LOCUS       NM_001398498            4773 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens Bcl2 modifying factor (BMF), transcript variant 8,
            mRNA.
ACCESSION   NM_001398498
VERSION     NM_001398498.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4773)
  AUTHORS   Fedele,P.L., Liao,Y., Gong,J.N., Yao,Y., van Delft,M.F.,
            Low,M.S.Y., Tai,L., Herold,M.J., Jackson,J.T., Teh,C.E., Tan,T.,
            O'Reilly,L.A., Tellier,J., Grigoriadis,G., Huang,D.C.S., Shi,W.,
            Nutt,S.L. and Willis,S.N.
  TITLE     The transcription factor IRF4 represses proapoptotic BMF and BIM to
            licence multiple myeloma survival
  JOURNAL   Leukemia 35 (7), 2114-2118 (2021)
   PUBMED   33149265
  REMARK    GeneRIF: The transcription factor IRF4 represses proapoptotic BMF
            and BIM to licence multiple myeloma survival.
REFERENCE   2  (bases 1 to 4773)
  AUTHORS   Xu,F., Li,J., Ni,M., Cheng,J., Zhao,H., Wang,S., Zhou,X. and Wu,X.
  TITLE     FBW7 suppresses ovarian cancer development by targeting the
            N6-methyladenosine binding protein YTHDF2
  JOURNAL   Mol Cancer 20 (1), 45 (2021)
   PUBMED   33658012
  REMARK    GeneRIF: FBW7 suppresses ovarian cancer development by targeting
            the N(6)-methyladenosine binding protein YTHDF2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4773)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4773)
  AUTHORS   Ye,K., Meng,W.X., Sun,H., Wu,B., Chen,M., Pang,Y.P., Gao,J.,
            Wang,H., Wang,J., Kaufmann,S.H. and Dai,H.
  TITLE     Characterization of an alternative BAK-binding site for BH3
            peptides
  JOURNAL   Nat Commun 11 (1), 3301 (2020)
   PUBMED   32620849
  REMARK    GeneRIF: Characterization of an alternative BAK-binding site for
            BH3 peptides.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4773)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4773)
  AUTHORS   Day,C.L., Puthalakath,H., Skea,G., Strasser,A., Barsukov,I.,
            Lian,L.Y., Huang,D.C. and Hinds,M.G.
  TITLE     Localization of dynein light chains 1 and 2 and their pro-apoptotic
            ligands
  JOURNAL   Biochem J 377 (Pt 3), 597-605 (2004)
   PUBMED   14561217
REFERENCE   7  (bases 1 to 4773)
  AUTHORS   Morales,A.A., Olsson,A., Celsing,F., Osterborg,A., Jondal,M. and
            Osorio,L.M.
  TITLE     Expression and transcriptional regulation of functionally distinct
            Bmf isoforms in B-chronic lymphocytic leukemia cells
  JOURNAL   Leukemia 18 (1), 41-47 (2004)
   PUBMED   14574334
  REMARK    GeneRIF: Up or downregulation of Bmf isoforms may have a role in
            regulating growth and survival in B cells and leukemic B-CLL cells
REFERENCE   8  (bases 1 to 4773)
  AUTHORS   Lei,K. and Davis,R.J.
  TITLE     JNK phosphorylation of Bim-related members of the Bcl2 family
            induces Bax-dependent apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2432-2437 (2003)
   PUBMED   12591950
REFERENCE   9  (bases 1 to 4773)
  AUTHORS   Puthalakath,H., Villunger,A., O'Reilly,L.A., Beaumont,J.G.,
            Coultas,L., Cheney,R.E., Huang,D.C. and Strasser,A.
  TITLE     Bmf: a proapoptotic BH3-only protein regulated by interaction with
            the myosin V actin motor complex, activated by anoikis
  JOURNAL   Science 293 (5536), 1829-1832 (2001)
   PUBMED   11546872
  REMARK    Erratum:[Science 2002 Aug 16;297(5584):1122]
REFERENCE   10 (bases 1 to 4773)
  AUTHORS   Hattori,A., Okumura,K., Nagase,T., Kikuno,R., Hirosawa,M. and
            Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen
  JOURNAL   DNA Res 7 (6), 357-366 (2000)
   PUBMED   11214971
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021755.9.
