LOCUS       NM_015054               5198 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens bridge-like lipid transfer protein family member 3B
            (BLTP3B), transcript variant 1, mRNA.
ACCESSION   NM_015054 XM_045423
VERSION     NM_015054.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5198)
  AUTHORS   Hanna,M.G., Suen,P.H., Wu,Y., Reinisch,K.M. and De Camilli,P.
  TITLE     SHIP164 is a chorein motif lipid transfer protein that controls
            endosome-Golgi membrane traffic
  JOURNAL   J Cell Biol 221 (6) (2022)
   PUBMED   35499567
  REMARK    GeneRIF: SHIP164 is a chorein motif lipid transfer protein that
            controls endosome-Golgi membrane traffic.
REFERENCE   2  (bases 1 to 5198)
  AUTHORS   Hawthorne,F., Feng,S., Metlapally,R., Li,Y.J., Tran-Viet,K.N.,
            Guggenheim,J.A., Malecaze,F., Calvas,P., Rosenberg,T., Mackey,D.A.,
            Venturini,C., Hysi,P.G., Hammond,C.J. and Young,T.L.
  TITLE     Association mapping of the high-grade myopia MYP3 locus reveals
            novel candidates UHRF1BP1L, PTPRR, and PPFIA2
  JOURNAL   Invest Ophthalmol Vis Sci 54 (3), 2076-2086 (2013)
   PUBMED   23422819
  REMARK    GeneRIF: 3 genes identified by association study and supported by
            ocular expression and/or replication, UHRF1BP1L, PTPRR, and PPFIA2,
            are novel candidates for myopic development within the MYP3 locus
            that should be further studied.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5198)
  AUTHORS   Otto,G.P., Razi,M., Morvan,J., Stenner,F. and Tooze,S.A.
  TITLE     A novel syntaxin 6-interacting protein, SHIP164, regulates syntaxin
            6-dependent sorting from early endosomes
  JOURNAL   Traffic 11 (5), 688-705 (2010)
   PUBMED   20163565
  REMARK    GeneRIF: UHRF1BP1L was identified as an Syntaxin6 interacting
            protein (called SHIP164) which regulates sorting form coated early
            endosomes
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010203.14, CB988442.1, AB014601.2, AL136821.1 and AC126474.6.
            
            On Nov 22, 2018 this sequence version replaced NM_015054.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127017.1, SRR11853560.7497.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279907.12/ ENSP00000279907.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC010203.14        75673-75682
            11-583              CB988442.1         28-600
            584-4969            AB014601.2         15-4400
            4970-5185           AL136821.1         3765-3980
            5186-5198           AC126474.6         48035-48047         c
FEATURES             Location/Qualifiers
     source          1..5198
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.1"
     gene            1..5198
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /note="bridge-like lipid transfer protein family member
                     3B"
                     /db_xref="GeneID:23074"
                     /db_xref="HGNC:HGNC:29102"
                     /db_xref="MIM:619811"
     exon            1..283
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..4634
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /note="isoform a is encoded by transcript variant 1; UHRF1
                     (ICBP90) binding protein 1-like; syntaxin
                     6Habc-interacting protein of 164 kDa; syntaxin-6
                     Habc-interacting protein of 164 kDa; UHRF1 binding protein
                     1 like"
                     /codon_start=1
