LOCUS       NM_014680               7428 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens bridge-like lipid transfer protein family member 2
            (BLTP2), transcript variant 1, mRNA.
ACCESSION   NM_014680 XM_371036
VERSION     NM_014680.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7428)
  AUTHORS   Wang,L., Jin,W., Wu,X., Liu,Y. and Gu,W.
  TITLE     Circ_0000520 interacts with miR-512-5p to upregulate KIAA0100 to
            promote malignant behaviors in lung cancer
  JOURNAL   Histol Histopathol 38 (1), 73-89 (2023)
   PUBMED   35866672
  REMARK    GeneRIF: Circ_0000520 interacts with miR-512-5p to upregulate
            KIAA0100 to promote malignant behaviors in lung cancer.
REFERENCE   2  (bases 1 to 7428)
  AUTHORS   Zhong,Z., Pannu,V., Rosenow,M., Stark,A. and Spetzler,D.
  TITLE     KIAA0100 Modulates Cancer Cell Aggression Behavior of MDA-MB-231
            through Microtubule and Heat Shock Proteins
  JOURNAL   Cancers (Basel) 10 (6), 180 (2018)
   PUBMED   29867023
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7428)
  AUTHORS   Guo,J., Wang,M. and Liu,X.
  TITLE     MicroRNA-195 suppresses tumor cell proliferation and metastasis by
            directly targeting BCOX1 in prostate carcinoma
  JOURNAL   J Exp Clin Cancer Res 34 (1), 91 (2015)
   PUBMED   26338045
  REMARK    GeneRIF: loss of miR-195 expression and thus uncontrolled BCOX1
            upregulation might drive prostate cancer metastasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7428)
  AUTHORS   Liu,T., Zhang,X.Y., He,X.H., Geng,J.S., Liu,Y., Kong,D.J.,
            Shi,Q.Y., Liu,F., Wei,W. and Pang,D.
  TITLE     High levels of BCOX1 expression are associated with poor prognosis
            in patients with invasive ductal carcinomas of the breast
  JOURNAL   PLoS One 9 (1), e86952 (2014)
   PUBMED   24489812
  REMARK    GeneRIF: High BCOX1 expression may serve as a novel marker of poor
            prognosis and a potential therapeutic target for patients with
            invasive ductal carcinomas of the breast.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7428)
  AUTHORS   Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
            Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
  TITLE     Full-length transcriptome analysis of human retina-derived cell
            lines ARPE-19 and Y79 using the vector-capping method
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6662-6670 (2011)
   PUBMED   21697133
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7428)
  AUTHORS   Song,J., Yang,W., Shih,Ie.M., Zhang,Z. and Bai,J.
  TITLE     Identification of BCOX1, a novel gene overexpressed in breast
            cancer
  JOURNAL   Biochim Biophys Acta 1760 (1), 62-69 (2006)
   PUBMED   16289875
  REMARK    GeneRIF: BCOX1 mRNA signal is mainly located in the cytoplasm of
            breast carcinoma epithelial cells. mRNA expression was moderately
            elevated in ductal in situ carcinoma, peaked in invasive breast
            carcinoma and metastatic breast carcinoma cells (MET) (BCOX1)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AW161205.1, D43947.3,
            DB152098.1 and BM999622.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014680.4.
