttttttt tttaaagaca tacatggtct
     4501 tgctttgtcg cccaggctgg agtgcagtgg cagtgtcatg gctcactgca gcctcaacct
     4561 gctgggctca agcaatcctc ccacttcagc ccgagttgct gggatgacag gcacacgcca
     4621 ccatacccag ctaattttta aattttttat agaaaccagg tctcactatg ttgcccaggc
     4681 cggtcttaaa ctttgcccag gccagtcttg aactcctgag ctcaagcaat cctcctgcct
     4741 cagcctccca aagtgctagg attacaggcg tgagccactt acccggcctc tgcctcttgt
     4801 taatttgacc acatcatgta cctgctgtgc ccgttccttc ctccgtagaa gagggtgctg
     4861 gtcctgccct tttgaggcct ccatgagggc caaatgtgcc atgggacact tagtgccatg
     4921 cctgcgcaga cctgtggaat aaacagcaat tctgagcagg ctcattttaa agggacttgc
     4981 aaatttgggc gttccttgtg tgccttcctc ataaaaccca ctcctcccag aatatgctta
     5041 gaggtgctgc tgtatttacc tgagagctat gcttttcatc aaaaacctaa acgtgatcat
     5101 ctcttggatg aggtgtggcc ctgcacactc gcctgctcgt ggaaggagtc tgggccagca
     5161 gtgacccacg cgctagggtc tctgctgagg aagtggcagg tgtgcggccc tgccctggcc
     5221 ccgtagtgag tgtggggccc acctgtgccc tcatgggcag ctgaaggggg agctttctac
     5281 cccaggttcc tttccttact gaaaagtctt gagcaaacag ttgccgctct ccaccccctg
     5341 ctttttaaaa aaaatttttt ctcacgtaag aaaatgttat ctgtgtgctg gggaaaattt
     5401 tgaaaataac aaaaaccaga atacaaacac ccataatcaa tcacagagat aaccactgtt
     5461 cataattcct tccagtcttc ttacttggca catatacatt tgtctttctt tatatatgac
     5521 atatggatat tttacaaagt taggatccta ctctatgcac tgcttggtga tcggatctat
     5581 tcaatgtaca aaatattttg aaagtttctg tgattaaatg ttctttgaaa acataa
//
