LOCUS       NM_001320973            2524 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens basic leucine zipper nuclear factor 1 (BLZF1),
            transcript variant 3, mRNA.
ACCESSION   NM_001320973
VERSION     NM_001320973.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2524)
  AUTHORS   Gao,J., Zhu,L., Yue,X., Jing,S., Tang,S., Lee,I. and Qian,Y.
  TITLE     Golgin45 assists mitosis via its nuclear localization sequence
  JOURNAL   Biochem Biophys Res Commun 735, 150845 (2024)
   PUBMED   39442450
  REMARK    GeneRIF: Golgin45 assists mitosis via its nuclear localization
            sequence.
REFERENCE   2  (bases 1 to 2524)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 2524)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 2524)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2524)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2524)
  AUTHORS   Tong,J.H., Fant,X., Benoit,G., Chen,S.J., Chen,Z. and Lanotte,M.
  TITLE     Genomic organization of the JEM-1 (BLZF1) gene on human chromosome
            1q24: molecular cloning and analysis of its promoter region
  JOURNAL   Genomics 69 (3), 380-390 (2000)
   PUBMED   11056056
REFERENCE   7  (bases 1 to 2524)
  AUTHORS   Tong,J.H., Duprez,E. and Lanotte,M.
  TITLE     JEM-1, a novel nuclear co-factor: localisation and functional
            interaction with AP-1
  JOURNAL   Leukemia 13 (12), 1982-1992 (1999)
   PUBMED   10602419
REFERENCE   8  (bases 1 to 2524)
  AUTHORS   Tong,J.H., Fant,X., Duprez,E., Benoit,G., Uphoff,C.C.,
            Drexler,H.G., Pla,J.C., Lofvenberg,E. and Lanotte,M.
  TITLE     Expression patterns of the JEM-1 gene in normal and tumor cells:
            ubiquity contrasting with a faint, but retinoid-induced, mRNA
            expression in promyelocytic NB4 cells
  JOURNAL   Leukemia 12 (11), 1733-1740 (1998)
   PUBMED   9823948
REFERENCE   9  (bases 1 to 2524)
  AUTHORS   Ting,N.S., Kao,P.N., Chan,D.W., Lintott,L.G. and Lees-Miller,S.P.
  TITLE     DNA-dependent protein kinase interacts with antigen receptor
            response element binding proteins NF90 and NF45
  JOURNAL   J Biol Chem 273 (4), 2136-2145 (1998)
   PUBMED   9442054
REFERENCE   10 (bases 1 to 2524)
  AUTHORS   Duprez,E., Tong,J.H., Derre,J., Chen,S.J., Berger,R., Chen,Z. and
            Lanotte,M.
  TITLE     JEM-1, a novel gene encoding a leucine-zipper nuclear factor
            upregulated during retinoid-induced maturation of NB4 promyelocytic
            leukaemia
  JOURNAL   Oncogene 14 (13), 1563-1570 (1997)
   PUBMED   9129147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U79751.1, AL021068.2 and CA336342.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001320973.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.73068.1,
                                           SRR1660809.144589.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367808.8/ ENSP00000356782.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1813              U79751.1           206-2018
            1814-2255           AL021068.2         98951-99392         c
            2256-2524           CA336342.1         77-345
FEATURES             Location/Qualifiers
     source          1..2524
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..2524
                     /gene="BLZF1"
                     /gene_synonym="GOLGIN-45; JEM-1; JEM-1s; JEM1"
                     /note="basic leucine zipper nuclear factor 1"
                     /db_xref="GeneID:8548"
                     /db_xref="HGNC:HGNC:1065"
                     /db_xref="MIM:608692"
     exon            1..148
                     /gene="BLZF1"
                     /gene_synonym="GOLGIN-45; JEM-1; JEM-1s; JEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            149..226
                     /gene="BLZF1"
                     /gene_synonym="GOLGIN-45; JEM-1; JEM-1s; JEM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1401
                     /gene="BLZF1"
                     /gene_synonym="GOLGIN-45; JEM-1; JEM-1s; JEM1"
                     /note="isoform 1 is encoded by transcript variant 3;
                     JEM-1short protein; cytoplasmic protein; p45 basic
                     leucine-zipper nuclear factor; leucine zipper nuclear
                     factor"
                     /codon_start=1
                     /product="golgin-45 isoform 1"
                     /protein_id="NP_001307902.1"
                     /db_xref="CCDS:CCDS1278.1"
                     /db_xref="GeneID:8548"
                     /db_xref="HGNC:HGNC:1065"
                     /db_xref="MIM:608692"
                     /translation="MTTKNLETKVTVTSSPIRGAGDGMETEEPPKSVEVTSGVQSRKH
                     HSLQSPWKKAVPSESPGVLQLGKMLTEKAMEVKAVRILVPKAAITHDIPNKNTKVKSL
