LOCUS       NM_001201               6087 bp    mRNA    linear   PRI 30-APR-2025
DEFINITION  Homo sapiens bone morphogenetic protein 3 (BMP3), mRNA.
ACCESSION   NM_001201
VERSION     NM_001201.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6087)
  AUTHORS   Sun,Z., Hu,J., Ren,W., Fang,Y., Hu,K., Yu,H., Liao,D., Liu,S.,
            Zhou,L., He,T. and Zhang,Y.
  TITLE     LncRNA SNHG3 regulates the BMSC osteogenic differentiation in bone
            metastasis of breast cancer by modulating the miR-1273g-3p/BMP3
            axis
  JOURNAL   Biochem Biophys Res Commun 594, 117-123 (2022)
   PUBMED   35081500
  REMARK    GeneRIF: LncRNA SNHG3 regulates the BMSC osteogenic differentiation
            in bone metastasis of breast cancer by modulating the
            miR-1273g-3p/BMP3 axis.
REFERENCE   2  (bases 1 to 6087)
  AUTHORS   Guo,H., Li,T., Peng,C., Mao,Q., Shen,B., Shi,M., Lu,H., Xiao,T.,
            Yang,A. and Liu,Y.
  TITLE     Overexpression of lncRNA A2M-AS1 inhibits cell growth and
            aggressiveness via regulating the miR-587/bone morphogenetic
            protein 3 axis in lung adenocarcinoma
  JOURNAL   Hum Exp Toxicol 41, 9603271221138971 (2022)
   PUBMED   36461613
  REMARK    GeneRIF: Overexpression of lncRNA A2M-AS1 inhibits cell growth and
            aggressiveness via regulating the miR-587/bone morphogenetic
            protein 3 axis in lung adenocarcinoma.
REFERENCE   3  (bases 1 to 6087)
  AUTHORS   Zeng,H.B., Dong,L.Q., Huang,Y.L., Xu,C., Zhao,X.H. and Wu,L.G.
  TITLE     USF2 reduces BMP3 expression via transcriptional activation of
            miR-34a, thus promoting osteogenic differentiation of BMSCs
  JOURNAL   J Bone Miner Metab 39 (6), 997-1008 (2021)
   PUBMED   34350522
  REMARK    GeneRIF: USF2 reduces BMP3 expression via transcriptional
            activation of miR-34a, thus promoting osteogenic differentiation of
            BMSCs.
REFERENCE   4  (bases 1 to 6087)
  AUTHORS   Song,B., Li,X., Xu,Q., Yin,S., Wu,S., Meng,X., Huang,C. and Li,J.
  TITLE     Inhibition of BMP3 increases the inflammatory response of
            fibroblast-like synoviocytes in rheumatoid arthritis
  JOURNAL   Aging (Albany NY) 12 (12), 12305-12323 (2020)
   PUBMED   32568738
  REMARK    GeneRIF: Inhibition of BMP3 increases the inflammatory response of
            fibroblast-like synoviocytes in rheumatoid arthritis.
REFERENCE   5  (bases 1 to 6087)
  AUTHORS   Wen,J., Liu,X., Qi,Y., Niu,F., Niu,Z., Geng,W., Zou,Z., Huang,R.,
            Wang,J. and Zou,H.
  TITLE     BMP3 suppresses colon tumorigenesis via ActRIIB/SMAD2-dependent and
            TAK1/JNK signaling pathways
  JOURNAL   J Exp Clin Cancer Res 38 (1), 428 (2019)
   PUBMED   31665064
  REMARK    GeneRIF: Results found that BMP3 gene was extensively
            hypermethylated and downregulated in colorectal cancer (CRC) and
            suggest that BMP3 acts as a tumor suppressor or has a growth
            rate-limiting role in CRC development and progression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6087)
  AUTHORS   Tabas,J.A., Zasloff,M., Wasmuth,J.J., Emanuel,B.S., Altherr,M.R.,
            McPherson,J.D., Wozney,J.M. and Kaplan,F.S.
