LOCUS       NM_000712               1074 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens biliverdin reductase A (BLVRA), transcript variant 1,
            mRNA.
ACCESSION   NM_000712
VERSION     NM_000712.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1074)
  AUTHORS   Liu,X., Zhang,C., Chen,L., Liu,S. and Zhou,Z.
  TITLE     UGT1A1 and BLVRA allele and genotype variants in neonatal patients
            with hyperbilirubinemia in southern China
  JOURNAL   Sci Rep 14 (1), 25744 (2024)
   PUBMED   39468242
  REMARK    GeneRIF: UGT1A1 and BLVRA allele and genotype variants in neonatal
            patients with hyperbilirubinemia in southern China.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1074)
  AUTHORS   Chen,X., Yang,F., Zhang,C., Wang,X., Yuan,C., Shi,D., Zhu,S.,
            Zhang,X., Chen,X. and Zhao,W.
  TITLE     BLVRA exerts its biological effects to induce malignant properties
            of hepatocellular carcinoma cells via Wnt/beta-catenin pathway
  JOURNAL   J Mol Histol 55 (2), 159-167 (2024)
   PUBMED   38216836
  REMARK    GeneRIF: BLVRA exerts its biological effects to induce malignant
            properties of hepatocellular carcinoma cells via Wnt/beta-catenin
            pathway.
REFERENCE   3  (bases 1 to 1074)
  AUTHORS   Fan,J., He,H.Y., Li,H.H., Wu,P.L., Tang,L., Deng,B.Y., Dong,W.H.
            and Wang,J.H.
  TITLE     Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1
            polymorphisms and susceptibility to neonatal severe
            hyperbilirubinemia in Chinese Han population
  JOURNAL   BMC Pediatr 24 (1), 82 (2024)
   PUBMED   38279097
  REMARK    GeneRIF: Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and
            HMOX1 polymorphisms and susceptibility to neonatal severe
            hyperbilirubinemia in Chinese Han population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1074)
  AUTHORS   Cimini,F.A., Barchetta,I., Zuliani,I., Pagnotta,S., Bertoccini,L.,
            Dule,S., Zampieri,M., Reale,A., Baroni,M.G., Cavallo,M.G. and
            Barone,E.
  TITLE     Biliverdin reductase-A protein levels are reduced in type 2
            diabetes and are associated with poor glycometabolic control
  JOURNAL   Life Sci 284, 119913 (2021)
   PUBMED   34453944
  REMARK    GeneRIF: Biliverdin reductase-A protein levels are reduced in type
            2 diabetes and are associated with poor glycometabolic control.
REFERENCE   5  (bases 1 to 1074)
  AUTHORS   Ceccarelli,V., Barchetta,I., Cimini,F.A., Bertoccini,L.,
            Chiappetta,C., Capoccia,D., Carletti,R., Di Cristofano,C.,
            Silecchia,G., Fontana,M., Leonetti,F., Lenzi,A., Baroni,M.G.,
            Barone,E. and Cavallo,M.G.
  TITLE     Reduced Biliverdin Reductase-A Expression in Visceral Adipose
            Tissue is Associated with Adipocyte Dysfunction and NAFLD in Human
            Obesity
  JOURNAL   Int J Mol Sci 21 (23), 9091 (2020)
   PUBMED   33260451
  REMARK    GeneRIF: Reduced Biliverdin Reductase-A Expression in Visceral
            Adipose Tissue is Associated with Adipocyte Dysfunction and NAFLD
            in Human Obesity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1074)
  AUTHORS   Cunningham,O., Dunne,A., Sabido,P., Lightner,D. and Mantle,T.J.
  TITLE     Studies on the specificity of the tetrapyrrole substrate for human
            biliverdin-IXalpha reductase and biliverdin-IXbeta reductase.
            Structure-activity relationships define models for both active
            sites
  JOURNAL   J Biol Chem 275 (25), 19009-19017 (2000)
   PUBMED   10858451
REFERENCE   7  (bases 1 to 1074)
  AUTHORS   Komuro,A., Tobe,T., Nakano,Y., Yamaguchi,T. and Tomita,M.
  TITLE     Cloning and characterization of the cDNA encoding human
            biliverdin-IX alpha reductase
  JOURNAL   Biochim Biophys Acta 1309 (1-2), 89-99 (1996)
   PUBMED   8950184
REFERENCE   8  (bases 1 to 1074)
  AUTHORS   Maines,M.D., Polevoda,B.V., Huang,T.J. and McCoubrey,W.K. Jr.
  TITLE     Human biliverdin IXalpha reductase is a zinc-metalloprotein.
            Characterization of purified and Escherichia coli expressed enzymes
  JOURNAL   Eur J Biochem 235 (1-2), 372-381 (1996)
   PUBMED   8631357
REFERENCE   9  (bases 1 to 1074)
  AUTHORS   Yamaguchi,T., Komoda,Y. and Nakajima,H.
  TITLE     Biliverdin-IX alpha reductase and biliverdin-IX beta reductase from
            human liver. Purification and characterization
  JOURNAL   J Biol Chem 269 (39), 24343-24348 (1994)
   PUBMED   7929092
REFERENCE   10 (bases 1 to 1074)
  AUTHORS   Maines,M.D. and Trakshel,G.M.
  TITLE     Purification and characterization of human biliverdin reductase
  JOURNAL   Arch Biochem Biophys 300 (1), 320-326 (1993)
   PUBMED   8424666
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM710258.1, U34877.1 and
            X93086.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000712.3.
