LOCUS       NM_001200               3545 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens bone morphogenetic protein 2 (BMP2), mRNA.
ACCESSION   NM_001200
VERSION     NM_001200.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3545)
  AUTHORS   Kang,R., Huang,L., Zeng,T., Ma,J. and Jin,D.
  TITLE     Long non-coding TRPM2-AS regulates fracture healing by targeting
            miR-545-3p/Bmp2
  JOURNAL   J Orthop Surg Res 19 (1), 466 (2024)
   PUBMED   39118176
  REMARK    GeneRIF: Long non-coding TRPM2-AS regulates fracture healing by
            targeting miR-545-3p/Bmp2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3545)
  AUTHORS   Mu,X., Ono,M., Nguyen,H.T.T., Wang,Z., Zhao,K., Komori,T.,
            Yonezawa,T., Kuboki,T. and Oohashi,T.
  TITLE     Exploring the Regulators of Keratinization: Role of BMP-2 in Oral
            Mucosa
  JOURNAL   Cells 13 (10), 807 (2024)
   PUBMED   38786031
  REMARK    GeneRIF: Exploring the Regulators of Keratinization: Role of BMP-2
            in Oral Mucosa.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3545)
  AUTHORS   Zhu,Q., Zhang,X., Lu,F., Miao,S., Zhang,C., Liu,Z., Gao,Z., Qi,M.,
            An,X., Geng,P., Wang,S., Ren,H., Han,F., Zhang,R. and Zha,D.
  TITLE     RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal squamous cell
            carcinoma via activation of the PI3K-AKT signaling pathway
  JOURNAL   Cell Commun Signal 22 (1), 227 (2024)
   PUBMED   38610001
  REMARK    GeneRIF: RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal
            squamous cell carcinoma via activation of the PI3K-AKT signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3545)
  AUTHORS   Musolf,A.M., Justice,C.M., Erdogan-Yildirim,Z., Goovaerts,S.,
            Cuellar,A., Shaffer,J.R., Marazita,M.L., Claes,P., Weinberg,S.M.,
            Li,J., Senders,C., Zwienenberg,M., Simeonov,E., Kaneva,R.,
            Roscioli,T., Di Pietro,L., Barba,M., Lattanzi,W., Cunningham,M.L.,
            Romitti,P.A. and Boyadjiev,S.A.
  TITLE     Whole genome sequencing identifies associations for nonsyndromic
            sagittal craniosynostosis with the intergenic region of BMP2 and
            noncoding RNA gene LINC01428
  JOURNAL   Sci Rep 14 (1), 8533 (2024)
   PUBMED   38609424
  REMARK    GeneRIF: Whole genome sequencing identifies associations for
            nonsyndromic sagittal craniosynostosis with the intergenic region
            of BMP2 and noncoding RNA gene LINC01428.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3545)
  AUTHORS   Dai,Q., Shi,R., Zhang,G., Wang,Y., Ye,L., Peng,L., Guo,S., He,J.,
            Yang,H. and Jiang,Y.
  TITLE     miR-539-5p targets BMP2 to regulate Treg activation in B-cell acute
            lymphoblastic leukemia through TGF-beta/Smads/MAPK
  JOURNAL   Exp Biol Med (Maywood) 249, 10111 (2024)
   PUBMED   38510491
  REMARK    GeneRIF: miR-539-5p targets BMP2 to regulate Treg activation in
            B-cell acute lymphoblastic leukemia through TGF-beta/Smads/MAPK.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3545)
  AUTHORS   Rao,V.V., Loffler,C., Wozney,J.M. and Hansmann,I.
  TITLE     The gene for bone morphogenetic protein 2A (BMP2A) is localized to
            human chromosome 20p12 by radioactive and nonradioactive in situ
            hybridization
  JOURNAL   Hum Genet 90 (3), 299-302 (1992)
   PUBMED   1487246
REFERENCE   7  (bases 1 to 3545)
  AUTHORS   Tabas,J.A., Zasloff,M., Wasmuth,J.J., Emanuel,B.S., Altherr,M.R.,
            McPherson,J.D., Wozney,J.M. and Kaplan,F.S.
