LOCUS       NM_198892               8012 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens BMP2 inducible kinase (BMP2K), transcript variant 1,
            mRNA.
ACCESSION   NM_198892
VERSION     NM_198892.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8012)
  AUTHORS   Schor,S., Pu,S., Nicolaescu,V., Azari,S., Koivomagi,M., Karim,M.,
            Cassonnet,P., Saul,S., Neveu,G., Yueh,A., Demeret,C.,
            Skotheim,J.M., Jacob,Y., Randall,G. and Einav,S.
  TITLE     The cargo adapter protein CLINT1 is phosphorylated by the
            Numb-associated kinase BIKE and mediates dengue virus infection
  JOURNAL   J Biol Chem 298 (6), 101956 (2022)
   PUBMED   35452674
  REMARK    GeneRIF: The cargo adapter protein CLINT1 is phosphorylated by the
            Numb-associated kinase BIKE and mediates dengue virus infection.
REFERENCE   2  (bases 1 to 8012)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 8012)
  AUTHORS   Cendrowski,J., Kaczmarek,M., Mazur,M., Kuzmicz-Kowalska,K.,
            Jastrzebski,K., Brewinska-Olchowik,M., Kominek,A., Piwocka,K. and
            Miaczynska,M.
  TITLE     Splicing variation of BMP2K balances abundance of COPII assemblies
            and autophagic degradation in erythroid cells
  JOURNAL   Elife 9, e58504 (2020)
   PUBMED   32795391
  REMARK    GeneRIF: Splicing variation of BMP2K balances abundance of COPII
            assemblies and autophagic degradation in erythroid cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8012)
  AUTHORS   Song,X., Li,M., Wu,W., Dang,W., Gao,Y., Bian,R., Bao,R., Hu,Y.,
            Hong,D., Gu,J. and Liu,Y.
  TITLE     Regulation of BMP2K in AP2M1-mediated EGFR internalization during
            the development of gallbladder cancer
  JOURNAL   Signal Transduct Target Ther 5 (1), 154 (2020)
   PUBMED   32792513
  REMARK    GeneRIF: Regulation of BMP2K in AP2M1-mediated EGFR internalization
            during the development of gallbladder cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8012)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 8012)
  AUTHORS   Arikawa,T., Omura,K. and Morita,I.
  TITLE     Regulation of bone morphogenetic protein-2 expression by endogenous
            prostaglandin E2 in human mesenchymal stem cells
  JOURNAL   J Cell Physiol 200 (3), 400-406 (2004)
   PUBMED   15254968
  REMARK    GeneRIF: PGE2 produced by COX-2 increased BMP-2 expression via
            binding the EP4 receptor.
REFERENCE   7  (bases 1 to 8012)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   8  (bases 1 to 8012)
  AUTHORS   Kearns,A.E., Donohue,M.M., Sanyal,B. and Demay,M.B.
  TITLE     Cloning and characterization of a novel protein kinase that impairs
            osteoblast differentiation in vitro
  JOURNAL   J Biol Chem 276 (45), 42213-42218 (2001)
   PUBMED   11500515
REFERENCE   9  (bases 1 to 8012)
  AUTHORS   Hoffmann,A. and Gross,G.
  TITLE     BMP signaling pathways in cartilage and bone formation
  JOURNAL   Crit Rev Eukaryot Gene Expr 11 (1-3), 23-45 (2001)
   PUBMED   11693963
  REMARK    Review article
REFERENCE   10 (bases 1 to 8012)
  AUTHORS   Ueki,N., Oda,T., Kondo,M., Yano,K., Noguchi,T. and Muramatsu,M.
  TITLE     Selection system for genes encoding nuclear-targeted proteins
  JOURNAL   Nat Biotechnol 16 (13), 1338-1342 (1998)
   PUBMED   9853615
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC098818.3, AL137661.1,
            AL137275.1 and AC093841.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 11, 2020 this sequence version replaced NM_198892.1.
