LOCUS       NM_014482               6036 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens bone morphogenetic protein 10 (BMP10), mRNA.
ACCESSION   NM_014482
VERSION     NM_014482.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6036)
  AUTHORS   Gkarmiris,K.I., Lindback,J., Alexander,J.H., Granger,C.B.,
            Kastner,P., Lopes,R.D., Ziegler,A., Oldgren,J., Siegbahn,A.,
            Wallentin,L. and Hijazi,Z.
  TITLE     Repeated Measurement of the Novel Atrial Biomarker BMP10 (Bone
            Morphogenetic Protein 10) Refines Risk Stratification in
            Anticoagulated Patients With Atrial Fibrillation: Insights From the
            ARISTOTLE Trial
  JOURNAL   J Am Heart Assoc 13 (7), e033720 (2024)
   PUBMED   38529655
  REMARK    GeneRIF: Repeated Measurement of the Novel Atrial Biomarker BMP10
            (Bone Morphogenetic Protein 10) Refines Risk Stratification in
            Anticoagulated Patients With Atrial Fibrillation: Insights From the
            ARISTOTLE Trial.
REFERENCE   2  (bases 1 to 6036)
  AUTHORS   Hennings,E., Blum,S., Aeschbacher,S., Coslovsky,M., Knecht,S.,
            Eken,C., Lischer,M., Paladini,R.E., Krisai,P., Reichlin,T.,
            Rodondi,N., Beer,J.H., Ammann,P., Conte,G., De Perna,M.L.,
            Kobza,R., Blum,M.R., Bossard,M., Kastner,P., Ziegler,A., Muller,C.,
            Bonati,L.H., Pfister,O., Zuern,C.S., Conen,D., Kuhne,M. and
            Osswald,S.
  CONSRTM   Swiss-AF Investigators
  TITLE     Bone Morphogenetic Protein 10-A Novel Biomarker to Predict Adverse
            Outcomes in Patients With Atrial Fibrillation
  JOURNAL   J Am Heart Assoc 12 (6), e028255 (2023)
   PUBMED   36926939
  REMARK    GeneRIF: Bone Morphogenetic Protein 10-A Novel Biomarker to Predict
            Adverse Outcomes in Patients With Atrial Fibrillation.
REFERENCE   3  (bases 1 to 6036)
  AUTHORS   Hijazi,Z., Benz,A.P., Lindback,J., Alexander,J.H., Connolly,S.J.,
            Eikelboom,J.W., Granger,C.B., Kastner,P., Lopes,R.D., Ziegler,A.,
            Oldgren,J., Siegbahn,A. and Wallentin,L.
  TITLE     Bone morphogenetic protein 10: a novel risk marker of ischaemic
            stroke in patients with atrial fibrillation
  JOURNAL   Eur Heart J 44 (3), 208-218 (2023)
   PUBMED   36380569
  REMARK    GeneRIF: Bone morphogenetic protein 10: a novel risk marker of
            ischaemic stroke in patients with atrial fibrillation.
REFERENCE   4  (bases 1 to 6036)
  AUTHORS   Guo,J., Liu,B., Thorikay,M., Yu,M., Li,X., Tong,Z., Salmon,R.M.,
            Read,R.J., Ten Dijke,P., Morrell,N.W. and Li,W.
  TITLE     Crystal structures of BMPRII extracellular domain in binary and
            ternary receptor complexes with BMP10
  JOURNAL   Nat Commun 13 (1), 2395 (2022)
   PUBMED   35504921
  REMARK    GeneRIF: Crystal structures of BMPRII extracellular domain in
            binary and ternary receptor complexes with BMP10.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6036)
  AUTHORS   Desroches-Castan,A., Tillet,E., Bouvard,C. and Bailly,S.
  TITLE     BMP9 and BMP10: Two close vascular quiescence partners that stand
            out
  JOURNAL   Dev Dyn 251 (1), 178-197 (2022)
   PUBMED   34240497
  REMARK    GeneRIF: BMP9 and BMP10: Two close vascular quiescence partners
            that stand out.