  TITLE     Bone morphogenetic protein: chromosomal localization of human genes
            for BMP1, BMP2A, and BMP3
  JOURNAL   Genomics 9 (2), 283-289 (1991)
   PUBMED   2004778
REFERENCE   8  (bases 1 to 3545)
  AUTHORS   Sampath,T.K., Coughlin,J.E., Whetstone,R.M., Banach,D., Corbett,C.,
            Ridge,R.J., Ozkaynak,E., Oppermann,H. and Rueger,D.C.
  TITLE     Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A,
            two members of the transforming growth factor-beta superfamily
  JOURNAL   J Biol Chem 265 (22), 13198-13205 (1990)
   PUBMED   2376592
REFERENCE   9  (bases 1 to 3545)
  AUTHORS   Wang,E.A., Rosen,V., D'Alessandro,J.S., Bauduy,M., Cordes,P.,
            Harada,T., Israel,D.I., Hewick,R.M., Kerns,K.M., LaPan,P. et al.
  TITLE     Recombinant human bone morphogenetic protein induces bone formation
  JOURNAL   Proc Natl Acad Sci U S A 87 (6), 2220-2224 (1990)
   PUBMED   2315314
REFERENCE   10 (bases 1 to 3545)
  AUTHORS   Wozney,J.M., Rosen,V., Celeste,A.J., Mitsock,L.M., Whitters,M.J.,
            Kriz,R.W., Hewick,R.M. and Wang,E.A.
  TITLE     Novel regulators of bone formation: molecular clones and activities
  JOURNAL   Science 242 (4885), 1528-1534 (1988)
   PUBMED   3201241
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL035668.15, BC069214.1,
            M22489.1, BM670141.1 and AA489383.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001200.3.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer, which plays a role in bone and
            cartilage development. Duplication of a regulatory region
            downstream of this gene causes a form of brachydactyly
            characterized by a malformed index finger and second toe in human
            patients. [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069214.1, SRR1803612.234723.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378827.5/ ENSP00000368104.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-412               AL035668.15        119698-120109
            413-1457            BC069214.1         1-1045
            1458-2421           M22489.1           584-1547
            2422-2594           AL035668.15        131135-131307
            2595-3262           BM670141.1         18-685              c
            3263-3545           AA489383.1         59-341              c
FEATURES             Location/Qualifiers
     source          1..3545
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p12.3"
     gene            1..3545
                     /gene="BMP2"
                     /gene_synonym="BDA2; BMP2A; SSFSC; SSFSC1"
                     /note="bone morphogenetic protein 2"
                     /db_xref="GeneID:650"
                     /db_xref="HGNC:HGNC:1069"
                     /db_xref="MIM:112261"
     exon            1..1190
                     /gene="BMP2"
                     /gene_synonym="BDA2; BMP2A; SSFSC; SSFSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1543
                     /gene="BMP2"
                     /gene_synonym="BDA2; BMP2A; SSFSC; SSFSC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1198..2388
                     /gene="BMP2"
                     /gene_synonym="BDA2; BMP2A; SSFSC; SSFSC1"
