LOCUS       NM_139317               1334 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens baculoviral IAP repeat containing 7 (BIRC7),
            transcript variant 1, mRNA.
ACCESSION   NM_139317
VERSION     NM_139317.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1334)
  AUTHORS   Che,D., Li,Y., Hang,B., Li,K., Wang,K. and Wang,H.
  TITLE     Livin expression promotes keratinocyte release of inflammatory
            mediators in psoriasis
  JOURNAL   Skin Res Technol 30 (2), e13603 (2024)
   PUBMED   38332513
  REMARK    GeneRIF: Livin expression promotes keratinocyte release of
            inflammatory mediators in psoriasis.
REFERENCE   2  (bases 1 to 1334)
  AUTHORS   Wang,K., You,X., Qu,Z., Che,D. and Cao,X.
  TITLE     Livin is protective in UVB-induced skin photodamage by regulating
            keratinocyte activation and inflammatory responses
  JOURNAL   J Cell Mol Med 28 (4), e18124 (2024)
   PUBMED   38332512
  REMARK    GeneRIF: Livin is protective in UVB-induced skin photodamage by
            regulating keratinocyte activation and inflammatory responses.
REFERENCE   3  (bases 1 to 1334)
  AUTHORS   Ye,Z., Pan,J., Yin,Z., Wang,S., Li,Y., Cai,X., Zheng,H. and Cao,Z.
  TITLE     Dendritic cells infected with recombinant adenoviral vector
            encoding mouse fibroblast activation protein-alpha and human livin
            alpha exert an antitumor effect against Lewis lung carcinoma in
            mice
  JOURNAL   Immun Inflamm Dis 11 (9), e1011 (2023)
   PUBMED   37773704
  REMARK    GeneRIF: Dendritic cells infected with recombinant adenoviral
            vector encoding mouse fibroblast activation protein-alpha and human
            livin alpha exert an antitumor effect against Lewis lung carcinoma
            in mice.
REFERENCE   4  (bases 1 to 1334)
  AUTHORS   Zhang,Z., Zhang,Y., Lao,S., Qiu,J., Pan,Z. and Feng,X.
  TITLE     The clinicopathological and prognostic significances of IGF-1R and
            Livin expression in patients with colorectal cancer
  JOURNAL   BMC Cancer 22 (1), 855 (2022)
   PUBMED   35931997
  REMARK    GeneRIF: The clinicopathological and prognostic significances of
            IGF-1R and Livin expression in patients with colorectal cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1334)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1334)
  AUTHORS   Vucic,D., Deshayes,K., Ackerly,H., Pisabarro,M.T., Kadkhodayan,S.,
            Fairbrother,W.J. and Dixit,V.M.
  TITLE     SMAC negatively regulates the anti-apoptotic activity of melanoma
            inhibitor of apoptosis (ML-IAP)
  JOURNAL   J Biol Chem 277 (14), 12275-12279 (2002)
   PUBMED   11801603
  REMARK    GeneRIF: SMAC negatively regulates the anti-apoptotic activity of
            melanoma inhibitor of apoptosis (ML-IAP).
REFERENCE   7  (bases 1 to 1334)
  AUTHORS   Ashhab,Y., Alian,A., Polliack,A., Panet,A. and Ben Yehuda,D.
  TITLE     Two splicing variants of a new inhibitor of apoptosis gene with
            different biological properties and tissue distribution pattern
  JOURNAL   FEBS Lett 495 (1-2), 56-60 (2001)
   PUBMED   11322947
REFERENCE   8  (bases 1 to 1334)
  AUTHORS   Kasof,G.M. and Gomes,B.C.
  TITLE     Livin, a novel inhibitor of apoptosis protein family member
  JOURNAL   J Biol Chem 276 (5), 3238-3246 (2001)
   PUBMED   11024045
REFERENCE   9  (bases 1 to 1334)
  AUTHORS   Lin,J.H., Deng,G., Huang,Q. and Morser,J.
  TITLE     KIAP, a novel member of the inhibitor of apoptosis protein family
  JOURNAL   Biochem Biophys Res Commun 279 (3), 820-831 (2000)
   PUBMED   11162435
REFERENCE   10 (bases 1 to 1334)
  AUTHORS   Vucic,D., Stennicke,H.R., Pisabarro,M.T., Salvesen,G.S. and
            Dixit,V.M.
  TITLE     ML-IAP, a novel inhibitor of apoptosis that is preferentially
            expressed in human melanomas
  JOURNAL   Curr Biol 10 (21), 1359-1366 (2000)
   PUBMED   11084335
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY358836.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_139317.2.
            
            Summary: This gene encodes a member of the inhibitor of apoptosis
            protein (IAP) family, and contains a single copy of a baculovirus
            IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR
            domain is essential for inhibitory activity and interacts with
            caspases, while the RING finger domain sometimes enhances
            antiapoptotic activity but does not inhibit apoptosis alone.
            Elevated levels of the encoded protein may be associated with
            cancer progression and play a role in chemotherapy sensitivity.
