LOCUS       NM_005180               3540 bp    mRNA    linear   PRI 26-FEB-2025
DEFINITION  Homo sapiens BMI1 proto-oncogene, polycomb ring finger (BMI1),
            transcript variant 1, mRNA.
ACCESSION   NM_005180
VERSION     NM_005180.9
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3540)
  AUTHORS   Szustka,A. and Krzeslak,A.
  TITLE     BMI-1 in Breast Cancer - Biological Role and Clinical Implications
  JOURNAL   Cell Physiol Biochem 58 (5), 584-596 (2024)
   PUBMED   39429016
  REMARK    GeneRIF: BMI-1 in Breast Cancer - Biological Role and Clinical
            Implications.
            Review article
REFERENCE   2  (bases 1 to 3540)
  AUTHORS   Hsu,Y.C., Luo,C.W., Chang,S.J., Lai,C.Y., Yang,Y.T., Chen,Y.Z.,
            Liu,W.T., Wu,C.C., Sun,C.K., Hou,M.F. and Pan,M.R.
  TITLE     Targeting Bmi1 for Enhancing Anoikis Sensitivity and Inhibiting
            Metastasis in Colorectal Cancer
  JOURNAL   Cancer Genomics Proteomics 21 (5), 523-532 (2024)
   PUBMED   39191496
  REMARK    GeneRIF: Targeting Bmi1 for Enhancing Anoikis Sensitivity and
            Inhibiting Metastasis in Colorectal Cancer.
REFERENCE   3  (bases 1 to 3540)
  AUTHORS   Li,Q., Fu,T., Wei,N., Wang,Q. and Zhang,X.
  TITLE     Bmi-1 promotes the proliferation, migration and invasion, and
            inhibits cell apoptosis of human retinoblastoma cells via RKIP
  JOURNAL   Sci Rep 14 (1), 14544 (2024)
   PUBMED   38914697
  REMARK    GeneRIF: Bmi-1 promotes the proliferation, migration and invasion,
            and inhibits cell apoptosis of human retinoblastoma cells via RKIP.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3540)
  AUTHORS   Park,I.K., Qian,D., Kiel,M., Becker,M.W., Pihalja,M.,
            Weissman,I.L., Morrison,S.J. and Clarke,M.F.
  TITLE     Bmi-1 is required for maintenance of adult self-renewing
            haematopoietic stem cells
  JOURNAL   Nature 423 (6937), 302-305 (2003)
   PUBMED   12714971
REFERENCE   5  (bases 1 to 3540)
  AUTHORS   Satijn,D.P. and Otte,A.P.
  TITLE     RING1 interacts with multiple Polycomb-group proteins and displays
            tumorigenic activity
  JOURNAL   Mol Cell Biol 19 (1), 57-68 (1999)
   PUBMED   9858531
REFERENCE   6  (bases 1 to 3540)
  AUTHORS   Alkema,M.J., Jacobs,J., Voncken,J.W., Jenkins,N.A., Copeland,N.G.,
            Satijn,D.P., Otte,A.P., Berns,A. and van Lohuizen,M.
  TITLE     MPc2, a new murine homolog of the Drosophila polycomb protein is a
            member of the mouse polycomb transcriptional repressor complex
  JOURNAL   J Mol Biol 273 (5), 993-1003 (1997)
   PUBMED   9367786
REFERENCE   7  (bases 1 to 3540)
  AUTHORS   Satijn,D.P., Gunster,M.J., van der Vlag,J., Hamer,K.M., Schul,W.,
            Alkema,M.J., Saurin,A.J., Freemont,P.S., van Driel,R. and Otte,A.P.
  TITLE     RING1 is associated with the polycomb group protein complex and
            acts as a transcriptional repressor
  JOURNAL   Mol Cell Biol 17 (7), 4105-4113 (1997)
   PUBMED   9199346
REFERENCE   8  (bases 1 to 3540)
  AUTHORS   Gunster,M.J., Satijn,D.P., Hamer,K.M., den Blaauwen,J.L., de
            Bruijn,D., Alkema,M.J., van Lohuizen,M., van Driel,R. and Otte,A.P.
