LOCUS       NM_001397426            6306 bp    mRNA    linear   PRI 27-AUG-2023
DEFINITION  Homo sapiens BLACAT1 overlapping LEMD1 locus (BLACAT1), mRNA.
ACCESSION   NM_001397426
VERSION     NM_001397426.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6306)
  AUTHORS   Hua X, Li J, Shang M, He W, Gao P, Min L and Peng X.
  TITLE     Pathogenesis of psoriasis via miR-149-5p/AKT1axis by long noncoding
            RNA BLACAT1
  JOURNAL   Skin Res Technol 29 (5), e13339 (2023)
   PUBMED   37204030
  REMARK    GeneRIF: Pathogenesis of psoriasis via miR-149-5p/AKT1axis by long
            noncoding RNA BLACAT1.
REFERENCE   2  (bases 1 to 6306)
  AUTHORS   El Sharkawi FZ, El Sabah M, Atya HB and Khaled HM.
  TITLE     Urinary BLACAT1 as a non-invasive biomarker for bladder cancer
  JOURNAL   Mol Biol Rep 50 (5), 4339-4345 (2023)
   PUBMED   36939965
  REMARK    GeneRIF: Urinary BLACAT1 as a non-invasive biomarker for bladder
            cancer.
REFERENCE   3  (bases 1 to 6306)
  AUTHORS   Cheng J, Yang Q, Han X, Wang H, Wu K and Zhao H.
  TITLE     Yin Yang 1-stimulated long noncoding RNA bladder cancer-associated
            transcript 1 upregulation facilitates esophageal carcinoma
            progression via the microRNA-5590-3p/programmed cell death-ligand 1
            pathway
  JOURNAL   Bioengineered 13 (4), 10244-10257 (2022)
   PUBMED   35435118
  REMARK    GeneRIF: Yin Yang 1-stimulated long noncoding RNA bladder
            cancer-associated transcript 1 upregulation facilitates esophageal
            carcinoma progression via the microRNA-5590-3p/programmed cell
            death-ligand 1 pathway.
REFERENCE   4  (bases 1 to 6306)
  AUTHORS   Li Z, Wang Y, Wu Y, Liu Y, Zhao Y, Chen X, Li M and Zhao R.
  TITLE     Role of BLACAT1 in IL-1beta-Induced Human Articular Chondrocyte
            Apoptosis and Extracellular Matrix Degradation via the miR-149-5p/
            HMGCR Axis
  JOURNAL   Protein Pept Lett 29 (7), 584-594 (2022)
   PUBMED   35657039
  REMARK    GeneRIF: Role of BLACAT1 in IL-1beta-Induced Human Articular
            Chondrocyte Apoptosis and Extracellular Matrix Degradation via the
            miR-149-5p/ HMGCR Axis.
REFERENCE   5  (bases 1 to 6306)
  AUTHORS   Zhang X, Wei X, Liu J, Yang J and Jin P.
  TITLE     Up-regulation of long non-coding RNA BLACAT1 predicts aggressive
            clinicopathologic characteristics and poor prognosis of glioma
  JOURNAL   Medicine (Baltimore) 100 (11), e20722 (2021)
   PUBMED   33725920
  REMARK    GeneRIF: Up-regulation of long non-coding RNA BLACAT1 predicts
            aggressive clinicopathologic characteristics and poor prognosis of
            glioma.
REFERENCE   6  (bases 1 to 6306)
  AUTHORS   Ye JR, Liu L and Zheng F.
  TITLE     Long Noncoding RNA Bladder Cancer Associated Transcript 1 Promotes
            the Proliferation, Migration, and Invasion of Nonsmall Cell Lung
            Cancer Through Sponging miR-144
  JOURNAL   DNA Cell Biol 36 (10), 845-852 (2017)
   PUBMED   28885863
  REMARK    GeneRIF: combining experiments of miR-144 and BLACAT1 indicated
            that miR-144 could reverse the function of BLACAT1 on nonsmall cell
            lung cancer
REFERENCE   7  (bases 1 to 6306)
  AUTHORS   Su J, Zhang E, Han L, Yin D, Liu Z, He X, Zhang Y, Lin F, Lin Q,
            Mao P, Mao W and Shen D.