                     /note="bone morphogenetic protein 2A"
                     /codon_start=1
                     /product="bone morphogenetic protein 2 preproprotein"
                     /protein_id="NP_001191.1"
                     /db_xref="CCDS:CCDS13099.1"
                     /db_xref="GeneID:650"
                     /db_xref="HGNC:HGNC:1069"
                     /db_xref="MIM:112261"
                     /translation="MVAGTRCLLALLLPQVLLGGAAGLVPELGRRKFAAASSGRPSSQ
                     PSDEVLSEFELRLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERA
                     ASRANTVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDA
                     LGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTA
                     QGHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPL
                     HKREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLA
                     DHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEG
                     CGCR"
     exon            1544..3545
                     /gene="BMP2"
                     /gene_synonym="BDA2; BMP2A; SSFSC; SSFSC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3234..3239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMP2"
                     /gene_synonym="BDA2; BMP2A; SSFSC; SSFSC1"
                     /note="hexamer: AATAAA"
     polyA_site      3262
                     /gene="BMP2"
                     /gene_synonym="BDA2; BMP2A; SSFSC; SSFSC1"
                     /note="major polyA site"
     regulatory      3524..3529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMP2"
                     /gene_synonym="BDA2; BMP2A; SSFSC; SSFSC1"
                     /note="hexamer: AATAAA"
     polyA_site      3545
                     /gene="BMP2"
                     /gene_synonym="BDA2; BMP2A; SSFSC; SSFSC1"
ORIGIN      
        1 gccgccgccg ccgtcgccgc cgccggagtc ctcgccccgc cgcgctgcgc ccggctcgcg
       61 ctgcgctagt cgctccgctt cccacacccc gccggggact ggcagccgcc gccgcacatc
      121 tgccgccaca gcctccgccg gctacccgaa cgttctcggg gccagcgccg agtggatcac
      181 cggggaccgc gaggcacccg cgcgccgcag accccgcgcg ggctggagca cccggcagag
      241 cgcgccacag cgccgtggcc tctgctgccc gggctgcgcc agagccgcgg acgggcgcgc
      301 agagcgccgg ggactccgga gccgatccct agcgccgcga tgcggagcac ctactgcagg
      361 agatcggggg cctgggacgc gctggccgag gtgtgatcgg accccaggct agccacaaag
      421 ggcacttggc cccagggcta ggagagcgag gggagagcac agccacccgc ctcggcggcc
      481 cgggactcgg ctcgactcgc cggagaatgc gcccgaggac gacggggcgc cagagccgcg
      541 gtgctttcaa ctggcgagcg cgaatggggg tgcactggag taaggcagag tgatgcgggg
      601 gggcaactcg cctggcaccg agatcgccgc cgtgcccttc cctggacccg gcgtcgccca
      661 ggatggctgc cccgagccat gggccgcggc ggagctagcg cggagcgccc gaccctcgac
      721 ccccgagtcc cggagccggc cccgcgcggg gccacgcgtc cctcgggcgc tggttcctaa
      781 ggaggacgac agcaccagct tctcctttct cccttccctt ccctgccccg cactcctccc
      841 cctgctcgct gttgttgtgt gtcagcactt ggctggggac ttcttgaact tgcagggaga
      901 ataacttgcg caccccactt tgcgccggtg cctttgcccc agcggagcct gcttcgccat
      961 ctccgagccc caccgcccct ccactcctcg gccttgcccg acactgagac gctgttccca