            
            Summary: This gene was initially characterized in human as having
            high expression levels in breast carcinomas and breast cancer cell
            lines. This gene also has increased expression in prostrate cancer
            cells relative to normal prostrate tissues. Expression of this gene
            is negatively regulated by direct binding of the microRNA miR-195
            to its 3' UTR. miR-195 has been shown to modulate the invasiveness
            of prostrate cancer cells and xenograft metastases by downgrading
            expression of this gene. In mouse, the protein encoded by this gene
            was identified as an antigen on acute monocytic leukemia cells. In
            human, alternative splicing results in multiple transcript variants
            encoding distinct isoforms; some of these isoforms are predicted to
            contain an RNA pol II promoter FMP27 protein domain and a
            Golgi-body-localization APT1 domain. [provided by RefSeq, Apr
            2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: D43947.3, SRR11853564.11874.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000528896.7/ ENSP00000436773.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AW161205.1         2-28
            28-5019             D43947.3           1-4992
            5020-5030           DB152098.1         479-489
            5031-7420           D43947.3           5004-7393
            7421-7428           BM999622.1         24-31               c
FEATURES             Location/Qualifiers
     source          1..7428
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..7428
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /note="bridge-like lipid transfer protein family member 2"
                     /db_xref="GeneID:9703"
                     /db_xref="HGNC:HGNC:28960"
                     /db_xref="MIM:610664"
     exon            1..170
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..6810
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cancer/testis antigen 101; antigen MLAA-22;
                     U937-associated antigen; breast cancer-overexpressed gene
                     1 protein; breast cancer overexpressed gene 1; protein
                     hobbit homolog"
                     /codon_start=1
                     /product="bridge-like lipid transfer protein family member
                     2 isoform 1 precursor"
                     /protein_id="NP_055495.2"
                     /db_xref="CCDS:CCDS32595.1"
                     /db_xref="GeneID:9703"
                     /db_xref="HGNC:HGNC:28960"
                     /db_xref="MIM:610664"
                     /translation="MPLFFSALLVLLLVALSALFLGRWLVVRLATKWCQRKLQAELKI
                     GSFRFFWIQNVSLKFQQHQQTVEIDNLWISSKLLSHDLPHYVALCFGEVRIRTDLQKV
                     SDLSAPFSQSAGVDQKELSFSPSLLKIFCQLFSIHVDAINIMVLKVDTSESLWHIQIS
                     RSRFLLDSDGKRLICEVSLCKINSKVLKSGQLEDTCLVELSLALDLCLKVGISSRHLT
                     AITVDVWTLHAELHEGLFQSQLLCQGPSLASKPVPCSEVTENLVEPTLPGLFLLQQLP
                     DQVKVKMENTSVVLSMNSQKRHLTWTLKLLQFLYHRDEDQLPLRSFTANSDMAQMSTE
                     LLLEDGLLLSQSRQRIVCLNSLKASVQVTTIDLSASLVLNTCIIHYRHQEFSHWLHLL
                     ALETQGSSSPVLKQRKKRTFPQILAPIIFSTSISNVNISIQLGDTPPFALGFNSISLD
                     YQHLRPQSIHQRGVLTVDHLCWRVGSDSHIQRAPHPPNMHVWGEALVLDSFTLQGSYN
                     QPLGLSSTQSDTLFLDCTIRGLQVEASDTCAQCLSRILSLMGPQSGKSAVSRHSSFGE
                     SVSLLWKVDLKVEDMNLFTLSALVGASEVRLDTLTILGSAETSTVGIQGLVLALVKSV
                     TEKMQPCCKAPDIPTPVLSLSMLSITYHSSIRSLEVQCGAGLTLLWSPPDHMYLYQHV
