LOCUS       NM_020183               6902 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens basic helix-loop-helix ARNT like 2 (BMAL2), transcript
            variant 1, mRNA.
ACCESSION   NM_020183 XR_017873
VERSION     NM_020183.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6902)
  AUTHORS   Wang,J., Ren,J., Tu,X., Yuan,H., Ye,Z., Wang,X., Cui,J., Wang,J.,
            Tang,Y., Han,P. and Bai,Y.
  TITLE     ARNTL2 facilitates bladder cancer progression through potentiating
            ENO1-mediated glycolysis in a SLC31A1-independent and -dependent
            manner
  JOURNAL   Life Sci 355, 122974 (2024)
   PUBMED   39147318
  REMARK    GeneRIF: ARNTL2 facilitates bladder cancer progression through
            potentiating ENO1-mediated glycolysis in a SLC31A1-independent and
            -dependent manner.
REFERENCE   2  (bases 1 to 6902)
  AUTHORS   Zou,W., Lei,Y., Ding,C., Xiao,H., Wang,S., Liang,S., Luo,W.,
            Long,Z., He,S., Li,Q., Qiao,H., Liu,N. and Mao,Y.
  TITLE     The circadian gene ARNTL2 promotes nasopharyngeal carcinoma
            invasiveness and metastasis through suppressing AMOTL2-LATS-YAP
            pathway
  JOURNAL   Cell Death Dis 15 (7), 466 (2024)
   PUBMED   38956029
  REMARK    GeneRIF: The circadian gene ARNTL2 promotes nasopharyngeal
            carcinoma invasiveness and metastasis through suppressing
            AMOTL2-LATS-YAP pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6902)
  AUTHORS   Zhou,M., Aziz,M., Li,J., Jha,A., Ma,G., Murao,A. and Wang,P.
  TITLE     BMAL2 promotes eCIRP-induced macrophage endotoxin tolerance
  JOURNAL   Front Immunol 15, 1426682 (2024)
   PUBMED   38938563
  REMARK    GeneRIF: BMAL2 promotes eCIRP-induced macrophage endotoxin
            tolerance.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6902)
  AUTHORS   Jia,W.J., Mu,J. and Cui,W.J.
  TITLE     [Effects of BMAL2 on Aerobic Glycolysis and Cell Proliferation in
            Acute Myeloid Leukemia Cells]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 32 (2), 402-408 (2024)
   PUBMED   38660843
  REMARK    GeneRIF: [Effects of BMAL2 on Aerobic Glycolysis and Cell
            Proliferation in Acute Myeloid Leukemia Cells].
REFERENCE   5  (bases 1 to 6902)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 6902)
  AUTHORS   Schoenhard,J.A., Eren,M., Johnson,C.H. and Vaughan,D.E.
  TITLE     Alternative splicing yields novel BMAL2 variants: tissue
            distribution and functional characterization
  JOURNAL   Am J Physiol Cell Physiol 283 (1), C103-C114 (2002)
   PUBMED   12055078
  REMARK    GeneRIF: Alternative splicing yields novel BMAL2 variants: tissue
            distribution and functional characterization.
REFERENCE   7  (bases 1 to 6902)
  AUTHORS   Okano,T., Yamamoto,K., Okano,K., Hirota,T., Kasahara,T., Sasaki,M.,
            Takanaka,Y. and Fukada,Y.
  TITLE     Chicken pineal clock genes: implication of BMAL2 as a bidirectional
            regulator in circadian clock oscillation
  JOURNAL   Genes Cells 6 (9), 825-836 (2001)
   PUBMED   11554928
REFERENCE   8  (bases 1 to 6902)
  AUTHORS   Maemura,K., de la Monte,S.M., Chin,M.T., Layne,M.D., Hsieh,C.M.,
            Yet,S.F., Perrella,M.A. and Lee,M.E.
  TITLE     CLIF, a novel cycle-like factor, regulates the circadian
            oscillation of plasminogen activator inhibitor-1 gene expression
  JOURNAL   J Biol Chem 275 (47), 36847-36851 (2000)
   PUBMED   11018023
REFERENCE   9  (bases 1 to 6902)
  AUTHORS   Ikeda,M., Yu,W., Hirai,M., Ebisawa,T., Honma,S., Yoshimura,K.,
            Honma,K.I. and Nomura,M.
