LOCUS       NM_017754               9567 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens bridge-like lipid transfer protein family member 3A
            (BLTP3A), mRNA.
ACCESSION   NM_017754
VERSION     NM_017754.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9567)
  AUTHORS   Hanna,M.G., Suen,P.H., Wu,Y., Reinisch,K.M. and De Camilli,P.
  TITLE     SHIP164 is a chorein motif lipid transfer protein that controls
            endosome-Golgi membrane traffic
  JOURNAL   J Cell Biol 221 (6) (2022)
   PUBMED   35499567
REFERENCE   2  (bases 1 to 9567)
  AUTHORS   Dan,W., Shi,L., Wang,L., Wu,D., Huang,X. and Zhong,Y.
  TITLE     PP7080 expedites the proliferation and migration of lung
            adenocarcinoma cells via sponging miR-670-3p and regulating
            UHRF1BP1
  JOURNAL   J Gene Med 23 (8), e3341 (2021)
   PUBMED   33844396
  REMARK    GeneRIF: PP7080 expedites the proliferation and migration of lung
            adenocarcinoma cells via sponging miR-670-3p and regulating
            UHRF1BP1.
REFERENCE   3  (bases 1 to 9567)
  AUTHORS   Wen,L., Liu,L., Shen,X., Li,H., Zhu,Z., Huang,H., Cai,M., Qian,D.,
            Shen,S., Qiu,Y., Cui,Y. and Sheng,Y.
  TITLE     The association of the UHRF1BP1 gene with systemic lupus
            erythematosus was replicated in a Han Chinese population from
            mainland China
  JOURNAL   Ann Hum Genet 84 (3), 221-228 (2020)
   PUBMED   31691269
  REMARK    GeneRIF: The association of the UHRF1BP1 gene with systemic lupus
            erythematosus was replicated in a Han Chinese population from
            mainland China.
REFERENCE   4  (bases 1 to 9567)
  AUTHORS   El Baroudi,M., Machiels,J.P. and Schmitz,S.
  TITLE     Expression of SESN1, UHRF1BP1, and miR-377-3p as prognostic markers
            in mutated TP53 squamous cell carcinoma of the head and neck
  JOURNAL   Cancer Biol Ther 18 (10), 775-782 (2017)
   PUBMED   28886272
  REMARK    GeneRIF: Study shows that SESN1 mRNA, UHRF1BP11 mRNA and
            miRNA-377-3p levels are prognostically relevant in human
            papillomavirus-negative head and neck squamous cell carcinoma
            patients.
            Review article
REFERENCE   5  (bases 1 to 9567)
  AUTHORS   Martin,J.E., Assassi,S., Diaz-Gallo,L.M., Broen,J.C., Simeon,C.P.,
            Castellvi,I., Vicente-Rabaneda,E., Fonollosa,V., Ortego-Centeno,N.,
            Gonzalez-Gay,M.A., Espinosa,G., Carreira,P., Camps,M., Sabio,J.M.,
            D'alfonso,S., Vonk,M.C., Voskuyl,A.E., Schuerwegh,A.J., Kreuter,A.,
            Witte,T., Riemekasten,G., Hunzelmann,N., Airo,P., Beretta,L.,
            Scorza,R., Lunardi,C., Van Laar,J., Chee,M.M., Worthington,J.,
            Herrick,A., Denton,C., Fonseca,C., Tan,F.K., Arnett,F., Zhou,X.,
            Reveille,J.D., Gorlova,O., Koeleman,B.P., Radstake,T.R., Vyse,T.,
            Mayes,M.D., Alarcon-Riquelme,M.E. and Martin,J.
