LOCUS       NM_001003943            4531 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens Bcl2 modifying factor (BMF), transcript variant 4,
            mRNA.
ACCESSION   NM_001003943
VERSION     NM_001003943.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4531)
  AUTHORS   Fedele,P.L., Liao,Y., Gong,J.N., Yao,Y., van Delft,M.F.,
            Low,M.S.Y., Tai,L., Herold,M.J., Jackson,J.T., Teh,C.E., Tan,T.,
            O'Reilly,L.A., Tellier,J., Grigoriadis,G., Huang,D.C.S., Shi,W.,
            Nutt,S.L. and Willis,S.N.
  TITLE     The transcription factor IRF4 represses proapoptotic BMF and BIM to
            licence multiple myeloma survival
  JOURNAL   Leukemia 35 (7), 2114-2118 (2021)
   PUBMED   33149265
  REMARK    GeneRIF: The transcription factor IRF4 represses proapoptotic BMF
            and BIM to licence multiple myeloma survival.
REFERENCE   2  (bases 1 to 4531)
  AUTHORS   Xu,F., Li,J., Ni,M., Cheng,J., Zhao,H., Wang,S., Zhou,X. and Wu,X.
  TITLE     FBW7 suppresses ovarian cancer development by targeting the
            N6-methyladenosine binding protein YTHDF2
  JOURNAL   Mol Cancer 20 (1), 45 (2021)
   PUBMED   33658012
  REMARK    GeneRIF: FBW7 suppresses ovarian cancer development by targeting
            the N(6)-methyladenosine binding protein YTHDF2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4531)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4531)
  AUTHORS   Ye,K., Meng,W.X., Sun,H., Wu,B., Chen,M., Pang,Y.P., Gao,J.,
            Wang,H., Wang,J., Kaufmann,S.H. and Dai,H.
  TITLE     Characterization of an alternative BAK-binding site for BH3
            peptides
  JOURNAL   Nat Commun 11 (1), 3301 (2020)
   PUBMED   32620849
  REMARK    GeneRIF: Characterization of an alternative BAK-binding site for
            BH3 peptides.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4531)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4531)
  AUTHORS   Day,C.L., Puthalakath,H., Skea,G., Strasser,A., Barsukov,I.,
            Lian,L.Y., Huang,D.C. and Hinds,M.G.
  TITLE     Localization of dynein light chains 1 and 2 and their pro-apoptotic
            ligands
  JOURNAL   Biochem J 377 (Pt 3), 597-605 (2004)
   PUBMED   14561217
REFERENCE   7  (bases 1 to 4531)
  AUTHORS   Morales,A.A., Olsson,A., Celsing,F., Osterborg,A., Jondal,M. and
            Osorio,L.M.
  TITLE     Expression and transcriptional regulation of functionally distinct
            Bmf isoforms in B-chronic lymphocytic leukemia cells
  JOURNAL   Leukemia 18 (1), 41-47 (2004)
   PUBMED   14574334
  REMARK    GeneRIF: Up or downregulation of Bmf isoforms may have a role in
            regulating growth and survival in B cells and leukemic B-CLL cells
REFERENCE   8  (bases 1 to 4531)
  AUTHORS   Lei,K. and Davis,R.J.
  TITLE     JNK phosphorylation of Bim-related members of the Bcl2 family
            induces Bax-dependent apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2432-2437 (2003)
   PUBMED   12591950
REFERENCE   9  (bases 1 to 4531)
  AUTHORS   Puthalakath,H., Villunger,A., O'Reilly,L.A., Beaumont,J.G.,
            Coultas,L., Cheney,R.E., Huang,D.C. and Strasser,A.
  TITLE     Bmf: a proapoptotic BH3-only protein regulated by interaction with
            the myosin V actin motor complex, activated by anoikis
  JOURNAL   Science 293 (5536), 1829-1832 (2001)
   PUBMED   11546872
  REMARK    Erratum:[Science 2002 Aug 16;297(5584):1122]
REFERENCE   10 (bases 1 to 4531)
  AUTHORS   Hattori,A., Okumura,K., Nagase,T., Kikuno,R., Hirosawa,M. and
            Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen
  JOURNAL   DNA Res 7 (6), 357-366 (2000)
   PUBMED   11214971
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021755.9.
            
            On May 31, 2019 this sequence version replaced NM_001003943.2.
