LOCUS       NM_033201               2111 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens bMERB domain containing 1 (BMERB1), transcript variant
            1, mRNA.
ACCESSION   NM_033201
VERSION     NM_033201.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2111)
  AUTHORS   Rai,A., Oprisko,A., Campos,J., Fu,Y., Friese,T., Itzen,A.,
            Goody,R.S., Gazdag,E.M. and Muller,M.P.
  TITLE     bMERB domains are bivalent Rab8 family effectors evolved by gene
            duplication
  JOURNAL   Elife 5, e18675 (2016)
   PUBMED   27552051
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2111)
  AUTHORS   Zhang,S., Kanemitsu,Y., Fujitani,M. and Yamashita,T.
  TITLE     The newly identified migration inhibitory protein regulates the
            radial migration in the developing neocortex
  JOURNAL   Sci Rep 4, 5984 (2014)
   PUBMED   25099998
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2111)
  AUTHORS   Guan,W., Steffen,B.T., Lemaitre,R.N., Wu,J.H.Y., Tanaka,T.,
            Manichaikul,A., Foy,M., Rich,S.S., Wang,L., Nettleton,J.A.,
            Tang,W., Gu,X., Bandinelli,S., King,I.B., McKnight,B., Psaty,B.M.,
            Siscovick,D., Djousse,L., Chen,Y.I., Ferrucci,L., Fornage,M.,
            Mozafarrian,D., Tsai,M.Y. and Steffen,L.M.
  TITLE     Genome-wide association study of plasma N6 polyunsaturated fatty
            acids within the cohorts for heart and aging research in genomic
            epidemiology consortium
  JOURNAL   Circ Cardiovasc Genet 7 (3), 321-331 (2014)
   PUBMED   24823311
REFERENCE   4  (bases 1 to 2111)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2111)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK057180.1, BC008967.2 and AI377644.1.
            
            On Nov 22, 2018 this sequence version replaced NM_033201.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.354390.1,
                                           SRR1660805.251689.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300006.9/ ENSP00000300006.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-721               AK057180.1         121-841
            722-1926            BC008967.2         772-1976
            1927-2111           AI377644.1         4-188               c
FEATURES             Location/Qualifiers
     source          1..2111
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.11"
     gene            1..2111
                     /gene="BMERB1"
                     /gene_synonym="C16orf45; MINP"
                     /note="bMERB domain containing 1"
                     /db_xref="GeneID:89927"
                     /db_xref="HGNC:HGNC:19213"
     exon            1..172
                     /gene="BMERB1"
                     /gene_synonym="C16orf45; MINP"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..681
                     /gene="BMERB1"
                     /gene_synonym="C16orf45; MINP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     migration inhibitory protein; uncharacterized protein
                     C16orf45; bMERB domain-containing protein 1"
                     /codon_start=1
                     /product="bMERB domain-containing protein 1 isoform 1"
                     /protein_id="NP_149978.1"
                     /db_xref="CCDS:CCDS10561.1"
                     /db_xref="GeneID:89927"
                     /db_xref="HGNC:HGNC:19213"
                     /translation="MELKQSLSTHLEAEKPLRRYGAVEETAWKTERLGRNQLDIISMA
                     ETTMMPEEIELEMAKIQRLREVLVRRESELRFMMDDIQLCKDIMDLKQELQNLVAIPE
                     KEKTKLQKQREDELIQKIHKLVQKRDFLVDDAEVERLREQEEDKEMADFLRIKLKPLD
                     KVTKSPASSRAEKKAEPPPSKPTVAKTGLALIKDCCGATQCNIM"
     exon            173..296
                     /gene="BMERB1"
                     /gene_synonym="C16orf45; MINP"
                     /inference="alignment:Splign:2.1.0"
     exon            297..370
                     /gene="BMERB1"
                     /gene_synonym="C16orf45; MINP"
