LOCUS       NM_021073               3970 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens bone morphogenetic protein 5 (BMP5), transcript
            variant 1, mRNA.
ACCESSION   NM_021073
VERSION     NM_021073.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3970)
  AUTHORS   Jin,Y., Park,S., Park,S.Y., Lee,C.Y., Eum,D.Y., Shim,J.W.,
            Choi,S.H., Choi,Y.J., Park,S.J. and Heo,K.
  TITLE     G9a Knockdown Suppresses Cancer Aggressiveness by Facilitating Smad
            Protein Phosphorylation through Increasing BMP5 Expression in
            Luminal A Type Breast Cancer
  JOURNAL   Int J Mol Sci 23 (2), 589 (2022)
   PUBMED   35054776
  REMARK    GeneRIF: G9a Knockdown Suppresses Cancer Aggressiveness by
            Facilitating Smad Protein Phosphorylation through Increasing BMP5
            Expression in Luminal A Type Breast Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3970)
  AUTHORS   Correia,A.C.P., Calpe,S., Mostafavi,N., Hoefnagel,S.J.M.,
            Sancho-Serra,M.D.C., de Koning,P.S. and Krishnadath,K.K.
  TITLE     Detection of circulating BMP5 as a risk factor for Barrett's
            esophagus
  JOURNAL   Sci Rep 10 (1), 15579 (2020)
   PUBMED   32968094
  REMARK    GeneRIF: Detection of circulating BMP5 as a risk factor for
            Barrett's esophagus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3970)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3970)
  AUTHORS   Chen,E., Yang,F., He,H., Li,Q., Zhang,W., Xing,J., Zhu,Z.,
            Jiang,J., Wang,H., Zhao,X., Liu,R., Lei,L., Dong,J., Pei,Y.,
            Yang,Y., Pan,J., Zhang,P., Liu,S., Du,L., Zeng,Y. and Yang,J.
  TITLE     Alteration of tumor suppressor BMP5 in sporadic colorectal cancer:
            a genomic and transcriptomic profiling based study
  JOURNAL   Mol Cancer 17 (1), 176 (2018)
   PUBMED   30572883
  REMARK    GeneRIF: The tumor suppressor role of BMP5 highlights its crucial
            role in CRC initiation and development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3970)
  AUTHORS   Chen,E., Li,Q., Wang,H., Zhang,P., Zhao,X., Yang,F. and Yang,J.
  TITLE     MiR-32 promotes tumorigenesis of colorectal cancer by targeting
            BMP5
  JOURNAL   Biomed Pharmacother 106, 1046-1051 (2018)
   PUBMED   30119170
  REMARK    GeneRIF: Suggest a significant role of miR-32/BMP5 axis in
            colorectal cancer tumorigenesis.
REFERENCE   6  (bases 1 to 3970)
  AUTHORS   Wang,R.N., Green,J., Wang,Z., Deng,Y., Qiao,M., Peabody,M.,
            Zhang,Q., Ye,J., Yan,Z., Denduluri,S., Idowu,O., Li,M., Shen,C.,
            Hu,A., Haydon,R.C., Kang,R., Mok,J., Lee,M.J., Luu,H.L. and
            Shi,L.L.
  TITLE     Bone Morphogenetic Protein (BMP) signaling in development and human
            diseases
  JOURNAL   Genes Dis 1 (1), 87-105 (2014)
   PUBMED   25401122
REFERENCE   7  (bases 1 to 3970)
  AUTHORS   Sakaue,M., Kitazawa,S., Nishida,K., Kitazawa,R. and Maeda,S.
  TITLE     Molecular cloning and characterization of human bone morphogenic
            protein (BMP)-5 gene promoter
  JOURNAL   Biochem Biophys Res Commun 221 (3), 768-772 (1996)
   PUBMED   8630036
REFERENCE   8  (bases 1 to 3970)
  AUTHORS   Yamaji,N., Celeste,A.J., Thies,R.S., Song,J.J., Bernier,S.M.,
            Goltzman,D., Lyons,K.M., Nove,J., Rosen,V. and Wozney,J.M.
  TITLE     A mammalian serine/threonine kinase receptor specifically binds
            BMP-2 and BMP-4
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1944-1951 (1994)
   PUBMED   7811286
REFERENCE   9  (bases 1 to 3970)
  AUTHORS   Hahn,G.V., Cohen,R.B., Wozney,J.M., Levitz,C.L., Shore,E.M.,
            Zasloff,M.A. and Kaplan,F.S.
  TITLE     A bone morphogenetic protein subfamily: chromosomal localization of
            human genes for BMP5, BMP6, and BMP7
  JOURNAL   Genomics 14 (3), 759-762 (1992)
   PUBMED   1427904
REFERENCE   10 (bases 1 to 3970)
  AUTHORS   Celeste,A.J., Iannazzi,J.A., Taylor,R.C., Hewick,R.M., Rosen,V.,
            Wang,E.A. and Wozney,J.M.