  TITLE     Bone morphogenetic protein: chromosomal localization of human genes
            for BMP1, BMP2A, and BMP3
  JOURNAL   Genomics 9 (2), 283-289 (1991)
   PUBMED   2004778
REFERENCE   7  (bases 1 to 6087)
  AUTHORS   Paralkar,V.M., Nandedkar,A.K., Pointer,R.H., Kleinman,H.K. and
            Reddi,A.H.
  TITLE     Interaction of osteogenin, a heparin binding bone morphogenetic
            protein, with type IV collagen
  JOURNAL   J Biol Chem 265 (28), 17281-17284 (1990)
   PUBMED   2211625
REFERENCE   8  (bases 1 to 6087)
  AUTHORS   Dickinson,M.E., Kobrin,M.S., Silan,C.M., Kingsley,D.M.,
            Justice,M.J., Miller,D.A., Ceci,J.D., Lock,L.F., Lee,A.,
            Buchberg,A.M. et al.
  TITLE     Chromosomal localization of seven members of the murine TGF-beta
            superfamily suggests close linkage to several morphogenetic mutant
            loci
  JOURNAL   Genomics 6 (3), 505-520 (1990)
   PUBMED   1970330
REFERENCE   9  (bases 1 to 6087)
  AUTHORS   Rosen,V., Wozney,J.M., Wang,E.A., Cordes,P., Celeste,A., McQuaid,D.
            and Kurtzberg,L.
  TITLE     Purification and molecular cloning of a novel group of BMPs and
            localization of BMP mRNA in developing bone
  JOURNAL   Connect Tissue Res 20 (1-4), 313-319 (1989)
   PUBMED   2612162
REFERENCE   10 (bases 1 to 6087)
  AUTHORS   Wozney,J.M., Rosen,V., Celeste,A.J., Mitsock,L.M., Whitters,M.J.,
            Kriz,R.W., Hewick,R.M. and Wang,E.A.
  TITLE     Novel regulators of bone formation: molecular clones and activities
  JOURNAL   Science 242 (4885), 1528-1534 (1988)
   PUBMED   3201241
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093883.2.
            
            On May 21, 2020 this sequence version replaced NM_001201.4.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein suppresses osteoblast
            differentiation, and negatively regulates bone density, by
            modulating TGF-beta receptor availability to other ligands.
            [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M22491.1, BC117514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282701.4/ ENSP00000282701.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-893               AC093883.2         133705-134597
            894-1804            AC093883.2         148735-149645
            1805-6087           AC093883.2         156342-160624
FEATURES             Location/Qualifiers
     source          1..6087
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.21"
     gene            1..6087
                     /gene="BMP3"
                     /gene_synonym="BMP-3A"
                     /note="bone morphogenetic protein 3"
                     /db_xref="GeneID:651"
                     /db_xref="HGNC:HGNC:1070"
                     /db_xref="MIM:112263"
     exon            1..893
                     /gene="BMP3"
                     /gene_synonym="BMP-3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             578..1996
                     /gene="BMP3"
                     /gene_synonym="BMP-3A"
                     /note="bone morphogenetic protein 3 (osteogenic);
                     osteogenin; bone morphogenetic protein 3A"
                     /codon_start=1
                     /product="bone morphogenetic protein 3 preproprotein"
