LOCUS       NM_017693               3789 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens basic, immunoglobulin-like variable motif containing
            (BIVM), transcript variant 1, mRNA.
ACCESSION   NM_017693
VERSION     NM_017693.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3789)
  AUTHORS   Luo,X., Zhao,M., Chen,C., Lin,F., Li,X., Huang,H., Dou,L., Feng,J.,
            Xiao,S., Liu,D., He,J. and Yu,J.
  TITLE     Identification of genetic susceptibility in preterm newborns with
            bronchopulmonary dysplasia by whole-exome sequencing: BIVM gene may
            play a role
  JOURNAL   Eur J Pediatr 182 (4), 1707-1718 (2023)
   PUBMED   36757497
  REMARK    GeneRIF: Identification of genetic susceptibility in preterm
            newborns with bronchopulmonary dysplasia by whole-exome sequencing:
            BIVM gene may play a role.
REFERENCE   2  (bases 1 to 3789)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3789)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   4  (bases 1 to 3789)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 3789)
  AUTHORS   Kim,Y.C., Wu,Q., Chen,J., Xuan,Z., Jung,Y.C., Zhang,M.Q.,
            Rowley,J.D. and Wang,S.M.
  TITLE     The transcriptome of human CD34+ hematopoietic stem-progenitor
            cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (20), 8278-8283 (2009)
   PUBMED   19416867
REFERENCE   6  (bases 1 to 3789)
  AUTHORS   Yoder,J.A., Hawke,N.A., Eason,D.D., Mueller,M.G., Davids,B.J.,
            Gillin,F.D. and Litman,G.W.
  TITLE     BIVM, a novel gene widely distributed among deuterostomes, shares a
            core sequence with an unusual gene in Giardia lamblia
  JOURNAL   Genomics 79 (6), 750-755 (2002)
   PUBMED   12036287
REFERENCE   7  (bases 1 to 3789)
  AUTHORS   Christian,S.L., McDonough,J., Liu Cy,C.Y., Shaikh,S., Vlamakis,V.,
            Badner,J.A., Chakravarti,A. and Gershon,E.S.
  TITLE     An evaluation of the assembly of an approximately 15-Mb region on
            human chromosome 13q32-q33 linked to bipolar disorder and
            schizophrenia
  JOURNAL   Genomics 79 (5), 635-656 (2002)
   PUBMED   11991713
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF411385.1 and GD145579.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017693.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF411385.1, SRR1803617.268997.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257336.6/ ENSP00000257336.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3787              AF411385.1         71-3857
            3788-3789           GD145579.1         173-174
FEATURES             Location/Qualifiers
     source          1..3789
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q33.1"
     gene            1..3789
                     /gene="BIVM"
                     /note="basic, immunoglobulin-like variable motif
                     containing"
                     /db_xref="GeneID:54841"
                     /db_xref="HGNC:HGNC:16034"
                     /db_xref="MIM:619006"
     exon            1..403
                     /gene="BIVM"
                     /inference="alignment:Splign:2.1.0"
     exon            404..487
                     /gene="BIVM"
                     /inference="alignment:Splign:2.1.0"
     exon            488..1087
                     /gene="BIVM"
                     /inference="alignment:Splign:2.1.0"
     CDS             610..2121
                     /gene="BIVM"
                     /note="isoform a is encoded by transcript variant 1; basic