                     LATLQCRDLLRATVFPETVPSLALETSGTTSELEGRAPEPLPPKRLLNLTLEVSTAKL
                     TAFVAEDKFITLAAESVSLSRHGGSLQAYCPELAAGFDGNSIFNFKEVEVQLLPELEE
                     MILHRNPFPALQTLRNRVWLLSFGSVSVEFPYQYDFSRTLDEAVGVQKWLKGLHQGTR
                     AWASPSPVPLPPDLLLKVEHFSWVFLDDVFEVKLHDNYELMKDESKESAKRLQLLDAK
                     VAALRKQHGELLPARKIEELYASLERKNIEIYIQRSRRLYGNTPMRRALLTWSLAGLE
                     LVALADASFHGPEHVVEQVQELDPGSPFPPEGLDLVIQWCRMLKCNVKSFLVRIRDYP
                     RYLFEIRDWRLMGRLVGTEQSGQPCSRRRQILHLGLPWGNVAVERNMPPLKFYHDFHS
                     EIFQYTVVWGPCWDPAWTLIGQCVDLLTKPSADPSPPLPWWDKSRLLFHGDWHMDIEQ
                     ANLHQLATEDPYNTTENMHWEWSHLSFHWKPGQFVFKGDLDINVRTASKYDDCCFLHL
                     PDLCMTLDLQWLCHGNPHDHHSVTLRAPEFLPEVPLGQLHDSYRAFRSENLNLSIKMD
                     LTRHSGTISQPRILLYSSTLRWMQNFWATWTSVTRPICRGKLFNNLKPSKKKLGQHYK
                     QLSYTALFPQLQVHYWASFAQQRGIQIECSQGHVFTRGTQRLIPQAGTVMRRLISDWS
                     VTQMVSDLSQVTVHLMASPTEENADHCLDPLVTKTHLLSLSSLTYQRHSNRTAEEELS
                     ARDGDPTFHTHQLHLVDLRISWTTTNRDIAFGLYDGYKKAAVLKRNLSTEALKGLKID
                     PQMPAKKPKRGVPTSASAPPRVNTPSFSGQPDKGSSGGAYMLQKLIEETDRFVVFTEE
                     ESGMSDQLCGIAACQTDDIYNRNCLIELVNCQMVLRGAETEGCVIVSAAKAQLLQCQH
                     HPAWYGDTLKQKTSWTCLLDGMQYFATTESSPTEQDGRQLWLEVKNIEEHRQRSLDSV
                     QELMESGQAVGGMVTTTTDWNQPAEAQQAQQVQRIISRCNCRMYYISYSHDIDPELAT
                     QIKPPEVLENQEKEDLLKKQEGAVDTFTLIHHELEISTNPAQYAMILDIVNNLLLHVE
                     PKRKEHSEKKQRVRFQLEISSNPEEQRSSILHLQEAVRQHVAQIRQLEKQMYSIMKSL
                     QDDSKNENLLDLNQKLQLQLNQEKANLQLESEELNILIRCFKDFQLQRANKMELRKQQ
                     EDVSVVRRTEFYFAQARWRLTEEDGQLGIAELELQRFLYSKVNKSDDTAEHLLELGWF
                     TMNNLLPNAVYKVVLRPQSSCQSGRQLALRLFSKVRPPVGGISVKEHFEVNVVPLTIQ
                     LTHQFFHRMMGFFFPGRSVEDDEVGDEEDKSKLVTTGIPVVKPRQLIATDDAVPLGPG
                     KGVAQGLTRSSGVRRSFRKSPEHPVDDIDKMKERAAMNNSFIYIKIPQVPLCVSYKGE
                     KNSVDWGDLNLVLPCLEYHNNTWTWLDFAMAVKRDSRKALVAQVIKEKLRLKSATGSE
                     VRGKLETKSDLNMQQQEEEEKARLLIGLSVGDKNPGKKSIFGRRK"
     exon            171..300
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            301..350
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            351..498
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            499..617
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            618..678
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            679..868
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            869..992
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1117
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1185
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1331
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1450
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1614
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1873
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2079
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..3172
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3364
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3567
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            3568..3686
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            3687..3907
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            3908..4098
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            4099..4198
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            4199..4401
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            4402..4696
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            4697..4854