  TITLE     cDNA cloning of a novel bHLH-PAS transcription factor superfamily
            gene, BMAL2: its mRNA expression, subcellular distribution, and
            chromosomal localization
  JOURNAL   Biochem Biophys Res Commun 275 (2), 493-502 (2000)
   PUBMED   10964693
REFERENCE   10 (bases 1 to 6902)
  AUTHORS   Hogenesch,J.B., Gu,Y.Z., Moran,S.M., Shimomura,K., Radcliffe,L.A.,
            Takahashi,J.S. and Bradfield,C.A.
  TITLE     The basic helix-loop-helix-PAS protein MOP9 is a brain-specific
            heterodimeric partner of circadian and hypoxia factors
  JOURNAL   J Neurosci 20 (13), RC83 (2000)
   PUBMED   10864977
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092829.4 and AC068794.25.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 23, 2021 this sequence version replaced NM_020183.5.
            
            Summary: This gene encodes a basic helix-loop-helix transcription
            factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS
            proteins play important roles in adaptation to low atmospheric and
            cellular oxygen levels, exposure to certain environmental
            pollutants, and diurnal oscillations in light and temperature. This
            protein forms a transcriptionally active heterodimer with the
            circadian CLOCK protein, the structurally related MOP4, and
            hypoxia-inducible factors, such as HIF1alpha. Consistent with its
            role as a biologically relevant partner of circadian and hypoxia
            factors, this protein is coexpressed in regions of the brain such
            as the thalamus, hypothalamus, and amygdala. Alternatively spliced
            transcript variants encoding different isoforms have been described
            for this gene. [provided by RefSeq, Oct 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF246960.1, SRR14038195.171704.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2147975
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266503.10/ ENSP00000266503.5
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-268               AC092829.4         73795-74062         c
            269-419             AC092829.4         38486-38636         c
            420-521             AC092829.4         36668-36769         c
            522-563             AC092829.4         30511-30552         c
            564-721             AC092829.4         26494-26651         c
            722-801             AC092829.4         21338-21417         c
            802-894             AC092829.4         19578-19670         c
            895-1012            AC092829.4         17602-17719         c
            1013-1156           AC092829.4         16659-16802         c
            1157-1397           AC092829.4         6124-6364           c
            1398-1504           AC092829.4         5535-5641           c
            1505-1655           AC092829.4         5224-5374           c
            1656-1714           AC092829.4         4221-4279           c
            1715-1823           AC092829.4         3357-3465           c
            1824-1902           AC068794.25        11034-11112
            1903-2011           AC068794.25        13253-13361
            2012-6902           AC068794.25        15561-20451
FEATURES             Location/Qualifiers
     source          1..6902
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.23"
     gene            1..6902
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /note="basic helix-loop-helix ARNT like 2"
                     /db_xref="GeneID:56938"
                     /db_xref="HGNC:HGNC:18984"
                     /db_xref="MIM:614517"
     exon            1..268
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..2148
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor BMAL2; CYCLE-like factor; member of
                     PAS protein 9; brain and muscle ARNT-like 2; PAS
                     domain-containing protein 9; basic-helix-loop-helix-PAS
                     protein MOP9; class E basic helix-loop-helix protein 6;