  CONSRTM   Spanish Scleroderma Group; SLEGEN consortium; U.S. Scleroderma GWAS
            group; BIOLUPUS
  TITLE     A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS
            reveals new shared susceptibility loci
  JOURNAL   Hum Mol Genet 22 (19), 4021-4029 (2013)
   PUBMED   23740937
REFERENCE   6  (bases 1 to 9567)
  AUTHORS   Zhang,Y., Yang,W., Mok,C.C., Chan,T.M., Wong,R.W., Mok,M.Y.,
            Lee,K.W., Wong,S.N., Leung,A.M., Lee,T.L., Ho,M.H., Lee,P.P.,
            Wong,W.H., Yang,J., Zhang,J., Wong,C.M., Ng,I.O.,
            Garcia-Barcelo,M.M., Cherny,S.S., Tam,P.K., Sham,P.C., Lau,C.S. and
            Lau,Y.L.
  TITLE     Two missense variants in UHRF1BP1 are independently associated with
            systemic lupus erythematosus in Hong Kong Chinese
  JOURNAL   Genes Immun 12 (3), 231-234 (2011)
   PUBMED   21326321
  REMARK    GeneRIF: Cross-population confirmation establishes the involvement
            of UHRF1BP1 locus in SLE and indicates that distinct alleles are
            contributing to disease susceptibility.
REFERENCE   7  (bases 1 to 9567)
  AUTHORS   Orozco,G., Eyre,S., Hinks,A., Bowes,J., Morgan,A.W., Wilson,A.G.,
            Wordsworth,P., Steer,S., Hocking,L., Thomson,W., Worthington,J. and
            Barton,A.
  CONSRTM   UKRAG consortium
  TITLE     Study of the common genetic background for rheumatoid arthritis and
            systemic lupus erythematosus
  JOURNAL   Ann Rheum Dis 70 (3), 463-468 (2011)
   PUBMED   21068098
  REMARK    GeneRIF: Observational study and meta-analysis of gene-disease
            association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 9567)
  AUTHORS   Gateva,V., Sandling,J.K., Hom,G., Taylor,K.E., Chung,S.A., Sun,X.,
            Ortmann,W., Kosoy,R., Ferreira,R.C., Nordmark,G., Gunnarsson,I.,
            Svenungsson,E., Padyukov,L., Sturfelt,G., Jonsen,A.,
            Bengtsson,A.A., Rantapaa-Dahlqvist,S., Baechler,E.C., Brown,E.E.,
            Alarcon,G.S., Edberg,J.C., Ramsey-Goldman,R., McGwin,G. Jr.,
            Reveille,J.D., Vila,L.M., Kimberly,R.P., Manzi,S., Petri,M.A.,
            Lee,A., Gregersen,P.K., Seldin,M.F., Ronnblom,L., Criswell,L.A.,
            Syvanen,A.C., Behrens,T.W. and Graham,R.R.
  TITLE     A large-scale replication study identifies TNIP1, PRDM1, JAZF1,
            UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus
  JOURNAL   Nat Genet 41 (11), 1228-1233 (2009)
   PUBMED   19838195
  REMARK    GeneRIF: identified five new systemic lupus erythematosus
            susceptibility loci (P < 5 x 10(-8)): TNIP1 (odds ratio (OR) =
            1.27), PRDM1 (OR = 1.20), JAZF1 (OR = 1.20), UHRF1BP1 (OR = 1.17)
            and IL10 (OR = 1.19).
            GeneRIF: Observational study and meta-analysis of gene-disease
            association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 9567)
  AUTHORS   Unoki,M., Nishidate,T. and Nakamura,Y.