            Review article
REFERENCE   6  (bases 1 to 6036)
  AUTHORS   Sengle,G., Charbonneau,N.L., Ono,R.N., Sasaki,T., Alvarez,J.,
            Keene,D.R., Bachinger,H.P. and Sakai,L.Y.
  TITLE     Targeting of bone morphogenetic protein growth factor complexes to
            fibrillin
  JOURNAL   J Biol Chem 283 (20), 13874-13888 (2008)
   PUBMED   18339631
REFERENCE   7  (bases 1 to 6036)
  AUTHORS   Nakano,N., Hori,H., Abe,M., Shibata,H., Arimura,T., Sasaoka,T.,
            Sawabe,M., Chida,K., Arai,T., Nakahara,K., Kubo,T., Sugimoto,K.,
            Katsuya,T., Ogihara,T., Doi,Y., Izumi,T. and Kimura,A.
  TITLE     Interaction of BMP10 with Tcap may modulate the course of
            hypertensive cardiac hypertrophy
  JOURNAL   Am J Physiol Heart Circ Physiol 293 (6), H3396-H3403 (2007)
   PUBMED   17921333
  REMARK    GeneRIF: Hypertension induced expression of prohypertrophic BMP10,
            and the hypertrophic effect of BMP10 was modulated, at least in
            part, by its binding to Tcap at the Z disc.
REFERENCE   8  (bases 1 to 6036)
  AUTHORS   David,L., Mallet,C., Mazerbourg,S., Feige,J.J. and Bailly,S.
  TITLE     Identification of BMP9 and BMP10 as functional activators of the
            orphan activin receptor-like kinase 1 (ALK1) in endothelial cells
  JOURNAL   Blood 109 (5), 1953-1961 (2007)
   PUBMED   17068149
REFERENCE   9  (bases 1 to 6036)
  AUTHORS   Mazerbourg,S., Sangkuhl,K., Luo,C.W., Sudo,S., Klein,C. and
            Hsueh,A.J.
  TITLE     Identification of receptors and signaling pathways for orphan bone
            morphogenetic protein/growth differentiation factor ligands based
            on genomic analyses
  JOURNAL   J Biol Chem 280 (37), 32122-32132 (2005)
   PUBMED   16049014
REFERENCE   10 (bases 1 to 6036)
  AUTHORS   Neuhaus,H., Rosen,V. and Thies,R.S.
  TITLE     Heart specific expression of mouse BMP-10 a novel member of the
            TGF-beta superfamily
  JOURNAL   Mech Dev 80 (2), 181-184 (1999)
   PUBMED   10072785
  REMARK    GeneRIF: Describes the cloning and expression of murine BMP-10.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF101441.1 and AC097495.3.
            
            On Nov 22, 2018 this sequence version replaced NM_014482.2.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate the mature protein, which
            binds to the activin receptor-like kinase 1 (ALK1) and plays
            important roles in cardiovascular development including
            cardiomyocyte proliferation and regulation of heart size, closure
            of the ductus arteriosus, angiogenesis and ventricular
            trabeculation. [provided by RefSeq, Aug 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279827.5621.1, ERR279840.8196.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295379.2/ ENSP00000295379.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1464              AF101441.1         121-1584
            1465-6036           AC097495.3         78128-82699
FEATURES             Location/Qualifiers
     source          1..6036
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..6036
                     /gene="BMP10"
