LOCUS       NM_001398507            4530 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens Bcl2 modifying factor (BMF), transcript variant 17,
            mRNA.
ACCESSION   NM_001398507
VERSION     NM_001398507.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4530)
  AUTHORS   Fedele,P.L., Liao,Y., Gong,J.N., Yao,Y., van Delft,M.F.,
            Low,M.S.Y., Tai,L., Herold,M.J., Jackson,J.T., Teh,C.E., Tan,T.,
            O'Reilly,L.A., Tellier,J., Grigoriadis,G., Huang,D.C.S., Shi,W.,
            Nutt,S.L. and Willis,S.N.
  TITLE     The transcription factor IRF4 represses proapoptotic BMF and BIM to
            licence multiple myeloma survival
  JOURNAL   Leukemia 35 (7), 2114-2118 (2021)
   PUBMED   33149265
  REMARK    GeneRIF: The transcription factor IRF4 represses proapoptotic BMF
            and BIM to licence multiple myeloma survival.
REFERENCE   2  (bases 1 to 4530)
  AUTHORS   Xu,F., Li,J., Ni,M., Cheng,J., Zhao,H., Wang,S., Zhou,X. and Wu,X.
  TITLE     FBW7 suppresses ovarian cancer development by targeting the
            N6-methyladenosine binding protein YTHDF2
  JOURNAL   Mol Cancer 20 (1), 45 (2021)
   PUBMED   33658012
  REMARK    GeneRIF: FBW7 suppresses ovarian cancer development by targeting
            the N(6)-methyladenosine binding protein YTHDF2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4530)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4530)
  AUTHORS   Ye,K., Meng,W.X., Sun,H., Wu,B., Chen,M., Pang,Y.P., Gao,J.,
            Wang,H., Wang,J., Kaufmann,S.H. and Dai,H.
  TITLE     Characterization of an alternative BAK-binding site for BH3
            peptides
  JOURNAL   Nat Commun 11 (1), 3301 (2020)
   PUBMED   32620849
  REMARK    GeneRIF: Characterization of an alternative BAK-binding site for
            BH3 peptides.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4530)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4530)
  AUTHORS   Day,C.L., Puthalakath,H., Skea,G., Strasser,A., Barsukov,I.,
            Lian,L.Y., Huang,D.C. and Hinds,M.G.
  TITLE     Localization of dynein light chains 1 and 2 and their pro-apoptotic
            ligands
  JOURNAL   Biochem J 377 (Pt 3), 597-605 (2004)
   PUBMED   14561217
REFERENCE   7  (bases 1 to 4530)
  AUTHORS   Morales,A.A., Olsson,A., Celsing,F., Osterborg,A., Jondal,M. and
            Osorio,L.M.
  TITLE     Expression and transcriptional regulation of functionally distinct
            Bmf isoforms in B-chronic lymphocytic leukemia cells
  JOURNAL   Leukemia 18 (1), 41-47 (2004)
   PUBMED   14574334
  REMARK    GeneRIF: Up or downregulation of Bmf isoforms may have a role in
            regulating growth and survival in B cells and leukemic B-CLL cells
REFERENCE   8  (bases 1 to 4530)
  AUTHORS   Lei,K. and Davis,R.J.
  TITLE     JNK phosphorylation of Bim-related members of the Bcl2 family
            induces Bax-dependent apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2432-2437 (2003)
   PUBMED   12591950
REFERENCE   9  (bases 1 to 4530)
  AUTHORS   Puthalakath,H., Villunger,A., O'Reilly,L.A., Beaumont,J.G.,
            Coultas,L., Cheney,R.E., Huang,D.C. and Strasser,A.
  TITLE     Bmf: a proapoptotic BH3-only protein regulated by interaction with
            the myosin V actin motor complex, activated by anoikis
  JOURNAL   Science 293 (5536), 1829-1832 (2001)
   PUBMED   11546872
  REMARK    Erratum:[Science 2002 Aug 16;297(5584):1122]
REFERENCE   10 (bases 1 to 4530)
  AUTHORS   Hattori,A., Okumura,K., Nagase,T., Kikuno,R., Hirosawa,M. and
            Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen
  JOURNAL   DNA Res 7 (6), 357-366 (2000)
   PUBMED   11214971
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021755.9.