  TITLE     ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG
            through its SRA domain
  JOURNAL   Oncogene 23 (46), 7601-7610 (2004)
   PUBMED   15361834
REFERENCE   10 (bases 1 to 9567)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB636320.1, AB126777.1, AL033520.16 and AA287944.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017754.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.71702.1, AB126777.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000192788.6/ ENSP00000192788.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                DB636320.1         67-165
            100-4491            AB126777.1         1-4392
            4492-9292           AL033520.16        29668-34468
            9293-9567           AA287944.1         26-300              c
FEATURES             Location/Qualifiers
     source          1..9567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..9567
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /note="bridge-like lipid transfer protein family member
                     3A"
                     /db_xref="GeneID:54887"
                     /db_xref="HGNC:HGNC:21216"
                     /db_xref="MIM:619570"
     exon            1..212
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..4491
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /note="UHRF1 (ICBP90) binding protein 1; ICBP90 binding
                     protein 1; ubiquitin-like containing PHD and RING finger
                     domains 1-binding protein 1; UHRF1 binding protein 1"
                     /codon_start=1
                     /product="bridge-like lipid transfer protein family member
                     3A"
                     /protein_id="NP_060224.3"
                     /db_xref="CCDS:CCDS43455.1"
                     /db_xref="GeneID:54887"
                     /db_xref="HGNC:HGNC:21216"
                     /db_xref="MIM:619570"
                     /translation="MAGIIKKQILKHLSRFTKNLSPDKINLSTLKGEGQLTNLELDEE
                     VLQNVLELPTWLAITRVYCNRASIRIQWTKLKTHPICLCLDKVEVEMKTCEDPRPPNG
                     QSPIALASGQSEYGFAEKVVEGMFIIVNSITIKIHSKAFHASFELWQLQGYSVNPNWQ
                     QSDLRLTRITDPCRGEVLTFKEITWQTLRIEADATDNGDQDPVTTPLRLITNQGRIQI
                     ALKRRTKDCNVISSKLMFLLDDLLWVLTDSQLKAMMKYAESLSEAMEKSAHQRKSLAP
                     EPVQITPPAPSAQQSWAQAFGGSQGNSNSSSSRLSQYFEKFDVKESSYHLLISRLDLH
                     ICDDSQSREPGVSANRLMGGAMQLTFRKMAFDYYPFHWAGDSCKHWVRHCEAMETRGQ
                     WAQKLVMEFQSKMEKWHEETGLKPPWHLGVDSLFRRKADSLSSPRKNPLERSPSQGRQ
                     PAFQPPAWNRLRSSCMVVRVDDLDIHQVSTAGQPSKKPSTLLSCSRKLHNLPTQVSAI
                     HIEFTEYYFPDNQELPVPCPNLYIQLNGLTFTMDPVSLLWGNLFCLDLYRSLEQFKAI
                     YKLEDSSQKDEHLDIRLDAFWLKVSFPLEKRERAELHRPQALVFSASGMIATNTRHAP
                     HCSCSDLQSLFRGFAAAEFFHSNYDHFPKVPGGFSLLHMLFLHHAFQMDSCLPQPNTL
                     PPQRPKASWDLWSVHFTQISLDFEGTENFKGHTLNFVAPFPLSIWACLPLRWQQAQAR