            
            Summary: This gene is the human homolog of mouse BMP-2-inducible
            kinase. Bone morphogenic proteins (BMPs) play a key role in
            skeletal development and patterning. Expression of the mouse gene
            is increased during BMP-2 induced differentiation and the gene
            product is a putative serine/threonine protein kinase containing a
            nuclear localization signal. Therefore, the protein encoded by this
            human homolog is thought to be a protein kinase with a putative
            regulatory role in attenuating the program of osteoblast
            differentiation. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.345670.1,
                                           SRR14038193.612100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000502613.3/ ENSP00000424668.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC098818.3         87666-87693
            29-1181             AL137661.1         37-1189
            1182-3834           AL137275.1         65-2717
            3835-8012           AC093841.3         9053-13230
FEATURES             Location/Qualifiers
     source          1..8012
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.21"
     gene            1..8012
                     /gene="BMP2K"
                     /gene_synonym="BIKE; HRIHFB2017"
                     /note="BMP2 inducible kinase"
                     /db_xref="GeneID:55589"
                     /db_xref="HGNC:HGNC:18041"
                     /db_xref="MIM:617648"
     exon            1..372
                     /gene="BMP2K"
                     /gene_synonym="BIKE; HRIHFB2017"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..3680
                     /gene="BMP2K"
                     /gene_synonym="BIKE; HRIHFB2017"
                     /EC_number="2.7.11.1"
                     /note="isoform a is encoded by transcript variant 1;
                     BMP-2-inducible protein kinase"
                     /codon_start=1
                     /product="BMP-2-inducible protein kinase isoform a"
                     /protein_id="NP_942595.1"
                     /db_xref="CCDS:CCDS47083.1"
                     /db_xref="GeneID:55589"
                     /db_xref="HGNC:HGNC:18041"
                     /db_xref="MIM:617648"
                     /translation="MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVF
                     AVGRHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKEL
                     SGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFC
                     DTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVE
                     EEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDG
                     NFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIP
                     SALPEPMTASEAAARKSQIKARITDTIGPTETSIAPRQRPKANSATTATPSVLTIQSS
                     ATPVKVLAPGEFGNHRPKGALRPGNGPEILLGQGPPQQPPQQHRVLQQLQQGDWRLQQ
                     LHLQHRHPHQQQQQQQQQQQQQQQQQQQQQQQQQQQHHHHHHHHLLQDAYMQQYQHAT
                     QQQQMLQQQFLMHSVYQPQPSASQYPTMMPQYQQAFFQQQMLAQHQPSQQQASPEYLT
                     SPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSVADKEAIANFTNQKNISNPPDMSGW
                     NPFGEDNFSKLTEEELLDREFDLLRSNRLEERASSDKNVDSLSAPHNHPPEDPFGSVP
                     FISHSGSPEKKAEHSSINQENGTANPIKNGKTSPASKDQRTGKKTSVQGQVQKGNDES