  TITLE     Identification and characterization of interactions between the
            vertebrate polycomb-group protein BMI1 and human homologs of
            polyhomeotic
  JOURNAL   Mol Cell Biol 17 (4), 2326-2335 (1997)
   PUBMED   9121482
REFERENCE   9  (bases 1 to 3540)
  AUTHORS   Alkema,M.J., Bronk,M., Verhoeven,E., Otte,A., van 't Veer,L.J.,
            Berns,A. and van Lohuizen,M.
  TITLE     Identification of Bmi1-interacting proteins as constituents of a
            multimeric mammalian polycomb complex
  JOURNAL   Genes Dev 11 (2), 226-240 (1997)
   PUBMED   9009205
REFERENCE   10 (bases 1 to 3540)
  AUTHORS   Alkema,M.J., Wiegant,J., Raap,A.K., Berns,A. and van Lohuizen,M.
  TITLE     Characterization and chromosomal localization of the human
            proto-oncogene BMI-1
  JOURNAL   Hum Mol Genet 2 (10), 1597-1603 (1993)
   PUBMED   8268912
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL158211.29, DB225488.1,
            BC011652.2, BE008203.1 and AI274830.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005180.8.
            
            Summary: This gene encodes a ring finger protein that is major
            component of the polycomb group complex 1 (PRC1). This complex
            functions through chromatin remodeling as an essential epigenetic
            repressor of multiple regulatory genes involved in embryonic
            development and self-renewal in somatic stem cells. This protein
            also plays a central role in DNA damage repair. This gene is an
            oncogene and aberrant expression is associated with numerous
            cancers and is associated with resistance to certain
            chemotherapies. A pseudogene of this gene is found on chromosome X.
            Read-through transcription also exists between this gene and the
            upstream COMM domain containing 3 (COMMD3) gene. [provided by
            RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.241287.1,
                                           SRR1660805.206485.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376663.8/ ENSP00000365851.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               AL158211.29        76106-76216
            112-112             DB225488.1         1-1
            113-2565            BC011652.2         1-2453
            2566-2566           BE008203.1         163-163
            2567-3315           BC011652.2         2455-3203
            3316-3540           AI274830.1         7-231               c
FEATURES             Location/Qualifiers
     source          1..3540
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.2"
     gene            1..3540
                     /gene="BMI1"
                     /gene_synonym="flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51"
                     /note="BMI1 proto-oncogene, polycomb ring finger"
                     /db_xref="GeneID:648"
                     /db_xref="HGNC:HGNC:1066"
                     /db_xref="MIM:164831"
     exon            1..598
                     /gene="BMI1"
                     /gene_synonym="flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            599..729
                     /gene="BMI1"
                     /gene_synonym="flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     CDS             618..1598
                     /gene="BMI1"
                     /gene_synonym="flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51"
                     /note="murine leukemia viral (bmi-1) oncogene homolog; B
                     lymphoma Mo-MLV insertion region 1 homolog; ring finger
                     protein 51; polycomb group protein Bmi1; polycomb group