  TITLE     Identification of transforming growth factor beta family members
            present in bone-inductive protein purified from bovine bone
  JOURNAL   Proc Natl Acad Sci U S A 87 (24), 9843-9847 (1990)
   PUBMED   2263636
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291559.1, BC027958.1,
            AK303576.1, DA833638.1, BE501543.1, BQ025899.1 and AL133386.3.
            
            On Nov 22, 2018 this sequence version replaced NM_021073.3.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer, which plays a role in bone and
            cartilage development. Polymorphisms in this gene may be associated
            with osteoarthritis in human patients. This gene is differentially
            regulated in multiple human cancers. This gene encodes distinct
            protein isoforms that may be similarly proteolytically processed.
            [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291559.1, SRR1803612.138757.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398, SAMEA2162568
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370830.4/ ENSP00000359866.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AK291559.1         1-13
            14-2185             BC027958.1         1-2172
            2186-2696           AK303576.1         1364-1874
            2697-3268           DA833638.1         69-640
            3269-3779           BE501543.1         1-511               c
            3780-3874           BQ025899.1         106-200             c
            3875-3878           AL133386.3         33315-33318
            3879-3970           BQ025899.1         14-105              c
FEATURES             Location/Qualifiers
     source          1..3970
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.1"
     gene            1..3970
                     /gene="BMP5"
                     /note="bone morphogenetic protein 5"
                     /db_xref="GeneID:653"
                     /db_xref="HGNC:HGNC:1072"
                     /db_xref="MIM:112265"
     exon            1..1215
                     /gene="BMP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             726..2090
                     /gene="BMP5"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="bone morphogenetic protein 5 isoform 1
                     preproprotein"
                     /protein_id="NP_066551.1"
                     /db_xref="CCDS:CCDS4958.1"
                     /db_xref="GeneID:653"
                     /db_xref="HGNC:HGNC:1072"
                     /db_xref="MIM:112265"
                     /translation="MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLR
                     NHERREIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVR
                     ASLAEETRGARKGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSF
                     VNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISI
                     YQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETG
                     DGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQD
                     SSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNA
                     HMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRS
                     CGCH"
     exon            1216..1408
                     /gene="BMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1557
                     /gene="BMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1752
                     /gene="BMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1829
                     /gene="BMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1940
                     /gene="BMP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..3970
                     /gene="BMP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2144..2149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMP5"
                     /note="hexamer: AATAAA"
     polyA_site      2185
                     /gene="BMP5"
     regulatory      3950..3955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMP5"
                     /note="hexamer: ATTAAA"
     polyA_site      3970
                     /gene="BMP5"
                     /note="major polyA site"
ORIGIN      
        1 actctttaga tctctcttga agagggctgg tatatttgtg cctgctggag gtggaattaa
       61 cagtaagaag gagaaaggga ttgaatggac ttacaggaag gatttcaagt aaattcaggg
      121 aaacacattt acttgaatag tacaacctag agtattattt tacactaaga cgacacaaaa
      181 gatgttaaag ttatcaccaa gctgccggac agatatatat tccaacacca aggtgcagat
      241 cagcatagat ctgtgattca gaaatcagga tttgttttgg aaagagctca agggttgaga