  TITLE     Long noncoding RNA BLACAT1 indicates a poor prognosis of colorectal
            cancer and affects cell proliferation by epigenetically silencing
            of p15
  JOURNAL   Cell Death Dis 8 (3), e2665 (2017)
   PUBMED   28277544
  REMARK    GeneRIF: Mechanistic investigations demonstrated that BLACAT1 had a
            key role in G1/G0 arrest, and showed that BLACAT1 can repress p15
            expression by binding to EZH2, thus contributing to the regulation
            of CRC cell cycle and proliferation. Our results suggest that
            BLACAT1, as a cell cycle regulator, may serve as a potential target
            for colon cancer prevention and treatment in human CRC
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6306)
  AUTHORS   Hu Y, Pan J, Wang Y, Li L and Huang Y.
  TITLE     Long noncoding RNA linc-UBC1 is negative prognostic factor and
            exhibits tumor pro-oncogenic activity in gastric cancer
  JOURNAL   Int J Clin Exp Pathol 8 (1), 594-600 (2015)
   PUBMED   25755750
  REMARK    GeneRIF: Our study suggests that linc-UBC1 may represent a novel
            diagnostic, prognostic biomarker and a potential therapeutic target
            of gastric cancer
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6306)
  AUTHORS   Cabanski CR, White NM, Dang HX, Silva-Fisher JM, Rauck CE, Cicka D
            and Maher CA.
  TITLE     Pan-cancer transcriptome analysis reveals long noncoding RNAs with
            conserved function
  JOURNAL   RNA Biol 12 (6), 628-642 (2015)
   PUBMED   25864709
REFERENCE   10 (bases 1 to 6306)
  AUTHORS   He W, Cai Q, Sun F, Zhong G, Wang P, Liu H, Luo J, Yu H, Huang J
            and Lin T.
  TITLE     linc-UBC1 physically associates with polycomb repressive complex 2
            (PRC2) and acts as a negative prognostic factor for lymph node
            metastasis and survival in bladder cancer
  JOURNAL   Biochim Biophys Acta 1832 (10), 1528-1537 (2013)
   PUBMED   23688781
  REMARK    GeneRIF: Frequently overexpressed linc-UBC1 physically associates
            with PRC2 complex, and acts as a negative prognostic factor for
            lymph node metastasis and survival in bladder cancer
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098936.2.
            
            On Nov 16, 2021 this sequence version replaced NM_001397426.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA234729.1, SRR1803615.292793.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000629624.3/ ENSP00000498225.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC098936.2         109703-109831       c
            130-6306            AC098936.2         88672-94848         c
FEATURES             Location/Qualifiers
     source          1..6306
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..6306
                     /gene="BLACAT1"
                     /gene_synonym="linc-UBC1; LINC00912; onco-lncRNA-30"
                     /note="BLACAT1 overlapping LEMD1 locus"
                     /db_xref="GeneID:101669762"
                     /db_xref="HGNC:HGNC:48597"
                     /db_xref="MIM:615480"
     exon            1..129
                     /gene="BLACAT1"
