LOCUS       NM_001001786             876 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens BH3-like motif containing, cell death inducer (BLID),
            mRNA.
ACCESSION   NM_001001786
VERSION     NM_001001786.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 876)
  AUTHORS   Liu,X., Lu,Y., Xu,Y., Hou,S., Huang,J., Wang,B., Zhao,J., Xia,S.,
            Fan,S., Yu,X., Du,Y., Hou,L., Li,Z., Ding,Z., An,S., Huang,B.,
            Li,L., Tang,J., Ju,J., Guan,H. and Song,B.
  TITLE     Exosomal transfer of miR-501 confers doxorubicin resistance and
            tumorigenesis via targeting of BLID in gastric cancer
  JOURNAL   Cancer Lett 459, 122-134 (2019)
   PUBMED   31173853
  REMARK    GeneRIF: MiR-501 knockdown or BH3-like motif-containing protein,
            cell death inducer (BLID) overexpression could reverse the effects
            of ADR Exo on recipient cells.
            Erratum:[Cancer Lett. 2022 Jul 28;539:215695. doi:
            10.1016/j.canlet.2022.215695.. PMID: 35501203]
REFERENCE   2  (bases 1 to 876)
  AUTHORS   Li,X., Su,P., Liu,X., Kong,X., Zhang,X., Zhang,H. and Yang,Q.
  TITLE     Aberrant BLID expression is associated with breast cancer
            progression
  JOURNAL   Tumour Biol 35 (6), 5449-5452 (2014)
   PUBMED   24532431
  REMARK    GeneRIF: loss of BLID may contribute to the progression of
            intraductal proliferation lesions to breast cancer.
REFERENCE   3  (bases 1 to 876)
  AUTHORS   Yu,X. and Li,Z.
  TITLE     BLID: A Novel Tumor-Suppressor Gene
  JOURNAL   Oncol Res 22 (5-6), 333-338 (2014)
   PUBMED   26629946
  REMARK    Review article
REFERENCE   4  (bases 1 to 876)
  AUTHORS   Li,X., Kong,X., Wang,Y. and Yang,Q.
  TITLE     BRCC2 inhibits breast cancer cell growth and metastasis in vitro
            and in vivo via downregulating AKT pathway
  JOURNAL   Cell Death Dis 4 (8), e757 (2013)
   PUBMED   23928696
  REMARK    GeneRIF: BRCC2 functions as a novel tumor suppressor in breast
            cancer and may be a potential therapeutic target for breast cancer
            management.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 876)
  AUTHORS   Cavalli,L.R., Noone,A.M., Makambi,K.H., Rone,J.D., Kasid,U.N. and
            Haddad,B.R.
  TITLE     Frequent loss of the BLID gene in early-onset breast cancer
  JOURNAL   Cytogenet Genome Res 135 (1), 19-24 (2011)
   PUBMED   21846966
  REMARK    GeneRIF: Frequent loss of the BLID gene is observed in early-onset
            breast cancer.
REFERENCE   6  (bases 1 to 876)
  AUTHORS   Tassano,E., Acquila,M., Tavella,E., Micalizzi,C., Panarello,C. and
            Morerio,C.
  TITLE     MicroRNA-125b-1 and BLID upregulation resulting from a novel IGH
            translocation in childhood B-Cell precursor acute lymphoblastic
            leukemia
  JOURNAL   Genes Chromosomes Cancer 49 (8), 682-687 (2010)
   PUBMED   20544842
  REMARK    GeneRIF: BLID upregulation resulting from a novel IGH translocation
            is associated with childhood B-Cell precursor acute lymphoblastic
            leukemia.
REFERENCE   7  (bases 1 to 876)
  AUTHORS   Broustas,C.G., Ross,J.S., Yang,Q., Sheehan,C.E., Riggins,R.,
            Noone,A.M., Haddad,B.R., Seillier-Moiseiwitsch,F., Kallakury,B.V.,
            Haffty,B.G., Clarke,R. and Kasid,U.N.
  TITLE     The proapoptotic molecule BLID interacts with Bcl-XL and its
            downregulation in breast cancer correlates with poor disease-free
            and overall survival
  JOURNAL   Clin Cancer Res 16 (11), 2939-2948 (2010)
   PUBMED   20400521
  REMARK    GeneRIF: BLID is a new binding partner of Bcl-X(L) and a
            significant prognostic factor in breast cancer
REFERENCE   8  (bases 1 to 876)
  AUTHORS   Nakanishi,H., Yamada,R., Gotoh,N., Hayashi,H., Yamashiro,K.,
            Shimada,N., Ohno-Matsui,K., Mochizuki,M., Saito,M., Iida,T.,
            Matsuo,K., Tajima,K., Yoshimura,N. and Matsuda,F.