                     /inference="alignment:Splign:2.1.0"
     exon            371..485
                     /gene="BMERB1"
                     /gene_synonym="C16orf45; MINP"
                     /inference="alignment:Splign:2.1.0"
     exon            486..568
                     /gene="BMERB1"
                     /gene_synonym="C16orf45; MINP"
                     /inference="alignment:Splign:2.1.0"
     exon            569..2111
                     /gene="BMERB1"
                     /gene_synonym="C16orf45; MINP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1789..1794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMERB1"
                     /gene_synonym="C16orf45; MINP"
                     /note="hexamer: AATAAA"
     polyA_site      1816
                     /gene="BMERB1"
                     /gene_synonym="C16orf45; MINP"
                     /note="major polyA site"
     regulatory      2090..2095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMERB1"
                     /gene_synonym="C16orf45; MINP"
                     /note="hexamer: ATTAAA"
     polyA_site      2111
                     /gene="BMERB1"
                     /gene_synonym="C16orf45; MINP"
                     /note="major polyA site"
ORIGIN      
        1 ctccctgcag cccgcaacgg gaatggagta aagggagacc cgtcgacctg gccacgggga
       61 tcagcgatgg aattaaagca atctttgtcc acccatctgg aagccgagaa gcctctgagg
      121 cgctatgggg cggtggagga gacggcttgg aaaacggaga gactggggag aaatcagctg
      181 gacatcatct ccatggcgga gacaaccatg atgccagagg agattgagct ggagatggca
      241 aaaattcagc gtctccggga agtcttggtc cgccgggagt ctgagctcag gttcatgatg
      301 gatgacatcc agctctgcaa ggacatcatg gacttgaagc aggagctgca gaacttggtc
      361 gccatcccag aaaaagaaaa aaccaaactg cagaagcaga gagaggatga gctaatccag
      421 aagatccaca aactggtgca gaagagagac ttcctggtgg acgatgcgga ggtcgagcgg
      481 ttaagggagc aagaagaaga caaggaaatg gctgatttcc tgagaatcaa gttaaaacct
      541 ctagacaaag taaccaaatc tccagccagc tcccgggcag agaagaaagc agagccccca
      601 cctagcaagc ccacggtggc caagacgggg ctggcactga tcaaggattg ttgcggggcc
      661 acccagtgca acatcatgta gcccccacgt ggggtgccct gggccatggg gacccccccc
      721 caccctcttg tctttatagc ccccatttca ccggggccca agagctctcc aaggcagaag
      781 gggttgaagg caagcccgtg actgtcacca gaggccatgg gcacggcagg cgggcctggc
      841 caccctgtac agagtgtagc agtagggagt ctctcaccgt cgcatggtcc tccccagagc
      901 atgccgaacc caggagtctg tctcactgtt tatccaaaca ccaggaaagg tcctccctca
      961 aaaaagcata tctccacttc tctctagctg tatctaaccc accgtgtgaa tgaactggga
     1021 gaggggcatg ctccccagct gtgtgtagtc gtgacttctc aacaatctag caccatgtcg
     1081 gacacgttcc ccatccaccc tcctagctct gctctcagag ctaggcacat gggcacaggt
     1141 cccctcccgt ctgtcctctc ccagcaactg tgccctggag ggctccacat ggcccccgtg
     1201 tctctcgggc accacccata tagcagtccc agagggccca tctgtaaaga tcgagcttgt
     1261 gtgtggtgtc gtggtcacat ctcccgcttc cccccatcct gtgtctgggc acagttcaca
     1321 tcaggacagc gtccattgtg ctctcagtct gcctcaggtg tgtgcctgga gggggcctgg
     1381 actggcatgg atccagtgtg cagaagagcc agcagggaac cggaagctct gatgtcaagg
     1441 ccagagcagt tgagaatggg acccagagta gatgctgacc tgggcactcc accattccgg
     1501 ggccaccaca gagatgccag caggatgcca ctttgccagc ccgacacacg gacctttgta
     1561 aagaacagca acaggcagga gaggcagcgt gtgaccagat tgtgtcccgt cattgggtgg
     1621 catatgttaa ctagctgcca aacaacttca acccgtgtaa ttcatgtaca tttgcaacag
     1681 ccagcccggt acagcctgtg tgacttctct gtatgtgtgt gtgtgtcgtg accagcctaa
     1741 gtagttagca taactcaaga tgctgatgtg cagtcaccca tcagagaaaa taaaaatgga
     1801 aaccacgttc acagcatttt aaaagttttt actttttttc ttgattatgg aagtaatcca
     1861 tgtacatagt aaatcatttt aaaagtacaa aaagtatgaa gaagtttgtc ttaaaaaaaa
     1921 aaaaaattat tcctccaact agagaccact ctgatgtttc gacgttttaa aaaagtcttt
     1981 ttttgtgcat tttttcatcg ttgacatcat attgtggtat catttataac cagttttttc
     2041 ctacttatta taccaccatc ttccacatca ttaaaagctc tttgtaaaca ttaaacactc
     2101 ttcataaatc a
//
