LOCUS       NM_000713                799 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens biliverdin reductase B (BLVRB), mRNA.
ACCESSION   NM_000713
VERSION     NM_000713.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 799)
  AUTHORS   Zhou,H.L., Grimmett,Z.W., Venetos,N.M., Stomberski,C.T., Qian,Z.,
            McLaughlin,P.J., Bansal,P.K., Zhang,R., Reynolds,J.D., Premont,R.T.
            and Stamler,J.S.
  TITLE     An enzyme that selectively S-nitrosylates proteins to regulate
            insulin signaling
  JOURNAL   Cell 186 (26), 5812-5825 (2023)
   PUBMED   38056462
REFERENCE   2  (bases 1 to 799)
  AUTHORS   Chemaly,M., Marlevi,D., Iglesias,M.J., Lengquist,M., Kronqvist,M.,
            Bos,D., van Dam-Nolen,D.H.K., van der Kolk,A., Hendrikse,J.,
            Kassem,M., Matic,L., Odeberg,J., de Vries,M.R., Kooi,M.E. and
            Hedin,U.
  TITLE     Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque
            Hemorrhage and a Predictor of Ischemic Stroke in Patients with
            Symptomatic Carotid Atherosclerosis
  JOURNAL   Biomolecules 13 (6), 882 (2023)
   PUBMED   37371462
  REMARK    GeneRIF: Biliverdin Reductase B Is a Plasma Biomarker for
            Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in
            Patients with Symptomatic Carotid Atherosclerosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 799)
  AUTHORS   Duff,M.R., Redzic,J.S., Ryan,L.P., Paukovich,N., Zhao,R., Nix,J.C.,
            Pitts,T.M., Agarwal,P. and Eisenmesser,E.Z.
  TITLE     Structure, dynamics and function of the evolutionarily changing
            biliverdin reductase B family
  JOURNAL   J Biochem 168 (2), 191-202 (2020)
   PUBMED   32246827
  REMARK    GeneRIF: Structure, dynamics and function of the evolutionarily
            changing biliverdin reductase B family.
REFERENCE   4  (bases 1 to 799)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 799)
  AUTHORS   Li,Z., Nesbitt,N.M., Malone,L.E., Gnatenko,D.V., Wu,S., Wang,D.,
            Zhu,W., Girnun,G.D. and Bahou,W.F.
  TITLE     Heme degradation enzyme biliverdin IXbeta reductase is required for
            stem cell glutamine metabolism
  JOURNAL   Biochem J 475 (6), 1211-1223 (2018)
   PUBMED   29500232
  REMARK    GeneRIF: Early stages of lineage fate potential require glutamine
            anaplerotic functions and an intact Pentose phosphate pathway,
            which are, in part, regulated by BLVRB activity. In principle,
            BLVRB inhibition represents an alternative strategy for modulating
            cellular glutamine utilization with consequences for cancer and
            hematopoietic metabolism.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 799)
  AUTHORS   Saito,F., Yamaguchi,T., Komuro,A., Tobe,T., Ikeuchi,T., Tomita,M.
            and Nakajima,H.
  TITLE     Mapping of the newly identified biliverdin-IX beta reductase gene
            (BLVRB) to human chromosome 19q13.13-->q13.2 by fluorescence in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 71 (2), 179-181 (1995)
   PUBMED   7656592
REFERENCE   7  (bases 1 to 799)
  AUTHORS   Yamaguchi,T., Komoda,Y. and Nakajima,H.
  TITLE     Biliverdin-IX alpha reductase and biliverdin-IX beta reductase from
            human liver. Purification and characterization
  JOURNAL   J Biol Chem 269 (39), 24343-24348 (1994)
   PUBMED   7929092
REFERENCE   8  (bases 1 to 799)
  AUTHORS   Chikuba,K., Yubisui,T., Shirabe,K. and Takeshita,M.
  TITLE     Cloning and nucleotide sequence of a cDNA of the human erythrocyte
            NADPH-flavin reductase
  JOURNAL   Biochem Biophys Res Commun 198 (3), 1170-1176 (1994)
   PUBMED   8117274
REFERENCE   9  (bases 1 to 799)
  AUTHORS   Yamaguchi,T., Komuro,A., Nakano,Y., Tomita,M. and Nakajima,H.
  TITLE     Complete amino acid sequence of biliverdin-IX beta reductase from
            human liver
  JOURNAL   Biochem Biophys Res Commun 197 (3), 1518-1523 (1993)
   PUBMED   8280170
REFERENCE   10 (bases 1 to 799)
  AUTHORS   Hochstrasser,D.F., Frutiger,S., Paquet,N., Bairoch,A., Ravier,F.,
            Pasquali,C., Sanchez,J.C., Tissot,J.D., Bjellqvist,B., Vargas,R. et
            al.