                     /protein_id="NP_001192.4"
                     /db_xref="CCDS:CCDS3588.1"
                     /db_xref="GeneID:651"
                     /db_xref="HGNC:HGNC:1070"
                     /db_xref="MIM:112263"
                     /translation="MAGASRLLFLWLGCFCVSLAQGERPKPPFPELRKAVPGDRTAGG
                     GPDSELQPQDKVSEHMLRLYDRYSTVQAARTPGSLEGGSQPWRPRLLREGNTVRSFRA
                     AAAETLERKGLYIFNLTSLTKSENILSATLYFCIGELGNISLSCPVSGGCSHHAQRKH
                     IQIDLSAWTLKFSRNQSQLLGHLSVDMAKSHRDIMSWLSKDITQLLRKAKENEEFLIG
                     FNITSKGRQLPKRRLPFPEPYILVYANDAAISEPESVVSSLQGHRNFPTGTVPKWDSH
                     IRAALSIERRKKRSTGVLLPLQNNELPGAEYQYKKDEVWEERKPYKTLQAQAPEKSKN
                     KKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPK
                     SFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFF
                     DENKNVVLKVYPNMTVESCACR"
     exon            894..1804
                     /gene="BMP3"
                     /gene_synonym="BMP-3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..6087
                     /gene="BMP3"
                     /gene_synonym="BMP-3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5318..5323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMP3"
                     /gene_synonym="BMP-3A"
                     /note="hexamer: ATTAAA"
     polyA_site      5340
                     /gene="BMP3"
                     /gene_synonym="BMP-3A"
                     /note="major polyA site"
     regulatory      5972..5977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMP3"
                     /gene_synonym="BMP-3A"
                     /note="hexamer: AATAAA"
     polyA_site      5992
                     /gene="BMP3"
                     /gene_synonym="BMP-3A"
                     /note="major polyA site"
     regulatory      6063..6068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMP3"
                     /gene_synonym="BMP-3A"
                     /note="hexamer: AATAAA"
     polyA_site      6087
                     /gene="BMP3"
                     /gene_synonym="BMP-3A"
ORIGIN      
        1 ctctctctct catacacaca cacacacgca cacacgcgcg cgcgcgcgcg cacacacaca
       61 cacacgtaca ctaaaaaact cggaccagcc gcgccgcagc tgctccaatc cctggaaaag
      121 gcaatcgagc gccctccgga ccgctgcgca cagccccggc tccgacctgg cgcccaaaac
      181 agagctagtc ctagtccctc gcgcggccag tttggccggg tgttcccaaa aataaagcga
      241 ggagggaagg tacagacaga tcttgaaaac acccgggcca cacacgccgc gacctacagc
      301 tctttctcag cgttggagtg gagacggcgc ccgcagcgcc ctgcgcgggt gaggtccgcg
      361 cagctgctgg ggaagagccc acctgtcagg ctgcgctggg tcagcgcagc aagtggggct
      421 ggccgctatc tcgctgcacc cggccgcgtc ccgggctccg tgcgccctcg ccccagctgg
      481 tttggagttc aaccctcggc tccgccgccg gctccttgcg ccttcggagt gtcccgcagc
      541 gacgccggga gccgacgcgc cgcgcgggta cctagccatg gctggggcga gcaggctgct
      601 ctttctgtgg ctgggctgct tctgcgtgag cctggcgcag ggagagagac cgaagccacc
      661 tttcccggag ctccgcaaag ctgtgccagg tgaccgcacg gcaggtggtg gcccggactc
      721 cgagctgcag ccgcaagaca aggtctctga acacatgctg cggctctatg acaggtacag
      781 cacggtccag gcggcccgga caccgggctc cctggaggga ggctcgcagc cctggcgccc
      841 tcggctcctg cgcgaaggca acacggttcg cagctttcgg gcggcagcag cagaaactct
