LOCUS       NM_001398510            4403 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens Bcl2 modifying factor (BMF), transcript variant 20,
            mRNA.
ACCESSION   NM_001398510
VERSION     NM_001398510.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4403)
  AUTHORS   Fedele,P.L., Liao,Y., Gong,J.N., Yao,Y., van Delft,M.F.,
            Low,M.S.Y., Tai,L., Herold,M.J., Jackson,J.T., Teh,C.E., Tan,T.,
            O'Reilly,L.A., Tellier,J., Grigoriadis,G., Huang,D.C.S., Shi,W.,
            Nutt,S.L. and Willis,S.N.
  TITLE     The transcription factor IRF4 represses proapoptotic BMF and BIM to
            licence multiple myeloma survival
  JOURNAL   Leukemia 35 (7), 2114-2118 (2021)
   PUBMED   33149265
  REMARK    GeneRIF: The transcription factor IRF4 represses proapoptotic BMF
            and BIM to licence multiple myeloma survival.
REFERENCE   2  (bases 1 to 4403)
  AUTHORS   Xu,F., Li,J., Ni,M., Cheng,J., Zhao,H., Wang,S., Zhou,X. and Wu,X.
  TITLE     FBW7 suppresses ovarian cancer development by targeting the
            N6-methyladenosine binding protein YTHDF2
  JOURNAL   Mol Cancer 20 (1), 45 (2021)
   PUBMED   33658012
  REMARK    GeneRIF: FBW7 suppresses ovarian cancer development by targeting
            the N(6)-methyladenosine binding protein YTHDF2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4403)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4403)
  AUTHORS   Ye,K., Meng,W.X., Sun,H., Wu,B., Chen,M., Pang,Y.P., Gao,J.,
            Wang,H., Wang,J., Kaufmann,S.H. and Dai,H.
  TITLE     Characterization of an alternative BAK-binding site for BH3
            peptides
  JOURNAL   Nat Commun 11 (1), 3301 (2020)
   PUBMED   32620849
  REMARK    GeneRIF: Characterization of an alternative BAK-binding site for
            BH3 peptides.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4403)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4403)
  AUTHORS   Day,C.L., Puthalakath,H., Skea,G., Strasser,A., Barsukov,I.,
            Lian,L.Y., Huang,D.C. and Hinds,M.G.
  TITLE     Localization of dynein light chains 1 and 2 and their pro-apoptotic
            ligands
  JOURNAL   Biochem J 377 (Pt 3), 597-605 (2004)
   PUBMED   14561217
REFERENCE   7  (bases 1 to 4403)
  AUTHORS   Morales,A.A., Olsson,A., Celsing,F., Osterborg,A., Jondal,M. and
            Osorio,L.M.
  TITLE     Expression and transcriptional regulation of functionally distinct
            Bmf isoforms in B-chronic lymphocytic leukemia cells
  JOURNAL   Leukemia 18 (1), 41-47 (2004)
   PUBMED   14574334
  REMARK    GeneRIF: Up or downregulation of Bmf isoforms may have a role in
            regulating growth and survival in B cells and leukemic B-CLL cells
REFERENCE   8  (bases 1 to 4403)
  AUTHORS   Lei,K. and Davis,R.J.
  TITLE     JNK phosphorylation of Bim-related members of the Bcl2 family
            induces Bax-dependent apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2432-2437 (2003)
   PUBMED   12591950
REFERENCE   9  (bases 1 to 4403)
  AUTHORS   Puthalakath,H., Villunger,A., O'Reilly,L.A., Beaumont,J.G.,
            Coultas,L., Cheney,R.E., Huang,D.C. and Strasser,A.
  TITLE     Bmf: a proapoptotic BH3-only protein regulated by interaction with
            the myosin V actin motor complex, activated by anoikis
  JOURNAL   Science 293 (5536), 1829-1832 (2001)
   PUBMED   11546872
  REMARK    Erratum:[Science 2002 Aug 16;297(5584):1122]
REFERENCE   10 (bases 1 to 4403)
  AUTHORS   Hattori,A., Okumura,K., Nagase,T., Kikuno,R., Hirosawa,M. and
            Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen
  JOURNAL   DNA Res 7 (6), 357-366 (2000)
   PUBMED   11214971
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021755.9.