                     KLLLASEGRLKPSASFGSPVQSEALAPDSMSHPRSKTEHDLKSLSGLTEVMEILKEGS
                     SGMDNKGPLTELEDVADVHMLVHSPAHVRVRLDHYQYLALLRLKEVLQRLQEQLTKDT
                     ESMTGSPLQNQTACIGVLFPSAEVALLMHPAPGAVDADSAGSDSTSLVDSELSPSEDR
                     ELKSDASSDQGPASPEKVLEESSIENQDVSQERPHSNGELQDSGPLAQQLAGKGHEAV
                     ESLQAKKLSRTQASSSPAALKPPAGRETAVNGQGELIPLKNIEGELSSAIHMTKDATK
                     EALHATMDLTKEAVSLTKDAFSLGRDRMTSTMHKMLSLPPAKEPMAKTDEGVAAPVSG
                     GAARLRFFSMKRTVSQQSFDGVSLDSSGPEDRISVDSDGSDSFVMLLESESGPESVPP
                     GSLSNVSDNAGVQGSPLVNNYGQGSPAANSSVSPSGEDLIFHPVSVLVLKVNEVSFGI
                     EVRGEDLTVALQAEELTLQQLGTVGLWQFLHGQCPGTCFQESSTLKTGHIRPAVGLRF
                     EVGPGAAVHSPLASQNGFLHLLLHGCDLELLTSVLSGLGPFLEDEEIPVVVPMQIELL
                     NSSITLKDDIPPIYPTSPGPIPITLAMEHVVLKRSDDGVFHIGAAAQDKPSAEVLKSE
                     KRQPPKEQVFLVPTGEVFEQQVKELPILQKELIETKQALANANQDKEKLLQEIRKYNP
                     FFEL"
     exon            213..375
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            376..414
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..506
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            507..696
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            697..837
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1008
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1201
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1288
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1459
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1599
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1741
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1935
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..3383
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3384..3580
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3581..3735
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3736..3886
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3887..4149
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4150..4258
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4259..4365
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4366..9567
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9547..9552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /note="hexamer: ATTAAA"
     polyA_site      9567
                     /gene="BLTP3A"
                     /gene_synonym="C6orf107; dJ349A12.1; ICBP90; SHIP164B;
                     UHRF1BP1"
                     /note="major polyA site"
ORIGIN      
        1 gtggcggagc gccaggcgcc caaagagggg cgagaaagcg ccatggcggc ggcggcggct
       61 gtgtccggtg ctcacgccgc ggcgaggtga ggggaccgcc tcttctccac aactgaggag
      121 gccacagctg ccggcccacc cgccttccac gcgggccgcg gctccggcat ggccgggatc
      181 attaagaagc agatcctgaa acacctgtcc cggttcacta agaatctttc cccagacaaa
      241 atcaacctga gcaccctgaa aggggagggt cagctgacca acctggagct ggatgaagag