            
            Summary: The protein encoded by this gene belongs to the BCL2
            protein family. BCL2 family members form hetero- or homodimers and
            act as anti- or pro-apoptotic regulators that are involved in a
            wide variety of cellular activities. This protein contains a single
            BCL2 homology domain 3 (BH3), and has been shown to bind BCL2
            proteins and function as an apoptotic activator. This protein is
            found to be sequestered to myosin V motors by its association with
            dynein light chain 2, which may be important for sensing
            intracellular damage and triggering apoptosis. Alternatively
            spliced transcript variants encoding different isoforms have been
            identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (4) lacks an in-frame coding exon,
            compared to variant 1. It encodes a shorter isoform (bmf-3),
            compared to isoform bmf-1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP280415.1, ERR3218366.903666.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AC021755.9         126475-126581       c
            108-235             AC021755.9         125961-126088       c
            236-532             AC021755.9         123497-123793       c
            533-4531            AC021755.9         105592-109590       c
FEATURES             Location/Qualifiers
     source          1..4531
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..4531
                     /gene="BMF"
                     /note="Bcl2 modifying factor"
                     /db_xref="GeneID:90427"
                     /db_xref="HGNC:HGNC:24132"
                     /db_xref="MIM:606266"
     exon            1..107
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     exon            108..235
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     exon            236..532
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..630
                     /gene="BMF"
                     /note="isoform bmf-3 is encoded by transcript variant 4;
                     bcl-2-modifying factor"
                     /codon_start=1
                     /product="bcl-2-modifying factor isoform bmf-3"
                     /protein_id="NP_001003943.1"
                     /db_xref="CCDS:CCDS32196.1"
                     /db_xref="GeneID:90427"
                     /db_xref="HGNC:HGNC:24132"
                     /db_xref="MIM:606266"
                     /translation="MEPSQCVEELEDDVFQPEDGEPVTQPGSLLSADLFAQSLLDCPL
                     SRLQLFPLTHCCGPGLRPTSQEDKATQTLSPASPSQGVMLPCGVTEEPQRLFYAPAEP
                     KSCVVADPPLPAQPCFEWRREQERGRP"
     exon            533..4531
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4511..4516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMF"
                     /note="hexamer: AATAAA"
     polyA_site      4531
                     /gene="BMF"
                     /note="major polyA site"
ORIGIN      
        1 attttggaaa caataccgca ccgtgcggag tggcctcctc ccgccccggc ctgtgcccgc
       61 cgccgccgcc gcccctgcct gcgcctcccg cctcctgccg cagcccgctg ggctttttcc
      121 ctccttccca atcgagtctg ggcgtccagc ccccgagtgc tcgtcacgct ggaccctggc
      181 gcggagccct ggcatcacga ctcggaggcc gagactctct cctggagtca cccaggagag
      241 atggagccat ctcagtgtgt ggaggagctg gaggatgatg tgttccaacc agaggatggg
      301 gagccggtga cccaacccgg gagcttgctc tctgctgacc tgtttgccca gagcctactg
      361 gactgccccc tcagccgact tcagctcttc cctctcaccc actgctgtgg ccctggcctt
      421 cgacccacca gccaggaaga caaagctacc cagactctca gcccagcctc ccccagccaa
      481 ggtgtcatgc tgccttgtgg ggtgactgag gaaccccagc gactctttta tgcaccagca
      541 gaaccaaaat cgtgtgtggt ggcagatcct cctcttcctg cacaaccttg ctttgaatgg
      601 agaagagaac aggaacgggg caggccctag gtgagggtgg gctgccctct tcacatgggg
      661 caccaggaac accgtctgga acaggaagga catcgggcag gactgacact gtgtcttgtg
      721 aaattgtttt tttgttgtta ttttgtgttt taattttttt taatttctct ctgagtgtac
      781 atacaacata ctcaagcggg accttctttc tctgtcaggc ccttgacctg gaatgggggc
      841 ctttgtcaaa cactgttgaa ggagaggctg atgtgtctgt gatggtgaga attcccaagg
      901 gctctgacaa gtagattctt cgactgagga atctaccagt tgtcgaagat gatccgttag
      961 tgatgttctc tgggaagtgg actgtggttt ttccagagga actcagttaa gaaatcgaga
     1021 gtggattaga ctcccagttc caccaaacct atgagccttc cactgtggat gggggccgtg