            
            Summary: The protein encoded by this gene belongs to the BCL2
            protein family. BCL2 family members form hetero- or homodimers and
            act as anti- or pro-apoptotic regulators that are involved in a
            wide variety of cellular activities. This protein contains a single
            BCL2 homology domain 3 (BH3), and has been shown to bind BCL2
            proteins and function as an apoptotic activator. This protein is
            found to be sequestered to myosin V motors by its association with
            dynein light chain 2, which may be important for sensing
            intracellular damage and triggering apoptosis. Alternatively
            spliced transcript variants encoding different isoforms have been
            identified. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853560.9484.1,
                                           SRR14038193.2832968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004, SAMEA2152474
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AC021755.9         126475-126581       c
            108-235             AC021755.9         125961-126088       c
            236-316             AC021755.9         124060-124140       c
            317-613             AC021755.9         123497-123793       c
            614-774             AC021755.9         121882-122042       c
            775-4773            AC021755.9         105592-109590       c
FEATURES             Location/Qualifiers
     source          1..4773
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..4773
                     /gene="BMF"
                     /note="Bcl2 modifying factor"
                     /db_xref="GeneID:90427"
                     /db_xref="HGNC:HGNC:24132"
                     /db_xref="MIM:606266"
     exon            1..107
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     exon            108..235
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     exon            236..316
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     exon            317..613
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..876
                     /gene="BMF"
                     /note="isoform bmf-1 is encoded by transcript variant 8;
                     bcl-2-modifying factor"
                     /codon_start=1
                     /product="bcl-2-modifying factor isoform bmf-1"
                     /protein_id="NP_001385427.1"
                     /db_xref="CCDS:CCDS10052.1"
                     /db_xref="GeneID:90427"
                     /db_xref="HGNC:HGNC:24132"
                     /db_xref="MIM:606266"
                     /translation="MEPSQCVEELEDDVFQPEDGEPVTQPGSLLSADLFAQSLLDCPL
                     SRLQLFPLTHCCGPGLRPTSQEDKATQTLSPASPSQGVMLPCGVTEEPQRLFYGNAGY
                     RLPLPASFPAVLPIGEQPPEGQWQHQAEVQIARKLQCIADQFHRLHVQQHQQNQNRVW
                     WQILLFLHNLALNGEENRNGAGPR"
     exon            614..774
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     exon            775..4773
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4753..4758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMF"