                     /note="bone morphogenetic protein 10"
                     /db_xref="GeneID:27302"
                     /db_xref="HGNC:HGNC:20869"
                     /db_xref="MIM:608748"
     exon            1..373
                     /gene="BMP10"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1314
                     /gene="BMP10"
                     /codon_start=1
                     /product="bone morphogenetic protein 10 preproprotein"
                     /protein_id="NP_055297.1"
                     /db_xref="CCDS:CCDS1890.1"
                     /db_xref="GeneID:27302"
                     /db_xref="HGNC:HGNC:20869"
                     /db_xref="MIM:608748"
                     /translation="MGSLVLTLCALFCLAAYLVSGSPIMNLEQSPLEEDMSLFGDVFS
                     EQDGVDFNTLLQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFATDRTSMPSA
                     NIIRSFKNEDLFSQPVSFNGLRKYPLLFNVSIPHHEEVIMAELRLYTLVQRDRMIYDG
                     VDRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTH
                     QLEVHIESKHDEAEDASSGRLEIDTSAQNKHNPLLIVFSDDQSSDKERKEELNEMISH
                     EQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKE
                     IGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPT
                     KLEPISILYLDKGVVTYKFKYEGMAVSECGCR"
     exon            374..6036
                     /gene="BMP10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5813..5818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMP10"
                     /note="hexamer: AATAAA"
     polyA_site      5840
                     /gene="BMP10"
                     /note="major polyA site"
     regulatory      6012..6017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMP10"
                     /note="hexamer: AATAAA"
     polyA_site      6036
                     /gene="BMP10"
ORIGIN      
        1 taaaccttcc tggcttggcc taggagctcg agcggagtca tgggctctct ggtcctgaca
       61 ctgtgcgctc ttttctgcct ggcagcttac ttggtttctg gcagccccat catgaaccta
      121 gagcagtctc ctctggaaga agatatgtcc ctctttggtg atgttttctc agagcaagac
      181 ggtgtcgact ttaacacact gctccagagc atgaaggatg agtttcttaa gacactaaac
      241 ctctctgaca tccccacgca ggattcagcc aaggtggacc caccagagta catgttggaa
      301 ctctacaaca aatttgcaac agatcggacc tccatgccct ctgccaacat cattaggagt
      361 ttcaagaatg aagatctgtt ttcccagccg gtcagtttta atgggctccg aaaatacccc
      421 ctcctcttca atgtgtccat tcctcaccat gaagaggtca tcatggctga acttaggcta
      481 tacacactgg tgcaaaggga tcgtatgata tacgatggag tagaccggaa aattaccatt
      541 tttgaagtgc tggagagcaa aggggataat gagggagaaa gaaacatgct ggtcttggtg
      601 tctggggaga tatatggaac caacagtgag tgggagactt ttgatgtcac agatgccatc
      661 agacgttggc aaaagtcagg ctcatccacc caccagctgg aggtccacat tgagagcaaa
      721 cacgatgaag ctgaggatgc cagcagtgga cggctagaaa tagataccag tgcccagaat
      781 aagcataacc ctttgctcat cgtgttttct gatgaccaaa gcagtgacaa ggagaggaag
      841 gaggaactga atgaaatgat ttcccatgag caacttccag agctggacaa cttgggcctg
      901 gatagctttt ccagtggacc tggggaagag gctttgttgc agatgagatc aaacatcatc
      961 tatgactcca ctgcccgaat cagaaggaac gccaaaggaa actactgtaa gaggaccccg