                     ESDFESDPPSPKSSEEEEQDDEEVLQGEQGDFNDDDTEPENLGHRPLLMDSEDEEEEE
                     KHSSDSDYEQAKAKYSDMSSVYRDRSGSGPTQDLNTILLTSAQLSSDVAVETPKQEFD
                     VFGAVPFFAVRAQQPQQEKNEKNLPQHRFPAAGLEQEEFDVFTKAPFSKKVNVQECHA
                     VGPEAHTIPGYPKSVDVFGSTPFQPFLTSTSKSESNEDLFGLVPFDEITGSQQQKVKQ
                     RSLQKLSSRQRRTKQDMSKSNGKRHHGTPTSTKKTLKPTYRTPERARRHKKVGRRDSQ
                     SSNEFLTISDSKENISVALTDGKDRGNVLQPEESLLDPFGAKPFHSPDLSWHPPHQGL
                     SDIRADHNTVLPGRPRQNSLHGSFHSADVLKMDDFGAVPFTELVVQSITPHQSQQSQP
                     VELDPFGAAPFPSKQ"
     exon            373..491
                     /gene="BMP2K"
                     /gene_synonym="BIKE; HRIHFB2017"
                     /inference="alignment:Splign:2.1.0"
     exon            492..597
                     /gene="BMP2K"
                     /gene_synonym="BIKE; HRIHFB2017"
                     /inference="alignment:Splign:2.1.0"
     exon            598..740
                     /gene="BMP2K"
                     /gene_synonym="BIKE; HRIHFB2017"
                     /inference="alignment:Splign:2.1.0"
     exon            741..862
                     /gene="BMP2K"
                     /gene_synonym="BIKE; HRIHFB2017"
                     /inference="alignment:Splign:2.1.0"
     exon            863..944
                     /gene="BMP2K"
                     /gene_synonym="BIKE; HRIHFB2017"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1077
                     /gene="BMP2K"
                     /gene_synonym="BIKE; HRIHFB2017"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1181
                     /gene="BMP2K"
                     /gene_synonym="BIKE; HRIHFB2017"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1261
                     /gene="BMP2K"
                     /gene_synonym="BIKE; HRIHFB2017"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1425
                     /gene="BMP2K"
                     /gene_synonym="BIKE; HRIHFB2017"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1703
                     /gene="BMP2K"
                     /gene_synonym="BIKE; HRIHFB2017"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1802
                     /gene="BMP2K"
                     /gene_synonym="BIKE; HRIHFB2017"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1987
                     /gene="BMP2K"
                     /gene_synonym="BIKE; HRIHFB2017"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2145
                     /gene="BMP2K"
                     /gene_synonym="BIKE; HRIHFB2017"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2256
                     /gene="BMP2K"
                     /gene_synonym="BIKE; HRIHFB2017"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..8012
                     /gene="BMP2K"
                     /gene_synonym="BIKE; HRIHFB2017"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7979..7984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMP2K"
                     /gene_synonym="BIKE; HRIHFB2017"
                     /note="hexamer: AATAAA"
     polyA_site      8012
                     /gene="BMP2K"
                     /gene_synonym="BIKE; HRIHFB2017"
                     /note="major polyA site"
ORIGIN      
        1 agctgcagcg gagccgcgga gcgggcggcg gggcccaggc tgtgcgcttg gggagcgcgg