            
            Summary: The protein encoded by this gene belongs to the biliverdin
            reductase family, members of which catalyze the conversion of
            biliverdin to bilirubin in the presence of NADPH or NADH. Mutations
            in this gene are associated with hyperbiliverdinemia. Alternatively
            spliced transcript variants have been found for this gene.
            [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005341.1, SRR1803612.450024.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265523.9/ ENSP00000265523.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-330               BM710258.1         8-337
            331-1072            U34877.1           311-1052
            1073-1074           X93086.1           1057-1058
FEATURES             Location/Qualifiers
     source          1..1074
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p13"
     gene            1..1074
                     /gene="BLVRA"
                     /gene_synonym="BLVR; BVR; BVRA; BVRalpha"
                     /note="biliverdin reductase A"
                     /db_xref="GeneID:644"
                     /db_xref="HGNC:HGNC:1062"
                     /db_xref="MIM:109750"
     exon            1..55
                     /gene="BLVRA"
                     /gene_synonym="BLVR; BVR; BVRA; BVRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            56..88
                     /gene="BLVRA"
                     /gene_synonym="BLVR; BVR; BVRA; BVRalpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..967
                     /gene="BLVRA"
                     /gene_synonym="BLVR; BVR; BVRA; BVRalpha"
                     /EC_number="1.3.1.24"
                     /note="BVR A; biliverdin-IX alpha-reductase; testis tissue
                     sperm-binding protein Li 61n; biliverdin reductase
                     IXalpha"
                     /codon_start=1
                     /product="biliverdin reductase A"
                     /protein_id="NP_000703.2"
                     /db_xref="CCDS:CCDS5472.1"
                     /db_xref="GeneID:644"
                     /db_xref="HGNC:HGNC:1062"
                     /db_xref="MIM:109750"
                     /translation="MNAEPERKFGVVVVGVGRAGSVRMRDLRNPHPSSAFLNLIGFVS
                     RRELGSIDGVQQISLEDALSSQEVEVAYICSESSSHEDYIRQFLNAGKHVLVEYPMTL
                     SLAAAQELWELAEQKGKVLHEEHVELLMEEFAFLKKEVVGKDLLKGSLLFTAGPLEEE
                     RFGFPAFSGISRLTWLVSLFGELSLVSATLEERKEDQYMKMTVCLETEKKSPLSWIEE
                     KGPGLKRNRYLSFHFKSGSLENVPNVGVNKNIFLKDQNIFVQKLLGQFSEKELAAEKK
                     RILHCLGLAEEIQKYCCSRK"
     exon            89..210
                     /gene="BLVRA"
                     /gene_synonym="BLVR; BVR; BVRA; BVRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            211..330
                     /gene="BLVRA"
                     /gene_synonym="BLVR; BVR; BVRA; BVRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            331..428
                     /gene="BLVRA"
                     /gene_synonym="BLVR; BVR; BVRA; BVRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            429..536
                     /gene="BLVRA"
                     /gene_synonym="BLVR; BVR; BVRA; BVRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            537..708
                     /gene="BLVRA"
                     /gene_synonym="BLVR; BVR; BVRA; BVRalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            709..1074
                     /gene="BLVRA"
                     /gene_synonym="BLVR; BVR; BVRA; BVRalpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1050..1055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BLVRA"
                     /gene_synonym="BLVR; BVR; BVRA; BVRalpha"
                     /note="hexamer: ATTAAA"
     polyA_site      1074
                     /gene="BLVRA"
                     /gene_synonym="BLVR; BVR; BVRA; BVRalpha"
                     /note="major polyA site"
ORIGIN      
        1 ggtccgcaaa gccggtggcg cccggaggct gcacggagag cggtgcccgc gtcagtgacc
       61 gaaggaagag accaagatga atgcagagcc cgagaggaag tttggcgtgg tggtggttgg
      121 tgttggccga gccggctccg tgcggatgag ggacttgcgg aatccacacc cttcctcagc
      181 gttcctgaac ctgattggct tcgtgtcgag aagggagctc gggagcattg atggagtcca
      241 gcagatttct ttggaggatg ctctttccag ccaagaggtg gaggtcgcct atatctgcag
      301 tgagagctcc agccatgagg actacatcag gcagttcctt aatgctggca agcacgtcct
      361 tgtggaatac cccatgacac tgtcattggc ggccgctcag gaactgtggg agctggctga
      421 gcagaaagga aaagtcttgc acgaggagca tgttgaactc ttgatggagg aattcgcttt
      481 cctgaaaaaa gaagtggtgg ggaaagacct gctgaaaggg tcgctcctct tcacagctgg
      541 cccgttggaa gaagagcggt ttggcttccc tgcattcagc ggcatctctc gcctgacctg
      601 gctggtctcc ctctttgggg agctttctct tgtgtctgcc actttggaag agcgaaagga
      661 agatcagtat atgaaaatga cagtgtgtct ggagacagag aagaaaagtc cactgtcatg
      721 gattgaagaa aaaggacctg gtctaaaacg aaacagatat ttaagcttcc atttcaagtc
      781 tgggtccttg gagaatgtgc caaatgtagg agtgaataag aacatatttc tgaaagatca
      841 aaatatattt gtccagaaac tcttgggcca gttctctgag aaggaactgg ctgctgaaaa
      901 gaaacgcatc ctgcactgcc tggggcttgc agaagaaatc cagaaatatt gctgttcaag
      961 gaagtaagag gaggaggtga tgtagcactt ccaagatggc accagcattt ggttcttctc
     1021 aagagttgac cattatctct attcttaaaa ttaaacatgt tggggaaaca agaa
//