      301 agaactcaaa agcaagtgaa gattactttg ggaactacag tttatcagaa gatcaacttt
      361 tgctaattca aataccaaag gcctgattat cataaattca tataggaatg cataggtcat
      421 ctgatcaaat aatattagcc gtcttctgct acatcaatgc agcaaaaact cttaacaact
      481 gtggataatt ggaaatctga gtttcagctt tcttagaaat aactactctt gacatattcc
      541 aaaatattta aaataggaca ggaaaatcgg tgaggatgtt gtgctcagaa atgtcactgt
      601 catgaaaaat aggtaaattt gttttttcag ctactgggaa actgtacctc ctagaacctt
      661 aggttttttt tttttttaag aggacaagaa ggactaaaaa tatcaacttt tgcttttgga
      721 caaaaatgca tctgactgta tttttactta agggtattgt gggtttcctc tggagctgct
      781 gggttctagt gggttatgca aaaggaggtt tgggagacaa tcatgttcac tccagtttta
      841 tttatagaag actacggaac cacgaaagac gggaaataca aagggaaatt ctctctatct
      901 tgggtttgcc tcacagaccc agaccatttt cacctggaaa acaagcgtcc tctgcacctc
      961 tctttatgct ggatctctac aatgccatga ccaatgaaga aaatcctgaa gagtcggagt
     1021 actcagtaag ggcatccttg gcagaagaga ccagaggggc aagaaaggga tacccagcct
     1081 ctcccaatgg gtatcctcgt cgcatacagt tatctcggac gactcctctg accacccaga
     1141 gtcctcctct agccagcctc catgatacca actttctgaa tgatgctgac atggtcatga
     1201 gctttgtcaa cttagttgaa agagacaagg atttttctca ccagcgaagg cattacaaag
     1261 aatttcgatt tgatcttacc caaattcctc atggagaggc agtgacagca gctgaattcc
     1321 ggatatacaa ggaccggagc aacaaccgat ttgaaaatga aacaattaag attagcatat
     1381 atcaaatcat caaggaatac acaaataggg atgcagatct gttcttgtta gacacaagaa
     1441 aggcccaagc tttagatgtg ggttggcttg tctttgatat cactgtgacc agcaatcatt
     1501 gggtgattaa tccccagaat aatttgggct tacagctctg tgcagaaaca ggggatggac
     1561 gcagtatcaa cgtaaaatct gctggtcttg tgggaagaca gggacctcag tcaaaacaac
     1621 cattcatggt ggccttcttc aaggcgagtg aggtacttct tcgatccgtg agagcagcca
     1681 acaaacgaaa aaatcaaaac cgcaataaat ccagctctca tcaggactcc tccagaatgt
     1741 ccagtgttgg agattataac acaagtgagc aaaaacaagc ctgtaagaag cacgaactct
     1801 atgtgagctt ccgggatctg ggatggcagg actggattat agcaccagaa ggatacgctg
     1861 cattttattg tgatggagaa tgttcttttc cacttaacgc ccatatgaat gccaccaacc
     1921 acgctatagt tcagactctg gttcatctga tgtttcctga ccacgtacca aagccttgtt
     1981 gtgctccaac caaattaaat gccatctctg ttctgtactt tgatgacagc tccaatgtca
     2041 ttttgaaaaa atatagaaat atggtagtac gctcatgtgg ctgccactaa tattaaataa
     2101 tattgataat aacaaaaaga tctgtattaa ggtttatggc tgcaataaaa agcatacttt
     2161 cagacaaacg gggaatttcc taaaattagt ctggctcatt ttgactcttt tcctatgtac
     2221 aatatcatgt atatagtcat ttttatttat ttaaacgtat atattctctt ctgtggaggc
     2281 tttatcaata aaatctattt cataggccac tacattatac aatagatcat ctagtataat
     2341 tttcaatggg ttatgctgag tccattcaat tccatttcaa catttttttc taatacaatt
     2401 ttacataatt ttctgagatt agacagaact cctttgactg tttaatattg tggaaggaaa
     2461 ttgaataatt tagttatatt gtgccaatga aaaccatgat agaatattta tttagaaata
     2521 agacttaaaa aaataacaac ccaaacaaaa attcttggat aaacacaatt tctcttttag
     2581 agttcctgct tcattagata aagtgaaatg ttgaactgga tttgaataaa taaacggtag
     2641 gcagaacata gaagctgaaa gattgcacag aattgtttta actgtttgct ttaacagaag
     2701 tggtgtaact gtaggagcat gttccttttt ggcttgtgga ttgtagattt tgcaaagagc
     2761 tcaaagcttc aggagacagg cttgagcctg tgtccatagc tttccaagtt aacactaatt
     2821 gtagtacaac cttcttacct caaataaatc atgtctgcct attatctaga acactactgc
     2881 tgcagaattt ttttttcaga tttaaaaacc tagtccaaaa taaagaaaca tttacatgtg
     2941 ctccactttc ctccccacag gcaagagtca ctgcatgcgt aaaatgtaca agagcagaag
     3001 atgccgaaag aaccattttc tttagctctc ctttataact gagtttgctg attgatgtga
     3061 tgcaagggat tttatttaga agtaaaagca ctgaaactaa actggaggaa attaccaaaa
     3121 gtcccagaat ggctttgaca gaattgccat ttctaaagaa cagctgaaat tcatttttca
     3181 tatctttgag agtgagctca atgaaaacct tattttgtaa aggcattttg taaaccttct
     3241 tccaagcaca aataattcca aacaggaagg ttctgttgtg tgtgtgtgtg tgtgtgtgtc
     3301 tgtgtgtgca tgtgtgttct tccctctaaa attaatttat tttctctatc tattagaatg
     3361 ccctctaagg cctttcttta acacacactg actttttgaa gaatgatctt tagattgata
     3421 acttgctatt tatggtgact ctgtggttag gcttatttac cgttaatcta aagtattcat
     3481 aaagcaccat ttattaatca tccttttgga tctttcaaac caaacgtata ccaaaaatgt
     3541 cttcaaaaat gttatggctt tgtttgtaat tcgggtatat taaaatgttg ttttgaaata
     3601 cagtttatct taaagaaaat ttgacagtaa ctatattaag gggtacatta agtaatatat
     3661 ttttaattaa tggtgtacca ttgagagaat aagaaatgga agtctattgt tttattcttt
     3721 aaatgtgctg tttaaatata tttccatatt ttaaaatata ttaaacagat gctaatttct
     3781 gctgttcttg atttggttct ttatttaaaa ggaatacaaa atgtaagtat atcataaatt
     3841 gagacaataa gaatatttat caaatgtaaa ctgtttgtgg atcacatgat tctttatgtt
     3901 gttcttaatt gccaaaattg ttttttgtgt tgttaataat tatctcacta ttaaatgtgc
     3961 aaagcaacaa
//