       61 aatgtgaggc ttggcgggcc gcagcacgct cggacgggcc aggggcggcg acccctcgcg
      121 gacgcccggc tgcgcgccgg gccggggact tgcccttgca cgctccctgc gccctccagc
      181 tcgccggcgg gaccatgaag aagttctctc ggatgcccaa gtcggagggc ggcagcggcg
      241 gcggagcggc gggtggcggg gctggcgggg ccggggccgg ggccggctgc ggctccggcg
      301 gctcgtccgt gggggtccgg gtgttcgcgg tcggccgcca ccaggtcacc ctggaagagt
      361 cgctggccga aggtggattc tccacagttt tcctcgtgcg tactcacggt ggaatccgat
      421 gtgcattgaa gcgaatgtat gtcaataaca tgccagacct caatgtttgt aaaagggaaa
      481 ttacaattat gaaagagcta tctggtcaca aaaatattgt gggctatttg gactgtgctg
      541 ttaattcaat tagtgataat gtatgggaag tccttatctt aatggaatat tgtcgagctg
      601 gacaggtagt gaatcaaatg aataagaagc tacagacggg ttttacagaa ccagaagtgt
      661 tacagatatt ctgtgatacc tgtgaagctg ttgcaaggtt gcatcagtgt aagactccaa
      721 taattcaccg ggatctgaag gtagaaaata ttttgttgaa tgatggtggg aactatgtac
      781 tttgtgactt tggcagtgcc actaataaat ttcttaatcc tcaaaaagat ggagttaatg
      841 tagtagaaga agaaattaaa aagtatacaa ctctgtcata cagagcccct gaaatgatca
      901 acctttatgg agggaaaccc atcaccacca aggctgatat ctgggcactg ggatgtctac
      961 tctataaact ttgtttcttc actcttcctt ttggtgagag tcaggttgct atctgtgatg
     1021 gcaacttcac catcccagac aattctcgtt actcccgtaa catacattgc ttaataaggt
     1081 tcatgcttga accagatccg gaacatagac ctgatatatt tcaagtgtca tattttgcat
     1141 ttaaatttgc caaaaaggat tgtccagtct ccaacatcaa taattcttct attccttcag
     1201 ctcttcctga accgatgact gctagtgaag cagctgctag gaaaagccaa ataaaagcca
     1261 gaataacaga taccattgga ccaacagaaa cctcaattgc accaagacaa agaccaaagg
     1321 ccaactctgc tactactgcc actcccagtg tgctgaccat tcaaagttca gcaacacctg
     1381 ttaaagtcct tgctcctggt gaattcggta accatagacc aaaaggggca ctaagacctg
     1441 gaaatggccc tgaaatttta ttgggtcagg gacctcctca gcagccgcca cagcagcata
     1501 gagtactcca gcaactacag cagggagatt ggagattaca gcaactccat ttacagcatc
     1561 gtcatcctca ccagcagcag cagcagcagc agcagcaaca gcaacagcag cagcagcaac
     1621 agcaacagca gcagcagcag cagcagcagc agcaccacca ccaccaccac caccacctac
     1681 ttcaagatgc ttatatgcag cagtatcaac atgcaacaca gcagcaacag atgcttcaac
     1741 aacaattttt aatgcattcg gtatatcaac cacaaccttc tgcatcacag tatcctacaa
     1801 tgatgccgca gtatcagcag gctttctttc aacagcagat gctagctcaa catcagccgt
     1861 ctcaacaaca ggcatcacct gaatatctta cctcccctca agagttctca ccagccttag
     1921 tttcctacac ttcatcactt ccagctcagg ttggaaccat aatggactcc tcctatagtg
     1981 ccaataggtc agttgctgat aaagaggcca ttgcaaattt cacaaatcag aagaacatca
     2041 gcaatccacc tgatatgtca gggtggaatc cttttggaga ggataatttc tctaagttaa
     2101 cagaagagga actattggac agagaatttg accttctaag atcaaatagg ctcgaggaga
     2161 gagcatcctc agataagaat gtagactcac tttctgctcc acataaccat cctccagaag
     2221 atccttttgg ttctgttcct ttcatttctc attcaggttc tcctgaaaag aaagctgaac
     2281 attcatctat aaatcaagaa aatggcactg caaaccctat caagaacggt aaaacaagtc
     2341 cagcatctaa agatcagcgg actggaaaga aaacctcagt acagggtcaa gtgcaaaagg
     2401 ggaatgatga atctgaaagt gattttgaat cagatccccc ttctcctaag agcagtgaag
     2461 aggaagagca agatgatgaa gaagttcttc agggggaaca aggagatttt aatgatgatg
     2521 atactgaacc agaaaatctg ggtcataggc ctctcctcat ggattctgaa gatgaggaag
     2581 aagaggagaa acatagctct gattctgatt atgagcaggc taaagcaaag tacagtgaca
     2641 tgagctctgt ctacagagac agatctggca gtggaccaac ccaagatctt aatacaatac