            
            Summary: The protein encoded by this gene belongs to the BCL2
            protein family. BCL2 family members form hetero- or homodimers and
            act as anti- or pro-apoptotic regulators that are involved in a
            wide variety of cellular activities. This protein contains a single
            BCL2 homology domain 3 (BH3), and has been shown to bind BCL2
            proteins and function as an apoptotic activator. This protein is
            found to be sequestered to myosin V motors by its association with
            dynein light chain 2, which may be important for sensing
            intracellular damage and triggering apoptosis. Alternatively
            spliced transcript variants encoding different isoforms have been
            identified. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1515060.1,
                                           SRR14372079.468030.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AC021755.9         126475-126581       c
            108-404             AC021755.9         123497-123793       c
            405-4403            AC021755.9         105592-109590       c
FEATURES             Location/Qualifiers
     source          1..4403
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..4403
                     /gene="BMF"
                     /note="Bcl2 modifying factor"
                     /db_xref="GeneID:90427"
                     /db_xref="HGNC:HGNC:24132"
                     /db_xref="MIM:606266"
     exon            1..107
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     exon            108..404
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..502
                     /gene="BMF"
                     /note="isoform bmf-3 is encoded by transcript variant 20;
                     bcl-2-modifying factor"
                     /codon_start=1
                     /product="bcl-2-modifying factor isoform bmf-3"
                     /protein_id="NP_001385439.1"
                     /db_xref="CCDS:CCDS32196.1"
                     /db_xref="GeneID:90427"
                     /db_xref="HGNC:HGNC:24132"
                     /db_xref="MIM:606266"
                     /translation="MEPSQCVEELEDDVFQPEDGEPVTQPGSLLSADLFAQSLLDCPL
                     SRLQLFPLTHCCGPGLRPTSQEDKATQTLSPASPSQGVMLPCGVTEEPQRLFYAPAEP
                     KSCVVADPPLPAQPCFEWRREQERGRP"
     exon            405..4403
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4383..4388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMF"
                     /note="hexamer: AATAAA"
     polyA_site      4403
                     /gene="BMF"
                     /note="major polyA site"
ORIGIN      
        1 attttggaaa caataccgca ccgtgcggag tggcctcctc ccgccccggc ctgtgcccgc
       61 cgccgccgcc gcccctgcct gcgcctcccg cctcctgccg cagcccggag agatggagcc
      121 atctcagtgt gtggaggagc tggaggatga tgtgttccaa ccagaggatg gggagccggt
      181 gacccaaccc gggagcttgc tctctgctga cctgtttgcc cagagcctac tggactgccc
      241 cctcagccga cttcagctct tccctctcac ccactgctgt ggccctggcc ttcgacccac
      301 cagccaggaa gacaaagcta cccagactct cagcccagcc tcccccagcc aaggtgtcat
      361 gctgccttgt ggggtgactg aggaacccca gcgactcttt tatgcaccag cagaaccaaa
      421 atcgtgtgtg gtggcagatc ctcctcttcc tgcacaacct tgctttgaat ggagaagaga
      481 acaggaacgg ggcaggccct aggtgagggt gggctgccct cttcacatgg ggcaccagga
      541 acaccgtctg gaacaggaag gacatcgggc aggactgaca ctgtgtcttg tgaaattgtt
      601 tttttgttgt tattttgtgt tttaattttt tttaatttct ctctgagtgt acatacaaca
      661 tactcaagcg ggaccttctt tctctgtcag gcccttgacc tggaatgggg gcctttgtca
      721 aacactgttg aaggagaggc tgatgtgtct gtgatggtga gaattcccaa gggctctgac
      781 aagtagattc ttcgactgag gaatctacca gttgtcgaag atgatccgtt agtgatgttc
      841 tctgggaagt ggactgtggt ttttccagag gaactcagtt aagaaatcga gagtggatta
      901 gactcccagt tccaccaaac ctatgagcct tccactgtgg atgggggccg tgatcctgat
      961 ggtcacattg ctttaaccca gcagggcttc ggccaggggc tttccacttg aggatagcag
     1021 cttcactagg ctggccggcc agctccacat ctgactgggt tcttacttct cagccagtac
     1081 ctgccccatg ggctcaagga ttcctggcca gctcctgcca cctccagcag acctcaggga