                     /product="bridge-like lipid transfer protein family member
                     3B isoform a"
                     /protein_id="NP_055869.1"
                     /db_xref="CCDS:CCDS31882.1"
                     /db_xref="GeneID:23074"
                     /db_xref="HGNC:HGNC:29102"
                     /db_xref="MIM:619811"
                     /translation="MAGIIKKQILKHLSRFTKNLSPDKINLSTLKGEGELKNLELDEE
                     VLQNMLDLPTWLAINKVFCNKASIRIPWTKLKTHPICLSLDKVIMEMSTCEEPRSPNG
                     PSPIATASGQSEYGFAEKVVEGISVSVNSIVIRIGAKAFNASFELSQLRIYSVNAHWE
                     HGDLRFTRIQDPQRGEVLTFKEINWQMIRIEADATQSSHLEIMCAPVRLITNQSKIRV
                     TLKRRLKDCNVIATKLVLILDDLLWVLTDSQLKAMVQYAKSLSEAIEKSTEQRKSMAP
                     EPTQSSTVVASAQQVKTTQTSNAPDVNDAIVKLFNDFDVKETSHHLVISHLDLHICDD
                     IHAKEKESNRRITGGAMQLSFTQLTIDYYPYHKAGDSCNHWMYFSDATKTKNGWANEL
                     LHEFECNVEMLKQAVKDHNVGSPPKSPTHASPQHTQTEKDYPLKGTCRTPSVLSQQSK
                     AKLMSSSVVVRLADFNIYQVSTAEQCRSSPKSMICCNKKSLYLPQEMSAVYIEFTEYY
                     YPDGKDFPIPSPNLYSQLNALQFTVDERSILWLNQFLLDLKQSLNQFMAVYKLNDNSK
                     SDEHVDVRVDGLMLKFVIPSEVKSECHQDQPRAISIQSSEMIATNTRHCPNCRHSDLE
                     ALFQDFKDCDFFSKTYTSFPKSCDNFNLLHPIFQRHAHEQDTKMHEIYKGNITPQLNK
                     NTLKTSAATDVWAVYFSQFWIDYEGMKSGKGRPISFVDSFPLSIWICQPTRYAESQKE
                     PQTCNQVSLNTSQSESSDLAGRLKRKKLLKEYYSTESEPLTNGGQKPSSSDTFFRFSP
                     SSSEADIHLLVHVHKHVSMQINHYQYLLLLFLHESLILLSENLRKDVEAVTGSPASQT
                     SICIGILLRSAELALLLHPVDQANTLKSPVSESVSPVVPDYLPTENGDFLSSKRKQIS
                     RDINRIRSVTVNHMSDNRSMSVDLSHIPLKDPLLFKSASDTNLQKGISFMDYLSDKHL
                     GKISEDESSGLVYKSGSGEIGSETSDKKDSFYTDSSSILNYREDSNILSFDSDGNQNI
                     LSSTLTSKGNETIESIFKAEDLLPEAASLSENLDISKEETPPVRTLKSQSSLSGKPKE
                     RCPPNLAPLCVSYKNMKRSSSQMSLDTISLDSMILEEQLLESDGSDSHMFLEKGNKKN
                     STTNYRGTAESVNAGANLQNYGETSPDAISTNSEGAQENHDDLMSVVVFKITGVNGEI
                     DIRGEDTEICLQVNQVTPDQLGNISLRHYLCNRPVGSDQKAVIHSKSSPEISLRFESG
                     PGAVIHSLLAEKNGFLQCHIENFSTEFLTSSLMNIQHFLEDETVATVMPMKIQVSNTK
                     INLKDDSPRSSTVSLEPAPVTVHIDHLVVERSDDGSFHIRDSHMLNTGNDLKENVKSD
                     SVLLTSGKYDLKKQRSVTQATQTSPGVPWPSQSANFPEFSFDFTREQLMEENESLKQE
                     LAKAKMALAEAHLEKDALLHHIKKMTVE"
     exon            284..446
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            447..485
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            486..577
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            578..767
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            768..908
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1079
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1260
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1344
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1527
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1646
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1788
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1982
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..3487
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3488..3663
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..3806
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3807..3957
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3958..4211
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            4212..4320