      901 tgaaagaaaa ggactgtata tcttcaatct gacatcgcta accaagtctg aaaacatttt
      961 gtctgccaca ctgtatttct gtattggaga gctaggaaac atcagcctga gttgtccagt
     1021 gtctggagga tgctcccatc atgctcagag gaaacacatt cagattgatc tttctgcatg
     1081 gaccctcaaa ttcagcagaa accaaagtca actccttggc catctgtcag tggatatggc
     1141 caaatctcat cgagatatta tgtcctggct gtctaaagat atcactcaac tcttgaggaa
     1201 ggccaaagaa aatgaagagt tcctcatagg atttaacatt acgtccaagg gacgccagct
     1261 gccaaagagg aggttacctt ttccagagcc ttatatcttg gtatatgcca atgatgccgc
     1321 catttctgag ccagaaagtg tggtatcaag cttacaggga caccggaatt ttcccactgg
     1381 aactgttccc aaatgggata gccacatcag agctgccctt tccattgagc ggaggaagaa
     1441 gcgctctact ggggtcttgc tgcctctgca gaacaacgag cttcctgggg cagaatacca
     1501 gtataaaaag gatgaggtgt gggaggagag aaagccttac aagacccttc aggctcaggc
     1561 ccctgaaaag agtaagaata aaaagaaaca gagaaagggg cctcatcgga agagccagac
     1621 gctccaattt gatgagcaga ccctgaaaaa ggcaaggaga aagcagtgga ttgaacctcg
     1681 gaattgcgcc aggagatacc tcaaggtaga ctttgcagat attggctgga gtgaatggat
     1741 tatctccccc aagtcctttg atgcctatta ttgctctgga gcatgccagt tccccatgcc
     1801 aaagtctttg aagccatcaa atcatgctac catccagagt atagtgagag ctgtgggggt
     1861 cgttcctggg attcctgagc cttgctgtgt accagaaaag atgtcctcac tcagtatttt
     1921 attctttgat gaaaataaga atgtagtgct taaagtatac cctaacatga cagtagagtc
     1981 ttgcgcttgc agataacctg gcaaagaact catttgaatg cttaattcaa tcattagttt
     2041 atttttatgg acttcttcct gttttttttt tttttttttt tgcactgcca atgcattttg
     2101 tttcaaaaga ttatttctat agtcagaggg gaatgagcaa atagactgaa gattgccacc
     2161 aaggaaaaga actgtatttg tttctgaatg taacttaaag caagattttt agtaaatatg
     2221 gacatctatt tctctttttg taatcaaaca caacaactta tcaaactgtt tttagaactg
     2281 ttagagaaca cactggttta tttttgtaat gttctttgaa aacagaatgg agaagcagca
     2341 atagcttgtc atttatctca tttaatgact aatgggaaat agagaacaat ttcgcgtttt
     2401 gaattaggct tattgcctta gaatcctgag aaagtgctaa ataatcaact ctgatgtttt
     2461 tcttaagttc ttgagactct tgtttatcct tgtttttcct ccacaagtca ttgtctaagt
     2521 gtaatggaaa gtttatgctg agcgttagtg tgtatgtatg tgcgtacatg cgccaggtgc
     2581 ctgtgccctc tgtaggatgg tttgcttaat atggttttat aattcagttt acacaggatt
     2641 ctttattttt tttaattttg tattttggca aacaccattc agttataaga actttgccaa
     2701 atatgataga ataattcaag agcatataca gagagttacc acttgaccca gctatttaat
     2761 tgcaaataca gttgttttca tttcatttcc taccagaaaa aggaatcaga aacctagttt
     2821 ttgaaaacac aagtgtaatt cctcttttgt acttcttttt cacaaatgct tttatttatt
     2881 ctaaattgaa tttaaaaatc cttcctaaag ccattaactc tttaattctc ctgatatgcc
     2941 tttacttcct atgaagttat tggtagatgt tgaggcccaa aaactggtag aatattgaag
     3001 atcttcttaa atgaccaatt taaccataac caaatattga atatcattct tcagtcacat
     3061 ctaagtcagg cactttttca catagatcag ggcttttggc tcagtcacga aatctacaag
     3121 ttagcaaagc ttacaaaaca ttattcgtca ggtatgggaa tcaaatatag acacttgttt
     3181 gtctttgctt tccatttcta tgtgtcacat acatatatgt gtcctcttat aactttagtc
     3241 ttcaaaatta tttcaatatc cttcttctca ctatatttat ttgtgtgatg gaaatgcttt
     3301 caggccgtag atcattgttg gtgttaatct gtggttaatc ctcattttag ttccgtctta
     3361 tctgatactt agaaatatct cagccatttt ggaggctgtg cagtatcaga agacgtggag
     3421 tttgttctgt ctctgcctgt agctaattat ggtggttcag tcatttaata aatatgtttt
