LOCUS       NM_001719               4021 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens bone morphogenetic protein 7 (BMP7), mRNA.
ACCESSION   NM_001719
VERSION     NM_001719.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4021)
  AUTHORS   Salama,M.A., Anwar Ismail,A., Islam,M.S., K,G. AR, Al Kawas,S.,
            Samsudin,A.R. and A,C. SA.
  TITLE     Impact of Bone Morphogenetic Protein 7 and Prostaglandin receptors
            on osteoblast healing and organization of collagen
  JOURNAL   PLoS One 19 (5), e0303202 (2024)
   PUBMED   38753641
  REMARK    GeneRIF: Impact of Bone Morphogenetic Protein 7 and Prostaglandin
            receptors on osteoblast healing and organization of collagen.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4021)
  AUTHORS   Sun,K. and Liu,R.
  TITLE     Genetic predisposition of BMP7 polymorphisms to lumbar disk
            herniation in the Chinese Han population
  JOURNAL   Cell Cycle 23 (4), 466-477 (2024)
   PUBMED   38651735
  REMARK    GeneRIF: Genetic predisposition of BMP7 polymorphisms to lumbar
            disk herniation in the Chinese Han population.
REFERENCE   3  (bases 1 to 4021)
  AUTHORS   Qu,X., Huang,D., Zhou,X. and Ruan,W.
  TITLE     SCUBE1 promotes pulmonary artery smooth muscle cell proliferation
            and migration in acute pulmonary embolism by modulating BMP7
  JOURNAL   PeerJ 12, e16719 (2024)
   PUBMED   38259670
  REMARK    GeneRIF: SCUBE1 promotes pulmonary artery smooth muscle cell
            proliferation and migration in acute pulmonary embolism by
            modulating BMP7.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4021)
  AUTHORS   Vasan,R., Yadav,J., Aiyappa-Maudsley,R., Deen,S., Storr,S.J. and
            Martin,S.G.
  TITLE     High BMP7 expression is associated with poor prognosis in ovarian
            cancer
  JOURNAL   J Cell Mol Med 27 (21), 3378-3387 (2023)
   PUBMED   37688374
  REMARK    GeneRIF: High BMP7 expression is associated with poor prognosis in
            ovarian cancer.
REFERENCE   5  (bases 1 to 4021)
  AUTHORS   Boon,M.R., van der Horst,G., van der Pluijm,G., Tamsma,J.T.,
            Smit,J.W. and Rensen,P.C.
  TITLE     Bone morphogenetic protein 7: a broad-spectrum growth factor with
            multiple target therapeutic potency
  JOURNAL   Cytokine Growth Factor Rev 22 (4), 221-229 (2011)
   PUBMED   21924665
  REMARK    GeneRIF: the involvement of BMP7 in several pathological
            conditions, such as incomplete fracture healing, osteoarthritis,
            the development of bone metastases, renal fibrosis and obesity.
            Review article
REFERENCE   6  (bases 1 to 4021)
  AUTHORS   Helder,M.N., Ozkaynak,E., Sampath,K.T., Luyten,F.P., Latin,V.,
            Oppermann,H. and Vukicevic,S.
  TITLE     Expression pattern of osteogenic protein-1 (bone morphogenetic
            protein-7) in human and mouse development
  JOURNAL   J Histochem Cytochem 43 (10), 1035-1044 (1995)
   PUBMED   7560881
REFERENCE   7  (bases 1 to 4021)
  AUTHORS   Liu,F., Ventura,F., Doody,J. and Massague,J.
  TITLE     Human type II receptor for bone morphogenic proteins (BMPs):
            extension of the two-kinase receptor model to the BMPs
  JOURNAL   Mol Cell Biol 15 (7), 3479-3486 (1995)
   PUBMED   7791754
REFERENCE   8  (bases 1 to 4021)
  AUTHORS   Hahn,G.V., Cohen,R.B., Wozney,J.M., Levitz,C.L., Shore,E.M.,
            Zasloff,M.A. and Kaplan,F.S.