     2701 tcctcacctc agcccaatta tcctctgatg ttgcagtgga gactcccaaa caggagtttg
     2761 atgtatttgg cgctgtcccc ttctttgcag tgcgtgctca acagccccag caagaaaaga
     2821 atgaaaagaa cctccctcaa cacaggtttc ctgctgcagg actggagcag gaggaatttg
     2881 atgtattcac aaaggcgcct tttagcaaga aggtgaatgt acaagaatgc catgcagtgg
     2941 ggcctgaggc acatactatc cctggttatc ccaaaagtgt agatgtattt ggctccactc
     3001 catttcagcc cttcctcaca tcaacaagta aaagtgaaag caatgaggac ctttttgggc
     3061 ttgtgccctt tgatgaaata acggggagcc agcagcaaaa agtcaaacag cgcagcttac
     3121 agaaactgtc ctctcgccaa aggcgcacaa agcaggatat gtccaaaagt aatgggaagc
     3181 ggcatcatgg cacgccaact agcacaaaga agactttgaa gcctacctat cgcactccag
     3241 agagggctcg caggcacaaa aaagtgggcc gccgagactc tcaaagtagc aatgaatttt
     3301 taaccatctc agactccaag gagaacatta gtgttgcact gactgatggg aaagataggg
     3361 ggaatgtctt acaacctgag gagagcctgt tggacccctt cggtgccaag cccttccatt
     3421 ctccagacct gtcatggcac cctccacatc agggcctgag cgacatccgt gctgatcaca
     3481 atactgtcct gccagggcgg ccaagacaaa attcactaca tgggtcattc catagtgcag
     3541 atgtattgaa aatggatgat tttggtgccg tgccctttac agaacttgtg gtgcaaagca
     3601 tcactccaca tcagtcccaa cagtcccaac cagtcgaatt agacccattt ggtgctgctc
     3661 catttccttc taaacagtag atacttctga tggattctcg gcattaactc ctgtttcaaa
     3721 aaagtgtgaa cagttttatg aatttgaaag aaaatttggt agctctttat agcattcatt
     3781 cttaaagatc agtcagaata ggtgatttct aaataaacca aatagaagaa tgaagtatct
     3841 ctacagggta gtaacttgat tcctcttcag gagaaaaggg agctaaattg caagctctaa
     3901 ctaagggttt ctgctactga catcacaaca cagaaatgca agtgtggtac ttccagtgaa
     3961 agcacatggc acctttctag gtgtgtagcc actgagaagg gacagtgaaa ctgttatttt
     4021 tgatatcaga atgtcatttt tatgtgcata tccctaaaat tagggttatt tctacataca
     4081 ctagttacac ttgtgaattt tttttaaggt ctcttttaat ttccagacag ttaaaaacaa
     4141 tctagttatc ttaaagcatt agaaagttat tatctggaga gtgcagagat ttcagtccat
     4201 acacctttct ccacaaagca gagccagaag taactgacta ttgtgcctaa aactctgttt
     4261 catttttaaa aacaagtgcc attaaaatgg aatatctaat gataagcata tgaaataatg
     4321 tgtaattagc tcaatttaac tattccacaa cttacatatt ccaaaacaat gttatacatg
     4381 ataaatatat ataatttttg tcagttaaaa caaattaaaa aaatggacta tcgtcgcaca
     4441 gaagcctaga acaaaaatat gaagagaaat atctgacatt tgtaaagaaa ttataagaag
     4501 aaaaaaagat acagaacaga aaacattcac tactttagaa acactttatg catggcttct
     4561 tgccccaaac ttttattgtg atggccctaa taaagcagat tattggaaaa attggaggac
     4621 aagggttgta taaaaatttt attttatgaa gaaaatatgt agcggaaact gaattttcaa
     4681 gacatttaca atgtgaaatc atgttgcatt taacaatgta ctttattagc aacttcacca
     4741 aatattcccc aagtcataag caacaattat ttttattagg ttttgggggg tggagtagtt
     4801 ttaataaagt gcacagaatg gtgacaccca caaagcctta tataaaggca ggattcatgc
     4861 atcctgctgc aagtacctct gcactaatat accagatcct aaaatgcata taaggtggac
     4921 tagcatctta attctgctag ttgattgtgt ctttactgaa aagaacccag ctaccaattt
     4981 gccttttttt acaccacaaa tcctaattag aaacttgagg ttttatagaa atcatttaat
     5041 gatagagatt acatatgtga attaatgtga atatagtatc tgtgcttcct gtgtctatga
     5101 ctattttaag atataattgt gctgcgctat cagattaaca tttggaagtt tctagaacag
     5161 ttaatgctat ttacagaaag gagtagaaac tcatcaactg gcactctctt tgatttttat
     5221 attttaaatt aactctcttc gatctcaaag tatattttac gagtaatttt attaggaatc
     5281 tcttatagtg ccccaatggg ataagctatt tgcctatttt cacagttctg aacttggaaa