  TITLE     A genome-wide association analysis identified a novel susceptible
            locus for pathological myopia at 11q24.1
  JOURNAL   PLoS Genet 5 (9), e1000660 (2009)
   PUBMED   19779542
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   9  (bases 1 to 876)
  AUTHORS   Cavalli,L.R., Santos,S.C., Broustas,C.G., Rone,J.D., Kasid,U.N. and
            Haddad,B.R.
  TITLE     Assignment of the BLID gene to 11q24.1 by fluorescence in situ
            hybridization
  JOURNAL   Cancer Genet Cytogenet 186 (2), 120-121 (2008)
   PUBMED   18940476
  REMARK    GeneRIF: BLID gene is assigned to 11p24.1.
REFERENCE   10 (bases 1 to 876)
  AUTHORS   Broustas,C.G., Gokhale,P.C., Rahman,A., Dritschilo,A., Ahmad,I. and
            Kasid,U.
  TITLE     BRCC2, a novel BH3-like domain-containing protein, induces
            apoptosis in a caspase-dependent manner
  JOURNAL   J Biol Chem 279 (25), 26780-26788 (2004)
   PUBMED   15069058
  REMARK    GeneRIF: BRCC2 is a novel BH3-like domain-containing protein which
            induces apoptosis in a caspase-dependent manner
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF303179.1, BC130363.1 and
            AP001924.5.
            
            On May 17, 2019 this sequence version replaced NM_001001786.2.
            
            Summary: This gene encodes a BH3-like motif containing protein
            involved in cell death. The encoded protein may induce apoptosis in
            a caspase-dependent manner. The protein is localized in both the
            cytoplasm and the mitochondrion. [provided by RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF303179.1, BC130361.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 15069058
            MANE Ensembl match                 :: ENST00000560104.2/
                                                  ENSP00000453153.1
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-326               AF303179.1         1-326
            327-327             BC130363.1         205-205
            328-862             AF303179.1         328-862
            863-876             AP001924.5         164938-164951       c
FEATURES             Location/Qualifiers
     source          1..876
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.1"
     gene            1..876
                     /gene="BLID"
                     /gene_synonym="BRCC2"
                     /note="BH3-like motif containing, cell death inducer"
                     /db_xref="GeneID:414899"
                     /db_xref="HGNC:HGNC:33495"
                     /db_xref="MIM:608853"
     exon            1..876
                     /gene="BLID"
                     /gene_synonym="BRCC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..620
                     /gene="BLID"
                     /gene_synonym="BRCC2"
                     /note="breast cancer cell 2; breast cancer cell protein 2"
                     /codon_start=1
                     /product="BH3-like motif-containing cell death inducer"
                     /protein_id="NP_001001786.2"
                     /db_xref="CCDS:CCDS31693.1"
                     /db_xref="GeneID:414899"
                     /db_xref="HGNC:HGNC:33495"
                     /db_xref="MIM:608853"
                     /translation="MVTLLPIEGQEIHFFEILESECVLYTGWIERASGSSIYPEAKAR
                     LPLEALLGSNKEPMLPKETVLSLKRYNLGSSAMKRNVPGHVLQRPSYLTRIQVTLLCN
                     SSAEAL"
     regulatory      793..798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BLID"
                     /gene_synonym="BRCC2"
                     /note="hexamer: AATAAA"
     polyA_site      812
                     /gene="BLID"
                     /gene_synonym="BRCC2"
                     /note="major polyA site"
ORIGIN      
        1 atgatgttgt gtttggagaa aagagagaag agaattgaat aagtacatga ccccttggaa
       61 gctgttttca gttgaggatt ttggtgagta gccacttgaa atcaagggaa attccatgaa
      121 tagcaggagc tgggaagaaa ggaagaggag gaaggatccc accacttttt tcttcccatc
      181 taacaccgtg cttatgcaaa gcatagtcca tatgagatct gccttataaa aacttgctga
      241 ataaagcgaa tggaagttaa attttggact ttcttccata atagcttcaa attatggtga
      301 ctttgttgcc tatagagggc caggaaatac atttctttga gatcctagaa tctgagtgtg
      361 tgctctacac aggatggata gagcgagcct ctggcagttc catttatcca gaggcaaaag
      421 cacgcctgcc actggaggcg ctcttgggtt ccaacaaaga acctatgttg cctaaggaaa
      481 cagtgctttc tcttaaaagg tacaatcttg gctcctctgc catgaagcgg aatgttcctg
      541 gacatgtgct tcagagacct tcctatttaa ccaggataca agttacattg ttatgcaatt
      601 cctctgctga ggccctgtaa aaggagtgag ttaggacaga tgcagcaaga tattaggaca
      661 gatttcgccc attattcagg ctgcacaaca cagaaggaaa cttgatttca ataagaccca
      721 attcttaaca gtcttttcta cccactttta cccataactt ttccaaattt ggttcaaatt
      781 gtgcagagaa acaataaaat ttttaaaaag gataaactgg ctagttaaaa gtaaatggca
      841 tttaattaaa acaaatcttg caaattcatg aaaaaa
//