     3481 gagcatctat tttgtgaaag gcactgtgtt acctgtgtgt ctttagtgtc ctcactggta
     3541 aaatgaagag gctggccatg agctggaagg gttaagttta taattccagc tatttcacac
     3601 ccgtcttcct tgaaggaatg atagtgatag atataaaaac actgtaagtc cctcttttaa
     3661 taaactaaat gaaagaacat cctatacttc gctgtttgta aattagtatg gcattcgctt
     3721 tggtttaagt ggtattttat tgcaaaccca ttaaaagaat aactcatgaa aagaagctct
     3781 ttgacacctt ggggtacaca aatgttggtg tgggtgtgtg ttaattctgt gagtgagaca
     3841 caccagttct aaaaaaaatg agtgaagttc tggtgcctga gttaccatgc tttcttctag
     3901 ttcttacagt agcataaaat taaagattca aagtgagatg gaggataaaa ttacttttta
     3961 atacatgttc tcaaacattt gaaaataaaa gtatatgata gaagggggcc agagtgtggc
     4021 caccatcctg atcgtactgt ttttcaataa agaaaacttt ttcattggta gatttggtga
     4081 aattctaaat ttaggttttt ttctagagct gtatcaacca aaacttctgg caattcccag
     4141 tatcacttct tagccttctt atatccaaat gcctgtttat tacctttctt aatttgaatc
     4201 aatgcctagt tattacagat tgcaccccac aatggccaaa aacccactac ataataaaat
     4261 ttacaggtac taactagtta agattatatt ttaagtagca attgatataa aattacaaca
     4321 caatgaaaga acttgggtaa tctcttagca atggaaatag gttttaacca gcagtttttc
     4381 tgggtgcttt gtaactatca ttttactaat gaattgagga tgtattatgg tttaaattgg
     4441 aagagtttta ttcccaaaga ataaagcaag attatctttc agtagtagag attgaagtaa
     4501 atgtattaat attttaatta atacagattt actaagagta gttagaaaat ttagtaagtg
     4561 cctgttttac aaattgttag gtactagttt ctgtataatt cctacacaga agctttagaa
     4621 atctcctgat attaaattat taaattggca ttcatgaaaa gagaagctac aattataaac
     4681 tccatttgct aaatcatgca taatactctc tctctctctt cccccacaag taatctctct
     4741 accccatgca gtgtgcacac acacacacac acagtcagtt actgaaaaaa ataattcttt
     4801 ttcttttttt ttttaaatgg agtttcactc ttgtcgccca ggctggagtg cagtggcgtg
     4861 atctcggccc actgcaacct ccacctccca ggttcaagca gttctcctgc ctcagcctcc
     4921 tgagtagctg ggattacagg tgtccgccac catgcctggc taattttttt atttgataaa
     4981 aagaattctt tttctcaata actgttctct tgaattcaaa ttaagggact gccaaagtca
     5041 attagaatat tttaaaaata ctttgttgta acctgtgtaa ataatataca atttacagga
     5101 tttgggattg tagaacttaa actggaagac tggattcctc agatctcagg actataacat
     5161 tccagataaa tttttacatt ccctttgctg tatattaact gatgatcatt tatatgttaa
     5221 gattttttac cttaatattt ctgaataaaa ctcttattgc ccatttaata ttttcatagg
     5281 caatcaaatg tgagtaatac tgctaagagt ctgatttatt aaaaatattt gtataattca
     5341 ttcagtttag tttttcagtt tagtctttct gctttcactt ttctctgtgc taacaagtaa
     5401 ctaatgtctg ggcattgact tcttattgaa tcaaagttgg gttaggcata gctatgcaca
     5461 cctgatgtgt aagattaaag aagagattaa ataagaaatc ttgggtaagt tggacttttc
     5521 tgtatagctc ttttttcctc tgagttgtat tttaatgtag tttataagtg ataaaatgat
     5581 ccttgttttc taaaagccag tccttccctt cagctttcca cagtttctgt aaatgtttaa
     5641 tacttgtaca gtcaatggca attttaaata tatatatata tataatatat gtatatggaa
     5701 aaggttcaaa gatgctttta atttatttaa tgactattgc cttcctataa taataatttt
     5761 catccttaat tatgataata cttttagcaa gaaaaattcc tttttactac agtttttaga
     5821 tgcaaaatgc agtttggttc tttagtcaaa tccacttaga gggtatattg cagtgaaact
     5881 gtgaaggata cttcactacc aatgtataag ctttgttgaa tttgtatcat tttctttcag
     5941 taatgaaaag ctattcatta tacagtatgg aaataaaaat tgcttcattg accattcatt
     6001 tttacttatt gggaaatact atatttccag acattttcaa gtgtgctgca tttaaaagag
     6061 gtaataaagc ttaagcatag agttgaa
//
