LOCUS       NM_001003940            4692 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens Bcl2 modifying factor (BMF), transcript variant 1,
            mRNA.
ACCESSION   NM_001003940
VERSION     NM_001003940.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4692)
  AUTHORS   Fedele,P.L., Liao,Y., Gong,J.N., Yao,Y., van Delft,M.F.,
            Low,M.S.Y., Tai,L., Herold,M.J., Jackson,J.T., Teh,C.E., Tan,T.,
            O'Reilly,L.A., Tellier,J., Grigoriadis,G., Huang,D.C.S., Shi,W.,
            Nutt,S.L. and Willis,S.N.
  TITLE     The transcription factor IRF4 represses proapoptotic BMF and BIM to
            licence multiple myeloma survival
  JOURNAL   Leukemia 35 (7), 2114-2118 (2021)
   PUBMED   33149265
  REMARK    GeneRIF: The transcription factor IRF4 represses proapoptotic BMF
            and BIM to licence multiple myeloma survival.
REFERENCE   2  (bases 1 to 4692)
  AUTHORS   Xu,F., Li,J., Ni,M., Cheng,J., Zhao,H., Wang,S., Zhou,X. and Wu,X.
  TITLE     FBW7 suppresses ovarian cancer development by targeting the
            N6-methyladenosine binding protein YTHDF2
  JOURNAL   Mol Cancer 20 (1), 45 (2021)
   PUBMED   33658012
  REMARK    GeneRIF: FBW7 suppresses ovarian cancer development by targeting
            the N(6)-methyladenosine binding protein YTHDF2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4692)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4692)
  AUTHORS   Ye,K., Meng,W.X., Sun,H., Wu,B., Chen,M., Pang,Y.P., Gao,J.,
            Wang,H., Wang,J., Kaufmann,S.H. and Dai,H.
  TITLE     Characterization of an alternative BAK-binding site for BH3
            peptides
  JOURNAL   Nat Commun 11 (1), 3301 (2020)
   PUBMED   32620849
  REMARK    GeneRIF: Characterization of an alternative BAK-binding site for
            BH3 peptides.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4692)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4692)
  AUTHORS   Day,C.L., Puthalakath,H., Skea,G., Strasser,A., Barsukov,I.,
            Lian,L.Y., Huang,D.C. and Hinds,M.G.
  TITLE     Localization of dynein light chains 1 and 2 and their pro-apoptotic
            ligands
  JOURNAL   Biochem J 377 (Pt 3), 597-605 (2004)
   PUBMED   14561217
REFERENCE   7  (bases 1 to 4692)
  AUTHORS   Morales,A.A., Olsson,A., Celsing,F., Osterborg,A., Jondal,M. and
            Osorio,L.M.
  TITLE     Expression and transcriptional regulation of functionally distinct
            Bmf isoforms in B-chronic lymphocytic leukemia cells
  JOURNAL   Leukemia 18 (1), 41-47 (2004)
   PUBMED   14574334
  REMARK    GeneRIF: Up or downregulation of Bmf isoforms may have a role in
            regulating growth and survival in B cells and leukemic B-CLL cells
REFERENCE   8  (bases 1 to 4692)
  AUTHORS   Lei,K. and Davis,R.J.
  TITLE     JNK phosphorylation of Bim-related members of the Bcl2 family
            induces Bax-dependent apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2432-2437 (2003)
   PUBMED   12591950
REFERENCE   9  (bases 1 to 4692)
  AUTHORS   Puthalakath,H., Villunger,A., O'Reilly,L.A., Beaumont,J.G.,
            Coultas,L., Cheney,R.E., Huang,D.C. and Strasser,A.
  TITLE     Bmf: a proapoptotic BH3-only protein regulated by interaction with
            the myosin V actin motor complex, activated by anoikis
  JOURNAL   Science 293 (5536), 1829-1832 (2001)
   PUBMED   11546872
  REMARK    Erratum:[Science 2002 Aug 16;297(5584):1122]
REFERENCE   10 (bases 1 to 4692)
  AUTHORS   Hattori,A., Okumura,K., Nagase,T., Kikuno,R., Hirosawa,M. and
            Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen
  JOURNAL   DNA Res 7 (6), 357-366 (2000)
   PUBMED   11214971
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021755.9.