  TITLE     Human liver protein map: a reference database established by
            microsequencing and gel comparison
  JOURNAL   Electrophoresis 13 (12), 992-1001 (1992)
   PUBMED   1286669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG340491.1, BC109371.1, BU528444.1 and AC010271.8.
            
            On May 17, 2019 this sequence version replaced NM_000713.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.298786.1, AK312137.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2149004
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263368.9/ ENSP00000263368.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BG340491.1         74-83
            11-774              BC109371.1         1-764
            775-783             BU528444.1         443-451
            784-799             AC010271.8         143141-143156       c
FEATURES             Location/Qualifiers
     source          1..799
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..799
                     /gene="BLVRB"
                     /gene_synonym="BVRB; FLR; HEL-S-10; SDR43U1"
                     /note="biliverdin reductase B"
                     /db_xref="GeneID:645"
                     /db_xref="HGNC:HGNC:1063"
                     /db_xref="MIM:600941"
     exon            1..136
                     /gene="BLVRB"
                     /gene_synonym="BVRB; FLR; HEL-S-10; SDR43U1"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..678
                     /gene="BLVRB"
                     /gene_synonym="BVRB; FLR; HEL-S-10; SDR43U1"
                     /EC_number="1.5.1.30"
                     /note="short chain dehydrogenase/reductase family 43U,
                     member 1; epididymis secretory protein Li 10; FR; GHBP;
                     BVR-B; NADPH-flavin reductase; NADPH-dependent diaphorase;
                     green heme-binding protein; biliverdin-IX beta-reductase;
                     SNO-CoA-assisted nitrosyltransferase;
                     S-nitroso-CoA-assisted nitrosyltransferase"
                     /codon_start=1
                     /product="flavin reductase (NADPH)"
                     /protein_id="NP_000704.1"
                     /db_xref="CCDS:CCDS33029.1"
                     /db_xref="GeneID:645"
                     /db_xref="HGNC:HGNC:1063"
                     /db_xref="MIM:600941"
                     /translation="MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEG
                     PRPAHVVVGDVLQAADVDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHG
                     VDKVVACTSAFLLWDPTKVPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLT
                     GAYTVTLDGRGPSRVISKHDLGHFMLRCLTTDEYDGHSTYPSHQYQ"
     exon            137..301
                     /gene="BLVRB"
                     /gene_synonym="BVRB; FLR; HEL-S-10; SDR43U1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..391
                     /gene="BLVRB"
                     /gene_synonym="BVRB; FLR; HEL-S-10; SDR43U1"
                     /inference="alignment:Splign:2.1.0"
     exon            392..520
                     /gene="BLVRB"
                     /gene_synonym="BVRB; FLR; HEL-S-10; SDR43U1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..799
                     /gene="BLVRB"
                     /gene_synonym="BVRB; FLR; HEL-S-10; SDR43U1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      738..743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BLVRB"
                     /gene_synonym="BVRB; FLR; HEL-S-10; SDR43U1"
                     /note="hexamer: AATAAA"
     polyA_site      778
                     /gene="BLVRB"
                     /gene_synonym="BVRB; FLR; HEL-S-10; SDR43U1"
                     /note="major polyA site"
     polyA_site      799
                     /gene="BLVRB"
                     /gene_synonym="BVRB; FLR; HEL-S-10; SDR43U1"
ORIGIN      
        1 agtgggttcc cgcgcgtgcc gagactctga ggccttgcac ccccacgatc ccgtacgatg
       61 gccgtcaaga agatcgcgat cttcggcgcc actggccaga ccgggctcac caccctggcg
      121 caggcggtgc aagcaggtta cgaagtgaca gtgctggtgc gggactcctc caggctgcca
      181 tcagaggggc cccggccggc ccacgtggta gtgggagatg ttctgcaggc agccgatgtg
      241 gacaagaccg tggctgggca ggacgctgtc atcgtgctgc tgggcacccg caatgacctc
      301 agtcccacga cagtgatgtc cgagggcgcc cggaacattg tggcagccat gaaggctcat
      361 ggtgtggaca aggtcgtggc ctgcacctcg gctttcctgc tctgggaccc taccaaggtg
      421 cccccacgac tgcaggctgt gactgatgac cacatccgga tgcacaaggt gctgcgggaa
      481 tcaggcctga agtacgtggc tgtgatgccg ccacacatag gagaccagcc actaactggg
      541 gcgtacacag tgaccctgga tggacgaggg ccctcaaggg tcatctccaa acatgacctg
      601 ggccatttca tgctgcgctg cctcaccacc gatgagtacg acggacacag cacctacccc
      661 tcccaccagt accagtagca ctctgtcccc atctgggagg gtggcattct gggacatgag
      721 gagcaaagga agggggcaat aaatgttgag ccaagagctt caaattactc tagagaaacc
      781 gactgtgtga ctcttcctc
//