                     RING finger protein 4; BMI1 polycomb ring finger oncogene;
                     BMI1 polycomb ring finger proto-oncogene"
                     /codon_start=1
                     /product="polycomb complex protein BMI-1"
                     /protein_id="NP_005171.4"
                     /db_xref="CCDS:CCDS7138.1"
                     /db_xref="GeneID:648"
                     /db_xref="HGNC:HGNC:1066"
                     /db_xref="MIM:164831"
                     /translation="MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIV
                     RYLETSKYCPICDVQVHKTRPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAAHP
                     SADAANGSNEDRGEVADEDKRIITDDEIISLSIEFFDQNRLDRKVNKDKEKSKEEVND
                     KRYLRCPAAMTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWRRN
                     GPLPLKYRVRPTCKRMKISHQRDGLTNAGELESDSGSDKANSPAGGIPSTSSCLPSPS
                     TPVQSPHPQFPHISSTMNGTSNSPSGNHQSSFANRPRKSSVNGSSATSSG"
     exon            730..826
                     /gene="BMI1"
                     /gene_synonym="flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            827..882
                     /gene="BMI1"
                     /gene_synonym="flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            883..933
                     /gene="BMI1"
                     /gene_synonym="flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1042
                     /gene="BMI1"
                     /gene_synonym="flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1088
                     /gene="BMI1"
                     /gene_synonym="flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1187
                     /gene="BMI1"
                     /gene_synonym="flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1268
                     /gene="BMI1"
                     /gene_synonym="flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..3540
                     /gene="BMI1"
                     /gene_synonym="flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3103..3108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMI1"
                     /gene_synonym="flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51"
                     /note="hexamer: ATTAAA"
     polyA_site      3124
                     /gene="BMI1"
                     /gene_synonym="flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51"
                     /note="major polyA site"
     regulatory      3516..3521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMI1"
                     /gene_synonym="flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51"
                     /note="hexamer: AGTAAA"
     polyA_site      3540
                     /gene="BMI1"
                     /gene_synonym="flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51"
                     /note="major polyA site"
ORIGIN      
        1 agtttccact ctgccttcag cggtgcattt ttttccaccc tcccctcccc ctcctcccct
       61 ccccccgctc gcacgcacac acacggcgcc ccccgcccgc ccgcctcccc cacagcaact
      121 atgaaataat cgtagtatga gaggcagaga tcggggcgag acaatgggga tgtgggcgcg
      181 ggagccccgt tccggcttag cagcacctcc cagccccgca gaataaaacc gatcgcgccc
      241 cctccgcgcg cgccctcccc cgagtgcgga gcgggaggag gcggcggcgg ccgaggagga
      301 ggaggaggag gccccggagg aggaggcgtt ggaggtcgag gcggaggcgg aggaggagga
      361 ggccgaggcg ccggaggagg ccgaggcgcc ggagcaggag gaggccggcc ggaggcggca
      421 tgagacgagc gtggcggccg cggctgctcg gggccgcgct ggttgcccat tgacagcggc
      481 gtctgcagct cgcttcaaga tggccgcttg gctcgcattc attttctgct gaacgacttt
      541 taactttcat tgtcttttcc gcccgcttcg atcgcctcgc gccggctgct ctttccggga