                     /gene_synonym="linc-UBC1; LINC00912; onco-lncRNA-30"
                     /inference="alignment:Splign:2.1.0"
     exon            130..6306
                     /gene="BLACAT1"
                     /gene_synonym="linc-UBC1; LINC00912; onco-lncRNA-30"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..267
                     /gene="BLACAT1"
                     /gene_synonym="linc-UBC1; LINC00912; onco-lncRNA-30"
                     /note="long intergenic non-protein coding RNA 912; long
                     intergenic noncoding RNA up-regulated in bladder cancer;
                     bladder cancer associated transcript 1 (non-protein
                     coding)"
                     /codon_start=1
                     /product="bladder cancer associated transcript 1"
                     /protein_id="NP_001384355.1"
                     /db_xref="CCDS:CCDS91151.1"
                     /db_xref="GeneID:101669762"
                     /db_xref="HGNC:HGNC:48597"
                     /db_xref="MIM:615480"
                     /translation="MPQFTFACFCGLHGFCKMKRKKEEVHRERETAV"
     regulatory      6287..6292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BLACAT1"
                     /gene_synonym="linc-UBC1; LINC00912; onco-lncRNA-30"
                     /note="hexamer: AATAAA"
     polyA_site      6306
                     /gene="BLACAT1"
                     /gene_synonym="linc-UBC1; LINC00912; onco-lncRNA-30"
                     /note="major polyA site"
ORIGIN      
        1 ccactggaag ctacagcaga gaatcggaca aggagggaag aaagagattg gtgaggggga
       61 gagagagaga aagagagaga gagacacaaa ggaagtgagt gcaagaggag ccggcttagc
      121 atctaaacta tctctggtga gtgttccccc agcctggcgt agggcatgcc ccagttcact
      181 ttcgcctgct tctgtggtct ccacggcttc tgcaaaatga agaggaagaa ggaggaagtt
      241 cacagagagc gggagacggc ggtgtgatca gaaccagggc ccctccatca agcccccagc
      301 aggtcccagg cctgatggtg cctgcttctg gctggggctt ggagcaggaa gccgtgtgtg
      361 tatcttaagt cttgatttag ccagtgctct tctcagcctg actctcaccc gagggcatca
      421 gcctcctgtg tgcctctcat cctcctcatg cccacaccca ttagcttcca attctcagac
      481 ctccttggag agaggcccca gccacacaag ggggaacccc aggacctgcc gcatgccttc
      541 cagagactga gaagccccag ggaggccaag gagtgaaact tctttcctgc cctgagagct
      601 tcgggggact cttctcaggg taaccgcatg aggcatgtgc cgccttgggc taggagagct
      661 gttgctaaat gggaaactgg ctgctctagc agagaacttc cagcagccct gaccctggag
      721 aaggcctcca gggcggaagt gtgagactct cctgggattc caggacctgg ggcaagaatc
      781 cttttccagc cccctgccag catcctcctg ggccaggtgg ggccaggcct gaggtggcca
      841 gcccagtgag gaggaaggca gaggtggcca gtggctccgt ggctccctct gttcttgctc
      901 tccagaaagc agtgtttcct ccagccccgg ccctgaccca cccgtgttca tgatgcctgt
      961 gcctccttgc cagcatcaca gatgtgggga ggcctgttcc ccaggccctg actcccctcc
     1021 tcagggactg tcttgccgtg gccagactga gggacccctt tcctggactg agccgtgccc
     1081 tcccttgatt ctcctgtctc ccctgccttt ttcttctctc ctcagaagcc atagagggga
     1141 ctgcgttcat atgtggtgcc ttcagtggaa actcttaggg tggggggacc tctaggacct
     1201 tcctcgactt tttccctcat cccccacccc cgccaacctt ccagcttcag cctctgccct
     1261 tacccccagc ccatttccag gaggtaggaa gcaaaagaaa aaagcatttc cttccctctt