            
            On Nov 22, 2018 this sequence version replaced NM_001003940.1.
            
            Summary: The protein encoded by this gene belongs to the BCL2
            protein family. BCL2 family members form hetero- or homodimers and
            act as anti- or pro-apoptotic regulators that are involved in a
            wide variety of cellular activities. This protein contains a single
            BCL2 homology domain 3 (BH3), and has been shown to bind BCL2
            proteins and function as an apoptotic activator. This protein is
            found to be sequestered to myosin V motors by its association with
            dynein light chain 2, which may be important for sensing
            intracellular damage and triggering apoptosis. Alternatively
            spliced transcript variants encoding different isoforms have been
            identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Transcript variants 1 and 2 encode the longest isoform
            (bmf-1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070043.1, SRR1163655.633331.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354670.9/ ENSP00000346697.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AC021755.9         126475-126581       c
            108-235             AC021755.9         125961-126088       c
            236-532             AC021755.9         123497-123793       c
            533-693             AC021755.9         121882-122042       c
            694-4692            AC021755.9         105592-109590       c
FEATURES             Location/Qualifiers
     source          1..4692
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..4692
                     /gene="BMF"
                     /note="Bcl2 modifying factor"
                     /db_xref="GeneID:90427"
                     /db_xref="HGNC:HGNC:24132"
                     /db_xref="MIM:606266"
     exon            1..107
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     exon            108..235
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     exon            236..532
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..795
                     /gene="BMF"
                     /note="isoform bmf-1 is encoded by transcript variant 1;
                     bcl-2-modifying factor"
                     /codon_start=1
                     /product="bcl-2-modifying factor isoform bmf-1"
                     /protein_id="NP_001003940.1"
                     /db_xref="CCDS:CCDS10052.1"
                     /db_xref="GeneID:90427"
                     /db_xref="HGNC:HGNC:24132"
                     /db_xref="MIM:606266"
                     /translation="MEPSQCVEELEDDVFQPEDGEPVTQPGSLLSADLFAQSLLDCPL
                     SRLQLFPLTHCCGPGLRPTSQEDKATQTLSPASPSQGVMLPCGVTEEPQRLFYGNAGY
                     RLPLPASFPAVLPIGEQPPEGQWQHQAEVQIARKLQCIADQFHRLHVQQHQQNQNRVW
                     WQILLFLHNLALNGEENRNGAGPR"
     exon            533..693
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     exon            694..4692