                     /note="hexamer: AATAAA"
     polyA_site      4773
                     /gene="BMF"
                     /note="major polyA site"
ORIGIN      
        1 attttggaaa caataccgca ccgtgcggag tggcctcctc ccgccccggc ctgtgcccgc
       61 cgccgccgcc gcccctgcct gcgcctcccg cctcctgccg cagcccgctg ggctttttcc
      121 ctccttccca atcgagtctg ggcgtccagc ccccgagtgc tcgtcacgct ggaccctggc
      181 gcggagccct ggcatcacga ctcggaggcc gagactctct cctggagtca cccaggtacc
      241 ctgcatgcat atagctgctg attctactcc tgctattgct cacaaccctc agagtcaaac
      301 tttgtgaccg gcctaggaga gatggagcca tctcagtgtg tggaggagct ggaggatgat
      361 gtgttccaac cagaggatgg ggagccggtg acccaacccg ggagcttgct ctctgctgac
      421 ctgtttgccc agagcctact ggactgcccc ctcagccgac ttcagctctt ccctctcacc
      481 cactgctgtg gccctggcct tcgacccacc agccaggaag acaaagctac ccagactctc
      541 agcccagcct cccccagcca aggtgtcatg ctgccttgtg gggtgactga ggaaccccag
      601 cgactctttt atggcaatgc tggctatcgg cttcctctcc ctgccagttt cccagcagtc
      661 ttgcccattg gggagcagcc ccccgaaggg cagtggcaac atcaagcaga ggtacagatt
      721 gcccgaaagc ttcagtgcat tgcagaccag ttccaccggc ttcatgtgca gcaacaccag
      781 cagaaccaaa atcgtgtgtg gtggcagatc ctcctcttcc tgcacaacct tgctttgaat
      841 ggagaagaga acaggaacgg ggcaggccct aggtgagggt gggctgccct cttcacatgg
      901 ggcaccagga acaccgtctg gaacaggaag gacatcgggc aggactgaca ctgtgtcttg
      961 tgaaattgtt tttttgttgt tattttgtgt tttaattttt tttaatttct ctctgagtgt
     1021 acatacaaca tactcaagcg ggaccttctt tctctgtcag gcccttgacc tggaatgggg
     1081 gcctttgtca aacactgttg aaggagaggc tgatgtgtct gtgatggtga gaattcccaa
     1141 gggctctgac aagtagattc ttcgactgag gaatctacca gttgtcgaag atgatccgtt
     1201 agtgatgttc tctgggaagt ggactgtggt ttttccagag gaactcagtt aagaaatcga
     1261 gagtggatta gactcccagt tccaccaaac ctatgagcct tccactgtgg atgggggccg
     1321 tgatcctgat ggtcacattg ctttaaccca gcagggcttc ggccaggggc tttccacttg
     1381 aggatagcag cttcactagg ctggccggcc agctccacat ctgactgggt tcttacttct
     1441 cagccagtac ctgccccatg ggctcaagga ttcctggcca gctcctgcca cctccagcag
     1501 acctcaggga gggttgagtt tctctaagga cccctcaaac atgtcgcaaa atgaaccaaa
     1561 cttctggcta ggcctcaaaa ctgacttggt cccacttgga ggccccagga ttggtcctga
     1621 ggtacagagc cactgccacc actggcggcc tgggaccagc tgggtgtcag ccacggatga
     1681 gccgaatagc cagtcagcat gttgctgctg gcagcctgtg cctttgtcag ctcttctttc
     1741 aaaagacccc accgacagac cgcattccac ccccaacatc ggcactgagg gacatcgggg
     1801 gcaagtttgc agtggggccg gaaaatatgg tggccaccct accatgagag tcagccgtag
     1861 gggaccccag accccttggt ttccttggaa acaacatacc tcttccccct tatccccagt
     1921 cctttttcat acctagtggg atacagaaga agccaggaca gtggctttgc cagctaagtg
     1981 acttttagag taacagataa cgattagagt ggggaaccgt caaagctggg tacacatttc
     2041 ctatcttcct ccagcttcca gctaggccag aagggcatgc tctggaaccc agcaggatca
     2101 cagctgcctg tgcacgtctt cccttctctc cctgctgcgg cacttatgga gaggatctaa
     2161 agcagccggt gtggcagctc cgatagcagg cacagggaat ctgttaacca gacgctagaa
     2221 actaaattat aacttttgca tatgtgagaa aagacaacat tggtgctaac agtgaagtaa
     2281 ggcccaaagg aaagacggct tccctggaca aagaagacct cagggctacc caaggaaata