     1141 gggttgagtt tctctaagga cccctcaaac atgtcgcaaa atgaaccaaa cttctggcta
     1201 ggcctcaaaa ctgacttggt cccacttgga ggccccagga ttggtcctga ggtacagagc
     1261 cactgccacc actggcggcc tgggaccagc tgggtgtcag ccacggatga gccgaatagc
     1321 cagtcagcat gttgctgctg gcagcctgtg cctttgtcag ctcttctttc aaaagacccc
     1381 accgacagac cgcattccac ccccaacatc ggcactgagg gacatcgggg gcaagtttgc
     1441 agtggggccg gaaaatatgg tggccaccct accatgagag tcagccgtag gggaccccag
     1501 accccttggt ttccttggaa acaacatacc tcttccccct tatccccagt cctttttcat
     1561 acctagtggg atacagaaga agccaggaca gtggctttgc cagctaagtg acttttagag
     1621 taacagataa cgattagagt ggggaaccgt caaagctggg tacacatttc ctatcttcct
     1681 ccagcttcca gctaggccag aagggcatgc tctggaaccc agcaggatca cagctgcctg
     1741 tgcacgtctt cccttctctc cctgctgcgg cacttatgga gaggatctaa agcagccggt
     1801 gtggcagctc cgatagcagg cacagggaat ctgttaacca gacgctagaa actaaattat
     1861 aacttttgca tatgtgagaa aagacaacat tggtgctaac agtgaagtaa ggcccaaagg
     1921 aaagacggct tccctggaca aagaagacct cagggctacc caaggaaata ggaggagtct
     1981 agagtagact cacaaatctg aacaagccca agtcttccag ttctgaggag aggaggtctt
     2041 cagtactatt gaaggagaca ttgatcttct ggatgtacag ttgtgcaggt tgttcactgc
     2101 acaagggcac ctgcagctaa tggaggctgg aattcagctt gtgttctgct cactaagctg
     2161 tgtgcgtgcc ctggtgtggg gctacttctc ccaagaagaa ggggtgcctt tcctaatttg
     2221 caaaggtgcc atatgggctc acagcaccct ggaggagaag ggcctcaaac tgtgcatgta
     2281 agcctttgtt ttgttctgct cagatattct ggatattacc tcttcttggt cagaattcta
     2341 ttctcagggt gtgtaccatg atttgtctgc taagaagacg ggttcctgct ttgcagagaa
     2401 ggagccgggg accagcttga agactggctc tgggacacac tgaccattgt gaaattcagc
     2461 cttccctgtg ggtctccata ccattttatg atgtgtatgg gacatacgtt gttctcccct
     2521 ctctggatca aggtggtgac aggcagcctg ctgccgtatg cttcagtggc acacaccaaa
     2581 aaaccgggat tatttacagc agccactatt cacccctttt ggcagactct ccacctgagt
     2641 tcagtgagag agaaaatgat ttagatcttg gtgctggggc aaggccatca gcttcagaga
     2701 ccttgccagg cccaggctgg gtgccctgtg gcctgagaac tgagcccaga ctttgacaaa
     2761 cccacctcaa catcaagcct ggggcaggtg gaaggtggtc tgactgcact gtctccatct
     2821 tatgcaaagc caggaactca ctcactgtct taagtgagcc agggcaaaat ttacacccct
     2881 cacgtttccc tctcccttct tccccaccaa caaaacccag gaggtagctg gcagagtagc
     2941 tgtcaggaag gagaaaggtt ctttctggct ggttgttttt aattggctta gtgatctaaa
     3001 ctggcccctt cctcctctgc ctggtgagtt ggcctaaaca ttcctcaagt ctagcctcag
     3061 gagacctgcc cctccccccc gacctccacc ccctcagact ccatccccca cccccaggag
     3121 cctggctgtc tctagcgagg ggtggagaat cagatttaga gggagggaga gtctgacctg
     3181 gatcctgacc tgtaaccagc tgaagacggt ggaggctttg tggcttgctg agggtggggg
     3241 ttgggagagg gactggaaac cttcctcctc gggaaagaaa tgcctgggag gaagggaagc
     3301 ctgatattca gggtcaaaac agcccttcta attcacaacc ccaaagcagg ggtttctaga
     3361 agttggtcaa cagatctggt gagggaagtc cccaggccag acgctggact cctgcaatga
     3421 gggtggagga ctcagcctgg cctctgcctg gcctgtttca aagtctgggc cactggcagc
     3481 cttctcttgc tcaatccgag gtggaaaaag atcacctccc agtgacctcc ctcagccccc
     3541 aggggagtag gtctgtgtcc aaagctatgt ggcaggcttg tttgaaggac ccagaggggc
     3601 ccagctgacc tgtctcactg ctcctggcag cccagcccca tcggcaggtg gcccctgcct
     3661 gggggttatt cgggatggtt cagccagggc ctcccaggaa gagtgctgtg gagccacggt
     3721 gactgtcctg gacagcaagg agcatgctac cccagtgagc acttcttttt gagggacttg
     3781 atggggaggt ggggtaggca gaagggacgt ggcagaagcg ggaagacttt ggtcaccatg
     3841 gctctgcagg ccttctgcaa atcagtgctg gcctgggctg gaaacagctc tgtgtgtgaa
     3901 ggtgaggact cttggaagca ggccatcctg gccagacacc ctagcaggaa ggggctcacc
     3961 tgtcaccctt aggcagcctg agggctggtg gggacttttg agtcttgagg ggatagcgga
     4021 aaaagctgag ctcataggtg cccagccagc ctcccagcta aaggtgctca gagccccact
     4081 gccccctctc tctgtgcagg tggccagtgc ccctccctgc tctgggagca ttgctagcct
     4141 tctaccccat ccctggatcc acaggggcta tcgaggagac ccagtgagaa tgtagcattt
     4201 tgttcatccc cagggtagct gccctggggt ctgggcactc tgcctctggg agagaggaag
     4261 aagaaagggg ccccattttt taaaaaactg tacagagcct ttggctttat gtgtttatgt
     4321 tcttcacatg catatgtgtg tatgtgtgta tatctttccc cccatcaatt ggtacaattt
     4381 ttaataaaat catttaaagc aaa
//