      601 ttttttatca agcagaaatg catcgaacaa cgagaatcaa gatcactgag ctaaatcccc
      661 acctgatgtg tgtgctttgt ggagggtact tcattgatgc cacaaccata atagaatgtc
      721 tacattcctt ctgtaaaacg tgtattgttc gttacctgga gaccagcaag tattgtccta
      781 tttgtgatgt ccaagttcac aagaccagac cactactgaa tataaggtca gataaaactc
      841 tccaagatat tgtatacaaa ttagttccag ggcttttcaa aaatgaaatg aagagaagaa
      901 gggattttta tgcagctcat ccttctgctg atgctgccaa tggctctaat gaagatagag
      961 gagaggttgc agatgaagat aagagaatta taactgatga tgagataata agcttatcca
     1021 ttgaattctt tgaccagaac agattggatc ggaaagtaaa caaagacaaa gagaaatcta
     1081 aggaggaggt gaatgataaa agatacttac gatgcccagc agcaatgact gtgatgcact
     1141 taagaaagtt tctcagaagt aaaatggaca tacctaatac tttccagatt gatgtcatgt
     1201 atgaggagga acctttaaag gattattata cactaatgga tattgcctac atttatacct
     1261 ggagaaggaa tggtccactt ccattgaaat acagagttcg acctacttgt aaaagaatga
     1321 agatcagtca ccagagagat ggactgacaa atgctggaga actggaaagt gactctggga
     1381 gtgacaaggc caacagccca gcaggaggta ttccctccac ctcttcttgt ttgcctagcc
     1441 ccagtactcc agtgcagtct cctcatccac agtttcctca catttccagt actatgaatg
     1501 gaaccagcaa cagccccagc ggtaaccacc aatcttcttt tgccaataga cctcgaaaat
     1561 catcagtaaa tgggtcatca gcaacttctt ctggttgata cctgagactg ttaaggaaaa
     1621 aaattttaaa cccctgattt atatagatat cttcatgcca ttacagcttt ctagatgcta
     1681 atacatgtga ctatcgtcca atttgctttc ttttgtagtg acattaaatt tggctataaa
     1741 agatggacta catgtgatac tcctatggac gttaattgaa aagaaagatt gttgttataa
     1801 agaattggtt tcttggaaag caggcaagac tttttctctg tgttaggaaa gatgggaaat
     1861 ggtttctgta accattgttt ggatttggaa gtactctgca gtggacataa gcattgggcc
     1921 atagtttgtt aatctcaact aacgcctaca ttacattctc cttgatcgtt cttgttatta
     1981 cgctgttttg tgaacctgta gaaaacaagt gctttttatc ttgaaattca accaacggaa
     2041 agaatatgca tagaataatg cattctatgt agccatgtca ctgtgaataa cgatttcttg
     2101 catatttagc cattttgatt cctgtttgat ttatacttct ctgttgctac gcaaaaccga
     2161 tcaaagaaaa gtgaacttca gttttacaat ctgtatgcct aaaagcgggt actaccgttt
     2221 attttactga cttgtttaaa tgattcgctt ttgtaagaat cagatggcat tatgcttgtt
     2281 gtacaatgcc atattggtat atgacataac aggaaacagt attgtatgat atatttataa
     2341 atgctataaa gaaatattgt gtttcatgca ttcagaaatg attgttaaaa ttctcccaac
     2401 tggttcgacc tttgcagata cccataacct atgttgagcc ttgcttacca gcaaagaata
     2461 tttttaatgt ggatatctaa ttctaaagtc tgttccatta gaagcaattg gcacatcttt
     2521 ctatacttta tatacttttc tccagtaata catgtttact ttaaagattg ttgcagtgaa
     2581 gaaaaacctt taactgagaa atatggaaac cgtcttaatt ttccattggc tatgatggaa
     2641 ttaatattgt attttaaaaa tgcatattga tcactataat tctaaaacaa ttttttaaat
     2701 aaaccagcag gttgctaaaa gaaggcattt tatctaaagt tattttaata ggtggtatag
     2761 cagtaatttt aaatttaaga gttgctttta cagttaacaa tggaatatgc cttctctgct
     2821 atgtctgaaa atagaagcta tttattatga gcttctacag gtatttttaa atagagcaag
     2881 catgttgaat ttaaaatatg aataacccca cccaacaatt ttcagtttat tttttgcttt
     2941 ggtcgaactt ggtgtgtgtt catcacccat cagttatttg tgagggtgtt tattctatat
     3001 gaatattgtt tcatgtttgt atgggaaaat tgtagctaaa catttcattg tccccagtct
     3061 gcaaaagaag cacaattcta ttgctttgtc ttgcttatag tcattaaatc attactttta
     3121 catatattgc tgttacttct gctttcttta aaaatatagt aaaggatgtt ttatgaagtc
     3181 acaagataca tatattttta ttttgaccta aatttgtaca gtcccattgt aagtgttgtt
     3241 tctaattata gatgtaaaat gaaatttcat ttgtaattgg aaaaaatcca ataaaaagga
     3301 tattcattta gaaaatagct aagatcttta ataaaaattt gatatgaaaa gcacaatgtg
     3361 cagaagttat ggaaaaccta tagaggatta caacaggtaa acgttaaaga gaatacattg
     3421 ctgacttata gtgatgtggc taagaagtac atgctttgtt gtaaaattgc ttgaaagccc
     3481 attgaaagat gtatctgttt atttacagtc tttgaagtaa aagttaccaa tgtttgccaa
//