  TITLE     A bone morphogenetic protein subfamily: chromosomal localization of
            human genes for BMP5, BMP6, and BMP7
  JOURNAL   Genomics 14 (3), 759-762 (1992)
   PUBMED   1427904
REFERENCE   9  (bases 1 to 4021)
  AUTHORS   Celeste,A.J., Iannazzi,J.A., Taylor,R.C., Hewick,R.M., Rosen,V.,
            Wang,E.A. and Wozney,J.M.
  TITLE     Identification of transforming growth factor beta family members
            present in bone-inductive protein purified from bovine bone
  JOURNAL   Proc Natl Acad Sci U S A 87 (24), 9843-9847 (1990)
   PUBMED   2263636
REFERENCE   10 (bases 1 to 4021)
  AUTHORS   Ozkaynak,E., Rueger,D.C., Drier,E.A., Corbett,C., Ridge,R.J.,
            Sampath,T.K. and Oppermann,H.
  TITLE     OP-1 cDNA encodes an osteogenic protein in the TGF-beta family
  JOURNAL   EMBO J 9 (7), 2085-2093 (1990)
   PUBMED   2357959
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA740733.1, AK291186.1,
            AL157414.19 and BM683430.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001719.2.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer, which plays a role in bone, kidney and
            brown adipose tissue development. Additionally, this protein
            induces ectopic bone formation and may promote fracture healing in
            human patients. [provided by RefSeq, Jul 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.2558310.1,
                                           SRR7346977.1462537.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395863.8/ ENSP00000379204.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-429               DA740733.1         11-439
            430-2179            AK291186.1         16-1765
            2180-3418           AL157414.19        102424-103662       c
            3419-4021           BM683430.1         19-621              c
FEATURES             Location/Qualifiers
     source          1..4021
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.31"
     gene            1..4021
                     /gene="BMP7"
                     /gene_synonym="OP-1"
                     /note="bone morphogenetic protein 7"
                     /db_xref="GeneID:655"
                     /db_xref="HGNC:HGNC:1074"
                     /db_xref="MIM:112267"
     exon            1..937
                     /gene="BMP7"
                     /gene_synonym="OP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             520..1815
                     /gene="BMP7"
                     /gene_synonym="OP-1"
                     /note="osteogenic protein 1"
                     /codon_start=1
                     /product="bone morphogenetic protein 7 preproprotein"
                     /protein_id="NP_001710.1"
                     /db_xref="CCDS:CCDS13455.1"
                     /db_xref="GeneID:655"
                     /db_xref="HGNC:HGNC:1074"
                     /db_xref="MIM:112267"
                     /translation="MHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHR
                     RLRSQERREMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGGQG
                     FSYPYKAVFSTQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDL
                     SKIPEGEAVTAAEFRIYKDYIRERFDNETFRISVYQVLQEHLGRESDLFLLDSRTLWA
                     SEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPF
                     MVAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHE
                     LYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETVP
                     KPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH"
     exon            938..1130
                     /gene="BMP7"
                     /gene_synonym="OP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1279
                     /gene="BMP7"
                     /gene_synonym="OP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1477
                     /gene="BMP7"
                     /gene_synonym="OP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1554
                     /gene="BMP7"
                     /gene_synonym="OP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1665
                     /gene="BMP7"
                     /gene_synonym="OP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..4021
                     /gene="BMP7"
                     /gene_synonym="OP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2259..2264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMP7"
                     /gene_synonym="OP-1"
                     /note="hexamer: AATAAA"
     polyA_site      2279
                     /gene="BMP7"
                     /gene_synonym="OP-1"
                     /note="major polyA site"
     regulatory      3996..4001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMP7"
                     /gene_synonym="OP-1"
                     /note="hexamer: AATAAA"
     polyA_site      4021
                     /gene="BMP7"
                     /gene_synonym="OP-1"
ORIGIN      
        1 actctggcgc tcccgaggcg gcctcttgtg cgatccaggg cgcacaaggc tgggagagcg
       61 ccccggggcc cctgctatcc gcgccggagg ttggaagagg gtgggttgcc gccgcccgag
      121 ggcgagagcg ccagaggagc gggaagaagg agcgctcgcc cgcccgcctg cctcctcgct
      181 gcctccccgg cgttggctct ctggactcct aggcttgctg gctgctcctc ccacccgcgc
      241 ccgcctcctc actcgccttt tcgttcgccg gggctgcttt ccaagccctg cggtgcgccc
      301 gggcgagtgc ggggcgaggg gcccggggcc agcaccgagc agggggcggg ggtccgggca
      361 gagcgcggcc ggccggggag gggccatgtc tggcgcgggc gcagcggggc ccgtctgcag
      421 caagtgaccg agcggcgcgg acggccgcct gccccctctg ccacctgggg cggtgcgggc
      481 ccggagcccg gagcccgggt agcgcgtaga gccggcgcga tgcacgtgcg ctcactgcga
      541 gctgcggcgc cgcacagctt cgtggcgctc tgggcacccc tgttcctgct gcgctccgcc
      601 ctggccgact tcagcctgga caacgaggtg cactcgagct tcatccaccg gcgcctccgc
      661 agccaggagc ggcgggagat gcagcgcgag atcctctcca ttttgggctt gccccaccgc
      721 ccgcgcccgc acctccaggg caagcacaac tcggcaccca tgttcatgct ggacctgtac
      781 aacgccatgg cggtggagga gggcggcggg cccggcggcc agggcttctc ctacccctac
      841 aaggccgtct tcagtaccca gggcccccct ctggccagcc tgcaagatag ccatttcctc
      901 accgacgccg acatggtcat gagcttcgtc aacctcgtgg aacatgacaa ggaattcttc
      961 cacccacgct accaccatcg agagttccgg tttgatcttt ccaagatccc agaaggggaa
     1021 gctgtcacgg cagccgaatt ccggatctac aaggactaca tccgggaacg cttcgacaat
     1081 gagacgttcc ggatcagcgt ttatcaggtg ctccaggagc acttgggcag ggaatcggat
     1141 ctcttcctgc tcgacagccg taccctctgg gcctcggagg agggctggct ggtgtttgac
     1201 atcacagcca ccagcaacca ctgggtggtc aatccgcggc acaacctggg cctgcagctc
     1261 tcggtggaga cgctggatgg gcagagcatc aaccccaagt tggcgggcct gattgggcgg
     1321 cacgggcccc agaacaagca gcccttcatg gtggctttct tcaaggccac ggaggtccac