                     GHHKGEFLGQSEGVIEPNKELSEVKNVLEKLKNSERRLLQDKEGLSNQLRVQTEVNRE
                     LKKLLVASVGDDLQYHFERLAREKNQLILENEALGRNTAQLSEQLERMSIQCDVWRSK
                     FLASRVMADELTNSRAALQRQNRDAHGAIQDLLSEREQFRQEMIATQKLLEELLVSLQ
                     WGREQTYSPSVQPHSTAELALTNHKLAKAVNSHLLGNVGINNQKKIPSTVEFCSTPAE
                     KMAETVLRILDPVTCKESSPDNPFFESSPTTLLATKKNIGRFHPYTRYENITFNCCNH
                     CRGELIAL"
     exon            227..666
                     /gene="BLZF1"
                     /gene_synonym="GOLGIN-45; JEM-1; JEM-1s; JEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..866
                     /gene="BLZF1"
                     /gene_synonym="GOLGIN-45; JEM-1; JEM-1s; JEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            867..995
                     /gene="BLZF1"
                     /gene_synonym="GOLGIN-45; JEM-1; JEM-1s; JEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1215
                     /gene="BLZF1"
                     /gene_synonym="GOLGIN-45; JEM-1; JEM-1s; JEM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..2524
                     /gene="BLZF1"
                     /gene_synonym="GOLGIN-45; JEM-1; JEM-1s; JEM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2502..2507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BLZF1"
                     /gene_synonym="GOLGIN-45; JEM-1; JEM-1s; JEM1"
                     /note="hexamer: AATAAA"
     polyA_site      2524
                     /gene="BLZF1"
                     /gene_synonym="GOLGIN-45; JEM-1; JEM-1s; JEM1"
                     /note="major polyA site"
ORIGIN      
        1 aggagtgaga gagctgctgg atatgcggag ggactgggcg ggtcggcttc cgaatggaag
       61 aggtctgtga gaagttaacc tggtgatacc gatccgaaga gcctatcaag tgaagccccc
      121 tgaaatacgg agaataagaa tcttagaggt tgttcagcag aagtcttgga gtgcattttc
      181 agtggttaag gtgaaaaaat gactactaaa aatttagaaa ccaaagtcac cgttacttca
      241 tccccaatcc gaggagcagg agatggaatg gaaactgagg aaccacctaa atctgttgaa
      301 gttacctccg gagtccaatc tagaaagcat catagtcttc agagtccatg gaagaaagca
      361 gttccatcag agagcccagg agttcttcag ctagggaaaa tgctcactga aaaagcaatg
      421 gaagttaaag ctgtaagaat attagttccc aaagctgcta taactcatga tatccccaac
      481 aaaaatacaa aggttaagtc tctgggacat cataaaggag aattccttgg tcagtcagag
      541 ggagttatag aacctaataa ggaactctca gaggtaaaga atgtattgga aaagctcaag
      601 aattctgaaa gaaggttact acaggacaaa gaaggtcttt caaaccagct ccgtgtacag
      661 acagaggtaa atcgtgagtt aaaaaagtta ctggtggctt ctgttgggga tgatcttcag
      721 tatcactttg aacgtctagc ccgtgagaaa aatcagctta ttttagaaaa tgaagcccta
      781 ggtcgaaaca cagctcagct ttctgaacag ttagaacgta tgtcaataca gtgtgatgta
      841 tggcgaagta aattccttgc aagcagggta atggcagatg agttaaccaa ctcaagagca
      901 gctttacagc gtcaaaaccg tgatgcacac ggggctatac aagatctcct aagtgaacgg
      961 gaacagtttc gtcaagaaat gatagctacc cagaaattat tggaggagct cttagtttcc
     1021 ttgcaatggg gaagagagca aacttactcc cctagtgtac aaccccacag cacagcagag
     1081 ctagcattaa caaatcacaa gttggcaaaa gcagtaaatt ctcatcttct gggaaatgtt
     1141 ggcattaaca atcaaaaaaa gattccatca acagttgaat tctgcagcac cccagctgag
     1201 aaaatggctg aaacggttct aagaatttta gatccagtta cctgcaaaga gagttcacct
     1261 gataatccat tttttgagtc ttcaccaacc accttacttg ctacaaagaa aaatattgga
     1321 cgatttcatc cctatactag atatgaaaat ataactttca attgctgcaa tcactgccgg
     1381 ggagaactga ttgcccttta acagtcaata tgttggaggc atgctaaggt acttccttat
     1441 tacccaagag tcattattat ttgggagctg gggttcttac aatgctagaa ataatatcac
     1501 ttcctattta cataatgtat acacccaaag atattttatg tactagactc cagattaccc
     1561 tttcttaata aatatctcag ggtaaggaaa gaaagaaact gtatagatat atttaaaata
     1621 gagaatactt tccaagcaat acatgatact tttcctaaaa gactctaaaa gaaaaagatt
     1681 ctgtaactct cttttagcac caaattattg tttatcttgc tggatatttt atatgaacag
     1741 tgttaattta gatgcactaa agcaaaggta ggcaaactac aaccatgagt caaacatggc
     1801 cacacccatt catgtgctat tgtctaagct ggttttgcac tacaactgca gagttgaata
     1861 gatgcagcag atcctttaca gaaaaagttt tctgacctca attctaaagt aattgtagta
     1921 gggagctgga ggactttctt tccctttatg gtaatttttt gagctacaaa agagccttgc
     1981 agaaatgggt gaagggatta atcttttaaa aataaatgct atatattagg aaaataaaaa
     2041 atattttaga gccaagttaa caagtacttc agcaaaacat gctagtttta tgcaggggat
     2101 tctgtattcc aaatggatac aatccgacat atataaaaga aacagattct taactattga
     2161 ctcttattta gcaaatgcaa cagacaagaa tatccaactt gatatttata aaaggtagac
     2221 tttttccaaa agtgtataag ctcaaagaaa aaatgcaacc tgtcaattaa tatatactat
     2281 gtaatatata ttattgtgta tttatgatta gccatcataa atgcccattg cttggccttt
     2341 aagaataatc acaaaatatt tatattaaat tatacaaatt tgttgcagaa gtgcctgtga
     2401 gagaaatctt caaaagacaa acctggtcaa ataataataa ttttaatgtc aatgattttt
     2461 tttgtctgac tcatctgagt tatatttagt tttcaagtgg caataaattt atctaccttc
     2521 ttta
//