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            4855..5061
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            5062..5161
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            5162..5344
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            5345..5466
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            5467..5622
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            5623..5744
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            5745..5925
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            5926..6012
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            6013..6123
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            6124..6259
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            6260..6390
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            6391..6492
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            6493..6627
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     exon            6628..7428
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7143..7148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /note="hexamer: AATATA"
     polyA_site      7165
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
                     /note="major polyA site"
     polyA_site      7391
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
     polyA_site      7428
                     /gene="BLTP2"
                     /gene_synonym="BCOX; BCOX1; CT101; FMP27; Hob; KIAA0100"
ORIGIN      
        1 ctgcgcgcgc agctggtcgg cccgcggcgg tgctgcgcgg atccggcgtc ggggcccggc
       61 atggcggggg ccggggccaa gccgggccgg acccggacct aaatgcctct gttcttctcc
      121 gcgctgttgg tcttgctgct agttgcgctt agcgccctct ttctaggccg gtggcttgtg
      181 gtccggttgg ccaccaagtg gtgtcagcgg aagctgcagg cggagctaaa gattggctcc
      241 ttccgctttt tttggatcca gaatgtcagt cttaagtttc agcaacacca gcaaacagtg
      301 gaaattgata acctgtggat ttccagcaaa ctccttagcc atgatcttcc acactatgtg
      361 gcattgtgct ttggagaagt gcgtatcaga acggacctac agaaagtttc tgacctgtct
      421 gccccattct cccagagcgc tggggtggat caaaaggaac tgtccttcag cccatcctta
      481 ttgaagatct tctgccaact attctccatt catgtagatg ctataaacat catggttctc
      541 aaggtggata cctctgagtc cttatggcat attcagatca gtagaagcag atttcttttg
      601 gatagtgatg ggaaaaggct aatctgtgag gtgagcttat gtaagatcaa cagcaaagtt
      661 ctaaagagtg gtcagctgga ggacacctgc ctagtggagc tttcactggc cctggacctg
      721 tgtctaaagg tgggcattag cagtcggcat ctcactgcta tcactgtgga tgtgtggaca
      781 ctccatgctg aactgcatga gggcctcttc cagagccaac tgctgtgcca gggcccaagc
      841 ctagcatcta agcctgttcc ctgttcagag gtgacagaaa acttagttga gccaactctg
      901 cctggcctat tccttctcca gcagctgcca gaccaggtca aggttaagat ggagaacaca
      961 agcgtggtat tgtccatgaa tagtcaaaag aggcacctga cttggactct gaagctgctg
     1021 cagttcctgt accaccgtga tgaggatcag ctgccccttc gaagcttcac agcaaactct
     1081 gatatggcac agatgagcac tgaactgctg ctggaagatg ggttgttgtt gtcccagagt
     1141 cgccaacgca ttgtctgcct caactccctc aaggctagtg tgcaggtgac caccattgac
     1201 ctctcagcct ccctagttct gaacacttgc atcattcact accggcacca ggaattctct
     1261 cactggctgc acctgctagc actggaaacc caagggtcta gttcacctgt tctaaagcaa
     1321 aggaaaaaaa gaaccttccc ccaaatcctg gctcccatca tctttagcac ctccatctcc
     1381 aatgtcaaca tttccattca acttggagat acaccacctt ttgccttggg attcaattct
     1441 atctctctgg attaccagca cctcaggcca caaagcatcc atcagcgggg cgtcctaact
     1501 gtggaccacc tctgctggcg tgtgggcagt gactcccaca ttcagcgggc gccacaccca
     1561 cccaatatgc atgtttgggg tgaggcactt gttctggact ccttcacact acagggtagc