            
            Summary: The protein encoded by this gene belongs to the BCL2
            protein family. BCL2 family members form hetero- or homodimers and
            act as anti- or pro-apoptotic regulators that are involved in a
            wide variety of cellular activities. This protein contains a single
            BCL2 homology domain 3 (BH3), and has been shown to bind BCL2
            proteins and function as an apoptotic activator. This protein is
            found to be sequestered to myosin V motors by its association with
            dynein light chain 2, which may be important for sensing
            intracellular damage and triggering apoptosis. Alternatively
            spliced transcript variants encoding different isoforms have been
            identified. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3550945.1,
                                           SRR14038192.1746452.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154405 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AC021755.9         124258-124330       c
            74-370              AC021755.9         123497-123793       c
            371-531             AC021755.9         121882-122042       c
            532-4530            AC021755.9         105592-109590       c
FEATURES             Location/Qualifiers
     source          1..4530
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..4530
                     /gene="BMF"
                     /note="Bcl2 modifying factor"
                     /db_xref="GeneID:90427"
                     /db_xref="HGNC:HGNC:24132"
                     /db_xref="MIM:606266"
     exon            1..73
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     exon            74..370
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..633
                     /gene="BMF"
                     /note="isoform bmf-1 is encoded by transcript variant 17;
                     bcl-2-modifying factor"
                     /codon_start=1
                     /product="bcl-2-modifying factor isoform bmf-1"
                     /protein_id="NP_001385436.1"
                     /db_xref="CCDS:CCDS10052.1"
                     /db_xref="GeneID:90427"
                     /db_xref="HGNC:HGNC:24132"
                     /db_xref="MIM:606266"
                     /translation="MEPSQCVEELEDDVFQPEDGEPVTQPGSLLSADLFAQSLLDCPL
                     SRLQLFPLTHCCGPGLRPTSQEDKATQTLSPASPSQGVMLPCGVTEEPQRLFYGNAGY
                     RLPLPASFPAVLPIGEQPPEGQWQHQAEVQIARKLQCIADQFHRLHVQQHQQNQNRVW
                     WQILLFLHNLALNGEENRNGAGPR"
     exon            371..531
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     exon            532..4530
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4510..4515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMF"
                     /note="hexamer: AATAAA"
     polyA_site      4530
                     /gene="BMF"
                     /note="major polyA site"
ORIGIN      
        1 ggcttttgtt tttgctgctg agcctggagc tcagctcaga ctgagataag aatttccttg
       61 ggacaatgac tctgagagat ggagccatct cagtgtgtgg aggagctgga ggatgatgtg
      121 ttccaaccag aggatgggga gccggtgacc caacccggga gcttgctctc tgctgacctg
      181 tttgcccaga gcctactgga ctgccccctc agccgacttc agctcttccc tctcacccac
      241 tgctgtggcc ctggccttcg acccaccagc caggaagaca aagctaccca gactctcagc
      301 ccagcctccc ccagccaagg tgtcatgctg ccttgtgggg tgactgagga accccagcga
      361 ctcttttatg gcaatgctgg ctatcggctt cctctccctg ccagtttccc agcagtcttg
      421 cccattgggg agcagccccc cgaagggcag tggcaacatc aagcagaggt acagattgcc
      481 cgaaagcttc agtgcattgc agaccagttc caccggcttc atgtgcagca acaccagcag
      541 aaccaaaatc gtgtgtggtg gcagatcctc ctcttcctgc acaaccttgc tttgaatgga
      601 gaagagaaca ggaacggggc aggccctagg tgagggtggg ctgccctctt cacatggggc
      661 accaggaaca ccgtctggaa caggaaggac atcgggcagg actgacactg tgtcttgtga
      721 aattgttttt ttgttgttat tttgtgtttt aatttttttt aatttctctc tgagtgtaca
      781 tacaacatac tcaagcggga ccttctttct ctgtcaggcc cttgacctgg aatgggggcc
      841 tttgtcaaac actgttgaag gagaggctga tgtgtctgtg atggtgagaa ttcccaaggg
      901 ctctgacaag tagattcttc gactgaggaa tctaccagtt gtcgaagatg atccgttagt
      961 gatgttctct gggaagtgga ctgtggtttt tccagaggaa ctcagttaag aaatcgagag
     1021 tggattagac tcccagttcc accaaaccta tgagccttcc actgtggatg ggggccgtga