      301 gttctacaga atgtactgga gctgcccacc tggttagcca tcactcgggt ctactgcaac
      361 agggcctcca tccggatcca gtggacaaag ttgaagacac accctatttg cttgtgtctg
      421 gataaggtag aggtggagat gaagacatgt gaggatcctc ggccccccaa tggacagtct
      481 cccattgccc ttgcttcagg acagagtgaa tatggctttg ccgaaaaggt ggtggaaggg
      541 atgttcatca ttgtcaattc tatcaccatc aagattcact ccaaggcctt ccacgcttct
      601 tttgaattgt ggcagctcca gggctatagt gtcaacccca actggcagca gagtgacctt
      661 cgccttaccc gcatcactga cccctgccga ggagaggttt taacatttaa ggaaataact
      721 tggcaaacac tccgaattga ggcagatgct acagacaatg gtgatcagga cccagtcacc
      781 actccattga ggcttattac gaaccaaggc aggatccaaa tagccctcaa aagaagaacc
      841 aaagattgca atgtgatatc ctccaagctg atgttcctgt tggatgacct gctctgggtg
      901 ctgactgact cacagctcaa ggctatgatg aagtatgcag agtcactgag tgaagccatg
      961 gagaagtcag cccatcaaag aaagagcctg gcccctgaac ctgtgcagat cactccacca
     1021 gcccccagtg cccagcagtc ctgggcccag gcatttggtg gcagccaggg caacagcaac
     1081 agcagcagca gccgcctcag ccagtacttt gagaaatttg atgtgaaaga gtcctcctac
     1141 catctgctca tctcccgcct ggacctgcac atttgtgatg atagccagtc ccgagagcca
     1201 ggtgtctctg ccaacagact catgggtggt gccatgcagc ttaccttccg caagatggcg
     1261 tttgactatt accctttcca ttgggcaggt gatagctgca aacattgggt acgccactgt
     1321 gaggccatgg agacccgagg ccagtgggcc cagaagctgg tgatggaatt tcagagcaaa
     1381 atggagaagt ggcatgaaga gacgggtctg aaaccaccct ggcaccttgg agtagactct
     1441 ctctttcgga gaaaagcaga ttctctttcc agtcctcgaa agaaccctct tgagagaagc
     1501 ccctctcagg gcagacagcc tgcctttcag cctccagcat ggaaccgctt acgctctagc
     1561 tgcatggtgg tacgggtgga tgacctggac atccaccagg tttccaccgc tggacagcca
     1621 agtaaaaagc catctacact cctttcctgc agtcggaaac ttcacaacct ccctacccag
     1681 gtctctgcca ttcatattga gttcacagag tattacttcc cagataatca ggagcttcca
     1741 gttccttgtc ctaatctcta cattcagtta aatggtctga catttactat ggatcctgtc
     1801 agtttgctct ggggaaacct cttttgcctg gatttatacc gcagcttgga gcagttcaaa
     1861 gctatctaca agctggaaga ttcaagtcag aaagatgaac acttggacat ccgactagat
     1921 gcattctggt tgaaggtgag ctttccactg gaaaagagag agcgggcaga gttgcatcgt
     1981 ccccaggccc ttgtcttctc tgcgtcaggc atgattgcca ccaatacacg tcatgctcca
     2041 cattgtagtt gttcagacct ccagagtctc ttccggggtt ttgctgctgc tgagttcttt
     2101 cattccaatt atgatcactt tcctaaggtt ccaggtggct ttagccttct gcacatgctt
     2161 tttttgcatc atgcctttca gatggattcc tgcctgcctc agcctaatac cctccctccc
     2221 cagagaccta aggcttcctg ggatctctgg tctgtccact ttacccagat ctccttggac
     2281 tttgagggaa cagaaaactt caaaggccat accttgaatt ttgtagcccc cttccccctg
     2341 tccatttggg cctgcctacc cctccgctgg cagcaagccc aggcacggaa gcttcttttg
     2401 gcctcagagg ggaggctgaa accatcagcc agttttggaa gtcctgtcca gtctgaggct
     2461 cttgcccctg actctatgtc ccatccgcgg tcaaagactg aacatgactt gaaaagctta
     2521 tcaggactta cagaagtcat ggaaattctg aaagaaggca gtagtggtat ggacaacaaa