     1621 tataaccagc ctctgggcct gtccagcacc cagtcagata ccctttttct tgattgtacc
     1681 attcgaggac ttcaggtgga agcatcagat acctgtgccc aatgtctgtc tcgtatctta
     1741 tccctgatgg gtccacaatc tgggaagtca gctgtctcta ggcactcttc atttggggaa
     1801 tctgtgtcat tactgtggaa ggtggacttg aaggtcgaag acatgaactt gtttaccctt
     1861 tctgccttgg ttggtgcttc agaggtacga ctggacaccc taactatcct gggcagtgca
     1921 gagacgtcca ctgtggggat tcaaggactt gtgttagcgc tggtgaaatc agtcacggag
     1981 aagatgcaac cctgttgcaa ggcccctgac atccctaccc cagtgctcag cctttccatg
     2041 ctctccatca cctatcacag cagcatccgc tctctggagg ttcagtgtgg tgcagggctg
     2101 accttacttt ggagcccccc agatcacatg tacctgtacc agcatgtcct ggccactcta
     2161 cagtgccgag acctactaag agccactgtg tttcctgaga ctgtaccatc ccttgcacta
     2221 gagacttcag gaactacttc tgagctagaa ggccgtgccc ctgagccatt acccccaaag
     2281 cggctgctaa acctaaccct ggaggtgagc acagccaagc tcacagcttt tgtagctgag
     2341 gacaagttca ttaccctggc tgcagagagt gtgtcactga gccggcatgg aggttccctg
     2401 caggcatact gtccagagct ggctgctggc tttgatggca atagtatctt caacttcaag
     2461 gaggtggagg tgcagctgct acctgagctg gaagagatga tcctccaccg gaaccccttc
     2521 cctgcgctgc agaccctccg gaaccgtgtt tggctcctct ctttcggctc agtctcggtg
     2581 gagtttcctt atcagtatga cttttctcga actctagatg aggctgtggg agttcagaag
     2641 tggctgaagg gactacatca agggactcgt gcttgggcct ctccaagccc tgtcccactc
     2701 ccacctgatc tactcttaaa ggttgagcac ttctcatggg ttttcttgga tgatgttttt
     2761 gaggtgaaac ttcatgataa ctacgagctg atgaaggatg aaagtaagga gagtgccaaa
     2821 agactacagc tactggatgc taaagtggcc gcccttcgga agcagcatgg ggagttgttg
     2881 cctgcccgca aaattgagga gctctatgcc tctttggaac gcaaaaacat tgaaatctac
     2941 atccagcgtt cccgtcgtct ctatggcaac acacccatgc gccgggcact gcttacttgg
     3001 agcttagcag ggctagaact ggtagctctg gcagatgcct ccttccatgg tcctgagcat
     3061 gtggtagaac aggttcaaga gcttgatcca ggcagccctt ttccccctga gggattagat
     3121 cttgtcattc agtggtgtcg aatgctcaag tgcaatgtca agagctttct ggttcggatc
     3181 agggactatc cacggtacct gtttgagatc cgtgactggc ggctaatggg tcgacttgtg
     3241 ggcaccgagc agagtggtca gccttgctcc cgtcggcgtc agatcttgca cttggggctt
     3301 ccgtggggta acgtggcagt ggagaggaac atgcccccac tcaaattcta ccatgacttt
     3361 cactcggaaa tattccagta cacagtggtg tggggcccat gctgggatcc agcctggaca
     3421 ctaattggcc agtgtgtgga cctcttgacc aagccctcag ctgaccccag cccacctttg
     3481 ccctggtggg acaagagccg tcttctgttc catggagact ggcacatgga cattgaacag
     3541 gcgaacctgc accagctggc cactgaggat ccatacaaca caactgaaaa tatgcactgg
     3601 gagtggagcc acctgtcttt tcattggaaa cctggtcagt ttgtgttcaa gggtgacttg
     3661 gatatcaacg tgagaacagc ctctaagtat gacgactgct gcttccttca cctgcctgac
     3721 ctctgcatga cactggacct gcagtggctg tgccatggga acccccatga tcaccatagt
     3781 gtcactctgc gggccccaga gttcctgcct gaggtgccct tgggccagct tcatgactcc
     3841 taccgggcct ttcgctcgga gaacctcaat ctctccatca agatggatct gactcggcac
     3901 agtggaacaa tatcccagcc ccgaattctg ctatatagta gtaccctgcg ctggatgcaa
     3961 aacttctggg caacttggac aagtgtcaca aggcctatct gcaggggaaa gctcttcaat
     4021 aacctgaaac ccagcaagaa gaaacttggt cagcactaca agcaactttc ctatacagcc
     4081 ctctttcccc agctgcaggt acattattgg gcctcatttg cccagcaacg gggcatccag
     4141 attgagtgca gtcagggcca tgtcttcact cgggggactc agcggcttat acctcaagca
     4201 ggcacagtga tgcggcgcct tatctctgat tggagtgtta cccagatggt gagtgaccta
     4261 agtcaggtga ccgttcacct gatggcctca cccactgaag agaatgctga tcactgtctt
     4321 gatcccttgg taacaaagac ccacctgctg agcttgtcct ccctcaccta ccaacggcat
     4381 agcaatcgca cagctgagga ggagctctct gctcgtgatg gggatcctac ctttcataca
     4441 catcagctgc acttagtaga tttacggatt tcctggacaa ctaccaatcg agacattgcc
     4501 tttgggttat atgatgggta caaaaaggca gctgtactca aacgtaatct ttctactgag