     5341 gaagcaaagt atatgtaact aaaccacata tttgtctttt tattgctttt tcccttcttt
     5401 tatatgctaa atcaaatata gatttgtgga tagggaagca atatgtgaat cacaatgtag
     5461 cagaggcaga ccaagcatta cattattatt tagagctgga ctgcaccaat tacttgtcct
     5521 cgtgccaaag gcaaatatgt ttgcaccttt tttttttttt ctgattctca ggttgattaa
     5581 tactgctaat gcaaatgctc aagtagatgt ttaaaaactt tacaaaatag attcaagtga
     5641 tactttcttt taaaagtgaa gagttgatga ttacacatag taaattcatg aactacagta
     5701 ggtttgtatc aaacaatttt ttttaatgaa aatctgttga ggtgtacaca atatgcttct
     5761 tgattgtatt agtccttggt ctctgctaga cctcatgagt ttcatcattt agaaaagggg
     5821 tagaggatga actaatgtct ccttcagatg taaacatgaa atacctagag ttttacttgc
     5881 ttttcaatac actgaataat tttaaatgat tctgacactg atgtagaccc tttgacttat
     5941 aaattctgag gaaacaactg acagcataaa atatttacat tcttataaca cagcacagtg
     6001 actttcttct ttcaagattg tagctcagag aaaagataca ggattcaatt gggggttcaa
     6061 taggatagaa atggagagat tcctttgtgt tgtagtagag gcattttcct aaggagtata
     6121 gatttatact ttgcattttc attcatcatc ccccagaatc atggtcaagg tgtaggtcac
     6181 tccacacagc tgatgctcag gttattccct tgtgagaatt atgagaataa agctcccaag
     6241 atatgtgaaa gtgcttaaca cagtacctgg cacacagcac tcaataaaag tttggctcta
     6301 ttatgggatg gttcaattct ggtttaagga aggaagaaag gttattatat atgtaccact
     6361 aagcaaatat atatatatat atatatttgg ggtttttttt ccctaatatt atttgggtgt
     6421 cccctgtgct tctttaggat gtagttataa ctaaacctgt tatacttgaa catcactaag
     6481 agaagtaaat tattatgaag ctagcaaaaa tcttgaggcc aaagttgttt cttaacagct
     6541 ttaataatgc ttgttgattt tgaataatcc tttaaaaagt ggaccatttg cttattttaa
     6601 tatcacgtca gtaaaatgtt agtattaaaa agatcagctt tttatggcat tgaagaatgt
     6661 atctgctaag acacaaaaat tgcatggtaa gtataatagg tggaggagga aaggttgtag
     6721 gccggatgaa aatttaactg actagaacat ttattcagga gtgtaattat tttcccttac
     6781 cccaatccct gtgtacgtgt tgggtatagt tacgacatta tccggatttg caaatagaca
     6841 caactttcag tcttaccctg tttattgttt aagagtgata gactgttgtc ctcttgctgg
     6901 tggaaaatct aaggtggagc ccactcttct atgctgaagt tcaccaggca gagcagtttt
     6961 cttacaagtc agctactctg cttggtttat tttaggtttt ggtacttcac gtaagcactg
     7021 ttagaaggta caagtgtatt aatatcacta gttttgaggc gcttgggtac atttgttttt
     7081 aatatattta gaatgtgcag taaacttttt tctcattttt ttttcttttt agcaaacttg
     7141 ttattttagg tccaattatt gagttgacag tctactgtga gaatgagatg acatatctac
     7201 tgtgagaata ccataaatga tgaatagttt atttgagaac ttttatactc agtggtgttt
     7261 tatatattaa gataaaaata tgtacacaca tgcatgtcac atctctctac tgtggagtta
     7321 atgtgaattt ttaaaaaatg gaattgcaac cacaatcata tctaagagaa cattcactcc
     7381 tagtgagggt ttacaaaagc tactaagaga ataaggtaga tgataatgca aagggtcatg
     7441 atttggggtt atttttgttt tattttaaaa tttatactgc tacttttgaa agaattgttt
     7501 ttatgactat gctctttttg tgattgaaaa gtcatctaat agaagctgta tagaagctac
     7561 tttttaattg ctggcaaaca gctttaagtg cactttcttt gattacactt ccattttttg
     7621 ttaaacttga attttctgaa gccttttatg taccactaag caaataactt taacctttaa
     7681 ataaagcaaa tttacatctt tattgtattt ctacttgtta caaaacatac ttgctaaagt
     7741 aacttcagtc ctcaaatata gctgggaaac aattatgaga tagactcagt ctccccctcc
     7801 cacccctttt cccctgccat atctaattaa gcactaactg attttattac tttattgcct
     7861 ttacactgct tattcttttt gactgaattc tgtccctgat tcactgtttt gtttgaaatt
     7921 taaagttatt ttcttactgt atttatcata cctgttttaa tctgttttct ttaaatgcaa
     7981 taaatcccaa atggattgca tattctttat aa
//