     1081 tcctgatggt cacattgctt taacccagca gggcttcggc caggggcttt ccacttgagg
     1141 atagcagctt cactaggctg gccggccagc tccacatctg actgggttct tacttctcag
     1201 ccagtacctg ccccatgggc tcaaggattc ctggccagct cctgccacct ccagcagacc
     1261 tcagggaggg ttgagtttct ctaaggaccc ctcaaacatg tcgcaaaatg aaccaaactt
     1321 ctggctaggc ctcaaaactg acttggtccc acttggaggc cccaggattg gtcctgaggt
     1381 acagagccac tgccaccact ggcggcctgg gaccagctgg gtgtcagcca cggatgagcc
     1441 gaatagccag tcagcatgtt gctgctggca gcctgtgcct ttgtcagctc ttctttcaaa
     1501 agaccccacc gacagaccgc attccacccc caacatcggc actgagggac atcgggggca
     1561 agtttgcagt ggggccggaa aatatggtgg ccaccctacc atgagagtca gccgtagggg
     1621 accccagacc ccttggtttc cttggaaaca acatacctct tcccccttat ccccagtcct
     1681 ttttcatacc tagtgggata cagaagaagc caggacagtg gctttgccag ctaagtgact
     1741 tttagagtaa cagataacga ttagagtggg gaaccgtcaa agctgggtac acatttccta
     1801 tcttcctcca gcttccagct aggccagaag ggcatgctct ggaacccagc aggatcacag
     1861 ctgcctgtgc acgtcttccc ttctctccct gctgcggcac ttatggagag gatctaaagc
     1921 agccggtgtg gcagctccga tagcaggcac agggaatctg ttaaccagac gctagaaact
     1981 aaattataac ttttgcatat gtgagaaaag acaacattgg tgctaacagt gaagtaaggc
     2041 ccaaaggaaa gacggcttcc ctggacaaag aagacctcag ggctacccaa ggaaatagga
     2101 ggagtctaga gtagactcac aaatctgaac aagcccaagt cttccagttc tgaggagagg
     2161 aggtcttcag tactattgaa ggagacattg atcttctgga tgtacagttg tgcaggttgt
     2221 tcactgcaca agggcacctg cagctaatgg aggctggaat tcagcttgtg ttctgctcac
     2281 taagctgtgt gcgtgccctg gtgtggggct acttctccca agaagaaggg gtgcctttcc
     2341 taatttgcaa aggtgccata tgggctcaca gcaccctgga ggagaagggc ctcaaactgt
     2401 gcatgtaagc ctttgttttg ttctgctcag atattctgga tattacctct tcttggtcag
     2461 aattctattc tcagggtgtg taccatgatt tgtctgctaa gaagacgggt tcctgctttg
     2521 cagagaagga gccggggacc agcttgaaga ctggctctgg gacacactga ccattgtgaa
     2581 attcagcctt ccctgtgggt ctccatacca ttttatgatg tgtatgggac atacgttgtt
     2641 ctcccctctc tggatcaagg tggtgacagg cagcctgctg ccgtatgctt cagtggcaca
     2701 caccaaaaaa ccgggattat ttacagcagc cactattcac cccttttggc agactctcca
     2761 cctgagttca gtgagagaga aaatgattta gatcttggtg ctggggcaag gccatcagct
     2821 tcagagacct tgccaggccc aggctgggtg ccctgtggcc tgagaactga gcccagactt
     2881 tgacaaaccc acctcaacat caagcctggg gcaggtggaa ggtggtctga ctgcactgtc
     2941 tccatcttat gcaaagccag gaactcactc actgtcttaa gtgagccagg gcaaaattta
     3001 cacccctcac gtttccctct cccttcttcc ccaccaacaa aacccaggag gtagctggca
     3061 gagtagctgt caggaaggag aaaggttctt tctggctggt tgtttttaat tggcttagtg
     3121 atctaaactg gccccttcct cctctgcctg gtgagttggc ctaaacattc ctcaagtcta
     3181 gcctcaggag acctgcccct cccccccgac ctccaccccc tcagactcca tcccccaccc
     3241 ccaggagcct ggctgtctct agcgaggggt ggagaatcag atttagaggg agggagagtc
     3301 tgacctggat cctgacctgt aaccagctga agacggtgga ggctttgtgg cttgctgagg
     3361 gtgggggttg ggagagggac tggaaacctt cctcctcggg aaagaaatgc ctgggaggaa
     3421 gggaagcctg atattcaggg tcaaaacagc ccttctaatt cacaacccca aagcaggggt
     3481 ttctagaagt tggtcaacag atctggtgag ggaagtcccc aggccagacg ctggactcct
     3541 gcaatgaggg tggaggactc agcctggcct ctgcctggcc tgtttcaaag tctgggccac
     3601 tggcagcctt ctcttgctca atccgaggtg gaaaaagatc acctcccagt gacctccctc
     3661 agcccccagg ggagtaggtc tgtgtccaaa gctatgtggc aggcttgttt gaaggaccca
     3721 gaggggccca gctgacctgt ctcactgctc ctggcagccc agccccatcg gcaggtggcc
     3781 cctgcctggg ggttattcgg gatggttcag ccagggcctc ccaggaagag tgctgtggag
     3841 ccacggtgac tgtcctggac agcaaggagc atgctacccc agtgagcact tctttttgag
     3901 ggacttgatg gggaggtggg gtaggcagaa gggacgtggc agaagcggga agactttggt
     3961 caccatggct ctgcaggcct tctgcaaatc agtgctggcc tgggctggaa acagctctgt
     4021 gtgtgaaggt gaggactctt ggaagcaggc catcctggcc agacacccta gcaggaaggg
     4081 gctcacctgt cacccttagg cagcctgagg gctggtgggg acttttgagt cttgagggga
     4141 tagcggaaaa agctgagctc ataggtgccc agccagcctc ccagctaaag gtgctcagag
     4201 ccccactgcc ccctctctct gtgcaggtgg ccagtgcccc tccctgctct gggagcattg
     4261 ctagccttct accccatccc tggatccaca ggggctatcg aggagaccca gtgagaatgt
     4321 agcattttgt tcatccccag ggtagctgcc ctggggtctg ggcactctgc ctctgggaga
     4381 gaggaagaag aaaggggccc cattttttaa aaaactgtac agagcctttg gctttatgtg
     4441 tttatgttct tcacatgcat atgtgtgtat gtgtgtatat ctttcccccc atcaattggt
     4501 acaattttta ataaaatcat ttaaagcaaa
//