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            4321..4514
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            4515..5198
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5168..5173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /note="hexamer: AATAAA"
     polyA_site      5198
                     /gene="BLTP3B"
                     /gene_synonym="SHIP164; SHIP164A; UHRF1BP1L"
                     /note="major polyA site"
ORIGIN      
        1 gagtctctta ggtgatgctg cagccaagat ggcgcccgcg gcggccgtgg cggcctgagc
       61 gtgatgctcc gggttctcgg cggcggctgt ggccttggcc ggggccttgg gtctctcccg
      121 gtcgtgagcg atcagcgcct ctccgccggc cgggctagcc gggacagaga ggagacggcc
      181 acgaagagag gaggcagtga gcaacaggac gagaccgcgg cgtctccagc ctcggtacca
      241 tggccgggat catcaagaaa caaatcttga agcacctctc cagatttacc aaaaatttat
      301 ctcctgacaa gataaatcta agtaccctta aaggagaagg tgaactgaag aatttggagt
      361 tggatgaaga agtactccag aatatgttgg atttgccaac atggcttgct atcaacaaag
      421 ttttttgtaa taaagcgtcc attaggatcc catggacaaa actgaaaaca catcccatct
      481 gtttgtccct ggataaagta ataatggaaa tgagtacatg tgaagaacca agaagcccta
      541 atggcccatc accaattgca actgcttcag gacaaagtga atacggcttt gctgaaaaag
      601 tagttgaggg aatttctgtt tctgtaaatt ctatagtcat cagaattgga gcaaaagcct
      661 tcaatgcatc atttgaactt tctcagcttc ggatctatag tgtaaatgca cactgggaac
      721 atggagattt gagatttact cgtattcagg atccacagag aggagaggtt ttgactttta
      781 aagaaataaa ttggcagatg ataagaatag aggcagatgc cacccaaagt tcacatcttg
      841 aaattatgtg tgctcctgtt cgattaataa ccaaccaatc aaaaatcaga gtcacactta
      901 aaagaaggtt aaaggactgc aatgtcatag caacaaagtt agttctaata ttggatgact
      961 tattatgggt tttgactgat tcccagttga aagctatggt acaatatgca aagtctctta
     1021 gtgaagcaat agaaaaatca acagaacaaa ggaagagtat ggctcctgaa cctacacaga
     1081 gctctacagt agtcgcatct gcccagcaag tgaagacaac gcaaacttca aatgctcctg
     1141 atgtaaatga tgcaattgtg aaactattca atgattttga tgttaaggaa acctcccatc
     1201 atttagtgat ttctcatcta gatctacaca tatgtgatga cattcatgct aaagaaaaag
     1261 agtcaaacag acgtattact ggaggggcaa tgcaactctc ttttacacag ctaactatag
     1321 attattatcc ttatcataaa gcaggagata gttgtaatca ttggatgtat tttagtgatg
     1381 caaccaaaac aaaaaatgga tgggccaatg agttattgca tgaatttgag tgcaacgttg
     1441 aaatgcttaa acaggctgtg aaggatcata atgtaggttc acctcctaaa tccccaacac
     1501 atgcctctcc ccagcacaca caaacagaga aggactaccc tctgaaaggg acatgcagaa
     1561 caccttcagt attatctcaa caatcaaaag ctaagctaat gtctagttct gttgtggtta
     1621 gacttgcaga tttcaatata taccaggtct ctacagcgga acaatgtcgt tcttccccca
     1681 aaagcatgat ttgctgcaat aaaaaatccc tatatcttcc acaagaaatg tcagctgtct
     1741 atatagaatt cacagaatat tactatccag atggaaagga ttttccaatt ccatctccca
     1801 acctctatag ccagctgaat gcactacagt ttactgtgga tgaaagaagc attctatggt
     1861 taaatcaatt tctgttggat ttaaaacaga gtcttaatca gttcatggct gtgtacaagt
     1921 tgaatgacaa ttcaaaatct gacgagcatg ttgatgttcg agttgatggc ttaatgctaa
     1981 agtttgtcat tccttctgaa gtgaaatctg aatgtcatca agatcagcca cgtgcaattt
     2041 ctattcagag ttctgaaatg attgccacaa atacaaggca ctgtccaaac tgtcgacatt
     2101 ctgacctaga agctttgttt caagacttta aagattgtga tttttttagt aaaacatata
     2161 ccagcttccc caaatcttgt gacaatttta atcttctaca tccaattttc cagagacatg
     2221 ctcatgaaca agataccaaa atgcatgaaa tttataaagg aaatattact ccccaattga
     2281 ataaaaacac tcttaaaact tctgctgcca cggatgtttg ggctgtgtac ttttctcaat
     2341 tttggataga ttatgaaggg atgaaaagtg gaaaaggacg gccaataagt tttgtagact