            Alternative splicing results in multiple transcript variants
            [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (alpha). Isoform alpha protects cells from staurosporine-induced
            apoptosis.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358836.1, AF301009.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000217169.8/ ENSP00000217169.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1334              AY358836.1         23-1356
FEATURES             Location/Qualifiers
     source          1..1334
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..1334
                     /gene="BIRC7"
                     /gene_synonym="KIAP; LIVIN; ML-IAP; MLIAP; RNF50"
                     /note="baculoviral IAP repeat containing 7"
                     /db_xref="GeneID:79444"
                     /db_xref="HGNC:HGNC:13702"
                     /db_xref="MIM:605737"
     exon            1..541
                     /gene="BIRC7"
                     /gene_synonym="KIAP; LIVIN; ML-IAP; MLIAP; RNF50"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1089
                     /gene="BIRC7"
                     /gene_synonym="KIAP; LIVIN; ML-IAP; MLIAP; RNF50"
                     /EC_number="2.3.2.27"
                     /note="isoform alpha is encoded by transcript variant 1;
                     melanoma inhibitor of apoptosis protein; kidney inhibitor
                     of apoptosis protein; livin inhibitor of apoptosis;
                     RING-type E3 ubiquitin transferase BIRC7; RING finger
                     protein 50"
                     /codon_start=1
                     /product="baculoviral IAP repeat-containing protein 7
                     isoform alpha"
                     /protein_id="NP_647478.1"
                     /db_xref="CCDS:CCDS13513.1"
                     /db_xref="GeneID:79444"
                     /db_xref="HGNC:HGNC:13702"
                     /db_xref="MIM:605737"
                     /translation="MGPKDSAKCLHRGPQPSHWAAGDGPTQERCGPRSLGSPVLGLDT
                     CRAWDHVDGQILGQLRPLTEEEEEEGAGATLSRGPAFPGMGSEELRLASFYDWPLTAE
                     VPPELLAAAGFFHTGHQDKVRCFFCYGGLQSWKRGDDPWTEHAKWFPSCQFLLRSKGR
                     DFVHSVQETHSQLLGSWDPWEEPEDAAPVAPSVPASGYPELPTPRREVQSESAQEPGG
                     VSPAEAQRAWWVLEPPGARDVEAQLRRLQEERTCKVCLDRAVSIVFVPCGHLVCAECA
                     PGLQLCPICRAPVRSRVRTFLS"
     exon            542..641
                     /gene="BIRC7"
                     /gene_synonym="KIAP; LIVIN; ML-IAP; MLIAP; RNF50"
                     /inference="alignment:Splign:2.1.0"
     exon            642..723
                     /gene="BIRC7"
                     /gene_synonym="KIAP; LIVIN; ML-IAP; MLIAP; RNF50"
                     /inference="alignment:Splign:2.1.0"
     exon            724..769
                     /gene="BIRC7"
                     /gene_synonym="KIAP; LIVIN; ML-IAP; MLIAP; RNF50"
                     /inference="alignment:Splign:2.1.0"
     exon            770..841
                     /gene="BIRC7"
                     /gene_synonym="KIAP; LIVIN; ML-IAP; MLIAP; RNF50"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1094
                     /gene="BIRC7"
                     /gene_synonym="KIAP; LIVIN; ML-IAP; MLIAP; RNF50"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1334
                     /gene="BIRC7"
                     /gene_synonym="KIAP; LIVIN; ML-IAP; MLIAP; RNF50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1309..1314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BIRC7"
                     /gene_synonym="KIAP; LIVIN; ML-IAP; MLIAP; RNF50"
                     /note="hexamer: AATAAA"
     polyA_site      1334
                     /gene="BIRC7"
                     /gene_synonym="KIAP; LIVIN; ML-IAP; MLIAP; RNF50"
                     /note="major polyA site"
ORIGIN      
        1 acttccagaa agctgtgggc cctgggatac tcccctccca gggtgtctgg tggcaggcct
       61 gtgcctatcc ctgctgtccc cagggtgggc cccgggggtc aggagctcca gaagggccag
      121 ctgggcatat tctgagattg gccatcagcc cccatttctg ctgcaaacct ggtcagagcc
      181 agtgttccct ccatgggacc taaagacagt gccaagtgcc tgcaccgtgg accacagccg
      241 agccactggg cagccggtga tggtcccacg caggagcgct gtggaccccg ctctctgggc
      301 agccctgtcc taggcctgga cacctgcaga gcctgggacc acgtggatgg gcagatcctg
      361 ggccagctgc ggcccctgac agaggaggaa gaggaggagg gcgccggggc caccttgtcc
      421 agggggcctg ccttccccgg catgggctct gaggagttgc gtctggcctc cttctatgac
      481 tggccgctga ctgctgaggt gccacccgag ctgctggctg ctgccggctt cttccacaca
      541 ggccatcagg acaaggtgag gtgcttcttc tgctatgggg gcctgcagag ctggaagcgc
      601 ggggacgacc cctggacgga gcatgccaag tggttcccca gctgtcagtt cctgctccgg
      661 tcaaaaggaa gagactttgt ccacagtgtg caggagactc actcccagct gctgggctcc
      721 tgggacccgt gggaagaacc ggaagacgca gcccctgtgg ccccctccgt ccctgcctct
      781 gggtaccctg agctgcccac acccaggaga gaggtccagt ctgaaagtgc ccaggagcca
      841 ggaggggtca gtccagccga ggcccagagg gcgtggtggg ttcttgagcc cccaggagcc
      901 agggatgtgg aggcgcagct gcggcggctg caggaggaga ggacgtgcaa ggtgtgcctg
      961 gaccgcgccg tgtccatcgt ctttgtgccg tgcggccacc tggtctgtgc tgagtgtgcc
     1021 cccggcctgc agctgtgccc catctgcaga gcccccgtcc gcagccgcgt gcgcaccttc
     1081 ctgtcctagg ccaggtgcca tggccggcca ggtgggctgc agagtgggct ccctgcccct
     1141 ctctgcctgt tctggactgt gttctgggcc tgctgaggat ggcagagctg gtgtccatcc
     1201 agcactgacc agccctgatt ccccgaccac cgcccagggt ggagaaggag gcccttgctt
     1261 ggcgtggggg atggcttaac tgtacctgtt tggatgcttc tgaatagaaa taaagtgggt
     1321 tttccctgga ggta
//