     2581 gggcctctga cagagctgga ggatgtagca gatgttcata tgcttgtaca ttccccggcc
     2641 catgtccgcg tgaggcttga ccactaccag tacttggctc tgcttcgcct gaaggaggtg
     2701 ctgcagaggc ttcaggagca gctgactaag gatacagagt caatgactgg gtctcccctg
     2761 cagaatcaga cagcttgcat tggagttctc tttcccagtg ctgaagtggc tctgcttatg
     2821 catcctgcac ccggtgctgt cgatgctgac tctgcaggct cagatagcac tagcctcgta
     2881 gattcagagc tatctccttc agaggatcgg gaactgaagt ctgatgcctc atcagaccag
     2941 ggcccagcaa gccctgagaa ggtcttggag gaaagtagca ttgaaaatca ggatgtatcc
     3001 caggagaggc cacatagcaa tggagaactg caggactcag gtccacttgc ccagcagctg
     3061 gcagggaagg gccatgaggc agtagagtcc ctacaggcca agaaactgag cagaacccaa
     3121 gcctccagct caccagctgc attgaagccc ccagctggca gggagactgc tgtgaatgga
     3181 cagggtgagc tcatcccctt gaagaacatt gagggagaat tgtcaagtgc tattcacatg
     3241 accaaggatg ccaccaagga ggctctacat gccaccatgg acctcaccaa ggaagctgtg
     3301 tccctgacta aggatgcctt cagtttgggc agagatcgaa tgacctccac catgcacaag
     3361 atgttgtccc tgcccccagc caaggagccc atggccaaga cagatgaggg ggtggcagcc
     3421 ccagtgagtg gaggtgctgc acgactccga tttttctcca tgaagaggac ggtatctcaa
     3481 cagtcatttg atggtgtctc attggatagc agtggccctg aagaccggat ttcagtggac
     3541 agtgatggca gtgatagctt tgtgatgctc ttggagtctg agtctggtcc agaatctgtt
     3601 ccaccaggat ctctttcaaa tgtctcagat aatgctggtg ttcaagggag ccctcttgtg
     3661 aataattatg gccaggggtc accagcagcc aacagttcag tttcacccag tggagaagac
     3721 ctcatctttc acccggtctc agttctggtc ctgaaggtga atgaggtgtc ttttgggatt
     3781 gaggtacgtg gtgaggacct gactgtggcc ctgcaagcag aggaactgac cctccagcag
     3841 ctgggcaccg tgggactctg gcagttcctg catggacagt gcccaggtac atgctttcag
     3901 gaatcctcaa ctttgaagac tggccacatc aggccagctg tgggccttcg ctttgaggtg
     3961 gggcctggag cagctgttca ttcccccctg gcctcacaaa atggcttcct acatttattg
     4021 cttcatggct gtgacctcga gctgctcact tcagtgctca gtggcctggg gcccttcttg
     4081 gaggatgagg agatcccggt ggtagtcccc atgcagattg agcttctgaa ctccagcatc
     4141 accctaaagg atgatatccc ccccatctat ccaacatctc caggccccat ccccatcact
     4201 ctggccatgg aacatgttgt gctgaagagg agtgatgatg gtgtgttcca cataggcgct
     4261 gctgctcagg acaaaccatc agctgaagta cttaaaagtg agaagagaca gcccccaaaa
     4321 gaacaggtgt ttttggtgcc cacaggagag gtttttgaac agcaggtgaa agaactgcct
     4381 atcctacaaa aagaacttat agaaactaaa caagccttgg ccaatgccaa ccaggataaa
     4441 gaaaaacttc ttcaggagat taggaaatat aaccccttct ttgagctctg aaaccagtgg
     4501 ctcagccatc tgtgccaagg agagaggcta tcaccagcaa tagcaccacc taggacagag
     4561 ggcactgtcc agtgctgaat aagtcactac ggatgccaga gggactgggg agcactcact
     4621 tcacttgtgt gggtgtgctt tccactagct gttcttactt ggactgagga caagggcaaa
     4681 gcatgattgt atcccaggaa actggggctt gccctgtgtg tggcacaagc atcatgtctt
     4741 gcctgtataa agccttttgg tcctctgtgt actaggtgga atcttctcaa cactgtaggg
     4801 ccatttcacc tcatggtttc atggcaggga catttgcttc cttcacaggc ctgtgtgaac
     4861 aagcaaaagt acccacctcc tcggtcaccc acagagccac caaagattcc atgtcccaga