                     /gene="BMF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4672..4677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMF"
                     /note="hexamer: AATAAA"
     polyA_site      4692
                     /gene="BMF"
                     /note="major polyA site"
ORIGIN      
        1 attttggaaa caataccgca ccgtgcggag tggcctcctc ccgccccggc ctgtgcccgc
       61 cgccgccgcc gcccctgcct gcgcctcccg cctcctgccg cagcccgctg ggctttttcc
      121 ctccttccca atcgagtctg ggcgtccagc ccccgagtgc tcgtcacgct ggaccctggc
      181 gcggagccct ggcatcacga ctcggaggcc gagactctct cctggagtca cccaggagag
      241 atggagccat ctcagtgtgt ggaggagctg gaggatgatg tgttccaacc agaggatggg
      301 gagccggtga cccaacccgg gagcttgctc tctgctgacc tgtttgccca gagcctactg
      361 gactgccccc tcagccgact tcagctcttc cctctcaccc actgctgtgg ccctggcctt
      421 cgacccacca gccaggaaga caaagctacc cagactctca gcccagcctc ccccagccaa
      481 ggtgtcatgc tgccttgtgg ggtgactgag gaaccccagc gactctttta tggcaatgct
      541 ggctatcggc ttcctctccc tgccagtttc ccagcagtct tgcccattgg ggagcagccc
      601 cccgaagggc agtggcaaca tcaagcagag gtacagattg cccgaaagct tcagtgcatt
      661 gcagaccagt tccaccggct tcatgtgcag caacaccagc agaaccaaaa tcgtgtgtgg
      721 tggcagatcc tcctcttcct gcacaacctt gctttgaatg gagaagagaa caggaacggg
      781 gcaggcccta ggtgagggtg ggctgccctc ttcacatggg gcaccaggaa caccgtctgg
      841 aacaggaagg acatcgggca ggactgacac tgtgtcttgt gaaattgttt ttttgttgtt
      901 attttgtgtt ttaatttttt ttaatttctc tctgagtgta catacaacat actcaagcgg
      961 gaccttcttt ctctgtcagg cccttgacct ggaatggggg cctttgtcaa acactgttga
     1021 aggagaggct gatgtgtctg tgatggtgag aattcccaag ggctctgaca agtagattct
     1081 tcgactgagg aatctaccag ttgtcgaaga tgatccgtta gtgatgttct ctgggaagtg
     1141 gactgtggtt tttccagagg aactcagtta agaaatcgag agtggattag actcccagtt
     1201 ccaccaaacc tatgagcctt ccactgtgga tgggggccgt gatcctgatg gtcacattgc
     1261 tttaacccag cagggcttcg gccaggggct ttccacttga ggatagcagc ttcactaggc
     1321 tggccggcca gctccacatc tgactgggtt cttacttctc agccagtacc tgccccatgg
     1381 gctcaaggat tcctggccag ctcctgccac ctccagcaga cctcagggag ggttgagttt
     1441 ctctaaggac ccctcaaaca tgtcgcaaaa tgaaccaaac ttctggctag gcctcaaaac
     1501 tgacttggtc ccacttggag gccccaggat tggtcctgag gtacagagcc actgccacca
     1561 ctggcggcct gggaccagct gggtgtcagc cacggatgag ccgaatagcc agtcagcatg
     1621 ttgctgctgg cagcctgtgc ctttgtcagc tcttctttca aaagacccca ccgacagacc
     1681 gcattccacc cccaacatcg gcactgaggg acatcggggg caagtttgca gtggggccgg
     1741 aaaatatggt ggccacccta ccatgagagt cagccgtagg ggaccccaga ccccttggtt
     1801 tccttggaaa caacatacct cttccccctt atccccagtc ctttttcata cctagtggga
     1861 tacagaagaa gccaggacag tggctttgcc agctaagtga cttttagagt aacagataac
     1921 gattagagtg gggaaccgtc aaagctgggt acacatttcc tatcttcctc cagcttccag
     1981 ctaggccaga agggcatgct ctggaaccca gcaggatcac agctgcctgt gcacgtcttc
     2041 ccttctctcc ctgctgcggc acttatggag aggatctaaa gcagccggtg tggcagctcc
     2101 gatagcaggc acagggaatc tgttaaccag acgctagaaa ctaaattata acttttgcat
     2161 atgtgagaaa agacaacatt ggtgctaaca gtgaagtaag gcccaaagga aagacggctt