     2401 cattccctct ttccatttgg atttgtcaac caacaagata tgcagagtca caaaaagagc
     2461 cgcagacttg taatcaggta tctctaaata catcacaaag tgaatctagt gatctggctg
     2521 gccgattgaa gcggaagaag ctcttgaagg agtattatag tacagagtct gagcctttga
     2581 caaatggtgg tcagaagcct tcttcatcag atacattttt cagattttcc ccttcctcgt
     2641 cagaggcaga tattcatctc ctagttcatg ttcataaaca tgtcagtatg cagattaatc
     2701 actaccagta tctgcttcta cttttcctgc atgagtcact tatcctgctt tcagagaact
     2761 taaggaaaga tgtagaagct gtaactggca gtcctgctag tcagacatcc atttgtattg
     2821 gaattttact tagaagtgca gaactggctc ttttgctcca tccagtggat caagcaaata
     2881 ctcttaagtc tcctgtttct gaaagtgtga gcccagtggt acctgattat ttgcctacag
     2941 aaaatgggga ttttttgtct tcaaaaagaa aacaaattag tagggatata aatagaatta
     3001 gaagtgtaac tgttaatcat atgtcagaca acagatctat gagtgttgac cttagccata
     3061 tccctttaaa ggatcctttg ctttttaaat cagctagtga tacaaatctg caaaaaggca
     3121 tttcttttat ggactattta tcagataaac atttagggaa aataagtgaa gatgaaagta
     3181 gtggacttgt ttacaaaagt ggctcaggag aaattggatc agaaacaagt gacaaaaagg
     3241 attcatttta tacagattca agtagtatct taaactacag agaagattcg aatatacttt
     3301 catttgatag tgatggtaat caaaacatac tttcaagtac tttaactagt aaaggaaatg
     3361 aaaccataga gtccatcttt aaagctgaag atttgcttcc agaagcagct tcactctctg
     3421 aaaacctgga tatcagtaaa gaagagaccc ccccagttag aacacttaaa tcacagtcat
     3481 ctttaagtgg aaagcctaag gaacgttgcc cacccaacct ggctcctctc tgtgtttctt
     3541 ataagaatat gaaaagaagc tcttcacaaa tgtcattgga taccatttca cttgacagca
     3601 tgatattgga agaacagtta ttagaaagtg atggaagtga tagccatatg tttttggaaa
     3661 aaggaaataa aaagaactca actacaaatt acaggggcac agcagaaagt gtgaatgctg
     3721 gtgcaaacct acagaattat ggtgaaactt ctccagatgc catcagtaca aattcagagg
     3781 gtgctcagga aaatcatgat gacctgatgt ccgttgtggt atttaaaatt actggtgtta
     3841 atggggaaat tgacatccga ggggaagata cagaaatctg tcttcaagtg aaccaggtga
     3901 caccagacca attaggcaat atcagccttc ggcattacct ttgtaatcgt ccagttggtt
     3961 ccgatcagaa agctgtaatt cattccaaat cctctcctga gatttctctg agatttgaaa
     4021 gtgggcctgg tgctgtaata cactctttac ttgcagaaaa aaatggattt ctgcagtgcc
     4081 acatagaaaa cttcagcact gagtttctta catcttctct tatgaatatt caacattttt
     4141 tggaagatga aactgttgca acagtaatgc caatgaagat acaagtttct aacacgaaaa
     4201 taaatttaaa agatgatagt ccccggagta gtacagtatc ccttgaacca gctcctgtaa
     4261 ctgtacatat tgatcatctt gtggtagaga gaagtgacga tggctctttt catatcagag
     4321 attctcacat gcttaacact ggaaatgatt tgaaagaaaa tgtcaaaagc gattcagtgc
     4381 tgctgaccag tggaaagtat gatctgaaga aacaacgcag tgtcacgcaa gccactcaga
     4441 caagcccagg ggttccttgg ccttctcagt cagctaactt tcctgagttc tcctttgact
     4501 tcactaggga acagctcatg gaagagaatg aatctcttaa acaggaactg gctaaagcta
     4561 aaatggctct tgcagaggct cacttggaaa aagatgctct tcttcatcat ataaagaaga
     4621 tgacagttga atagcaggag tggcagtcaa aactgaaatt atagctctgg agtaggaagg
     4681 ttatatttat aatgtggatg ttaccagtta ggggaagact tttattttca tgaaaagaca
     4741 ataaaacaaa atggaatgtg atgaagtggt gactatttca aagccagttt agaaagtatt
     4801 agtacgggca ttacaatctt ttggttgttt tgtgttttgg ggcttaaccc tcttttaagc
     4861 tgttgtgatc tagggaagtc aacacatagt gtaaaataat tacatgccta atgaaaagaa
     4921 gatgtcattt cctaattttg atatctcatt ttcggcattt tttaaaatgt aaaaggaaaa
     4981 cctcttgtgt tcacacagat tgctgaattg atttctccat atttgttaat aatttactat
     5041 tatttacaaa gattcaaatg cttttatgac taatgtaaaa tgaaaagagg cttacatttt
     5101 aaatgttatt aaaattatgt acttaaatct ataattattt aattattgta aaaagtccaa
     5161 gcagatcaat aaactatata attaatgggt ttggaaaa
//