     4921 gcttcccata gcagacctga aaagtccatg acctgagctt tggccatggt agtggagtgg
     4981 aacaggaaat agtccagcag aggagtgtgg gggaaggggg caggagaggc acaagaataa
     5041 gggagacctg gactctgcct ttttgggaaa aggaaccaag ctcatagcaa tttggctgat
     5101 aacacaatca gatttttcca ggttaagctt cctttctgtt atactttcat cattgtgatg
     5161 ctgtggtaga aagtaaataa cagtagtggc tcagtcattt aatctttccc ctctataata
     5221 caacttactt gaaatttaaa tcaagaaaaa atttctgacg ctgagctagg ttggtggcat
     5281 gatatgccag gggtcagtgg gggagcttgc ttctgagccc cctgttgtcc gcctggagtc
     5341 ctgcttgtct ttcccagctg tgctgagtgg ctcttctgtc tccctggggt ccctggcaca
     5401 tctgctttcc cagctctgtg accttaccag ttctctcctc agcccttggt ggtttgggag
     5461 ctgaatatat gttttaaact tttacataaa caactcaacc tgttgcctct cacttccctc
     5521 catcactgtg gcttttaaaa ctcatgtatt ttgactcaag tgaaaaaaac acaaaaatcc
     5581 ctcatcccag ctaggttttg ccccctgccc tataagagag ctatttcccc ctttctttcc
     5641 tttgaattct tctccaacac catcccttca ttcatactgc cctgtgatac acttgaagct
     5701 gtgttgattg gacagacgtt catcagctaa cttaccttta cttggcaaga tggtaaaata
     5761 gtaacttagt gatgttacta aagtctcgac cattcacctt tccatactga aggaaaggta
     5821 aaaaggtttc ttctatggga aattatgctt gacttgcata ctctagtttg atgaggataa
     5881 aaagaaacat gtaattgcag tggtgtttac aactaattga tcacaaccaa tcatagattt
     5941 ctttgttcct tctccactct caacacttca tttgactaga aaaaaaaaat gtattcacca
     6001 aggaacagga cccaatttgt tcagactttt gttaagtttc tttactaagg caatttttga
     6061 aacaccagtt actatgggat ggtgggaatt tttcatgctt aagaaataga gacttaggaa
     6121 caaagaaaca tctttctgga gaagatgcta atgggaagtt acctaaggct tgatgcttgg
     6181 ttcaacctta tttaaaattt ttataaatga cctgaaagta ggattttaca gtgaaatcaa
     6241 atgtcactac ttccaggcag tgaaaggtaa tctagaagag gtttaaaaaa cacaaaaccg
     6301 gtcgggcaca gcggctcacg cctgtaatcc cagcactttg ggaggccgag gcggggagat
     6361 cacgagttca ggagatcgag accatcctgg ccaacatggt gaaactttgt ttccactaaa
     6421 aatacaaaaa ttagctgggt gtggtggtgg gtgcctgtag ttccagccac tcgggaggct
     6481 gaagcaggag aatcgcttga acccgggagg cagaggttgc agtgagccga gatagcgcca
     6541 ttgcactcca gcctgtcaac agagtgagac tccgtctcac aacaaacaaa caaacacaaa
     6601 accacagaag ggttactaat aagcagggct gagaatactc agaaaactga caggtgaggt
     6661 tcaacataat ataaggaaat gtatttatgg aagaattatc aactgatatg cctgaacact
     6721 gttagaactc aggaaagaaa caagcattgc tgagggggag gagagatcaa tgtgctgctg
     6781 tggccaaaag cctaattgcc ctgtgggcat catcaggaag ggcttttgga gataacagag
     6841 aacagcactt tatacaaaac catggatatg tcttgatcgg attatctgtg tttctagtga
     6901 ccttatttac aagatatatg ataaagggag gaaaggtcca gagaacagcc aaaattatca
     6961 ggggatggag gtatatccat atgaggacac atttttaaaa tatagactct atcctgcaaa
     7021 gatgaaagca gaggggagtt agatcaaata tccaatcaag agcaaggacc cggtcctgta
     7081 ctactagctc tagggctcta tctcatagcc ttagtaaaga aagcacttct catagcaaat
     7141 cagaaatgta aggagctcat tgtctaagaa gggatgccac cagaaactat acatgggtgc
     7201 aggtttatga ggaatccttg catgacggcc ttctacaagg aattatagaa aagtagggct