                     immunoglobulin-like variable motif-containing protein"
                     /codon_start=1
                     /product="basic immunoglobulin-like variable
                     motif-containing protein isoform a"
                     /protein_id="NP_060163.2"
                     /db_xref="CCDS:CCDS9505.1"
                     /db_xref="GeneID:54841"
                     /db_xref="HGNC:HGNC:16034"
                     /db_xref="MIM:619006"
                     /translation="MPNVAETERSNDSGNGEHKSERKSPEENLQGAVKSFCTSASGAP
                     LGPKGDGHYPWSCPVTHTREKIYAICSDYAFLNQATSIYKTPNPSRSPCLPDSTSLSA
                     GNNSSRYIGIPTSTSEIIYNEENSLENLSNSLGKLPLAWEIDKSEFDGVTTNSKHKSG
                     NAKKQVSKRKTSDKKGRYQKECPQHSPLEDIKQRKVLDLRRWYCISRPQYKTSCGISS
                     LISCWNFLYSTMGAGNLPPITQEEALHILGFQPPFEDIRFGPFTGNTTLMRWFRQIND
                     HFHVKGCSYVLYKPHGKNKTAGETASGALSKLTRGLKDESLAYIYHCQNHYFCPIGFE
                     ATPVKANKAFSRGPLSPQEVEYWILIGESSRKHPAIHCKKWADIVTDLNTQNPEYLDI
                     RHLERGLQYRKTKKVGGNLHCIIAFQRLNWQRFGLWNFPFGTIRQESQPPTHAQGIAK
                     SESEDNISKKQHGRLGRSFSASFHQDSAWKKMSSIHERRNSGYQGYSDYDGND"
     exon            1088..1214
                     /gene="BIVM"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1310
                     /gene="BIVM"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1415
                     /gene="BIVM"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1510
                     /gene="BIVM"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1643
                     /gene="BIVM"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1730
                     /gene="BIVM"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1827
                     /gene="BIVM"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..3789
                     /gene="BIVM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2386..2391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BIVM"
                     /note="hexamer: ATTACA"
     polyA_site      2404
                     /gene="BIVM"
     regulatory      3764..3769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BIVM"
                     /note="hexamer: AATAAA"
     polyA_site      3789
                     /gene="BIVM"
                     /note="major polyA site"
ORIGIN      
        1 agttcgcgac aggacgagcg gaaatactgc caggatttta ccacctctcg cccatttatt
       61 tacttctcgg tcaccgcttt cgggggacag ataaacacca cagatgccca tcaaaggggc
      121 gcacgggtct ggaggcgcag ctcaggtttt tgcgttggtc accctgccct ccgcacgtgg
      181 agagggcagg cataaagcac cttgaaagga aggtgctgtc aatgctatcc gacgacctgt
      241 cgccgggcac cgcagcatcc tcgctcgctc cgatgggacg agggacgccg gccccagggt
      301 aacaggaggc gcctcgccgg ccgcgcgctg gatgctgtga tccaggtccg gagccgggtt
      361 ccgccgcggc cgcagcgacc cgaccccacc cgacaggcca gaggaatcag tttagacttg
      421 aaattcagtt tttcctgaaa ctgatcagaa gttagtgaca ccttgattgg atccgttttt
      481 ctgtcaggag ctcattttgc agctctcaag cttttatagc atgctgtaaa caattgtcaa
      541 agttgtttat caagaaacag atagagttgc aacttgtttc tagtaataga aacttttaca
      601 ctgcattcaa tgcctaacgt tgcagaaaca gaaaggtcaa atgattctgg aaatggtgag
      661 cacaaatctg agagaaagtc acctgaagag aatctacaag gtgctgtaaa atctttctgc
      721 acaagtgcct caggagcacc cttgggtccc aaaggagatg gtcattatcc atggagttgt
      781 ccagtgactc atacacggga aaaaatttat gccatctgtt cggactatgc ctttctcaac
      841 caggcgacct caatctataa aactccaaat ccatcccgct ctccttgcct ccctgatagt
      901 acctctttat ctgctggaaa taattcatca agatacattg gtatcccgac tagtacatcg