     1081 atcctgatgg tcacattgct ttaacccagc agggcttcgg ccaggggctt tccacttgag
     1141 gatagcagct tcactaggct ggccggccag ctccacatct gactgggttc ttacttctca
     1201 gccagtacct gccccatggg ctcaaggatt cctggccagc tcctgccacc tccagcagac
     1261 ctcagggagg gttgagtttc tctaaggacc cctcaaacat gtcgcaaaat gaaccaaact
     1321 tctggctagg cctcaaaact gacttggtcc cacttggagg ccccaggatt ggtcctgagg
     1381 tacagagcca ctgccaccac tggcggcctg ggaccagctg ggtgtcagcc acggatgagc
     1441 cgaatagcca gtcagcatgt tgctgctggc agcctgtgcc tttgtcagct cttctttcaa
     1501 aagaccccac cgacagaccg cattccaccc ccaacatcgg cactgaggga catcgggggc
     1561 aagtttgcag tggggccgga aaatatggtg gccaccctac catgagagtc agccgtaggg
     1621 gaccccagac cccttggttt ccttggaaac aacatacctc ttccccctta tccccagtcc
     1681 tttttcatac ctagtgggat acagaagaag ccaggacagt ggctttgcca gctaagtgac
     1741 ttttagagta acagataacg attagagtgg ggaaccgtca aagctgggta cacatttcct
     1801 atcttcctcc agcttccagc taggccagaa gggcatgctc tggaacccag caggatcaca
     1861 gctgcctgtg cacgtcttcc cttctctccc tgctgcggca cttatggaga ggatctaaag
     1921 cagccggtgt ggcagctccg atagcaggca cagggaatct gttaaccaga cgctagaaac
     1981 taaattataa cttttgcata tgtgagaaaa gacaacattg gtgctaacag tgaagtaagg
     2041 cccaaaggaa agacggcttc cctggacaaa gaagacctca gggctaccca aggaaatagg
     2101 aggagtctag agtagactca caaatctgaa caagcccaag tcttccagtt ctgaggagag
     2161 gaggtcttca gtactattga aggagacatt gatcttctgg atgtacagtt gtgcaggttg
     2221 ttcactgcac aagggcacct gcagctaatg gaggctggaa ttcagcttgt gttctgctca
     2281 ctaagctgtg tgcgtgccct ggtgtggggc tacttctccc aagaagaagg ggtgcctttc
     2341 ctaatttgca aaggtgccat atgggctcac agcaccctgg aggagaaggg cctcaaactg
     2401 tgcatgtaag cctttgtttt gttctgctca gatattctgg atattacctc ttcttggtca
     2461 gaattctatt ctcagggtgt gtaccatgat ttgtctgcta agaagacggg ttcctgcttt
     2521 gcagagaagg agccggggac cagcttgaag actggctctg ggacacactg accattgtga
     2581 aattcagcct tccctgtggg tctccatacc attttatgat gtgtatggga catacgttgt
     2641 tctcccctct ctggatcaag gtggtgacag gcagcctgct gccgtatgct tcagtggcac
     2701 acaccaaaaa accgggatta tttacagcag ccactattca ccccttttgg cagactctcc
     2761 acctgagttc agtgagagag aaaatgattt agatcttggt gctggggcaa ggccatcagc
     2821 ttcagagacc ttgccaggcc caggctgggt gccctgtggc ctgagaactg agcccagact
     2881 ttgacaaacc cacctcaaca tcaagcctgg ggcaggtgga aggtggtctg actgcactgt
     2941 ctccatctta tgcaaagcca ggaactcact cactgtctta agtgagccag ggcaaaattt
     3001 acacccctca cgtttccctc tcccttcttc cccaccaaca aaacccagga ggtagctggc
     3061 agagtagctg tcaggaagga gaaaggttct ttctggctgg ttgtttttaa ttggcttagt
     3121 gatctaaact ggccccttcc tcctctgcct ggtgagttgg cctaaacatt cctcaagtct
     3181 agcctcagga gacctgcccc tcccccccga cctccacccc ctcagactcc atcccccacc
     3241 cccaggagcc tggctgtctc tagcgagggg tggagaatca gatttagagg gagggagagt
     3301 ctgacctgga tcctgacctg taaccagctg aagacggtgg aggctttgtg gcttgctgag
     3361 ggtgggggtt gggagaggga ctggaaacct tcctcctcgg gaaagaaatg cctgggagga
     3421 agggaagcct gatattcagg gtcaaaacag cccttctaat tcacaacccc aaagcagggg
     3481 tttctagaag ttggtcaaca gatctggtga gggaagtccc caggccagac gctggactcc
     3541 tgcaatgagg gtggaggact cagcctggcc tctgcctggc ctgtttcaaa gtctgggcca
     3601 ctggcagcct tctcttgctc aatccgaggt ggaaaaagat cacctcccag tgacctccct
     3661 cagcccccag gggagtaggt ctgtgtccaa agctatgtgg caggcttgtt tgaaggaccc
     3721 agaggggccc agctgacctg tctcactgct cctggcagcc cagccccatc ggcaggtggc
     3781 ccctgcctgg gggttattcg ggatggttca gccagggcct cccaggaaga gtgctgtgga
     3841 gccacggtga ctgtcctgga cagcaaggag catgctaccc cagtgagcac ttctttttga
     3901 gggacttgat ggggaggtgg ggtaggcaga agggacgtgg cagaagcggg aagactttgg
     3961 tcaccatggc tctgcaggcc ttctgcaaat cagtgctggc ctgggctgga aacagctctg
     4021 tgtgtgaagg tgaggactct tggaagcagg ccatcctggc cagacaccct agcaggaagg
     4081 ggctcacctg tcacccttag gcagcctgag ggctggtggg gacttttgag tcttgagggg
     4141 atagcggaaa aagctgagct cataggtgcc cagccagcct cccagctaaa ggtgctcaga
     4201 gccccactgc cccctctctc tgtgcaggtg gccagtgccc ctccctgctc tgggagcatt
     4261 gctagccttc taccccatcc ctggatccac aggggctatc gaggagaccc agtgagaatg
     4321 tagcattttg ttcatcccca gggtagctgc cctggggtct gggcactctg cctctgggag
     4381 agaggaagaa gaaaggggcc ccatttttta aaaaactgta cagagccttt ggctttatgt
     4441 gtttatgttc ttcacatgca tatgtgtgta tgtgtgtata tctttccccc catcaattgg
     4501 tacaattttt aataaaatca tttaaagcaa a
//