     7261 acttggtaat atacaactga gagggtaact gtgtccctca acaaactact ccttagtgcc
     7321 tctttcaaag gcagaatgtt gatctgaatg gatcactggt caagtatggc atctctaatg
     7381 ttcttgaagg gggaggaagg agatctggta gctggaaaat ataattattc cacgttaggc
     7441 tcacctgaat tggtttaaaa tcatattctg attctcttct catcccttcc tcccctcacc
     7501 caccatatac ctctggcatc cctccatgca aagaaatgtc gaataggcat ttcttggtat
     7561 aatttaccta cacttgtgct tgtggggtgg gagtaaaaac atatccagta agtaccaagg
     7621 ctaacctcct aatggctgga gctcagttag gtctctgggc tctctaaagg agtccagagc
     7681 tcttgtccat gtcacaaatg gagccttaga atttctgtct ttccttatgt ggcagctttg
     7741 gccattgtgt cttgaaattc tccctcagga aatgtgatag gggatattat cccatgggat
     7801 tttagtaaaa atcagcttgc ctaatttcat attcgtgttc ataatgaaga aatgcgaagt
     7861 ggtggtagtc ctcaggatta agtgtaaagg aaaatatgca aggaaaaagt agcagtgtca
     7921 gcccttttgg actgcttatg atttctgcct tagagctaca agacttggaa caagaaataa
     7981 caatacctca agaaaatgtc tggagagata gcaccactgt ccctcaaaga cttcagccac
     8041 tgcacattac caattcagct gtgaagcatt tacaactgta ttatctgtga ttgtctgcat
     8101 ttcctgttta catgcatgtg ctggggatat gctttagtgt gtatggacta gagtttaaat
     8161 cctgtcttta actgggctgc aaggatggct atcaatccca aattctgttt tcaactcact
     8221 ggaataatta atctggtgtt cctgatataa aacaggtggg ttctattcac atgatggctg
     8281 ctctttacca tatatttcac ctgaccctca ttttgccatg ggcctcaacc tttatgtgtg
     8341 ctttttatgg ctctgaaagg actggctccc gtgtgtggaa tatacaaggt ataaacacca
     8401 cccctcacat acccctgtaa cttaaatgct tccatttaac tcacttagat tactttcccc
     8461 ttagtggtaa acgggttggg ggatgggtgg tagtgcaaag aaggtagttt gaaatattgc
     8521 catagtaata tgggaacttt ttattccaac cctttaccct ggcttttttt tctctcaata
     8581 tttgcctaaa attctaaaat gagttatagt aaaatcataa aactatggaa acaactgaac
     8641 tttggtacac aagttagttc gatgacatct tgttatttga gaacagtaaa aggtgtgtca
     8701 ttgcctcatg atttatcata gtcattacta agggtttcag agagaatctg gtgtgaagca
     8761 ctatcctttc agacactaag gcctttacct agttgctccc ctaccttctg tcggaatagg
     8821 attattccca tgcacctctg ggtaggtata ggtagtagct attgaacggg gattattttc
     8881 cccatggcac aaggggaaac actcttggat aaccttcaac aatgaggctt tgctaagtgg
     8941 ccagacttgg gatttgatct tcctcacttg ttatttatta agtttaagcc ttattcagta
     9001 tctctaattg caatagatat agttcctgtg acttctaaaa aaaattcctg ttaatgctga
     9061 gacagtatct tttttgtcag tttattaatt tttggtcaag atttagcctg agtcttaaag
     9121 catttatttg tggaatgccc cactgaagtg tcttctccat tggctaagta catgtttaaa
     9181 gccatgggtt ttaatgtaag atactttcag tatctaattc tgtttccccc actgagggtg
     9241 ctaaagagaa ttagaatctt tactaagaca tgctcaggaa agcttcacga gagaacagct
     9301 tcaaaatcct ccctatgaca ctgaatggta gtgaggaaag aattcttggg gatgccagtt
     9361 acatacaata gccttattac tgctaatcac tgtcaataaa aggtcacttc attcacctct
     9421 atttgaggaa aacaatgaga atgtatctga tgaactagaa tccttgtcag tattgggaaa
     9481 ttttaatgtt gcaatatcta gtcaaacttt gagtgtactg gttctgtgaa ccacctgaaa
     9541 aaacaaatta aatgtattaa accataa
//