     1021 ctctacatcg acttcaagga gattgggtgg gactcctgga tcatcgctcc gcctggatac
     1081 gaagcctatg aatgccgtgg tgtttgtaac taccccctgg cagagcatct cacacccaca
     1141 aagcatgcaa ttatccaggc cttggtccac ctcaagaatt cccagaaagc ttccaaagcc
     1201 tgctgtgtgc ccacaaagct agagcccatc tccatcctct atttagacaa aggcgtcgtc
     1261 acctacaagt ttaaatacga aggcatggcc gtctccgaat gtggctgtag atagaagaag
     1321 agtcctatgg cttatttaat aactgtaaat gtgtatattt ggtgttccta tttaatgaga
     1381 ttatttaata agggtgtaca gtaatagagg cttgctgcct tcaggaaatg gacaggtcag
     1441 tttgttgtag gaaatgcata ttttcctctc cagttaagtc cctttcaatc tgttttctct
     1501 ttggacttgc catttcctgg caatgccacc tccctgttga tttgaaaaca acccctaggc
     1561 aaaatacagt gtcaaaagac acacacttgt gtatgtatat ttgtacatac atgaacttac
     1621 aaaaatcttt tggttctatg caggcaggtt atactcatct acatgcatga ctcactcaaa
     1681 tgtatgcata ttaaaggcca atggtatgtt ctctgttacc tcttctctga gtaggattta
     1741 agtcaagata attgacatca gggttttaat catcctagga agtattaccc ttcctaaata
     1801 ctctggaaat gtaagtgtag cttttgtcag ttgagtttct gtagttgctc agagaggagg
     1861 ggcctggcaa aggatgcttg aagggaaggg ttaattgata cagaaaccaa atggacttaa
     1921 gaggtcttag aggtacaaca ggaaaaaatg aacccatgga ggaccaatgt gctccagagg
     1981 gcaactcctg gtcaaggcag gaaaacagaa gaaaccagca tgaaatctgt tcctgagaca
     2041 ataggaaagc aaggccatga gtactggcca ttgctgctgc agagagtaga ggggttggga
     2101 gggtacttga aggggagaaa gggagaaagg gaagaggata ttgatgttat cctcagaggc
     2161 tatcctcaga tgtgtctgta aaaccaaaag tggttctgtt taaagaatta aatcttttgg
     2221 acaaaataga agtatcaaag actaagagga ggaaaatcag aaggggtctg tctgttggaa
     2281 gaaaggatgt taatatcttt cttcacctgt taacactgtt cccttgtctc agcacccctg
     2341 ctttcctctg ctccatcttc ttccttccct ctttcttctt ggccctagtg cctctcacct
     2401 tcctcccatc cctgtgtccc tgctcttccc tggccttcat gatgcatgct gtgaactgga
     2461 aagggacacc taagtgcctt tgctctcagg gtgaaaggag ttagtgttct aatttctaaa
     2521 tcttcccgtg atatttaatt tgattttatt ttaataatat cctttatcaa atgttttgtt
     2581 catgaagaat acttagatat aagagaaaag aaaaccagaa taagtaagta taagaaaaag
     2641 aaaaccagag tccaaatgaa tggatttaaa taaacgaatt tatgaataga cacacaagca
     2701 aatgactcaa aagccaagcc tgaattttga aatcatgatt gtttcatggt agaaacccag
     2761 taactttccc atcttctcat cttaccatct tcccattttg caactggcca ggactgaaag
     2821 tggtgaggaa gtgttctgca caggaagggt ccggtgggtt ttcctggcag gtggcagcct
     2881 ccagtcttaa cccctaacca tttccctcta cctggcaagc atattctggg ctttgtgcag
     2941 gaggaaccag agcagagcag agcagtttcc aaactgttcc agcatctcca ggcagggaac
     3001 atggatggtt cctgttagaa ccaggaatgt ggtttccagt acgtcatccc ccattcaccc
     3061 ctactcatct taaggaatgc ttccttaaga agtctgacac ttttttcttt tttttaccct
     3121 ggaaaacaat cagtcccctt ttacaaatct cttaaggtta taaactcaaa ctgcactaga
     3181 caatagaggc aaggaaaact attttgaaga aggcccaatt tgaacctcag ctcgctagat
     3241 ctgttgtctg ctgggtgaat cctggggaat tcattgctca tggaagagtg gtgttttgac
     3301 cgtcagtggg tatacagtga ttgatgcttt gagaaagcca tgcaactcag aatcactatt
     3361 tgtggaacag cctccatata acatgatgtg tgtatgtgtg tgtgatgtat agctggcttt
     3421 gaataaccac gcttaatacc ctcagtggaa cgtggtgcat ccttcatact ccatggtaca
     3481 caatgtatac tcacatactc caaggtactt cttatccttt ctaaaggaca ctgtaataca