     2221 ccctggacaa agaagacctc agggctaccc aaggaaatag gaggagtcta gagtagactc
     2281 acaaatctga acaagcccaa gtcttccagt tctgaggaga ggaggtcttc agtactattg
     2341 aaggagacat tgatcttctg gatgtacagt tgtgcaggtt gttcactgca caagggcacc
     2401 tgcagctaat ggaggctgga attcagcttg tgttctgctc actaagctgt gtgcgtgccc
     2461 tggtgtgggg ctacttctcc caagaagaag gggtgccttt cctaatttgc aaaggtgcca
     2521 tatgggctca cagcaccctg gaggagaagg gcctcaaact gtgcatgtaa gcctttgttt
     2581 tgttctgctc agatattctg gatattacct cttcttggtc agaattctat tctcagggtg
     2641 tgtaccatga tttgtctgct aagaagacgg gttcctgctt tgcagagaag gagccgggga
     2701 ccagcttgaa gactggctct gggacacact gaccattgtg aaattcagcc ttccctgtgg
     2761 gtctccatac cattttatga tgtgtatggg acatacgttg ttctcccctc tctggatcaa
     2821 ggtggtgaca ggcagcctgc tgccgtatgc ttcagtggca cacaccaaaa aaccgggatt
     2881 atttacagca gccactattc accccttttg gcagactctc cacctgagtt cagtgagaga
     2941 gaaaatgatt tagatcttgg tgctggggca aggccatcag cttcagagac cttgccaggc
     3001 ccaggctggg tgccctgtgg cctgagaact gagcccagac tttgacaaac ccacctcaac
     3061 atcaagcctg gggcaggtgg aaggtggtct gactgcactg tctccatctt atgcaaagcc
     3121 aggaactcac tcactgtctt aagtgagcca gggcaaaatt tacacccctc acgtttccct
     3181 ctcccttctt ccccaccaac aaaacccagg aggtagctgg cagagtagct gtcaggaagg
     3241 agaaaggttc tttctggctg gttgttttta attggcttag tgatctaaac tggccccttc
     3301 ctcctctgcc tggtgagttg gcctaaacat tcctcaagtc tagcctcagg agacctgccc
     3361 ctcccccccg acctccaccc cctcagactc catcccccac ccccaggagc ctggctgtct
     3421 ctagcgaggg gtggagaatc agatttagag ggagggagag tctgacctgg atcctgacct
     3481 gtaaccagct gaagacggtg gaggctttgt ggcttgctga gggtgggggt tgggagaggg
     3541 actggaaacc ttcctcctcg ggaaagaaat gcctgggagg aagggaagcc tgatattcag
     3601 ggtcaaaaca gcccttctaa ttcacaaccc caaagcaggg gtttctagaa gttggtcaac
     3661 agatctggtg agggaagtcc ccaggccaga cgctggactc ctgcaatgag ggtggaggac
     3721 tcagcctggc ctctgcctgg cctgtttcaa agtctgggcc actggcagcc ttctcttgct
     3781 caatccgagg tggaaaaaga tcacctccca gtgacctccc tcagccccca ggggagtagg
     3841 tctgtgtcca aagctatgtg gcaggcttgt ttgaaggacc cagaggggcc cagctgacct
     3901 gtctcactgc tcctggcagc ccagccccat cggcaggtgg cccctgcctg ggggttattc
     3961 gggatggttc agccagggcc tcccaggaag agtgctgtgg agccacggtg actgtcctgg
     4021 acagcaagga gcatgctacc ccagtgagca cttctttttg agggacttga tggggaggtg
     4081 gggtaggcag aagggacgtg gcagaagcgg gaagactttg gtcaccatgg ctctgcaggc
     4141 cttctgcaaa tcagtgctgg cctgggctgg aaacagctct gtgtgtgaag gtgaggactc
     4201 ttggaagcag gccatcctgg ccagacaccc tagcaggaag gggctcacct gtcaccctta
     4261 ggcagcctga gggctggtgg ggacttttga gtcttgaggg gatagcggaa aaagctgagc
     4321 tcataggtgc ccagccagcc tcccagctaa aggtgctcag agccccactg ccccctctct
     4381 ctgtgcaggt ggccagtgcc cctccctgct ctgggagcat tgctagcctt ctaccccatc
     4441 cctggatcca caggggctat cgaggagacc cagtgagaat gtagcatttt gttcatcccc
     4501 agggtagctg ccctggggtc tgggcactct gcctctggga gagaggaaga agaaaggggc
     4561 cccatttttt aaaaaactgt acagagcctt tggctttatg tgtttatgtt cttcacatgc
     4621 atatgtgtgt atgtgtgtat atctttcccc ccatcaattg gtacaatttt taataaaatc
     4681 atttaaagca aa
//