                     member of PAS superfamily 9; aryl hydrocarbon receptor
                     nuclear translocator like 2; basic helix-loop-helix
                     ARNT-like protein 2"
                     /codon_start=1
                     /product="basic helix-loop-helix ARNT-like protein 2
                     isoform 1"
                     /protein_id="NP_064568.3"
                     /db_xref="CCDS:CCDS8712.1"
                     /db_xref="GeneID:56938"
                     /db_xref="HGNC:HGNC:18984"
                     /db_xref="MIM:614517"
                     /translation="MAAEEEAAAGGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSH
                     MTEFPRKRKGSDSDPSQSGIMTEKVVEKLSQNPLTYLLSTRIEISASSGSRVEDGEHQ
                     VKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSL
                     KGLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYD
                     QASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYS
                     GSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEER
                     NSKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAIL
                     GYLPQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQ
                     WFSFTNPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQSSEESSRQSCMSVPGMSTG
                     TVLGAGSIGTDIANEILDLQRLQSSSYLDDSSPTGLMKDTHTVNCRSMSNKELFPPSP
                     SEMGELEATRQNQSTVAVHSHEPLLSDGAQLDFDALCDNDDTAMAAFMNYLEAEGGLG
                     DPGDFSDIQWTL"
     exon            269..419
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /inference="alignment:Splign:2.1.0"
     exon            420..521
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /inference="alignment:Splign:2.1.0"
     exon            522..563
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /inference="alignment:Splign:2.1.0"
     exon            564..721
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /inference="alignment:Splign:2.1.0"
     exon            722..801
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /inference="alignment:Splign:2.1.0"
     exon            802..894
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1012
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1156
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1397
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1504
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1655
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1714
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1823
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1902
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2011
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..6902
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5684..5689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /note="hexamer: ATTAAA"
     polyA_site      5701
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /note="major polyA site"
     regulatory      5964..5969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /note="hexamer: AATAAA"
     polyA_site      5982
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /note="major polyA site"
     regulatory      6884..6889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /note="hexamer: AATAAA"
     polyA_site      6902
                     /gene="BMAL2"
                     /gene_synonym="ARNTL2; bHLHe6; CLIF; MOP9; PASD9"
                     /note="major polyA site"
ORIGIN      
        1 agagcggcgg gcggctggct ccagtccgca tgctcagtag ctgctgccgg ccgggctgcg
       61 gggcggcgtc ccgtgcgcgc ctacgggctg cggtggcggc cgccgcggca cccggcaggg
      121 cccgccagtc cccgcttccc tgctccagag ccgccgcctg ggccggggca gggcgggccc
      181 ggggctcctc catgctgcca gccgcggggc tgcggagccg accaagtggc tcctgcgatg
      241 gcggcggaag aggaggctgc ggcgggaggt aaagtgttga gagaggagaa ccagtgcatt
      301 gctcctgtgg tttccagccg cgtgagtcca gggacaagac caacagctat ggggtctttc
      361 agctcacaca tgacagagtt tccacgaaaa cgcaaaggaa gtgattcaga cccatcccag
      421 tcaggaatca tgacagaaaa agtggtggaa aagctttctc agaatcccct tacctatctt