     1321 tccttcttcc ttccttcctc tctcccttca ttttggtata acttagcctt ttgtctttaa
     1381 tcctggagtt ctccggggct agaagacagg cagagacgaa tgccagcagc agagatgctt
     1441 caggcagatt ctgtaagcct gttctccctc atcagggagc agctcagcca aggagcaaag
     1501 tcagaccccc tctagctccc cagggacaga atagcccttc tgacaggtaa acaggtgacc
     1561 tgggtagaga gggcaaggcc ccaagatagg agagtcaggg ctcccctttc cttggaatgt
     1621 gggcctctct gggcaactag ggagggcaaa agtcttcctc ggctggttcg cccaaaacct
     1681 gggagaagca agggcacatt ctatgctggc agcctctgcc tgcccagctc atgcccacac
     1741 tcaggggcct ttcctgggct ttgggcagat tgggtgggat tcaggttgtc tttatgaggc
     1801 ttgagcacag cttgagttcc tcctcccatc ctccaacccc ttcctttgcc cctacctcct
     1861 agcccccacc ttctacaatc tgttatttcc ttttatatcc aaagaattat aaacagaagt
     1921 ccttccctca agggaacagc aagattcagc aataaaggcc agtggggtca caaaggacag
     1981 aagaaaaact ccctggttct ttgtcctctt ggatagtaga ggccttgggt gaggcaaaga
     2041 gatgggcaga aaaagttacc ttgatacaga ggccagagag cctcctggag ggcatgtgtt
     2101 tccctagcgg tcacctgcga ggctgcaatc ctagaaaagt cacttctgtg gcagaggatg
     2161 aaattgtatc cccggagact cagagatatt gggtgttatg tcctgaccac acaggctcac
     2221 caggaggaaa ggttaggaaa gtggagaaag tacgtcctgg ggagcgggtg gccgaggaga
     2281 gctttcccct tgtgcgcctc tcaggccttg gcagggattg cagctgcagg ggtttggcag
     2341 tgagcccatc cagagagctt cctcccccgg gagaactccc ttggctccag agggatacta
     2401 gatatcttga gccctggctt tgggaacatg ggtggggtcc caaggtcaaa gtgttctgag
     2461 tggaggtcca gttgtcctct gcctccaagc cggcagcccc ttcttcaccc agggctgagg
     2521 ttggggccag cactgcagct ggaattgtct gagcaggagg tagcagcttc tagccaggca
     2581 caccccaacc ccacattcta ttgtccctca gtttccttct caggaaaatg gggactttgc
     2641 tccttttagc atctcaggaa gcagtctgga cacctgtgcc ctcctctagg cccttggatg
     2701 agcccaggga atagggaaag gccaaagcag ccccagcatt cgcagaccct gcgccctggg
     2761 cctctgactt cgggccaggc ttctgctcct tctagggttg gcctggctgc cctgccttcc
     2821 catcctctct ccatggttct ctcccagaga ctccaccttg aggtgggggc cctgagctct
     2881 tggggtgagg gaggggcaca tgggtagatg attctgtgga ggagatcagg cctcttgttc
     2941 ttgctgcgtg gcactgattc ctccttgcag atgggtgagg gggccagttt tccccatctg
     3001 taaagcgagg acttcccatg gccattttcc ctcttgggct tcaggctgct gaatggaaga
     3061 tcaagaagtg tgaagggtgc ttggggtcct tgtgacttga gtgttgccta ggaccctggc
     3121 ccacaggacc caaggggctt cttgtctcag gttgaaacct ttttatcaga atgtcatttc
     3181 cttctctgct cccagggaag ggctttttgc atgtagcata tgggttcata gaaatatata
     3241 gggagattgt tatttttagg aaaaaaaaag agcaataatt aactaactga aatacacatg
     3301 aagtgttaga gtgggatgca aggagcactg agctgggagc caggtctcct ggcttctagc
     3361 cctgcttgga aactaatgac ctatgtgacc ttagactagt catgtcttat ttctgagact
     3421 caggttcctc aactataaat aggggattac ataaatttcc tcttaagtct cctttggagt
     3481 ccagggctct gtgagtctgg gaagttgagc ctcagtgggg catagggttg tggaaccaga
     3541 gggtcgcagg tttcctctgc cctcacagat gcactccgtg cagacaacag acatatctgg
     3601 agggtggatg gaagtggtat ggtggctctg agaagtgaga gggggagtga gagggaaagg
     3661 caagtcaccc agagcttctg ctagaatctt cccctagcca gggcccagga ctccttgcag
     3721 ttctgcctct cttccctcct acagccaggc ccaaggggag taagtcagtt ggcctagact