     3541 tacacagtaa aacctcagct gaccaggata gtcctggtta gataaaaatt aagcaaattt
     3601 tctttatgtc taatacatat gacagtggtg tgctggtaaa acccttacaa ccagcaatcc
     3661 agggggagaa aaagccctga tttgtggatt tcaatgctgc aaacgctcct acatggtcta
     3721 tcttgagctg ccaaggtgat gtcaactggc ttgcaaaact tctaaaacct aagtcagctc
     3781 ttgggagctg tgcactggtg ctggcacacc gctgacattt agtatcccac tgacattagc
     3841 acaccgctga cattagcacc ctgatactag aatgttaagg atgtgccagc cctgctttcc
     3901 actgtgtgcg ctgctggctc cgggcttctg gagaaatctt gtctcgagca cttatagtca
     3961 ctcttctgtt aaagagatat gaaaatatag gctgttggcg atcaggctgc atagcccagt
     4021 tgtttctttc tgcccatcca gatgtaaacc tgcatttcta tgattttctg cttccctgtg
     4081 gaaagggagt gcagagagca acatattgtt attcaaatgt tgctagttgt atttttttgg
     4141 ctttttgtca gaaagtgaaa agacacagcc cgtagaggag ttctcccagc tcccaccgga
     4201 accccggcag cacaccggtg tcactttcaa ctcctgcatt gacaggaagc cagaatattg
     4261 tcagatcctt aaaaaggtag aatcttacta atgtttctct ggtcatagac cttcttctgg
     4321 gtcccatgcc agtttttttc ccccttttat tgcagaatta tcatcaccga agttgatata
     4381 gctaaacaac tcttgaggag aattatagca gagggacttg ggcagcccac agccaaaata
     4441 ttcatgtaag agtttctagg cttcccacta tttattgatt gatatattta tttttgtaaa
     4501 atattgtaga ataccaaata ttttattttt atgtctgtga ttcccttttg gatagagagt
     4561 cttctgggct tcagagtatg gctcacatat aatatatggc ctgtatttcc atctctctct
     4621 ttttgcatca gaatattcta ttggtttaag gaatcttgcc atagcttgcc ataattttgt
     4681 atatttgtgt cttgcaggca tgctgtgcct acaagcatgc tttgtagtat attttctgat
     4741 ttgtaaatag tacagtttta actgaagtgt agatgttcca ggaaatattt aaccaataca
     4801 ttgtcatgca gtttcataaa gtgatgttgt cagtttatca tgagaagcaa atattgtcag
     4861 gctgtgagag aatgtgattg ctactcagta aacggagatg ctatttaaat gaatcttttc
     4921 atcccccaaa tctggtactt cccctctgaa ttcacctgtt gccgtcactg acccagaaat
     4981 tcagagatgt gattggtcaa attcatttgt aattggacca attactttgt aaatgtcaaa
     5041 aatgttagct tagtgatttc caaaagagtc agccccaaag tgccgaattc tttcctgatg
     5101 tgtaaatttt ggtccgggga attaatgaca aaaacctttt ttttttaaga actgttacta
     5161 aatgtttcag tatttgttat gatttatatt cttcaagtaa aagatatttt catataagag
     5221 aattttatgt attcttctta cttgattcat caacagatta tgaagcctag cagtgttctg
     5281 gcaaaacctt tttaacttgc ctagaacaca gaagggatgt tgcccttttt aaggttgtag
     5341 atcttttcag agtcactgtg ggtcattctc aaccctttgc agttctgcaa gctcacatat
     5401 ggtgcaagag gaaatgctgg tatgactctg tgcattttct tgcccccaaa caggaacagt
     5461 tgatttccta cattaaatgg aaggtagatg tgactatgga agagaagtac acaggggtgt
     5521 ttctgcatgt gaaatatttg tcataagtta aaaacccatc atggaataac tgtttgttgt
     5581 gatcagcatg tttttatcac acatgggcac tggttttgtg agcacctggc ttgatagtgg
     5641 tggggcggcc aatgtgccag cgcccgccta ctgagcattc atggacattg gaaatcagcg
     5701 aacaccacag acacaccgaa tcagctgatg cacggtcatg ttctggggta aaacctgttc
     5761 attatccatg tccacatttg tatagttatc actagactaa aatgaagatg gaaataaata
     5821 ttttaccctg tgttcatgaa ccaaatgtgt accttcagag tctttttaag taaaataaaa
     5881 aaattatttt ggtgataatt atttgcagct tatttttcct tgaggtaagg tatttaattt
     5941 tgcacactcc ccactttttc atgtttctac ttgataacat atcccgatgg aataaaacta
     6001 attgctatat taataaagaa tggtctgaag aaacca
//