      481 ctttcaacaa ggatagaaat atcagcctcc agtggcagca gagtggaaga tggtgaacac
      541 caagttaaaa tgaaggcctt cagagaagct catagccaaa ctgaaaagcg gaggagagat
      601 aaaatgaata acctgattga agaactgtct gcaatgatcc ctcagtgcaa ccccatggcg
      661 cgtaaactgg acaaacttac agttttaaga atggctgttc aacacttgag atctttaaaa
      721 ggcttgacaa attcttatgt gggaagtaat tatagaccat catttcttca ggataatgag
      781 ctcagacatt taatccttaa gactgcagaa ggcttcttat ttgtggttgg atgtgaaaga
      841 ggaaaaattc tcttcgtttc taagtcagtc tccaaaatac ttaattatga tcaggctagt
      901 ttgactggac aaagcttatt tgacttctta catccaaaag atgttgccaa agtaaaggaa
      961 caactttctt cttttgatat ttcaccaaga gaaaagctaa tagatgccaa aactggtttg
     1021 caagttcaca gtaatctcca cgctggaagg acacgtgtgt attctggctc aagacgatct
     1081 tttttctgtc ggataaagag ttgtaaaatc tctgtcaaag aagagcatgg atgcttaccc
     1141 aactcaaaga agaaagagca cagaaaattc tatactatcc attgcactgg ttacttgaga
     1201 agctggcctc caaatattgt tggaatggaa gaagaaagga acagtaagaa agacaacagt
     1261 aattttacct gccttgtggc cattggaaga ttacagccat atattgttcc acagaacagt
     1321 ggagagatta atgtgaaacc aactgaattt ataacccggt ttgcagtgaa tggaaaattt
     1381 gtctatgtag atcaaagggc aacagcgatt ttaggatatc tgcctcagga acttttggga
     1441 acttcttgtt atgaatattt tcatcaagat gaccacaata atttgactga caagcacaaa
     1501 gcagttctac agagtaagga gaaaatactt acagattcct acaaattcag agcaaaagat
     1561 ggctcttttg taactttaaa aagccaatgg tttagtttca caaatccttg gacaaaagaa
     1621 ctggaatata ttgtatctgt caacacttta gttttgggac atagtgagcc tggagaagca
     1681 tcatttttac cttgtagctc tcaatcatca gaagaatcct ctagacagtc ctgtatgagt
     1741 gtacctggaa tgtctactgg aacagtactt ggtgctggta gtattggaac agatattgca
     1801 aatgaaattc tggatttaca gaggttacag tcttcttcat accttgatga ttcgagtcca
     1861 acaggtttaa tgaaagatac tcatactgta aactgcagga gtatgtcaaa taaggagttg
     1921 tttccaccaa gtccttctga aatgggggag ctagaggcta ccaggcaaaa ccagagtact
     1981 gttgctgtcc acagccatga gccactcctc agtgatggtg cacagttgga tttcgatgcc
     2041 ctatgtgaca atgatgacac agccatggct gcatttatga attacttaga agcagagggg
     2101 ggcctgggag accctgggga cttcagtgac atccagtgga ccctctagcc tttgattttt
     2161 aactccaaaa atgagaaaca ttttaaagca tttcatttac gaaaaactgt ctcaactatt
     2221 cttaagtact gtattgatat tgtttgtatc ttttattaat gttctaccac tttttataga
     2281 tttgcatctt cctgtcacag ggatgtgggg aaatacgttt tcctcccaag agaaccaagt
     2341 ttattataga ctcctttatt cagtgaaatg gcttataatc cactagttgc catatttttg
     2401 ctaaaatatt tctaaccaag aatactactt acatattgtt ttggctttgt tttatttttg
     2461 atgcagtttt ttttagttga ggtaatgtaa tatattgatg ttttcctttg tgtctaagat
     2521 tcatttataa tagtaggttt gtataatttg gaacattttc cattccttgc gaatttcctt
     2581 aattgaggat agggcttaca cactttaaga aaacagtgag tacttgaaca tttaaaggga
     2641 cagtgcaatt tatagtcata atcacattga atactgtatt tgatctttgg agacttaggc
     2701 aagcacagag ctgggatatt tatgctcagt tgagcacttt aagatgaatt ttaagtgaga
     2761 tgatttcttg cttaaaactc agaaagtcaa aagagtttca gctttcctta cagaaaagga
     2821 aggatcttgg gccctagatc ttggggatta acctctgcat ataagattta ctcttaatag
     2881 gccagacgtg gtggctcacg cctgtaatcc cagtactttg ggaggctgag acgggcagat
     2941 cacttgaggt caggagttca agaccagcct ggccaatatg gtgaaacccc gtttctacta
     3001 aaaatacaaa aaaaattacc caggcactca ctcttgaggt aactaaccaa ctcccacgat
     3061 aatgacagtc cattcatgag cgcaaaggcc tcatgaccta atggcacaca cctgtaatcc
     3121 caactgcttg ggaggctgag gcgagaggat tgcttgaacc tgggaggcag aggttgcagt
     3181 gagccgagat cgcaccactg cactccagtc tgggcaacag agtgagactt catctcaaaa
     3241 aaagtaaaaa aaaagattta atataatcac tgaagatctc tattatagat agattaggtt
     3301 tttgacattg gaaacatact tagggataga tttgtcctaa aggaaaaaag taggcccggg
     3361 cagattaaat gtcttgtgta aagtcacaca ttaaattcag tcacacatta aattcataga
     3421 gttttaaatg tttaatgtat ataaaccagt ttctttatac acatttggga aaacattggt
     3481 ctcacagatt aaatgattaa ctaactgacc caggaactag ttgtagcttt ctaagtaatt
     3541 aggcaattac agttattgcc tgtaaccaaa ggtaataaaa caaaatgaca agtacatgtt
     3601 taaaattatg aggcaatgag aaataattta aaaaccaatt ttctagttat aatttaaaat
     3661 ttggagagca tttttaacag taattaatcc agaggtggct caaattgagt ataagaatta