     3781 ctgactccag gtcctgtcta ggccatcaca ggcgccactc ttatgtacgt tctcactttc
     3841 tctctgtcac atacacacag catcaccacc accaccacca caaccacctg cagatagatg
     3901 ctcaagtgat tctagaagag atctcaagga ctggcgctct gctccagtta tgtaacccat
     3961 gggcttccct ttgcacagct cctcatgtgc tcatctccat gctgatcaaa ccaccccacc
     4021 tcattccttg ccttctgcaa ggggaagtgc ctcaggctgg agtttgtcct gtctacagac
     4081 tgaatatgca ttttgcccag tggctggaga tgtgctggtg gtggaatgtg ctggtgattg
     4141 tttctggatg gagagccaca gccccccagt gttctgccat gactgactcc tgaccttggc
     4201 aaattgcctc ctctctccca gcctcctcca taacaggtgg cgatgagtcc catttcctcc
     4261 ctacctcaca ggaaggcacg cattataaag ggcacactta tcagatgtgc ccagatgtgg
     4321 ctggaacttt tggagacaga tacttggttc acaactgcaa aggtgggctt tcaccagaga
     4381 agaaaatctc tgggctgctg agttcagtgg gctccttgca ggctggtcca ggaagtctgg
     4441 tgttcctcct gaaggtggct gctatgtcca gcaggtgatc aagctgacag taccacaaga
     4501 accaagaaac agaatctgtt cccaaggaat gaatgttcta tctctctgac ccaaaagcaa
     4561 gagcaagaga gagctgtcac catcatcacc ctgctcccaa cacaaacaca gccccccaag
     4621 tccatattgc tgacaagggt atctgccttg tcagggtgaa tcctctggac cccaggccat
     4681 ccctggagtg gtcagtgccc actgtgccgg ggttattgtg gccagtccgc ctgggttcgc
     4741 ttctctaaat ttccatggga taggaactat agatcatgaa gaagaaacag gaaccttgac
     4801 tcttcacgga ggagcccagg aggtcagaac catccaccag gagggtgagc ggtagctgcc
     4861 cagggcatcc ctggaggaag tcgtcatact gaggaagaaa ttgccaaagc caagagctcc
     4921 cagacctggg cagctcagga gctgacagaa accacccccc aggtctggag ttcaagggtt
     4981 ttcctcgtgg gctgctggtc tgtctctttc ccttctgggg cagccgtctc tcctccttca
     5041 gctcattccc gtgttccatc tgaggggcgg gaggaaggca ggagggggag atggcaggac
     5101 ccagacagat cctcaggact ctcccagcct ctgttgccat ggcaacactg ctatttttat
     5161 cccgttgttc atgatgctca aagctctaac tttctctgtt ccagagaggc caggctggtt
     5221 tctgccctca tcctttaaca cagcatcttc tcccagaggc ctgaggatgg gaaaaagtga
     5281 tggagaaaag gggaacccct aaggtcaccc ctcagccagg gggaactgtt taacaggggt
     5341 ttgtctctgc ccttttgagc ctttggtttt ctacctggct caggcaccca ggtttatgtt
     5401 ttctagatca aaactctgca tggtctccct gagagactgg aaaagagctg ccaatcagga
     5461 tggatttttt cctacacagg tatgacactg cagccacttc ccttcttggg aaaattaaac
     5521 ttcattctga agaatgtcct gttggtggta taagccaacc cctgccctcc taaaagggga
     5581 tagataatta aatttggtta attagcaatc agattcactg gggaattgaa accagtactt
     5641 ccctttcttc tgtccctcca ccaaagaacc ggaacaaatg gcttcatgtc tttgtccagt
     5701 ctttctgcct aaagcaaaat agcatatatt ctccaggctg aaaagtagat tcctcctcac
     5761 ccctactcaa gatggccaca tttcaatcca ggctcttgaa gacagggtct aatgaaagga
     5821 tttctgttct ttctctgtct gttccctctg gcccagcttc tagtcctctc cttatgtccc
     5881 cacctccatg gcagtggcaa gagacccctg agagtcaatg gtgctaacgt tccccaccta
     5941 tataccccta tgtagtttat cgagatttga acccagcacc tgggtggctg tgttgggcgg
     6001 atacatttca cgtcctcaag accacaaccc tggcgacagg tctggattaa ttctgtaaag
     6061 tagcaatcta tatcatgcta aactcctgca ctgaggttct tcctcggctg aactgactcg
     6121 tggatggtta agtttcctgg ggtggctgga acccatttac taagcctcta attggtttca
     6181 ttttggctca agttgcatgg tttcccgaat ctatgcacct ggagtaagca cttttctggt
     6241 tgccactgaa aagcatgccg gcaaacgctg ctctgttaat tgctgtaata aacagacttt
     6301 attata
//