     1381 ttccgcagca tccggtccac ggggagcaaa cagcgcagcc agaaccgctc caagacgccc
     1441 aagaaccagg aagccctgcg gatggccaac gtggcagaga acagcagcag cgaccagagg
     1501 caggcctgta agaagcacga gctgtatgtc agcttccgag acctgggctg gcaggactgg
     1561 atcatcgcgc ctgaaggcta cgccgcctac tactgtgagg gggagtgtgc cttccctctg
     1621 aactcctaca tgaacgccac caaccacgcc atcgtgcaga cgctggtcca cttcatcaac
     1681 ccggaaacgg tgcccaagcc ctgctgtgcg cccacgcagc tcaatgccat ctccgtcctc
     1741 tacttcgatg acagctccaa cgtcatcctg aagaaataca gaaacatggt ggtccgggcc
     1801 tgtggctgcc actagctcct ccgagaattc agaccctttg gggccaagtt tttctggatc
     1861 ctccattgct cgccttggcc aggaaccagc agaccaactg ccttttgtga gaccttcccc
     1921 tccctatccc caactttaaa ggtgtgagag tattaggaaa catgagcagc atatggcttt
     1981 tgatcagttt ttcagtggca gcatccaatg aacaagatcc tacaagctgt gcaggcaaaa
     2041 cctagcagga aaaaaaaaca acgcataaag aaaaatggcc gggccaggtc attggctggg
     2101 aagtctcagc catgcacgga ctcgtttcca gaggtaatta tgagcgccta ccagccaggc
     2161 cacccagccg tgggaggaag ggggcgtggc aaggggtggg cacattggtg tctgtgcgaa
     2221 aggaaaattg acccggaagt tcctgtaata aatgtcacaa taaaacgaat gaatgaaaat
     2281 ggttaggacg ttacagatat attttcctaa acaatttatc cccatttctc ggtttatcct
     2341 gatgcgtaaa cagaagctgt gtcaagtgga gggcggggag gtccctctcc attccctaca
     2401 gttttcatcc tgaggcttgc agaggcccag tgtttaccga ggtttgccca aatccaagat
     2461 ctagtgggag gggaaagagc aaatgtctgc tccgaggagg gcggtgtgtt gatctttgga
     2521 ggaaaaatat gttctgttgt tcagctggat ttgccgtggc agaaatgaaa ctaggtgtgt
     2581 gaaatacccg cagacatttg ggattggctt ttcacctcgc cccagtggta gtaaatccat
     2641 gtgaaattgc agaggggaca aggacagcaa gtaggatgga acttgcaact caaccctgtt
     2701 gttaagaagc accaatgggc cgggcacagt agctcccacc tgtaatccca gcactttggg
     2761 aggctgaggt gggcggatca tttgaggtca ggagttcgag accagcctgg ccaacatggt
     2821 gaaaccccat ctctactaaa aatacaaaaa ttagccgggc atggtggcac gcacctgtaa
     2881 tcccagctac tctggaggct gaggcaggag aattgcttga accccagagg tggaggttgc
     2941 agtgagccaa gatcgtccca ctgcactcca gcttgggtga caaaacaaga ctccatctca
     3001 aaagaaaaaa aaaacagcac caatgaagcc tagttctcca cgggagtggg gtgagcagga
     3061 gcactgcaca tcgccccagt ggaccctctg gtctttgtct gcagtggcat tccaaggctg
     3121 ggccctggca agggcacccg tggctgtctc ttcatttgca gaccctgatc agaagtctct
     3181 gcaaacaaat ttgctccttg aattaagggg gagatggcat aataggaggt ctgatgggtg
     3241 caggatgtgc tggacttaca ttgcaaatag aagccttgtt gagggtgaca tcctaaccaa
     3301 gtgtcccgat ttggaggtgg catttctgac gtggctcttg gtgtaagcct gccttgcctt
     3361 ggctggtgag tcccataaat agtatgcact cagcctccgg ccacaaacac aaggcctagg
     3421 ggagggctag actgtctgca aacgttttct gcatctgtaa agaaaacaag gtgatcgaaa
     3481 actgtggcca tgtggaaccc ggtcttgtgg gggactgttt ctccatcttg actcagacag
     3541 ttcctggaaa caccggggct ctgtttttat tttctttgat gtttttcttc tttagtagct
     3601 tgggctgcag cctccactct ctagtcactg gggaggagta ttttttgtta tgtttggttt
     3661 catttgctgg cagagctggg gctttttgtg tgatccctct tggtgtgagt tttctgaccc
     3721 aaccagcctc tggttagcat catttgtaca tttaaacctg taaatagttg ttacaaagca
     3781 aagagattat ttatttccat ccaaagctct tttgaacacc cccccccctt taatccctcg
     3841 ttcaggacga tgagcttgct ttccttcaac ctgtttgttt tcttatttaa gactatttat
     3901 taatggttgg accaatgtac tcacagctgt tgcgtcgagc agtccttagt gaaaattctg
     3961 tataaataga caaaatgaaa agggtttgac cttgcaataa aaggagacgt ttggttctgg
     4021 c
//