     3721 agattattta aaatactgca tgtctacctt ctcggggatc atactttata acactttctg
     3781 cttcagtagc tcttcatagc ttgccaagta tgctcccata ttttctctct cgtgcctcgc
     3841 aaatgaaagt cagataggct gggaactcat ggggcagccc tcagacttca atgtgggctt
     3901 caaatccagt ttcctgttct atatggtgct acatctttcc agaaaatttc cctcagagcc
     3961 cctcgccaaa acaaagcatt attttgaccc tgcatgctat ttctttagct gtaggtgata
     4021 gattagaact tctgtcagac atgttaatga caaacatacc aacagacaat aaccaaaagc
     4081 aaatgtttcc ttcaagtgtg aaatgtgcag gggcttcgtg ggcaaggatg tattggcaca
     4141 ctgtcctctt gaactgatag tgtcccagca atgttggagg gttggcacca ttcctggtcc
     4201 gacacttgag gacctgagag acatcaggtt tagaatgagc caaagaaatc ctacaagatg
     4261 gggagaattg gtgtgcagca gcctaagtgt tatagttaag tctaaagaag tatgaaagat
     4321 cccctgtgtt ctctaaattg agcagagggg cctgcctacc aatatcactt tttaggggac
     4381 tgaaccattg caggttagac ttggcttcca aagagtctgc ctaagccagg ggtggcaggg
     4441 taggccatca tagctggatg gcctcaaaag cagatggggg cagacttgcc ctcgtgatgc
     4501 caggatttga gaggcagagt ttctagaggg agaccagtgc tgcctctcac agtggcagtt
     4561 ttttctcttt gcaagaggag gggctgttca attccataga ccagtgggca gatagccagt
     4621 tgaatactct gtgcatggtt tgatccttta ttagttcgct ctaatatttt tctgtagatc
     4681 cttttgtcct ggactcaaaa tctaatccat gcattgtatg ataccgtagc tctcctaagg
     4741 tttgtgtttc cttcaaaatg ttttagtttt cttcaactaa atttgatttt tgctgttaga
     4801 agtgacatat ttttatggta tacactatgt tccttttttc tactgcgagt caattttttg
     4861 aattttcgtg agaaagaata tatctacaaa ttgcacgaaa gtatcataaa aacagtactc
     4921 tagacttttc ttttcttttc tttttttttt tttttttttt tttgagatgg agtctcgctc
     4981 tatcgcccag gctggagtgc agtggcgcga tcttggctca ctgccatctc tgcctcctgg
     5041 gttcacgcca ttctgcctca gcctccagag cagctgggac cacaggcgcc cgccaccaca
     5101 cctggctaat tttgctttgt attttcagta gagacggggt ttcaccatgt tagccaggat
     5161 ggtctcgatc tcctgacctc gtgatccgcc cacttcggcc tcccaaagtg ctgggattac
     5221 aggcatgagc cactgcgccc ggcctactct acactttttt taaccctaag aattaccact
     5281 acagtaatgt agtggagtgg gaagagtgcc tggaatcaga agaccctgtt gaggctgaat
     5341 ttagctgtat gacctcatgc aagccattta aactctgtgc ctcagcgtcc tcatttttaa
     5401 aaggaggttt gatctctatg tttacttcca gctctgattc tgggattcta atccacagga
     5461 cttgggtgtt agggtggaac ctagaactgt gctgtccagt gcagtagcca ctagccacat
     5521 gtggctactg agcacttgca atgtggctag tacaaagtga gatgtgctat caatgtaaga
     5581 tacataccag attttgaaga ctagtattac caaaagaatg taaaatatca cattaataat
     5641 tttatattaa ttacatgttc aaatgatatt ttggatatac tgaattaaaa cattaaaatt
     5701 agttctactt gtatcttttt acttttttaa tgtggctaga agaaaataaa attatacatg
     5761 tggctcagat tatatttcta ttggacagcg ctgctctaga acattatatt aagtggttat
     5821 tattgaagta gaccaaagtt tataccataa ggatattttt ccttaaatac catgtttgaa
     5881 gaacaattat ttattgatcc ttgaatctgt aagatcaaat aacaagtctc tatccatgtt
     5941 accaaattta aacttttgaa aataataaac tttaaaatat cagatgtgtt attacaggat
     6001 gatacttgga atcaagtgaa atgagttata tggtcatcac taaatttaga aatctattgt
     6061 gaaacaaaga caaacaggaa agtacagaat agagactttt agtaaataaa tggaatttaa
     6121 aagaaagtgt ttatttacag tgtcacgaca gaaaaggatg tctttgttgt catagtcttt
     6181 gagggatctc cgtaaaatct ggggcacagg tacaagaaat agccaatatt tagttcccag
     6241 accatgttta gtagtgtcca gtttcagatc atgctgccaa gaggtatctc cccctcaggt
     6301 gggtcatcac tgagccctgg aattggagac tcatacttgc ccagcacaat gttacgggca
     6361 gacaggccga catctatgat tagctagaag ccataaagaa aagctgctaa gtggccacta
     6421 ggtgccactt ttctgttttt gtaatgcttt cattagcaga tctttttttt ccaagctcca
     6481 tggggcctat gagaggcatt tatgattttt gtgcctacaa taagtcagcc tgtctggtgt
     6541 gagttgtttt atgagaaatg ctttccaagg gaggtctagg aagatcctga cacataagaa
     6601 ctttggctta gagagctttc caggtgtagt gccaataaaa actgacctgg aaagaaaacc
     6661 tgcccagcac ggaacatgct ttctgaactc acttgagagt gtatggtgta tgtcacttct
     6721 catatattct tgagtttaga tttgtctttt atacaatttt tagctctttt ccagttcact
     6781 tgtgctcgtc tgtatattgg tatttttaaa tttttgtggt aaataatgaa aagagtgaaa
     6841 ttatatttta taattactca tttgtagttt ttttttttaa tttaataaac ttcctccaaa
     6901 aa
//