      961 gaaattatct acaatgaaga aaatagcttg gaaaacttat ccaacagcct gggcaagcta
     1021 cctctcgcat gggaaattga taaatctgaa tttgatgggg tgaccacaaa ttcgaaacac
     1081 aaatcaggca atgcaaagaa acaagtttcc aagagaaaaa cttcagataa aaagggaaga
     1141 tatcagaagg aatgtcctca gcattctcct cttgaagata ttaaacagcg gaaagtatta
     1201 gacctcagac gatggtactg cataagccga ccacagtata agacttcttg tggcatctct
     1261 tcattaattt cttgttggaa tttcttatac agcacaatgg gagctggaaa ccttccacct
     1321 attacccaag aagaagcttt acatattctg ggctttcaac ctccatttga agatattagg
     1381 tttggtcctt tcacggggaa tacaacactt atgaggtggt ttagacaaat taatgaccac
     1441 ttccatgtaa aaggatgctc ttatgttcta tataagcctc atgggaagaa taaaacagca
     1501 ggagaaactg cttcaggggc cctgtcaaag ttaacccgtg gattgaaaga tgaatcgctg
     1561 gcttatatct atcattgcca aaatcattat ttttgtccaa ttggcttcga agcaacccct
     1621 gttaaagcta ataaagcatt cagcagggga cctctctcac cacaggaagt tgaatattgg
     1681 atcttaattg gagaatcaag tagaaaacat cctgccattc actgtaaaaa atgggcagat
     1741 attgttactg atctaaacac tcaaaatcca gaatacctgg atatccggca cttagagagg
     1801 ggactgcagt atagaaaaac aaagaaggtt gggggaaatt tgcattgcat catagcattc
     1861 cagagactta actggcaaag atttggcctt tggaactttc catttggaac cattagacaa
     1921 gaatcacaac ctccaacaca tgcccaggga attgccaaat ctgagagtga agacaatatt
     1981 tccaagaagc agcatgggcg tctgggccgg tctttcagtg ctagtttcca tcaggactcg
     2041 gcatggaaaa agatgtctag tatccatgag agaaggaaca gtggttacca gggttacagt
     2101 gattacgatg ggaatgattg actatgcttg ctactgaaca gctggcatta tatatgaaac
     2161 tgctatatac aggactgtat aaagacagta gaagatttta gtaagcctac attaaatagg
     2221 agcagatctt gtggtataaa aaataacctt gtagttctcc agatactaag cttgtatatg
     2281 attatggtgg gtgatttcag atatataagc agataagcac agattattgt cctttcaagt
     2341 taagagtata taatctggac agaaaatttc acaaaattca ataaaattac aactgttgtc
     2401 taaataagtg aaacacaaat tcacttaata gcatcaagat ttgaaatact taagcatgaa
     2461 gtgactttta taatgactcg atccctagac atttgttaca gatagtttta tgcctaagac
     2521 caagatgtaa agtaccatct gcccttaaaa aaaattgggg ctgtcaattt ctagttttca
     2581 ctcatggtta acacgcattt aaaattattt catgagtcta gtagttcttt gatttatagc
     2641 aggatcttgc ttgcctcatt tgtttcctgg ttatgttctt aggattctga ctaagaggca
     2701 aaagagaaaa gactcaagaa actgatcctg gagatcgaga ccatcctggc taacatggtg
     2761 aaaccccgtc tctactaaac atacaaaaaa ttagccgggt gtagtggtgg gcacctgtag
     2821 tcctagctac tcgagaggct gaggcaggag aatggcgtga acccgggagg tggagcttgc
     2881 agtgagcgga gatcgcgcca ctgcactcca gcctgggcga cagggcaaga ctctgtctca
     2941 aaaaaaaaaa aaaaaaaaaa gacggatcct tttttttggt gcaaatgggt gacttagtgc
     3001 attgattcag atttttaaaa tttcttgatg tggtttgtaa taatcaaata ttgacaagaa
     3061 ccttaggtct cgaaagactt ttataagtct agatgacgtt tgccttaggg gtaaagtaaa
     3121 agaacaattg gcaccttaag tttctatacc caaggttatc tgtgaaatga gatctcctga
     3181 tatttgattg ctttctcagt atggagtcat atgttgataa cagtactgaa gatgcataag
     3241 aaatgcccaa gtcactcaga ggacaactac ccatattcca gactctgagc tgtttccttt
     3301 ttaaaaatca tatagacaat tagctgtttg aagtgagtat taaatatttc agaagtgtga
     3361 atttcatgta tttgagctcc tctagttgct gttggttttt cttctgctgc caacctgtga
     3421 ctcacaaatg actaggatct cttgttcttt aattttaggg tcttgttcca ggactcaaat
     3481 cagtaacttg gtgattacaa ggtgctgaat gtgttggtaa ccatatcgca atacacctca
     3541 aggaaaaggt tcagattttt atttttaaaa tattttcatt tttttcttga attttatatc
     3601 cgtttgttca ctcgtacatg cctagcctac agaaggggat atatattatg aaatggtcat
     3661 ttttctgaag agaatatttt gcttgaaatg caaaggactg aaagagattt gtaggttgtt
     3721 gattttgtta cttcatactg gaacttttaa aaagatttca tcaaataaag ttttgttttc
     3781 tacttttaa
//