     2341 ggaggagtct agagtagact cacaaatctg aacaagccca agtcttccag ttctgaggag
     2401 aggaggtctt cagtactatt gaaggagaca ttgatcttct ggatgtacag ttgtgcaggt
     2461 tgttcactgc acaagggcac ctgcagctaa tggaggctgg aattcagctt gtgttctgct
     2521 cactaagctg tgtgcgtgcc ctggtgtggg gctacttctc ccaagaagaa ggggtgcctt
     2581 tcctaatttg caaaggtgcc atatgggctc acagcaccct ggaggagaag ggcctcaaac
     2641 tgtgcatgta agcctttgtt ttgttctgct cagatattct ggatattacc tcttcttggt
     2701 cagaattcta ttctcagggt gtgtaccatg atttgtctgc taagaagacg ggttcctgct
     2761 ttgcagagaa ggagccgggg accagcttga agactggctc tgggacacac tgaccattgt
     2821 gaaattcagc cttccctgtg ggtctccata ccattttatg atgtgtatgg gacatacgtt
     2881 gttctcccct ctctggatca aggtggtgac aggcagcctg ctgccgtatg cttcagtggc
     2941 acacaccaaa aaaccgggat tatttacagc agccactatt cacccctttt ggcagactct
     3001 ccacctgagt tcagtgagag agaaaatgat ttagatcttg gtgctggggc aaggccatca
     3061 gcttcagaga ccttgccagg cccaggctgg gtgccctgtg gcctgagaac tgagcccaga
     3121 ctttgacaaa cccacctcaa catcaagcct ggggcaggtg gaaggtggtc tgactgcact
     3181 gtctccatct tatgcaaagc caggaactca ctcactgtct taagtgagcc agggcaaaat
     3241 ttacacccct cacgtttccc tctcccttct tccccaccaa caaaacccag gaggtagctg
     3301 gcagagtagc tgtcaggaag gagaaaggtt ctttctggct ggttgttttt aattggctta
     3361 gtgatctaaa ctggcccctt cctcctctgc ctggtgagtt ggcctaaaca ttcctcaagt
     3421 ctagcctcag gagacctgcc cctccccccc gacctccacc ccctcagact ccatccccca
     3481 cccccaggag cctggctgtc tctagcgagg ggtggagaat cagatttaga gggagggaga
     3541 gtctgacctg gatcctgacc tgtaaccagc tgaagacggt ggaggctttg tggcttgctg
     3601 agggtggggg ttgggagagg gactggaaac cttcctcctc gggaaagaaa tgcctgggag
     3661 gaagggaagc ctgatattca gggtcaaaac agcccttcta attcacaacc ccaaagcagg
     3721 ggtttctaga agttggtcaa cagatctggt gagggaagtc cccaggccag acgctggact
     3781 cctgcaatga gggtggagga ctcagcctgg cctctgcctg gcctgtttca aagtctgggc
     3841 cactggcagc cttctcttgc tcaatccgag gtggaaaaag atcacctccc agtgacctcc
     3901 ctcagccccc aggggagtag gtctgtgtcc aaagctatgt ggcaggcttg tttgaaggac
     3961 ccagaggggc ccagctgacc tgtctcactg ctcctggcag cccagcccca tcggcaggtg
     4021 gcccctgcct gggggttatt cgggatggtt cagccagggc ctcccaggaa gagtgctgtg
     4081 gagccacggt gactgtcctg gacagcaagg agcatgctac cccagtgagc acttcttttt
     4141 gagggacttg atggggaggt ggggtaggca gaagggacgt ggcagaagcg ggaagacttt
     4201 ggtcaccatg gctctgcagg ccttctgcaa atcagtgctg gcctgggctg gaaacagctc
     4261 tgtgtgtgaa ggtgaggact cttggaagca ggccatcctg gccagacacc ctagcaggaa
     4321 ggggctcacc tgtcaccctt aggcagcctg agggctggtg gggacttttg agtcttgagg
     4381 ggatagcgga aaaagctgag ctcataggtg cccagccagc ctcccagcta aaggtgctca
     4441 gagccccact gccccctctc tctgtgcagg tggccagtgc ccctccctgc tctgggagca
     4501 ttgctagcct tctaccccat ccctggatcc acaggggcta tcgaggagac ccagtgagaa
     4561 tgtagcattt tgttcatccc cagggtagct gccctggggt ctgggcactc tgcctctggg
     4621 agagaggaag aagaaagggg ccccattttt taaaaaactg tacagagcct ttggctttat
     4681 gtgtttatgt tcttcacatg catatgtgtg tatgtgtgta tatctttccc cccatcaatt
     4741 ggtacaattt ttaataaaat catttaaagc aaa
//