     1021 gcgtgaaaag agagactgcg cggccggcac ccgggagaag gaggaggcaa agaaaaggaa
     1081 cggacattcg gtccttgcgc caggtccttt gaccagagtt tttccatgtg gacgctcttt
     1141 caatggacgt gtccccgcgt gcttcttaga cggactgcgg tctcctaaag gtcgaccatg
     1201 gtggccggga cccgctgtct tctagcgttg ctgcttcccc aggtcctcct gggcggcgcg
     1261 gctggcctcg ttccggagct gggccgcagg aagttcgcgg cggcgtcgtc gggccgcccc
     1321 tcatcccagc cctctgacga ggtcctgagc gagttcgagt tgcggctgct cagcatgttc
     1381 ggcctgaaac agagacccac ccccagcagg gacgccgtgg tgccccccta catgctagac
     1441 ctgtatcgca ggcactcagg tcagccgggc tcacccgccc cagaccaccg gttggagagg
     1501 gcagccagcc gagccaacac tgtgcgcagc ttccaccatg aagaatcttt ggaagaacta
     1561 ccagaaacga gtgggaaaac aacccggaga ttcttcttta atttaagttc tatccccacg
     1621 gaggagttta tcacctcagc agagcttcag gttttccgag aacagatgca agatgcttta
     1681 ggaaacaata gcagtttcca tcaccgaatt aatatttatg aaatcataaa acctgcaaca
     1741 gccaactcga aattccccgt gaccagactt ttggacacca ggttggtgaa tcagaatgca
     1801 agcaggtggg aaagttttga tgtcaccccc gctgtgatgc ggtggactgc acagggacac
     1861 gccaaccatg gattcgtggt ggaagtggcc cacttggagg agaaacaagg tgtctccaag
     1921 agacatgtta ggataagcag gtctttgcac caagatgaac acagctggtc acagataagg
     1981 ccattgctag taacttttgg ccatgatgga aaagggcatc ctctccacaa aagagaaaaa
     2041 cgtcaagcca aacacaaaca gcggaaacgc cttaagtcca gctgtaagag acaccctttg
     2101 tacgtggact tcagtgacgt ggggtggaat gactggattg tggctccccc ggggtatcac
     2161 gccttttact gccacggaga atgccctttt cctctggctg atcatctgaa ctccactaat
     2221 catgccattg ttcagacgtt ggtcaactct gttaactcta agattcctaa ggcatgctgt
     2281 gtcccgacag aactcagtgc tatctcgatg ctgtaccttg acgagaatga aaaggttgta
     2341 ttaaagaact atcaggacat ggttgtggag ggttgtgggt gtcgctagta cagcaaaatt
     2401 aaatacataa atatatatat atatatatat tttagaaaaa agaaaaaaac aaacaaacaa
     2461 aaaaacccca ccccagttga cactttaata tttcccaatg aagactttat ttatggaatg
     2521 gaatggaaaa aaaaacagct attttgaaaa tatatttata tctacgaaaa gaagttggga
     2581 aaacaaatat tttaatcaga gaattattcc ttaaagattt aaaatgtatt tagttgtaca
     2641 ttttatatgg gttcaacccc agcacatgaa gtataatggt cagatttatt ttgtatttat
     2701 ttactattat aaccactttt taggaaaaaa atagctaatt tgtatttata tgtaatcaaa
     2761 agaagtatcg ggtttgtaca taattttcca aaaattgtag ttgttttcag ttgtgtgtat
     2821 ttaagatgaa aagtctacat ggaaggttac tctggcaaag tgcttagcac gtttgctttt
     2881 ttgcagtgct actgttgagt tcacaagttc aagtccagaa aaaaaaagtg gataatccac
     2941 tctgctgact ttcaagatta ttatattatt caattctcag gaatgttgca gagtgattgt
     3001 ccaatccatg agaatttaca tccttattag gtggaatatt tggataagaa ccagacattg
     3061 ctgatctatt atagaaactc tcctcctgcc ccttaattta cagaaagaat aaagcaggat
     3121 ccatagaaat aattaggaaa acgatgaacc tgcaggaaag tgaatgatgg tttgttgttc
     3181 ttctttccta aattagtgat cccttcaaag gggctgatct ggccaaagta ttcaataaaa
     3241 cgtaagattt cttcattatt gatattgtgg tcatatatat ttaaaattga tatctcgtgg
     3301 ccctcatcaa gggttggaaa tttatttgtg ttttaccttt acctcatctg agagctcttt
     3361 attctccaaa gaacccagtt ttctaacttt ttgcccaaca cgcagcaaaa ttatgcacat
     3421 cgtgttttct gcccaccctc tgttctctga cctatcagct tgcttttctt tccaaggttg
     3481 tgtgtttgaa cacatttctc caaatgttaa acctatttca gataataaat atcaaatctc
     3541 tggca
//