     4561 gccctgaagg ggttaaagat tgatccacag atgccagcca aaaagccaaa gcggggtgtc
     4621 ccaactagtg cctcagcccc acctcgtgtt aacactccca gcttcagtgg acaacctgat
     4681 aaggggtcat caggaggtgc ttacatgttg cagaagctaa ttgaagagac agataggttt
     4741 gtagtgttca cagaagagga atcaggcatg agtgaccagt tgtgtggcat tgctgcctgc
     4801 cagacggatg acatatacaa ccgaaactgc cttattgaat tggtcaactg tcagatggtt
     4861 cttcgtggag cagagacaga aggctgtgtc attgtgtcag ctgccaaagc ccaactgctg
     4921 cagtgccagc accatccagc ctggtatggt gatacattga agcaaaagac atcctggact
     4981 tgcctcttgg atggcatgca gtactttgcc accactgaaa gcagccccac agagcaggat
     5041 ggccgacagc tctggttaga ggtgaagaat atcgaggagc accggcagcg tagtctggac
     5101 tctgtgcagg agctgatgga gagtgggcag gcagtgggcg gcatggttac cacaaccaca
     5161 gattggaacc agccagctga ggcacagcaa gcccagcaag tccagcggat catttcgcgt
     5221 tgcaactgcc gaatgtacta tattagttac agccatgaca ttgatcctga actagcaact
     5281 cagattaagc cacctgaagt tcttgagaac caggaaaagg aagatctcct aaagaagcag
     5341 gaaggggctg tggatacctt cacccttatc caccatgagc tggaaatttc caccaaccca
     5401 gctcagtatg ccatgatcct ggacattgtc aacaacctgc tgctccatgt agaacctaag
     5461 cggaaggaac atagtgagaa gaagcaacgg gtcaggttcc agcttgagat ctctagcaat
     5521 ccagaggagc aacgcagcag catactgcat ttgcaggagg ctgtgcggca gcatgtggcc
     5581 caaatacgac agctggagaa gcagatgtat tctatcatga agtctttgca ggatgacagc
     5641 aagaatgaga atctgcttga cctgaaccag aagcttcagt tgcagctaaa ccaggagaag
     5701 gccaacctgc agctggaaag tgaagaactg aatatcctca tcaggtgttt taaggatttc
     5761 caactgcagc gggctaacaa gatggagctg cgaaagcagc aagaagatgt gagtgtggtc
     5821 cgtcgcactg agttttactt tgctcaggca cggtggcgcc tgacagagga agatggacag
     5881 ctgggaattg ctgaattaga actgcagagg ttcctctaca gcaaggtgaa taagtctgat
     5941 gacacagcag aacatcttct ggagttgggc tggtttacca tgaacaacct cctccccaat
     6001 gctgtctata aggtagtact gcggccccag agctcctgcc agtctgggcg acagctagct
     6061 ctccgcctct tcagcaaagt tcggccccct gttgggggta tctctgttaa ggagcatttt
     6121 gaggtaaatg tggtgcctct caccatccag ctgacacacc agttcttcca cagaatgatg
     6181 ggctttttct ttcctggccg aagtgtggaa gatgatgaag ttggtgatga agaggataag
     6241 tccaaactgg tgactactgg aataccagtg gtgaagcctc ggcagctgat tgcaacagat
     6301 gatgcagtac cactgggccc tgggaagggt gtggcacagg gtttgactcg gagttctggg
     6361 gtcagaaggt catttcgcaa atcgccagag caccctgtgg atgacattga caagatgaaa
     6421 gagcgagctg ccatgaacaa ctccttcatc tacataaaga ttccacaggt tccactgtgt
     6481 gtcagctaca agggtgagaa gaacagtgtg gactggggtg accttaacct ggtgctgccc
     6541 tgtctggagt accacaacaa cacatggaca tggctagact ttgccatggc tgtcaaaagg
     6601 gacagccgca aagccctggt tgcccaggta atcaaagaga agctaaggct gaagtctgca
     6661 acaggctctg aggtccgggg aaagctagaa actaaatcgg acctgaacat gcaacagcag
     6721 gaagaggagg agaaagcccg gctcctcatt ggtttaagtg tgggcgacaa gaaccctggc
     6781 aagaagtcca tctttggcag gcgcaaatga tttggcgatt cgagtggctg cagtacagga
     6841 tctgactctg gctcaggctc cagggacttg tggggtggga ggggcttccc gttatccacg
     6901 aggatttgtg ggtgtcagag cccataggca tcactcttca gcacctggtc tgttcgctgc
     6961 agggcatggt ggacagtaat gctgagttct gtctcacact gatcaggctc agggccagag
     7021 aggcaacaag agagcaagac ccagggaatg ggcccagggc aggaccctat tcccttgggg
     7081 tcaagtgaaa gggtaggggg atagtcctga tcaagtgtga taaattttta tagacatata
     7141 taaatatata tatattatat atatatttct aagtgtaact gtccttcctc tgtgccagga
     7201 aacgggaggg ggctgatcct ctgatcctca ctccactgtc atgtttgaaa gaggtattgg
     7261 tgttctggag tgggggtcaa cccctcccca gtctctgtgc taagttcact tgggaggatg
     7321 gcagtaggag ccagggctgg ccatgggtcc cctacccttc cccgtaggat ataccctgga
     7381 gaatggcaaa atgatttaaa gagaaaaaaa aagatatttt aaatttga
//
